Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis

Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positiv...
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Autor*in:	Pettenuzzo, Tommaso [verfasserIn] Boscolo, Annalisa [verfasserIn] Pistollato, Elisa [verfasserIn] Pretto, Chiara [verfasserIn] Giacon, Tommaso Antonio [verfasserIn] Frasson, Sara [verfasserIn] Carbotti, Francesco Maria [verfasserIn] Medici, Francesca [verfasserIn] Pettenon, Giovanni [verfasserIn] Carofiglio, Giuliana [verfasserIn] Nardelli, Marco [verfasserIn] Cucci, Nicolas [verfasserIn] Tuccio, Clara Letizia [verfasserIn] Gagliardi, Veronica [verfasserIn] Schiavolin, Chiara [verfasserIn] Simoni, Caterina [verfasserIn] Congedi, Sabrina [verfasserIn] Monteleone, Francesco [verfasserIn] Zarantonello, Francesco [verfasserIn] Sella, Nicolò [verfasserIn] De Cassai, Alessandro [verfasserIn] Navalesi, Paolo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Conventional oxygen therapy Continuous positive airway pressure High-flow nasal oxygen Non-invasive ventilation General anesthesia Extubation Post-operative respiratory failure

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Critical care - BioMed Central, 1997, 28(2024), 1 vom: 08. Mai
Übergeordnetes Werk:	volume:28 ; year:2024 ; number:1 ; day:08 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s13054-024-04924-0

