Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study
Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clin...
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Gespeichert in:
| Autor*in: |
Lochmann, Mathilde [verfasserIn] Girodet, Magali [verfasserIn] Despax, Johanna [verfasserIn] Baudry, Valentine [verfasserIn] Duranti, Julie [verfasserIn] Mastroianni, Bénédicte [verfasserIn] Vanacker, Hélène [verfasserIn] Vinceneux, Armelle [verfasserIn] Brahmi, Mehdi [verfasserIn] Renard, Olivier [verfasserIn] Verlingue, Loïc [verfasserIn] Amini-Adle, Mona [verfasserIn] Swalduz, Aurélie [verfasserIn] Gautier, Julien [verfasserIn] Ducimetière, Françoise [verfasserIn] Anota, Amélie [verfasserIn] Cassier, Philippe A. [verfasserIn] Chvetzoff, Gisèle [verfasserIn] Christophe, Véronique [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Supportive care in cancer - Springer Berlin Heidelberg, 1993, 32(2024), 6 vom: 15. Mai |
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| Übergeordnetes Werk: |
volume:32 ; year:2024 ; number:6 ; day:15 ; month:05 |
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| DOI / URN: |
10.1007/s00520-024-08535-x |
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SPR055858597 |
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| 245 | 1 | 0 | |a Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study |
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| 520 | |a Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. | ||
| 650 | 4 | |a Doctor-patient communication |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Early-phase clinical trial |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Early palliative care |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Motives |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Girodet, Magali |e verfasserin |4 aut | |
| 700 | 1 | |a Despax, Johanna |e verfasserin |4 aut | |
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| 700 | 1 | |a Duranti, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Mastroianni, Bénédicte |e verfasserin |4 aut | |
| 700 | 1 | |a Vanacker, Hélène |e verfasserin |4 aut | |
| 700 | 1 | |a Vinceneux, Armelle |e verfasserin |4 aut | |
| 700 | 1 | |a Brahmi, Mehdi |e verfasserin |4 aut | |
| 700 | 1 | |a Renard, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Verlingue, Loïc |e verfasserin |4 aut | |
| 700 | 1 | |a Amini-Adle, Mona |e verfasserin |4 aut | |
| 700 | 1 | |a Swalduz, Aurélie |e verfasserin |4 aut | |
| 700 | 1 | |a Gautier, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Ducimetière, Françoise |e verfasserin |4 aut | |
| 700 | 1 | |a Anota, Amélie |e verfasserin |4 aut | |
| 700 | 1 | |a Cassier, Philippe A. |e verfasserin |4 aut | |
| 700 | 1 | |a Chvetzoff, Gisèle |e verfasserin |4 aut | |
| 700 | 1 | |a Christophe, Véronique |e verfasserin |4 aut | |
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10.1007/s00520-024-08535-x doi (DE-627)SPR055858597 (SPR)s00520-024-08535-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.81 bkl Lochmann, Mathilde verfasserin aut Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. Doctor-patient communication (dpeaa)DE-He213 Early-phase clinical trial (dpeaa)DE-He213 Early palliative care (dpeaa)DE-He213 Motives (dpeaa)DE-He213 Oncology mixed management (dpeaa)DE-He213 Girodet, Magali verfasserin aut Despax, Johanna verfasserin aut Baudry, Valentine verfasserin aut Duranti, Julie verfasserin aut Mastroianni, Bénédicte verfasserin aut Vanacker, Hélène verfasserin aut Vinceneux, Armelle verfasserin aut Brahmi, Mehdi verfasserin aut Renard, Olivier verfasserin aut Verlingue, Loïc verfasserin aut Amini-Adle, Mona verfasserin aut Swalduz, Aurélie verfasserin aut Gautier, Julien verfasserin aut Ducimetière, Françoise verfasserin aut Anota, Amélie verfasserin aut Cassier, Philippe A. verfasserin aut Chvetzoff, Gisèle verfasserin aut Christophe, Véronique verfasserin aut Enthalten in Supportive care in cancer Springer Berlin Heidelberg, 1993 32(2024), 6 vom: 15. Mai (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:32 year:2024 number:6 day:15 month:05 https://dx.doi.org/10.1007/s00520-024-08535-x X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 VZ AR 32 2024 6 15 05 |
