ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway

Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intest...
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Autor*in:	Li, Jinze [verfasserIn] Yan, Yingli [verfasserIn] Fu, Yang [verfasserIn] Chen, Zhe [verfasserIn] Yang, Yongjie [verfasserIn] Li, Yu [verfasserIn] Pan, Jie [verfasserIn] Li, Feiwu [verfasserIn] Zha, Cuifang [verfasserIn] Miao, Kai [verfasserIn] Ben, Lukuyu [verfasserIn] Saleemi, Muhammad Kashif [verfasserIn] Zhu, Yongwen [verfasserIn] Ye, Hui [verfasserIn] Yang, Lin [verfasserIn] Wang, Wence [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	ACE2 Tryptophan B AT1 mTOR Aryl hydrocarbon receptor

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Cellular & molecular biology letters - BioMed Central, 1996, 29(2024), 1 vom: 14. Juni
Übergeordnetes Werk:	volume:29 ; year:2024 ; number:1 ; day:14 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s11658-024-00603-8

Katalog-ID:	SPR056243359

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520			\|a Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway.
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allfields	10.1186/s11658-024-00603-8 doi (DE-627)SPR056243359 (SPR)s11658-024-00603-8-e DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.13 bkl 42.15 bkl Li, Jinze verfasserin aut ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. ACE2 (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 B (dpeaa)DE-He213 AT1 (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Aryl hydrocarbon receptor (dpeaa)DE-He213 Yan, Yingli verfasserin aut Fu, Yang verfasserin aut Chen, Zhe verfasserin aut Yang, Yongjie verfasserin aut Li, Yu verfasserin aut Pan, Jie verfasserin aut Li, Feiwu verfasserin aut Zha, Cuifang verfasserin aut Miao, Kai verfasserin aut Ben, Lukuyu verfasserin aut Saleemi, Muhammad Kashif verfasserin aut Zhu, Yongwen verfasserin aut Ye, Hui verfasserin aut Yang, Lin verfasserin aut Wang, Wence verfasserin aut Enthalten in Cellular & molecular biology letters BioMed Central, 1996 29(2024), 1 vom: 14. Juni (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:29 year:2024 number:1 day:14 month:06 https://dx.doi.org/10.1186/s11658-024-00603-8 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.13 VZ 42.15 VZ AR 29 2024 1 14 06
spelling	10.1186/s11658-024-00603-8 doi (DE-627)SPR056243359 (SPR)s11658-024-00603-8-e DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.13 bkl 42.15 bkl Li, Jinze verfasserin aut ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. ACE2 (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 B (dpeaa)DE-He213 AT1 (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Aryl hydrocarbon receptor (dpeaa)DE-He213 Yan, Yingli verfasserin aut Fu, Yang verfasserin aut Chen, Zhe verfasserin aut Yang, Yongjie verfasserin aut Li, Yu verfasserin aut Pan, Jie verfasserin aut Li, Feiwu verfasserin aut Zha, Cuifang verfasserin aut Miao, Kai verfasserin aut Ben, Lukuyu verfasserin aut Saleemi, Muhammad Kashif verfasserin aut Zhu, Yongwen verfasserin aut Ye, Hui verfasserin aut Yang, Lin verfasserin aut Wang, Wence verfasserin aut Enthalten in Cellular & molecular biology letters BioMed Central, 1996 29(2024), 1 vom: 14. Juni (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:29 year:2024 number:1 day:14 month:06 https://dx.doi.org/10.1186/s11658-024-00603-8 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.13 VZ 42.15 VZ AR 29 2024 1 14 06
allfields_unstemmed	10.1186/s11658-024-00603-8 doi (DE-627)SPR056243359 (SPR)s11658-024-00603-8-e DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.13 bkl 42.15 bkl Li, Jinze verfasserin aut ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. ACE2 (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 B (dpeaa)DE-He213 AT1 (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Aryl hydrocarbon receptor (dpeaa)DE-He213 Yan, Yingli verfasserin aut Fu, Yang verfasserin aut Chen, Zhe verfasserin aut Yang, Yongjie verfasserin aut Li, Yu verfasserin aut Pan, Jie verfasserin aut Li, Feiwu verfasserin aut Zha, Cuifang verfasserin aut Miao, Kai verfasserin aut Ben, Lukuyu verfasserin aut Saleemi, Muhammad Kashif verfasserin aut Zhu, Yongwen verfasserin aut Ye, Hui verfasserin aut Yang, Lin verfasserin aut Wang, Wence verfasserin aut Enthalten in Cellular & molecular biology letters BioMed Central, 1996 29(2024), 1 vom: 14. Juni (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:29 year:2024 number:1 day:14 month:06 https://dx.doi.org/10.1186/s11658-024-00603-8 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.13 VZ 42.15 VZ AR 29 2024 1 14 06
