An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction

An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomater...
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Autor*in:	Guo, Wentao [verfasserIn] Hu, Yuda [verfasserIn] Zhang, Xuxin [verfasserIn] Wang, Yanjun [verfasserIn] Li, Yihao [verfasserIn] Wang, Yonghong [verfasserIn] Ning, Ge [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Zearalenone Co O /MoS /Au nanocomposites Methylene blue Aptamer HCR Modified glassy carbon electrode

Anmerkung:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Microchimica acta - Springer Vienna, 1937, 191(2024), 7 vom: 04. Juni
Übergeordnetes Werk:	volume:191 ; year:2024 ; number:7 ; day:04 ; month:06

Links:	Volltext

DOI / URN:	10.1007/s00604-024-06439-5

Katalog-ID:	SPR056112297

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245	1	0	\|a An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
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520			\|a An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract
650		4	\|a Zearalenone \|7 (dpeaa)DE-He213
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650		4	\|a HCR \|7 (dpeaa)DE-He213
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700	1		\|a Wang, Yanjun \|e verfasserin \|4 aut
700	1		\|a Li, Yihao \|e verfasserin \|4 aut
700	1		\|a Wang, Yonghong \|e verfasserin \|0 (orcid)0000-0002-7487-2405 \|4 aut
700	1		\|a Ning, Ge \|e verfasserin \|4 aut
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912			\|a GBV_ILN_32
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
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912			\|a GBV_ILN_95
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912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
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912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2056
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
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912			\|a GBV_ILN_2507
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912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
912			\|a GBV_ILN_4335
912			\|a GBV_ILN_4336
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4393
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allfields	10.1007/s00604-024-06439-5 doi (DE-627)SPR056112297 (SPR)s00604-024-06439-5-e DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Guo, Wentao verfasserin aut An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213 Hu, Yuda verfasserin aut Zhang, Xuxin verfasserin aut Wang, Yanjun verfasserin aut Li, Yihao verfasserin aut Wang, Yonghong verfasserin (orcid)0000-0002-7487-2405 aut Ning, Ge verfasserin aut Enthalten in Microchimica acta Springer Vienna, 1937 191(2024), 7 vom: 04. Juni (DE-627)254630979 (DE-600)1462152-6 1436-5073 nnns volume:191 year:2024 number:7 day:04 month:06 https://dx.doi.org/10.1007/s00604-024-06439-5 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 VZ AR 191 2024 7 04 06
spelling	10.1007/s00604-024-06439-5 doi (DE-627)SPR056112297 (SPR)s00604-024-06439-5-e DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Guo, Wentao verfasserin aut An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213 Hu, Yuda verfasserin aut Zhang, Xuxin verfasserin aut Wang, Yanjun verfasserin aut Li, Yihao verfasserin aut Wang, Yonghong verfasserin (orcid)0000-0002-7487-2405 aut Ning, Ge verfasserin aut Enthalten in Microchimica acta Springer Vienna, 1937 191(2024), 7 vom: 04. Juni (DE-627)254630979 (DE-600)1462152-6 1436-5073 nnns volume:191 year:2024 number:7 day:04 month:06 https://dx.doi.org/10.1007/s00604-024-06439-5 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 VZ AR 191 2024 7 04 06
allfields_unstemmed	10.1007/s00604-024-06439-5 doi (DE-627)SPR056112297 (SPR)s00604-024-06439-5-e DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Guo, Wentao verfasserin aut An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213 Hu, Yuda verfasserin aut Zhang, Xuxin verfasserin aut Wang, Yanjun verfasserin aut Li, Yihao verfasserin aut Wang, Yonghong verfasserin (orcid)0000-0002-7487-2405 aut Ning, Ge verfasserin aut Enthalten in Microchimica acta Springer Vienna, 1937 191(2024), 7 vom: 04. Juni (DE-627)254630979 (DE-600)1462152-6 1436-5073 nnns volume:191 year:2024 number:7 day:04 month:06 https://dx.doi.org/10.1007/s00604-024-06439-5 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 VZ AR 191 2024 7 04 06
allfieldsGer	10.1007/s00604-024-06439-5 doi (DE-627)SPR056112297 (SPR)s00604-024-06439-5-e DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Guo, Wentao verfasserin aut An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213 Hu, Yuda verfasserin aut Zhang, Xuxin verfasserin aut Wang, Yanjun verfasserin aut Li, Yihao verfasserin aut Wang, Yonghong verfasserin (orcid)0000-0002-7487-2405 aut Ning, Ge verfasserin aut Enthalten in Microchimica acta Springer Vienna, 1937 191(2024), 7 vom: 04. Juni (DE-627)254630979 (DE-600)1462152-6 1436-5073 nnns volume:191 year:2024 number:7 day:04 month:06 https://dx.doi.org/10.1007/s00604-024-06439-5 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 VZ AR 191 2024 7 04 06
allfieldsSound	10.1007/s00604-024-06439-5 doi (DE-627)SPR056112297 (SPR)s00604-024-06439-5-e DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Guo, Wentao verfasserin aut An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213 Hu, Yuda verfasserin aut Zhang, Xuxin verfasserin aut Wang, Yanjun verfasserin aut Li, Yihao verfasserin aut Wang, Yonghong verfasserin (orcid)0000-0002-7487-2405 aut Ning, Ge verfasserin aut Enthalten in Microchimica acta Springer Vienna, 1937 191(2024), 7 vom: 04. Juni (DE-627)254630979 (DE-600)1462152-6 1436-5073 nnns volume:191 year:2024 number:7 day:04 month:06 https://dx.doi.org/10.1007/s00604-024-06439-5 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2360 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 35.00 VZ AR 191 2024 7 04 06
