A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome
Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a co...
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| Autor*in: |
Lanza, Giuseppe [verfasserIn] Mogavero, Maria P. [verfasserIn] Lanuzza, Bartolo [verfasserIn] Tripodi, Mariangela [verfasserIn] Cantone, Mariagiovanna [verfasserIn] Pennisi, Manuela [verfasserIn] Bella, Rita [verfasserIn] Ferri, Raffaele [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Current sleep medicine reports - Springer International Publishing, 2015, 10(2024), 2 vom: 05. Feb., Seite 207-216 |
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| Übergeordnetes Werk: |
volume:10 ; year:2024 ; number:2 ; day:05 ; month:02 ; pages:207-216 |
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| DOI / URN: |
10.1007/s40675-024-00282-z |
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SPR055870856 |
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| 520 | |a Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. | ||
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10.1007/s40675-024-00282-z doi (DE-627)SPR055870856 (SPR)s40675-024-00282-z-e DE-627 ger DE-627 rakwb eng 610 VZ Lanza, Giuseppe verfasserin (orcid)0000-0002-5659-662X aut A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. Sleep disorders (dpeaa)DE-He213 Restless legs syndrome (dpeaa)DE-He213 Transcranial magnetic stimulation (dpeaa)DE-He213 Cortical excitability (dpeaa)DE-He213 Cortico-spinal conductivity (dpeaa)DE-He213 Neuromodulation (dpeaa)DE-He213 Mogavero, Maria P. verfasserin (orcid)0000-0001-6662-2281 aut Lanuzza, Bartolo verfasserin (orcid)0000-0001-8404-1480 aut Tripodi, Mariangela verfasserin (orcid)0000-0002-5703-299X aut Cantone, Mariagiovanna verfasserin (orcid)0000-0002-9072-4971 aut Pennisi, Manuela verfasserin (orcid)0000-0003-0776-1411 aut Bella, Rita verfasserin (orcid)0000-0001-8332-6863 aut Ferri, Raffaele verfasserin (orcid)0000-0001-6937-3065 aut Enthalten in Current sleep medicine reports Springer International Publishing, 2015 10(2024), 2 vom: 05. Feb., Seite 207-216 (DE-627)81591394X (DE-600)2806592-X 2198-6401 nnns volume:10 year:2024 number:2 day:05 month:02 pages:207-216 https://dx.doi.org/10.1007/s40675-024-00282-z X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2024 2 05 02 207-216 |
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10.1007/s40675-024-00282-z doi (DE-627)SPR055870856 (SPR)s40675-024-00282-z-e DE-627 ger DE-627 rakwb eng 610 VZ Lanza, Giuseppe verfasserin (orcid)0000-0002-5659-662X aut A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. Sleep disorders (dpeaa)DE-He213 Restless legs syndrome (dpeaa)DE-He213 Transcranial magnetic stimulation (dpeaa)DE-He213 Cortical excitability (dpeaa)DE-He213 Cortico-spinal conductivity (dpeaa)DE-He213 Neuromodulation (dpeaa)DE-He213 Mogavero, Maria P. verfasserin (orcid)0000-0001-6662-2281 aut Lanuzza, Bartolo verfasserin (orcid)0000-0001-8404-1480 aut Tripodi, Mariangela verfasserin (orcid)0000-0002-5703-299X aut Cantone, Mariagiovanna verfasserin (orcid)0000-0002-9072-4971 aut Pennisi, Manuela verfasserin (orcid)0000-0003-0776-1411 aut Bella, Rita verfasserin (orcid)0000-0001-8332-6863 aut Ferri, Raffaele verfasserin (orcid)0000-0001-6937-3065 aut Enthalten in Current sleep medicine reports Springer International Publishing, 2015 10(2024), 2 vom: 05. Feb., Seite 207-216 (DE-627)81591394X (DE-600)2806592-X 2198-6401 nnns volume:10 year:2024 number:2 day:05 month:02 pages:207-216 https://dx.doi.org/10.1007/s40675-024-00282-z X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2024 2 05 02 207-216 |
| allfields_unstemmed |
10.1007/s40675-024-00282-z doi (DE-627)SPR055870856 (SPR)s40675-024-00282-z-e DE-627 ger DE-627 rakwb eng 610 VZ Lanza, Giuseppe verfasserin (orcid)0000-0002-5659-662X aut A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. Sleep disorders (dpeaa)DE-He213 Restless legs syndrome (dpeaa)DE-He213 Transcranial magnetic stimulation (dpeaa)DE-He213 Cortical excitability (dpeaa)DE-He213 Cortico-spinal conductivity (dpeaa)DE-He213 Neuromodulation (dpeaa)DE-He213 Mogavero, Maria P. verfasserin (orcid)0000-0001-6662-2281 aut Lanuzza, Bartolo verfasserin (orcid)0000-0001-8404-1480 aut Tripodi, Mariangela verfasserin (orcid)0000-0002-5703-299X aut Cantone, Mariagiovanna verfasserin (orcid)0000-0002-9072-4971 aut Pennisi, Manuela verfasserin (orcid)0000-0003-0776-1411 aut Bella, Rita verfasserin (orcid)0000-0001-8332-6863 aut Ferri, Raffaele verfasserin (orcid)0000-0001-6937-3065 aut Enthalten in Current sleep medicine reports Springer International Publishing, 2015 10(2024), 2 vom: 05. Feb., Seite 207-216 (DE-627)81591394X (DE-600)2806592-X 2198-6401 nnns volume:10 year:2024 number:2 day:05 month:02 pages:207-216 https://dx.doi.org/10.1007/s40675-024-00282-z X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2024 2 05 02 207-216 |
| allfieldsGer |
