Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension
Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients w...
Ausführliche Beschreibung
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| Autor*in: |
Luta, Xhyljeta [verfasserIn] Zanchi, Fabio [verfasserIn] Fresa, Marco [verfasserIn] Porccedu, Enrica [verfasserIn] Keller, Sanjiv [verfasserIn] Bouchardy, Judith [verfasserIn] Déglise, Sébastien [verfasserIn] Qanadli, Salah Dine [verfasserIn] Kirsch, Matthias [verfasserIn] Wuerzner, Grégoire [verfasserIn] Superti-Furga, Andrea [verfasserIn] Buso, Giacomo [verfasserIn] Mazzolai, Lucia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Orphanet journal of rare diseases - BioMed Central, 2006, 19(2024), 1 vom: 07. Juni |
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| Übergeordnetes Werk: |
volume:19 ; year:2024 ; number:1 ; day:07 ; month:06 |
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| DOI / URN: |
10.1186/s13023-024-03231-9 |
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SPR05616033X |
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| 520 | |a Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. | ||
| 650 | 4 | |a Rare vascular diseases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-atherosclerotic vascular diseases |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Arterial tortuosity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tortuosity index |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Computed tomography angiography |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zanchi, Fabio |e verfasserin |4 aut | |
| 700 | 1 | |a Fresa, Marco |e verfasserin |4 aut | |
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| 700 | 1 | |a Keller, Sanjiv |e verfasserin |4 aut | |
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| 700 | 1 | |a Déglise, Sébastien |e verfasserin |4 aut | |
| 700 | 1 | |a Qanadli, Salah Dine |e verfasserin |4 aut | |
| 700 | 1 | |a Kirsch, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Wuerzner, Grégoire |e verfasserin |4 aut | |
| 700 | 1 | |a Superti-Furga, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Buso, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzolai, Lucia |e verfasserin |4 aut | |
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10.1186/s13023-024-03231-9 doi (DE-627)SPR05616033X (SPR)s13023-024-03231-9-e DE-627 ger DE-627 rakwb eng 610 VZ Luta, Xhyljeta verfasserin (orcid)0000-0002-5716-4693 aut Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. Rare vascular diseases (dpeaa)DE-He213 Non-atherosclerotic vascular diseases (dpeaa)DE-He213 Arterial tortuosity (dpeaa)DE-He213 Tortuosity index (dpeaa)DE-He213 Computed tomography angiography (dpeaa)DE-He213 Zanchi, Fabio verfasserin aut Fresa, Marco verfasserin aut Porccedu, Enrica verfasserin aut Keller, Sanjiv verfasserin aut Bouchardy, Judith verfasserin aut Déglise, Sébastien verfasserin aut Qanadli, Salah Dine verfasserin aut Kirsch, Matthias verfasserin aut Wuerzner, Grégoire verfasserin aut Superti-Furga, Andrea verfasserin aut Buso, Giacomo verfasserin aut Mazzolai, Lucia verfasserin aut Enthalten in Orphanet journal of rare diseases BioMed Central, 2006 19(2024), 1 vom: 07. Juni (DE-627)50900637X (DE-600)2225857-7 1750-1172 nnns volume:19 year:2024 number:1 day:07 month:06 https://dx.doi.org/10.1186/s13023-024-03231-9 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 07 06 |