Katalog-ID:	SPR055785743

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520			\|a Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure.
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700	1		\|a Giacon, Tommaso Antonio \|e verfasserin \|4 aut
700	1		\|a Frasson, Sara \|e verfasserin \|4 aut
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allfields	10.1186/s13054-024-04924-0 doi (DE-627)SPR055785743 (SPR)s13054-024-04924-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pettenuzzo, Tommaso verfasserin aut Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213 Boscolo, Annalisa verfasserin aut Pistollato, Elisa verfasserin aut Pretto, Chiara verfasserin aut Giacon, Tommaso Antonio verfasserin aut Frasson, Sara verfasserin aut Carbotti, Francesco Maria verfasserin aut Medici, Francesca verfasserin aut Pettenon, Giovanni verfasserin aut Carofiglio, Giuliana verfasserin aut Nardelli, Marco verfasserin aut Cucci, Nicolas verfasserin aut Tuccio, Clara Letizia verfasserin aut Gagliardi, Veronica verfasserin aut Schiavolin, Chiara verfasserin aut Simoni, Caterina verfasserin aut Congedi, Sabrina verfasserin aut Monteleone, Francesco verfasserin aut Zarantonello, Francesco verfasserin aut Sella, Nicolò verfasserin aut De Cassai, Alessandro verfasserin aut Navalesi, Paolo verfasserin aut Enthalten in Critical care BioMed Central, 1997 28(2024), 1 vom: 08. Mai (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:28 year:2024 number:1 day:08 month:05 https://dx.doi.org/10.1186/s13054-024-04924-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 28 2024 1 08 05
spelling	10.1186/s13054-024-04924-0 doi (DE-627)SPR055785743 (SPR)s13054-024-04924-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pettenuzzo, Tommaso verfasserin aut Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213 Boscolo, Annalisa verfasserin aut Pistollato, Elisa verfasserin aut Pretto, Chiara verfasserin aut Giacon, Tommaso Antonio verfasserin aut Frasson, Sara verfasserin aut Carbotti, Francesco Maria verfasserin aut Medici, Francesca verfasserin aut Pettenon, Giovanni verfasserin aut Carofiglio, Giuliana verfasserin aut Nardelli, Marco verfasserin aut Cucci, Nicolas verfasserin aut Tuccio, Clara Letizia verfasserin aut Gagliardi, Veronica verfasserin aut Schiavolin, Chiara verfasserin aut Simoni, Caterina verfasserin aut Congedi, Sabrina verfasserin aut Monteleone, Francesco verfasserin aut Zarantonello, Francesco verfasserin aut Sella, Nicolò verfasserin aut De Cassai, Alessandro verfasserin aut Navalesi, Paolo verfasserin aut Enthalten in Critical care BioMed Central, 1997 28(2024), 1 vom: 08. Mai (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:28 year:2024 number:1 day:08 month:05 https://dx.doi.org/10.1186/s13054-024-04924-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 28 2024 1 08 05
allfields_unstemmed	10.1186/s13054-024-04924-0 doi (DE-627)SPR055785743 (SPR)s13054-024-04924-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pettenuzzo, Tommaso verfasserin aut Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213 Boscolo, Annalisa verfasserin aut Pistollato, Elisa verfasserin aut Pretto, Chiara verfasserin aut Giacon, Tommaso Antonio verfasserin aut Frasson, Sara verfasserin aut Carbotti, Francesco Maria verfasserin aut Medici, Francesca verfasserin aut Pettenon, Giovanni verfasserin aut Carofiglio, Giuliana verfasserin aut Nardelli, Marco verfasserin aut Cucci, Nicolas verfasserin aut Tuccio, Clara Letizia verfasserin aut Gagliardi, Veronica verfasserin aut Schiavolin, Chiara verfasserin aut Simoni, Caterina verfasserin aut Congedi, Sabrina verfasserin aut Monteleone, Francesco verfasserin aut Zarantonello, Francesco verfasserin aut Sella, Nicolò verfasserin aut De Cassai, Alessandro verfasserin aut Navalesi, Paolo verfasserin aut Enthalten in Critical care BioMed Central, 1997 28(2024), 1 vom: 08. Mai (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:28 year:2024 number:1 day:08 month:05 https://dx.doi.org/10.1186/s13054-024-04924-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 28 2024 1 08 05
allfieldsGer	10.1186/s13054-024-04924-0 doi (DE-627)SPR055785743 (SPR)s13054-024-04924-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pettenuzzo, Tommaso verfasserin aut Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213 Boscolo, Annalisa verfasserin aut Pistollato, Elisa verfasserin aut Pretto, Chiara verfasserin aut Giacon, Tommaso Antonio verfasserin aut Frasson, Sara verfasserin aut Carbotti, Francesco Maria verfasserin aut Medici, Francesca verfasserin aut Pettenon, Giovanni verfasserin aut Carofiglio, Giuliana verfasserin aut Nardelli, Marco verfasserin aut Cucci, Nicolas verfasserin aut Tuccio, Clara Letizia verfasserin aut Gagliardi, Veronica verfasserin aut Schiavolin, Chiara verfasserin aut Simoni, Caterina verfasserin aut Congedi, Sabrina verfasserin aut Monteleone, Francesco verfasserin aut Zarantonello, Francesco verfasserin aut Sella, Nicolò verfasserin aut De Cassai, Alessandro verfasserin aut Navalesi, Paolo verfasserin aut Enthalten in Critical care BioMed Central, 1997 28(2024), 1 vom: 08. Mai (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:28 year:2024 number:1 day:08 month:05 https://dx.doi.org/10.1186/s13054-024-04924-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 28 2024 1 08 05
allfieldsSound	10.1186/s13054-024-04924-0 doi (DE-627)SPR055785743 (SPR)s13054-024-04924-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pettenuzzo, Tommaso verfasserin aut Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213 Boscolo, Annalisa verfasserin aut Pistollato, Elisa verfasserin aut Pretto, Chiara verfasserin aut Giacon, Tommaso Antonio verfasserin aut Frasson, Sara verfasserin aut Carbotti, Francesco Maria verfasserin aut Medici, Francesca verfasserin aut Pettenon, Giovanni verfasserin aut Carofiglio, Giuliana verfasserin aut Nardelli, Marco verfasserin aut Cucci, Nicolas verfasserin aut Tuccio, Clara Letizia verfasserin aut Gagliardi, Veronica verfasserin aut Schiavolin, Chiara verfasserin aut Simoni, Caterina verfasserin aut Congedi, Sabrina verfasserin aut Monteleone, Francesco verfasserin aut Zarantonello, Francesco verfasserin aut Sella, Nicolò verfasserin aut De Cassai, Alessandro verfasserin aut Navalesi, Paolo verfasserin aut Enthalten in Critical care BioMed Central, 1997 28(2024), 1 vom: 08. Mai (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:28 year:2024 number:1 day:08 month:05 https://dx.doi.org/10.1186/s13054-024-04924-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 28 2024 1 08 05
