Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor
Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-we...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Venkatesan, K. [verfasserIn] Basha, N. Hussain [verfasserIn] Jagadish, T. [verfasserIn] Reddy, P. Vishnuvardhan [verfasserIn] Shaik, Hussain [verfasserIn] Pasupathi, M. [verfasserIn] |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Anmerkung: |
© Pleiades Publishing, Ltd. 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Russian Journal of Bioorganic Chemistry - Reimers, Karl Friedrich, Pleiades Publishing, 1977, 50(2024), 3 vom: Juni, Seite 1133-1140 |
|---|---|
| Übergeordnetes Werk: |
volume:50 ; year:2024 ; number:3 ; month:06 ; pages:1133-1140 |
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|---|
| DOI / URN: |
10.1134/S1068162024030336 |
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SPR056128649 |
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| 520 | |a Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. | ||
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10.1134/S1068162024030336 doi (DE-627)SPR056128649 (SPR)S1068162024030336-e DE-627 ger DE-627 rakwb eng Venkatesan, K. verfasserin aut Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2024 Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. Basha, N. Hussain verfasserin aut Jagadish, T. verfasserin aut Reddy, P. Vishnuvardhan verfasserin aut Shaik, Hussain verfasserin aut Pasupathi, M. verfasserin aut Enthalten in Reimers, Karl Friedrich Russian Journal of Bioorganic Chemistry Pleiades Publishing, 1977 50(2024), 3 vom: Juni, Seite 1133-1140 1 Online-Ressource (958 MB, 00:18:24:00) (DE-627)1820844331 nnnm volume:50 year:2024 number:3 month:06 pages:1133-1140 https://dx.doi.org/10.1134/S1068162024030336 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_23 GBV_ILN_30 GBV_ILN_63 GBV_ILN_118 GBV_ILN_122 GBV_ILN_140 GBV_ILN_264 GBV_ILN_2057 GBV_ILN_2403 AR 50 2024 3 06 1133-1140 |
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10.1134/S1068162024030336 doi (DE-627)SPR056128649 (SPR)S1068162024030336-e DE-627 ger DE-627 rakwb eng Venkatesan, K. verfasserin aut Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2024 Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. Basha, N. Hussain verfasserin aut Jagadish, T. verfasserin aut Reddy, P. Vishnuvardhan verfasserin aut Shaik, Hussain verfasserin aut Pasupathi, M. verfasserin aut Enthalten in Reimers, Karl Friedrich Russian Journal of Bioorganic Chemistry Pleiades Publishing, 1977 50(2024), 3 vom: Juni, Seite 1133-1140 1 Online-Ressource (958 MB, 00:18:24:00) (DE-627)1820844331 nnnm volume:50 year:2024 number:3 month:06 pages:1133-1140 https://dx.doi.org/10.1134/S1068162024030336 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_23 GBV_ILN_30 GBV_ILN_63 GBV_ILN_118 GBV_ILN_122 GBV_ILN_140 GBV_ILN_264 GBV_ILN_2057 GBV_ILN_2403 AR 50 2024 3 06 1133-1140 |
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10.1134/S1068162024030336 doi (DE-627)SPR056128649 (SPR)S1068162024030336-e DE-627 ger DE-627 rakwb eng Venkatesan, K. verfasserin aut Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2024 Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. Basha, N. Hussain verfasserin aut Jagadish, T. verfasserin aut Reddy, P. Vishnuvardhan verfasserin aut Shaik, Hussain verfasserin aut Pasupathi, M. verfasserin aut Enthalten in Reimers, Karl Friedrich Russian Journal of Bioorganic Chemistry Pleiades Publishing, 1977 50(2024), 3 vom: Juni, Seite 1133-1140 1 Online-Ressource (958 MB, 00:18:24:00) (DE-627)1820844331 nnnm volume:50 year:2024 number:3 month:06 pages:1133-1140 https://dx.doi.org/10.1134/S1068162024030336 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_23 GBV_ILN_30 GBV_ILN_63 GBV_ILN_118 GBV_ILN_122 GBV_ILN_140 GBV_ILN_264 GBV_ILN_2057 GBV_ILN_2403 AR 50 2024 3 06 1133-1140 |