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10.1186/s13023-024-03231-9 doi (DE-627)SPR05616033X (SPR)s13023-024-03231-9-e DE-627 ger DE-627 rakwb eng 610 VZ Luta, Xhyljeta verfasserin (orcid)0000-0002-5716-4693 aut Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. Rare vascular diseases (dpeaa)DE-He213 Non-atherosclerotic vascular diseases (dpeaa)DE-He213 Arterial tortuosity (dpeaa)DE-He213 Tortuosity index (dpeaa)DE-He213 Computed tomography angiography (dpeaa)DE-He213 Zanchi, Fabio verfasserin aut Fresa, Marco verfasserin aut Porccedu, Enrica verfasserin aut Keller, Sanjiv verfasserin aut Bouchardy, Judith verfasserin aut Déglise, Sébastien verfasserin aut Qanadli, Salah Dine verfasserin aut Kirsch, Matthias verfasserin aut Wuerzner, Grégoire verfasserin aut Superti-Furga, Andrea verfasserin aut Buso, Giacomo verfasserin aut Mazzolai, Lucia verfasserin aut Enthalten in Orphanet journal of rare diseases BioMed Central, 2006 19(2024), 1 vom: 07. Juni (DE-627)50900637X (DE-600)2225857-7 1750-1172 nnns volume:19 year:2024 number:1 day:07 month:06 https://dx.doi.org/10.1186/s13023-024-03231-9 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 07 06 |
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10.1186/s13023-024-03231-9 doi (DE-627)SPR05616033X (SPR)s13023-024-03231-9-e DE-627 ger DE-627 rakwb eng 610 VZ Luta, Xhyljeta verfasserin (orcid)0000-0002-5716-4693 aut Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. Rare vascular diseases (dpeaa)DE-He213 Non-atherosclerotic vascular diseases (dpeaa)DE-He213 Arterial tortuosity (dpeaa)DE-He213 Tortuosity index (dpeaa)DE-He213 Computed tomography angiography (dpeaa)DE-He213 Zanchi, Fabio verfasserin aut Fresa, Marco verfasserin aut Porccedu, Enrica verfasserin aut Keller, Sanjiv verfasserin aut Bouchardy, Judith verfasserin aut Déglise, Sébastien verfasserin aut Qanadli, Salah Dine verfasserin aut Kirsch, Matthias verfasserin aut Wuerzner, Grégoire verfasserin aut Superti-Furga, Andrea verfasserin aut Buso, Giacomo verfasserin aut Mazzolai, Lucia verfasserin aut Enthalten in Orphanet journal of rare diseases BioMed Central, 2006 19(2024), 1 vom: 07. Juni (DE-627)50900637X (DE-600)2225857-7 1750-1172 nnns volume:19 year:2024 number:1 day:07 month:06 https://dx.doi.org/10.1186/s13023-024-03231-9 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 07 06 |
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10.1186/s13023-024-03231-9 doi (DE-627)SPR05616033X (SPR)s13023-024-03231-9-e DE-627 ger DE-627 rakwb eng 610 VZ Luta, Xhyljeta verfasserin (orcid)0000-0002-5716-4693 aut Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. Rare vascular diseases (dpeaa)DE-He213 Non-atherosclerotic vascular diseases (dpeaa)DE-He213 Arterial tortuosity (dpeaa)DE-He213 Tortuosity index (dpeaa)DE-He213 Computed tomography angiography (dpeaa)DE-He213 Zanchi, Fabio verfasserin aut Fresa, Marco verfasserin aut Porccedu, Enrica verfasserin aut Keller, Sanjiv verfasserin aut Bouchardy, Judith verfasserin aut Déglise, Sébastien verfasserin aut Qanadli, Salah Dine verfasserin aut Kirsch, Matthias verfasserin aut Wuerzner, Grégoire verfasserin aut Superti-Furga, Andrea verfasserin aut Buso, Giacomo verfasserin aut Mazzolai, Lucia verfasserin aut Enthalten in Orphanet journal of rare diseases BioMed Central, 2006 19(2024), 1 vom: 07. Juni (DE-627)50900637X (DE-600)2225857-7 1750-1172 nnns volume:19 year:2024 number:1 day:07 month:06 https://dx.doi.org/10.1186/s13023-024-03231-9 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 07 06 |
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10.1186/s13023-024-03231-9 doi (DE-627)SPR05616033X (SPR)s13023-024-03231-9-e DE-627 ger DE-627 rakwb eng 610 VZ Luta, Xhyljeta verfasserin (orcid)0000-0002-5716-4693 aut Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. Rare vascular diseases (dpeaa)DE-He213 Non-atherosclerotic vascular diseases (dpeaa)DE-He213 Arterial tortuosity (dpeaa)DE-He213 Tortuosity index (dpeaa)DE-He213 Computed tomography angiography (dpeaa)DE-He213 Zanchi, Fabio verfasserin aut Fresa, Marco verfasserin aut Porccedu, Enrica verfasserin aut Keller, Sanjiv verfasserin aut Bouchardy, Judith verfasserin aut Déglise, Sébastien verfasserin aut Qanadli, Salah Dine verfasserin aut Kirsch, Matthias verfasserin aut Wuerzner, Grégoire verfasserin aut Superti-Furga, Andrea verfasserin aut Buso, Giacomo verfasserin aut Mazzolai, Lucia verfasserin aut Enthalten in Orphanet journal of rare diseases BioMed Central, 2006 19(2024), 1 vom: 07. Juni (DE-627)50900637X (DE-600)2225857-7 1750-1172 nnns volume:19 year:2024 number:1 day:07 month:06 https://dx.doi.org/10.1186/s13023-024-03231-9 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 07 06 |