language	English
source	Enthalten in Critical care 28(2024), 1 vom: 08. Mai volume:28 year:2024 number:1 day:08 month:05
sourceStr	Enthalten in Critical care 28(2024), 1 vom: 08. Mai volume:28 year:2024 number:1 day:08 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Conventional oxygen therapy Continuous positive airway pressure High-flow nasal oxygen Non-invasive ventilation General anesthesia Extubation Post-operative respiratory failure
dewey-raw	610
isfreeaccess_bool	true
container_title	Critical care
authorswithroles_txt_mv	Pettenuzzo, Tommaso @@aut@@ Boscolo, Annalisa @@aut@@ Pistollato, Elisa @@aut@@ Pretto, Chiara @@aut@@ Giacon, Tommaso Antonio @@aut@@ Frasson, Sara @@aut@@ Carbotti, Francesco Maria @@aut@@ Medici, Francesca @@aut@@ Pettenon, Giovanni @@aut@@ Carofiglio, Giuliana @@aut@@ Nardelli, Marco @@aut@@ Cucci, Nicolas @@aut@@ Tuccio, Clara Letizia @@aut@@ Gagliardi, Veronica @@aut@@ Schiavolin, Chiara @@aut@@ Simoni, Caterina @@aut@@ Congedi, Sabrina @@aut@@ Monteleone, Francesco @@aut@@ Zarantonello, Francesco @@aut@@ Sella, Nicolò @@aut@@ De Cassai, Alessandro @@aut@@ Navalesi, Paolo @@aut@@
publishDateDaySort_date	2024-05-08T00:00:00Z
hierarchy_top_id	331258269
dewey-sort	3610
id	SPR055785743
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR055785743</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240509064646.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240509s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13054-024-04924-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR055785743</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13054-024-04924-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Pettenuzzo, Tommaso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Conventional oxygen therapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Continuous positive airway pressure</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">High-flow nasal oxygen</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Non-invasive ventilation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">General anesthesia</subfield><subfield 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author	Pettenuzzo, Tommaso
spellingShingle	Pettenuzzo, Tommaso ddc 610 bkl 44.00 misc Conventional oxygen therapy misc Continuous positive airway pressure misc High-flow nasal oxygen misc Non-invasive ventilation misc General anesthesia misc Extubation misc Post-operative respiratory failure Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
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topic_title	610 VZ 44.00 bkl Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis Conventional oxygen therapy (dpeaa)DE-He213 Continuous positive airway pressure (dpeaa)DE-He213 High-flow nasal oxygen (dpeaa)DE-He213 Non-invasive ventilation (dpeaa)DE-He213 General anesthesia (dpeaa)DE-He213 Extubation (dpeaa)DE-He213 Post-operative respiratory failure (dpeaa)DE-He213
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title	Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
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title_full	Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
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author_browse	Pettenuzzo, Tommaso Boscolo, Annalisa Pistollato, Elisa Pretto, Chiara Giacon, Tommaso Antonio Frasson, Sara Carbotti, Francesco Maria Medici, Francesca Pettenon, Giovanni Carofiglio, Giuliana Nardelli, Marco Cucci, Nicolas Tuccio, Clara Letizia Gagliardi, Veronica Schiavolin, Chiara Simoni, Caterina Congedi, Sabrina Monteleone, Francesco Zarantonello, Francesco Sella, Nicolò De Cassai, Alessandro Navalesi, Paolo
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title_sort	effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
title_auth	Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
abstract	Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. © The Author(s) 2024
abstractGer	Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. © The Author(s) 2024
abstract_unstemmed	Background Re-intubation secondary to post-extubation respiratory failure in post-operative patients is associated with increased patient morbidity and mortality. Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. Conclusions In post-operative patients receiving NRS after extubation, NIV reduced the rate of re-intubation, compared to COT, when used for treatment of post-extubation respiratory failure and in patients at high risk of post-extubation respiratory failure. © The Author(s) 2024
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title_short	Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis
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Non-invasive respiratory support (NRS) alternative to conventional oxygen therapy (COT), i.e., high-flow nasal oxygen, continuous positive airway pressure, and non-invasive ventilation (NIV), has been proposed to prevent or treat post-extubation respiratory failure. Aim of the present study is assessing the effects of NRS application, compared to COT, on the re-intubation rate (primary outcome), and time to re-intubation, incidence of nosocomial pneumonia, patient discomfort, intensive care unit (ICU) and hospital length of stay, and mortality (secondary outcomes) in adult patients extubated after surgery. Methods A systematic review and network meta-analysis of randomized and non-randomized controlled trials. A search from Medline, Embase, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science from inception until February 2, 2024 was performed. Results Thirty-three studies (11,292 patients) were included. Among all NRS modalities, only NIV reduced the re-intubation rate, compared to COT (odds ratio 0.49, 95% confidence interval 0.28; 0.87, p = 0.015, $ I^{2} $ = 60.5%, low certainty of evidence). In particular, this effect was observed in patients receiving NIV for treatment, while not for prevention, of post-extubation respiratory failure, and in patients at high, while not low, risk of post-extubation respiratory failure. NIV reduced the rate of nosocomial pneumonia, ICU length of stay, and ICU, hospital, and long-term mortality, while not worsening patient discomfort. 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Effects of non-invasive respiratory support in post-operative patients: a systematic review and network meta-analysis

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