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10.1134/S1068162024030336 doi (DE-627)SPR056128649 (SPR)S1068162024030336-e DE-627 ger DE-627 rakwb eng Venkatesan, K. verfasserin aut Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2024 Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. Basha, N. Hussain verfasserin aut Jagadish, T. verfasserin aut Reddy, P. Vishnuvardhan verfasserin aut Shaik, Hussain verfasserin aut Pasupathi, M. verfasserin aut Enthalten in Reimers, Karl Friedrich Russian Journal of Bioorganic Chemistry Pleiades Publishing, 1977 50(2024), 3 vom: Juni, Seite 1133-1140 1 Online-Ressource (958 MB, 00:18:24:00) (DE-627)1820844331 nnnm volume:50 year:2024 number:3 month:06 pages:1133-1140 https://dx.doi.org/10.1134/S1068162024030336 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_23 GBV_ILN_30 GBV_ILN_63 GBV_ILN_118 GBV_ILN_122 GBV_ILN_140 GBV_ILN_264 GBV_ILN_2057 GBV_ILN_2403 AR 50 2024 3 06 1133-1140 |
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10.1134/S1068162024030336 doi (DE-627)SPR056128649 (SPR)S1068162024030336-e DE-627 ger DE-627 rakwb eng Venkatesan, K. verfasserin aut Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pleiades Publishing, Ltd. 2024 Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. Basha, N. Hussain verfasserin aut Jagadish, T. verfasserin aut Reddy, P. Vishnuvardhan verfasserin aut Shaik, Hussain verfasserin aut Pasupathi, M. verfasserin aut Enthalten in Reimers, Karl Friedrich Russian Journal of Bioorganic Chemistry Pleiades Publishing, 1977 50(2024), 3 vom: Juni, Seite 1133-1140 1 Online-Ressource (958 MB, 00:18:24:00) (DE-627)1820844331 nnnm volume:50 year:2024 number:3 month:06 pages:1133-1140 https://dx.doi.org/10.1134/S1068162024030336 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_23 GBV_ILN_30 GBV_ILN_63 GBV_ILN_118 GBV_ILN_122 GBV_ILN_140 GBV_ILN_264 GBV_ILN_2057 GBV_ILN_2403 AR 50 2024 3 06 1133-1140 |
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Venkatesan, K. |
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10.1134/S1068162024030336 |
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verfasserin |
| title_sort |
ultrasound assisted synthesis of phenothiazine based chalcone derivatives, their antibacterial studies and molecular docking against covid-19 virus spike protein inhibitor |
| title_auth |
Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor |
| abstract |
Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. © Pleiades Publishing, Ltd. 2024 |
| abstractGer |
Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. © Pleiades Publishing, Ltd. 2024 |
| abstract_unstemmed |
Abstract Objective: Phenothiazine and its derivatives have many biological effects, such as killing bacteria, protecting cells from damage, fighting cancer, and other drug-related effects. Methods: Phenothiazine-containing chalcone derivatives were tested for antibacterial activity using the agar-well diffusion method. For COVID-19, a molecular docking investigation of produced molecules was performed using AutoDock 2.0 software. Results and Discussion: Phenothiazine derivatives were characterized using spectral techniques such as IR, NMR, and mass spectral data. All the synthesized derivatives shown good antibacterial studies against various bacterial strains. The docking results of the synthesized ligand possesses good binding energy with 2AJF protein. Conclusions: This work presented standard procedures and focused on the synthesis and spectrum characterization of a series of phenothiazine integrated Chalcone derivatives employing ultrasonic irradiation. Phenothiazine and chalcone compounds have been shown to have potent antibacterial activity. The phenothiazine-based chalcone moieties in the drug’s formation of hydrogen bonds with the target enzyme make it an efficient antiviral agent, according to the docking finding. © Pleiades Publishing, Ltd. 2024 |
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Ultrasound Assisted Synthesis of Phenothiazine Based Chalcone Derivatives, Their Antibacterial Studies and Molecular Docking Against COVID-19 Virus Spike Protein Inhibitor |
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https://dx.doi.org/10.1134/S1068162024030336 |
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Basha, N. Hussain Jagadish, T. Reddy, P. Vishnuvardhan Shaik, Hussain Pasupathi, M. |
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