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Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension |
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Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension |
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Luta, Xhyljeta |
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Orphanet journal of rare diseases |
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Luta, Xhyljeta Zanchi, Fabio Fresa, Marco Porccedu, Enrica Keller, Sanjiv Bouchardy, Judith Déglise, Sébastien Qanadli, Salah Dine Kirsch, Matthias Wuerzner, Grégoire Superti-Furga, Andrea Buso, Giacomo Mazzolai, Lucia |
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10.1186/s13023-024-03231-9 |
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tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension |
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Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension |
| abstract |
Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. © The Author(s) 2024 |
| abstractGer |
Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. © The Author(s) 2024 |
| abstract_unstemmed |
Background Increased arterial tortuosity has been associated with various cardiovascular complications. However, the extent and role of arterial tortuosity in non-atherosclerotic vascular diseases remain to be fully elucidated. This study aimed to assess arterial tortuosity index (ATI) in patients with non-atherosclerotic vascular diseases and the associated factors. Methods This is a retrospective analysis of patients with non-atherosclerotic vascular diseases referred to the Malformation and Rare Vascular Disease Center at the University Hospital in Lausanne (Switzerland). Computed tomography angiography (CTA) images performed between October 2010 and April 2022 were retrieved and the aortic tortuosity index (ATI) was calculated. Patients were classified based on diagnosis into the following groups: arterial dissection & aneurysm, arteritis & autoimmune disease, hereditary connective tissue diseases, and fibromuscular dysplasia (FMD). Univariate and multivariate logistic regression analysis was used to determine potentially relevant predictors of aortic tortuosity. Results The mean age upon computed tomography angiography (CTA) was 46.8 (standard deviation [SD] 14.6) years and 59.1% of the patients were female. Mean ATI was higher in patients over 60 years old (1.27), in those with arterial aneurysms (mean: 1.11), and in those diagnosed with hypertension (mean: 1.13). When only patients over 60 years old were considered, those diagnosed with connective tissue diseases had the highest ATI. At multivariate regression analysis, increasing age (p < 0.05), presence of arterial aneurysms (p < 0.05), and hypertension (p < 0.05) were independently associated with ATI. Conclusions The ATI may be a promising tool in diagnostic evaluation, cardiovascular risk stratification, medical or surgical management, and prognostic assessment in several non-atherosclerotic vascular conditions. Further studies with longitudinal design and larger cohorts are needed to validate the role of ATI in the full spectrum of vascular diseases. © The Author(s) 2024 |
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Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension |
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Zanchi, Fabio Fresa, Marco Porccedu, Enrica Keller, Sanjiv Bouchardy, Judith Déglise, Sébastien Qanadli, Salah Dine Kirsch, Matthias Wuerzner, Grégoire Superti-Furga, Andrea Buso, Giacomo Mazzolai, Lucia |
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