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10.1007/s00520-024-08535-x doi (DE-627)SPR055858597 (SPR)s00520-024-08535-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.81 bkl Lochmann, Mathilde verfasserin aut Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. Doctor-patient communication (dpeaa)DE-He213 Early-phase clinical trial (dpeaa)DE-He213 Early palliative care (dpeaa)DE-He213 Motives (dpeaa)DE-He213 Oncology mixed management (dpeaa)DE-He213 Girodet, Magali verfasserin aut Despax, Johanna verfasserin aut Baudry, Valentine verfasserin aut Duranti, Julie verfasserin aut Mastroianni, Bénédicte verfasserin aut Vanacker, Hélène verfasserin aut Vinceneux, Armelle verfasserin aut Brahmi, Mehdi verfasserin aut Renard, Olivier verfasserin aut Verlingue, Loïc verfasserin aut Amini-Adle, Mona verfasserin aut Swalduz, Aurélie verfasserin aut Gautier, Julien verfasserin aut Ducimetière, Françoise verfasserin aut Anota, Amélie verfasserin aut Cassier, Philippe A. verfasserin aut Chvetzoff, Gisèle verfasserin aut Christophe, Véronique verfasserin aut Enthalten in Supportive care in cancer Springer Berlin Heidelberg, 1993 32(2024), 6 vom: 15. Mai (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:32 year:2024 number:6 day:15 month:05 https://dx.doi.org/10.1007/s00520-024-08535-x X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 VZ AR 32 2024 6 15 05 |
| allfields_unstemmed |
10.1007/s00520-024-08535-x doi (DE-627)SPR055858597 (SPR)s00520-024-08535-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.81 bkl Lochmann, Mathilde verfasserin aut Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. Doctor-patient communication (dpeaa)DE-He213 Early-phase clinical trial (dpeaa)DE-He213 Early palliative care (dpeaa)DE-He213 Motives (dpeaa)DE-He213 Oncology mixed management (dpeaa)DE-He213 Girodet, Magali verfasserin aut Despax, Johanna verfasserin aut Baudry, Valentine verfasserin aut Duranti, Julie verfasserin aut Mastroianni, Bénédicte verfasserin aut Vanacker, Hélène verfasserin aut Vinceneux, Armelle verfasserin aut Brahmi, Mehdi verfasserin aut Renard, Olivier verfasserin aut Verlingue, Loïc verfasserin aut Amini-Adle, Mona verfasserin aut Swalduz, Aurélie verfasserin aut Gautier, Julien verfasserin aut Ducimetière, Françoise verfasserin aut Anota, Amélie verfasserin aut Cassier, Philippe A. verfasserin aut Chvetzoff, Gisèle verfasserin aut Christophe, Véronique verfasserin aut Enthalten in Supportive care in cancer Springer Berlin Heidelberg, 1993 32(2024), 6 vom: 15. Mai (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:32 year:2024 number:6 day:15 month:05 https://dx.doi.org/10.1007/s00520-024-08535-x X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 VZ AR 32 2024 6 15 05 |
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10.1007/s00520-024-08535-x doi (DE-627)SPR055858597 (SPR)s00520-024-08535-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.81 bkl Lochmann, Mathilde verfasserin aut Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. Doctor-patient communication (dpeaa)DE-He213 Early-phase clinical trial (dpeaa)DE-He213 Early palliative care (dpeaa)DE-He213 Motives (dpeaa)DE-He213 Oncology mixed management (dpeaa)DE-He213 Girodet, Magali verfasserin aut Despax, Johanna verfasserin aut Baudry, Valentine verfasserin aut Duranti, Julie verfasserin aut Mastroianni, Bénédicte verfasserin aut Vanacker, Hélène verfasserin aut Vinceneux, Armelle verfasserin aut Brahmi, Mehdi verfasserin aut Renard, Olivier verfasserin aut Verlingue, Loïc verfasserin aut Amini-Adle, Mona verfasserin aut Swalduz, Aurélie verfasserin aut Gautier, Julien verfasserin aut Ducimetière, Françoise verfasserin aut Anota, Amélie verfasserin aut Cassier, Philippe A. verfasserin aut Chvetzoff, Gisèle verfasserin aut Christophe, Véronique verfasserin aut Enthalten in Supportive care in cancer Springer Berlin Heidelberg, 1993 32(2024), 6 vom: 15. Mai (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:32 year:2024 number:6 day:15 month:05 https://dx.doi.org/10.1007/s00520-024-08535-x X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 VZ AR 32 2024 6 15 05 |
| allfieldsSound |
10.1007/s00520-024-08535-x doi (DE-627)SPR055858597 (SPR)s00520-024-08535-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.81 bkl Lochmann, Mathilde verfasserin aut Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. Doctor-patient communication (dpeaa)DE-He213 Early-phase clinical trial (dpeaa)DE-He213 Early palliative care (dpeaa)DE-He213 Motives (dpeaa)DE-He213 Oncology mixed management (dpeaa)DE-He213 Girodet, Magali verfasserin aut Despax, Johanna verfasserin aut Baudry, Valentine verfasserin aut Duranti, Julie verfasserin aut Mastroianni, Bénédicte verfasserin aut Vanacker, Hélène verfasserin aut Vinceneux, Armelle verfasserin aut Brahmi, Mehdi verfasserin aut Renard, Olivier verfasserin aut Verlingue, Loïc verfasserin aut Amini-Adle, Mona verfasserin aut Swalduz, Aurélie verfasserin aut Gautier, Julien verfasserin aut Ducimetière, Françoise verfasserin aut Anota, Amélie verfasserin aut Cassier, Philippe A. verfasserin aut Chvetzoff, Gisèle verfasserin aut Christophe, Véronique verfasserin aut Enthalten in Supportive care in cancer Springer Berlin Heidelberg, 1993 32(2024), 6 vom: 15. Mai (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:32 year:2024 number:6 day:15 month:05 https://dx.doi.org/10.1007/s00520-024-08535-x X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 VZ AR 32 2024 6 15 05 |