10.1007/s40675-024-00282-z doi (DE-627)SPR055870856 (SPR)s40675-024-00282-z-e DE-627 ger DE-627 rakwb eng 610 VZ Lanza, Giuseppe verfasserin (orcid)0000-0002-5659-662X aut A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. Sleep disorders (dpeaa)DE-He213 Restless legs syndrome (dpeaa)DE-He213 Transcranial magnetic stimulation (dpeaa)DE-He213 Cortical excitability (dpeaa)DE-He213 Cortico-spinal conductivity (dpeaa)DE-He213 Neuromodulation (dpeaa)DE-He213 Mogavero, Maria P. verfasserin (orcid)0000-0001-6662-2281 aut Lanuzza, Bartolo verfasserin (orcid)0000-0001-8404-1480 aut Tripodi, Mariangela verfasserin (orcid)0000-0002-5703-299X aut Cantone, Mariagiovanna verfasserin (orcid)0000-0002-9072-4971 aut Pennisi, Manuela verfasserin (orcid)0000-0003-0776-1411 aut Bella, Rita verfasserin (orcid)0000-0001-8332-6863 aut Ferri, Raffaele verfasserin (orcid)0000-0001-6937-3065 aut Enthalten in Current sleep medicine reports Springer International Publishing, 2015 10(2024), 2 vom: 05. Feb., Seite 207-216 (DE-627)81591394X (DE-600)2806592-X 2198-6401 nnns volume:10 year:2024 number:2 day:05 month:02 pages:207-216 https://dx.doi.org/10.1007/s40675-024-00282-z X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2024 2 05 02 207-216 |
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10.1007/s40675-024-00282-z doi (DE-627)SPR055870856 (SPR)s40675-024-00282-z-e DE-627 ger DE-627 rakwb eng 610 VZ Lanza, Giuseppe verfasserin (orcid)0000-0002-5659-662X aut A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. Sleep disorders (dpeaa)DE-He213 Restless legs syndrome (dpeaa)DE-He213 Transcranial magnetic stimulation (dpeaa)DE-He213 Cortical excitability (dpeaa)DE-He213 Cortico-spinal conductivity (dpeaa)DE-He213 Neuromodulation (dpeaa)DE-He213 Mogavero, Maria P. verfasserin (orcid)0000-0001-6662-2281 aut Lanuzza, Bartolo verfasserin (orcid)0000-0001-8404-1480 aut Tripodi, Mariangela verfasserin (orcid)0000-0002-5703-299X aut Cantone, Mariagiovanna verfasserin (orcid)0000-0002-9072-4971 aut Pennisi, Manuela verfasserin (orcid)0000-0003-0776-1411 aut Bella, Rita verfasserin (orcid)0000-0001-8332-6863 aut Ferri, Raffaele verfasserin (orcid)0000-0001-6937-3065 aut Enthalten in Current sleep medicine reports Springer International Publishing, 2015 10(2024), 2 vom: 05. Feb., Seite 207-216 (DE-627)81591394X (DE-600)2806592-X 2198-6401 nnns volume:10 year:2024 number:2 day:05 month:02 pages:207-216 https://dx.doi.org/10.1007/s40675-024-00282-z X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_266 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 10 2024 2 05 02 207-216 |
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Sleep disorders Restless legs syndrome Transcranial magnetic stimulation Cortical excitability Cortico-spinal conductivity Neuromodulation |
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Lanza, Giuseppe @@aut@@ Mogavero, Maria P. @@aut@@ Lanuzza, Bartolo @@aut@@ Tripodi, Mariangela @@aut@@ Cantone, Mariagiovanna @@aut@@ Pennisi, Manuela @@aut@@ Bella, Rita @@aut@@ Ferri, Raffaele @@aut@@ |
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a topical review on transcranial magnetic stimulation in restless legs syndrome |
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A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome |
| abstract |
Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. By examining all these aspects, the review sheds light on the promise and limitations of applying TMS in the diagnostic refinement and therapeutic management of RLS. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR055870856</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240516064742.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240516s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40675-024-00282-z</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR055870856</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40675-024-00282-z-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lanza, Giuseppe</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-5659-662X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">A Topical Review on Transcranial Magnetic Stimulation in Restless Legs Syndrome</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose of Review This topical review aims to explore the potential of transcranial magnetic stimulation (TMS) as both a neurophysiological diagnostic tool and a novel therapeutic approach for restless legs syndrome (RLS). Recent Findings Overall, TMS data suggest that RLS should be regarded as a complex sensory-motor disorder in which cortical, subcortical, and spinal cord generators are involved, resulting in an enhanced cortical excitation and decreased inhibition. In this context, RLS symptoms are likely to arise at different levels of a complex network, eventually resulting in a modified, possibly temporary and circadian, excitability of a multifaceted neurophysiological drive. Therapeutically, the stimulation of the primary motor cortex (especially of the leg area), unilaterally or bilaterally, as well as of the primary somatosensory cortex (at least unilaterally), seems to safely reduce subjective symptoms and severity scale scores, with effects lasting for up to weeks. Summary This review delves into the pathophysiology of RLS through the “looking glass” of TMS and the existing clinical evidence and neuroplastic changes induced by TMS, as well as into the current challenges for clinicians and future directions for researchers. 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