language	English
source	Enthalten in Microchimica acta 191(2024), 7 vom: 04. Juni volume:191 year:2024 number:7 day:04 month:06
sourceStr	Enthalten in Microchimica acta 191(2024), 7 vom: 04. Juni volume:191 year:2024 number:7 day:04 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Zearalenone Co O /MoS /Au nanocomposites Methylene blue Aptamer HCR Modified glassy carbon electrode
dewey-raw	540
isfreeaccess_bool	false
container_title	Microchimica acta
authorswithroles_txt_mv	Guo, Wentao @@aut@@ Hu, Yuda @@aut@@ Zhang, Xuxin @@aut@@ Wang, Yanjun @@aut@@ Li, Yihao @@aut@@ Wang, Yonghong @@aut@@ Ning, Ge @@aut@@
publishDateDaySort_date	2024-06-04T00:00:00Z
hierarchy_top_id	254630979
dewey-sort	3540
id	SPR056112297
language_de	englisch
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. 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author	Guo, Wentao
spellingShingle	Guo, Wentao ddc 540 bkl 35.00 misc Zearalenone misc Co misc O misc /MoS misc /Au nanocomposites misc Methylene blue misc Aptamer misc HCR misc Modified glassy carbon electrode An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
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topic_title	540 VZ 35.00 bkl An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction Zearalenone (dpeaa)DE-He213 Co (dpeaa)DE-He213 O (dpeaa)DE-He213 /MoS (dpeaa)DE-He213 /Au nanocomposites (dpeaa)DE-He213 Methylene blue (dpeaa)DE-He213 Aptamer (dpeaa)DE-He213 HCR (dpeaa)DE-He213 Modified glassy carbon electrode (dpeaa)DE-He213
topic	ddc 540 bkl 35.00 misc Zearalenone misc Co misc O misc /MoS misc /Au nanocomposites misc Methylene blue misc Aptamer misc HCR misc Modified glassy carbon electrode
topic_unstemmed	ddc 540 bkl 35.00 misc Zearalenone misc Co misc O misc /MoS misc /Au nanocomposites misc Methylene blue misc Aptamer misc HCR misc Modified glassy carbon electrode
topic_browse	ddc 540 bkl 35.00 misc Zearalenone misc Co misc O misc /MoS misc /Au nanocomposites misc Methylene blue misc Aptamer misc HCR misc Modified glassy carbon electrode
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title	An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
ctrlnum	(DE-627)SPR056112297 (SPR)s00604-024-06439-5-e
title_full	An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
author_sort	Guo, Wentao
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author_browse	Guo, Wentao Hu, Yuda Zhang, Xuxin Wang, Yanjun Li, Yihao Wang, Yonghong Ning, Ge
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class	540 VZ 35.00 bkl
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author-letter	Guo, Wentao
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title_sort	an electrochemical aptasensor for zearalenone detection based on the $ co_{3} $$ o_{4} $/$ mos_{2} $/au nanocomposites and hybrid chain reaction
title_auth	An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
abstract	An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	An electrochemical aptasensor was used for the fast and sensitive detection of zearalenone (ZEN) based on the combination of $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and the hybrid chain reaction (HCR). The glassy carbon electrode was coated with $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanomaterials to immobilize the ZEN-cDNA that had been bound with ZEN-Apt by the principle of base complementary pairing. In the absence of ZEN, the HCR could not be triggered because the ZEN-cDNA could not be exposed. After ZEN was added to the surface of the electrode, a complex structure was produced on the modified electrode by the combination of ZEN and ZEN-Apt. Therefore, the ZEN-cDNA can raise the HCR to produce the long-strand dsDNA structure. Due to the formation of dsDNA, the methylene blue (MB) could be inserted into the superstructure of branched DNA and the peak currents of the MB redox signal dramatically increased. So the concentration of ZEN could be detected by the change of signal intensity. Under optimized conditions, the developed electrochemical biosensing strategy showed an outstanding linear detection range of 1.0×$ 10^{−10} $ mol/L to 1.0×$ 10^{−6} $ mol/L, a low detection limit (LOD) of 8.5×$ 10^{−11} $ mol/L with desirable selectivity and stability. Therefore, the fabricated platform possessed a great application potential in fields of food safety, medical detection, and drug analysis. Graphical Abstract © The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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container_issue	7
title_short	An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction
url	https://dx.doi.org/10.1007/s00604-024-06439-5
remote_bool	true
author2	Hu, Yuda Zhang, Xuxin Wang, Yanjun Li, Yihao Wang, Yonghong Ning, Ge
author2Str	Hu, Yuda Zhang, Xuxin Wang, Yanjun Li, Yihao Wang, Yonghong Ning, Ge
ppnlink	254630979
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doi_str	10.1007/s00604-024-06439-5
up_date	2024-07-10T07:13:19.836Z
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An electrochemical aptasensor for zearalenone detection based on the $ Co_{3} $$ O_{4} $/$ MoS_{2} $/Au nanocomposites and hybrid chain reaction

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