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Enthalten in Supportive care in cancer 32(2024), 6 vom: 15. Mai volume:32 year:2024 number:6 day:15 month:05 |
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Enthalten in Supportive care in cancer 32(2024), 6 vom: 15. Mai volume:32 year:2024 number:6 day:15 month:05 |
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Doctor-patient communication Early-phase clinical trial Early palliative care Motives Oncology mixed management |
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Supportive care in cancer |
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Lochmann, Mathilde @@aut@@ Girodet, Magali @@aut@@ Despax, Johanna @@aut@@ Baudry, Valentine @@aut@@ Duranti, Julie @@aut@@ Mastroianni, Bénédicte @@aut@@ Vanacker, Hélène @@aut@@ Vinceneux, Armelle @@aut@@ Brahmi, Mehdi @@aut@@ Renard, Olivier @@aut@@ Verlingue, Loïc @@aut@@ Amini-Adle, Mona @@aut@@ Swalduz, Aurélie @@aut@@ Gautier, Julien @@aut@@ Ducimetière, Françoise @@aut@@ Anota, Amélie @@aut@@ Cassier, Philippe A. @@aut@@ Chvetzoff, Gisèle @@aut@@ Christophe, Véronique @@aut@@ |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. 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| author |
Lochmann, Mathilde |
| spellingShingle |
Lochmann, Mathilde ddc 610 bkl 44.81 misc Doctor-patient communication misc Early-phase clinical trial misc Early palliative care misc Motives misc Oncology mixed management Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study |
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Lochmann, Mathilde |
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610 - Medicine & health |
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Lochmann, Mathilde Girodet, Magali Despax, Johanna Baudry, Valentine Duranti, Julie Mastroianni, Bénédicte Vanacker, Hélène Vinceneux, Armelle Brahmi, Mehdi Renard, Olivier Verlingue, Loïc Amini-Adle, Mona Swalduz, Aurélie Gautier, Julien Ducimetière, Françoise Anota, Amélie Cassier, Philippe A. Chvetzoff, Gisèle Christophe, Véronique |
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qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a french comprehensive cancer center: the palpha study |
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Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study |
| abstract |
Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Purpose The integration of palliative care (PC) into oncological management is recommended well before the end of life. It improves quality of life and symptom control and reduces the aggressiveness of end-of-life care. However, its appropriate timing is still debated. Entry into an early-phase clinical trial (ECT) represents hopes for the patient when standard treatments have failed. It is an opportune moment to integrate PC to preserve the patient’s general health status. The objective of this study was to evaluate the motives for acceptance or refusal of early PC management in patients included in an ECT. Methods Patients eligible to enter an ECT were identified and concomitant PC was proposed. All patients received exploratory interviews conducted by a researcher. Their contents were analyzed in a double-blind thematic analysis with a self-determination model. Results Motives for acceptance (PC acceptors: n = 27) were both intrinsic (e.g., pain relief, psychological support, anticipation of the future) and extrinsic (e.g., trust in the medical profession, for a relative, to support the advance of research). Motives for refusal (PC refusers: n = 3) were solely intrinsic (e.g., PC associated with death, negative representation of psychological support, no need for additional care, claim of independence). Conclusions The motives of acceptors and refusers are not internalized in the same way and call for different autonomy needs. Acceptors and refusers are influenced by opposite representations of PC and a different perception of mixed management. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| score |
7.400522 |