Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis
Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydati...
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| Autor*in: |
Kalifu, Baheti [verfasserIn] Meng, Yuan [verfasserIn] Ma, Zhi-Gang [verfasserIn] Ma, Chao [verfasserIn] Tian, Guang-Lei [verfasserIn] Wang, Jin-Guo [verfasserIn] Chen, Xiong [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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© The Author(s) 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Egyptian liver journal - Springer Berlin Heidelberg, 2011, 14(2024), 1 vom: 10. Juni |
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| Übergeordnetes Werk: |
volume:14 ; year:2024 ; number:1 ; day:10 ; month:06 |
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10.1186/s43066-024-00345-4 |
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SPR056199007 |
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| 520 | |a Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. | ||
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| 650 | 4 | |a Liver fibrosis |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Ma, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Guang-Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jin-Guo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xiong |e verfasserin |4 aut | |
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10.1186/s43066-024-00345-4 doi (DE-627)SPR056199007 (SPR)s43066-024-00345-4-e DE-627 ger DE-627 rakwb eng Kalifu, Baheti verfasserin aut Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. Hepatic cystic hydatid (dpeaa)DE-He213 Liver fibrosis (dpeaa)DE-He213 LX-2 (dpeaa)DE-He213 circRNA-049637 (dpeaa)DE-He213 Meng, Yuan verfasserin aut Ma, Zhi-Gang verfasserin aut Ma, Chao verfasserin aut Tian, Guang-Lei verfasserin aut Wang, Jin-Guo verfasserin aut Chen, Xiong verfasserin aut Enthalten in Egyptian liver journal Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 10. Juni (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:14 year:2024 number:1 day:10 month:06 https://dx.doi.org/10.1186/s43066-024-00345-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER AR 14 2024 1 10 06 |
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10.1186/s43066-024-00345-4 doi (DE-627)SPR056199007 (SPR)s43066-024-00345-4-e DE-627 ger DE-627 rakwb eng Kalifu, Baheti verfasserin aut Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. Hepatic cystic hydatid (dpeaa)DE-He213 Liver fibrosis (dpeaa)DE-He213 LX-2 (dpeaa)DE-He213 circRNA-049637 (dpeaa)DE-He213 Meng, Yuan verfasserin aut Ma, Zhi-Gang verfasserin aut Ma, Chao verfasserin aut Tian, Guang-Lei verfasserin aut Wang, Jin-Guo verfasserin aut Chen, Xiong verfasserin aut Enthalten in Egyptian liver journal Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 10. Juni (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:14 year:2024 number:1 day:10 month:06 https://dx.doi.org/10.1186/s43066-024-00345-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER AR 14 2024 1 10 06 |
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10.1186/s43066-024-00345-4 doi (DE-627)SPR056199007 (SPR)s43066-024-00345-4-e DE-627 ger DE-627 rakwb eng Kalifu, Baheti verfasserin aut Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. Hepatic cystic hydatid (dpeaa)DE-He213 Liver fibrosis (dpeaa)DE-He213 LX-2 (dpeaa)DE-He213 circRNA-049637 (dpeaa)DE-He213 Meng, Yuan verfasserin aut Ma, Zhi-Gang verfasserin aut Ma, Chao verfasserin aut Tian, Guang-Lei verfasserin aut Wang, Jin-Guo verfasserin aut Chen, Xiong verfasserin aut Enthalten in Egyptian liver journal Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 10. Juni (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:14 year:2024 number:1 day:10 month:06 https://dx.doi.org/10.1186/s43066-024-00345-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER AR 14 2024 1 10 06 |
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10.1186/s43066-024-00345-4 doi (DE-627)SPR056199007 (SPR)s43066-024-00345-4-e DE-627 ger DE-627 rakwb eng Kalifu, Baheti verfasserin aut Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. Hepatic cystic hydatid (dpeaa)DE-He213 Liver fibrosis (dpeaa)DE-He213 LX-2 (dpeaa)DE-He213 circRNA-049637 (dpeaa)DE-He213 Meng, Yuan verfasserin aut Ma, Zhi-Gang verfasserin aut Ma, Chao verfasserin aut Tian, Guang-Lei verfasserin aut Wang, Jin-Guo verfasserin aut Chen, Xiong verfasserin aut Enthalten in Egyptian liver journal Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 10. Juni (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:14 year:2024 number:1 day:10 month:06 https://dx.doi.org/10.1186/s43066-024-00345-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER AR 14 2024 1 10 06 |
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10.1186/s43066-024-00345-4 doi (DE-627)SPR056199007 (SPR)s43066-024-00345-4-e DE-627 ger DE-627 rakwb eng Kalifu, Baheti verfasserin aut Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. Hepatic cystic hydatid (dpeaa)DE-He213 Liver fibrosis (dpeaa)DE-He213 LX-2 (dpeaa)DE-He213 circRNA-049637 (dpeaa)DE-He213 Meng, Yuan verfasserin aut Ma, Zhi-Gang verfasserin aut Ma, Chao verfasserin aut Tian, Guang-Lei verfasserin aut Wang, Jin-Guo verfasserin aut Chen, Xiong verfasserin aut Enthalten in Egyptian liver journal Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 10. Juni (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:14 year:2024 number:1 day:10 month:06 https://dx.doi.org/10.1186/s43066-024-00345-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER AR 14 2024 1 10 06 |
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Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis |
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Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. © The Author(s) 2024 |
| abstractGer |
Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. © The Author(s) 2024 |
| abstract_unstemmed |
Introduction and objectives In diseases characterized by fibrosis, hepatic stellate cells (HSCs) are mesenchymal cells that play an important role in liver fibrosis. circRNAs are involved in regulating hydatid exocyst formation through miRNA sponge adsorption. The mechanisms of hepatic cystic hydatid outer cyst formation, HSC, and liver fibrosis are unclear. Materials and methods Based on our sequencing data, we validated the mechanism by which circRNA-049637 regulated hepatic cystic hydatid growth and promoted outer fibrocystic wall formation. Results Our results revealed that circRNA_049637 silencing promoted the proliferation of LX-2 human HSCs, affected the cell cycle, and increased the mRNA and protein expression levels of liver fibrosis-related indicators such as α-SMA, COL1A1, COL3A1, and TGFβRII. Conclusions CircRNA_049637 may induce the formation of hepatic hydatid cysts by promoting hepatic fibrosis via HSC activation. © The Author(s) 2024 |
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Silencing circ-RNA-049637 influences hydatid outer cyst wall formation by liver fibrosis |
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https://dx.doi.org/10.1186/s43066-024-00345-4 |
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Meng, Yuan Ma, Zhi-Gang Ma, Chao Tian, Guang-Lei Wang, Jin-Guo Chen, Xiong |
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Meng, Yuan Ma, Zhi-Gang Ma, Chao Tian, Guang-Lei Wang, Jin-Guo Chen, Xiong |
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10.1186/s43066-024-00345-4 |
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2024-07-03T20:48:21.628Z |
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