allfieldsGer	10.1186/s11658-024-00603-8 doi (DE-627)SPR056243359 (SPR)s11658-024-00603-8-e DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.13 bkl 42.15 bkl Li, Jinze verfasserin aut ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. ACE2 (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 B (dpeaa)DE-He213 AT1 (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Aryl hydrocarbon receptor (dpeaa)DE-He213 Yan, Yingli verfasserin aut Fu, Yang verfasserin aut Chen, Zhe verfasserin aut Yang, Yongjie verfasserin aut Li, Yu verfasserin aut Pan, Jie verfasserin aut Li, Feiwu verfasserin aut Zha, Cuifang verfasserin aut Miao, Kai verfasserin aut Ben, Lukuyu verfasserin aut Saleemi, Muhammad Kashif verfasserin aut Zhu, Yongwen verfasserin aut Ye, Hui verfasserin aut Yang, Lin verfasserin aut Wang, Wence verfasserin aut Enthalten in Cellular & molecular biology letters BioMed Central, 1996 29(2024), 1 vom: 14. Juni (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:29 year:2024 number:1 day:14 month:06 https://dx.doi.org/10.1186/s11658-024-00603-8 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.13 VZ 42.15 VZ AR 29 2024 1 14 06
allfieldsSound	10.1186/s11658-024-00603-8 doi (DE-627)SPR056243359 (SPR)s11658-024-00603-8-e DE-627 ger DE-627 rakwb eng 570 VZ BIODIV DE-30 fid 42.13 bkl 42.15 bkl Li, Jinze verfasserin aut ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. ACE2 (dpeaa)DE-He213 Tryptophan (dpeaa)DE-He213 B (dpeaa)DE-He213 AT1 (dpeaa)DE-He213 mTOR (dpeaa)DE-He213 Aryl hydrocarbon receptor (dpeaa)DE-He213 Yan, Yingli verfasserin aut Fu, Yang verfasserin aut Chen, Zhe verfasserin aut Yang, Yongjie verfasserin aut Li, Yu verfasserin aut Pan, Jie verfasserin aut Li, Feiwu verfasserin aut Zha, Cuifang verfasserin aut Miao, Kai verfasserin aut Ben, Lukuyu verfasserin aut Saleemi, Muhammad Kashif verfasserin aut Zhu, Yongwen verfasserin aut Ye, Hui verfasserin aut Yang, Lin verfasserin aut Wang, Wence verfasserin aut Enthalten in Cellular & molecular biology letters BioMed Central, 1996 29(2024), 1 vom: 14. Juni (DE-627)363772340 (DE-600)2108724-6 1689-1392 nnns volume:29 year:2024 number:1 day:14 month:06 https://dx.doi.org/10.1186/s11658-024-00603-8 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER FID-BIODIV SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 42.13 VZ 42.15 VZ AR 29 2024 1 14 06
language	English
source	Enthalten in Cellular & molecular biology letters 29(2024), 1 vom: 14. Juni volume:29 year:2024 number:1 day:14 month:06
sourceStr	Enthalten in Cellular & molecular biology letters 29(2024), 1 vom: 14. Juni volume:29 year:2024 number:1 day:14 month:06
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title_sort	ace2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mtor pathway
title_auth	ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
abstract	Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. © The Author(s) 2024
abstractGer	Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. © The Author(s) 2024
abstract_unstemmed	Abstract The membrane-delimited receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), angiotensin-converting enzyme 2 (ACE2), which is expressed in the intestine, collaborates with broad neutral amino acid transporter 1 ($ B^{0} $AT1). Tryptophan (Trp) is transported into intestinal epithelial cells by ACE2 and $ B^{0} $AT1. However, whether ACE2 and its binding protein $ B^{0} $AT1 are involved in Trp-mediated alleviation of intestinal injury is largely unknown. Here, we used weaned piglets and IPEC-J2 cells as models and found that ACE2/$ B^{0} $AT1 alleviated lipopolysaccharide (LPS)-induced diarrhea and promoted intestinal barrier recovery via transport of Trp. The levels of the aryl hydrocarbon receptor (AhR) and mechanistic target of rapamycin (mTOR) pathways were altered by ACE2. Dietary Trp supplementation in LPS-treated weaned piglets revealed that Trp alleviated diarrhea by promoting ACE2/$ B^{0} $AT1 expression, and examination of intestinal morphology revealed that the damage to the intestinal barrier was repaired. Our study demonstrated that ACE2 accompanied by $ B^{0} $AT1 mediated the alleviation of diarrhea by Trp through intestinal barrier repair via the mTOR pathway. © The Author(s) 2024
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container_issue	1
title_short	ACE2 mediates tryptophan alleviation on diarrhea by repairing intestine barrier involved mTOR pathway
url	https://dx.doi.org/10.1186/s11658-024-00603-8
remote_bool	true
author2	Yan, Yingli Fu, Yang Chen, Zhe Yang, Yongjie Li, Yu Pan, Jie Li, Feiwu Zha, Cuifang Miao, Kai Ben, Lukuyu Saleemi, Muhammad Kashif Zhu, Yongwen Ye, Hui Yang, Lin Wang, Wence
author2Str	Yan, Yingli Fu, Yang Chen, Zhe Yang, Yongjie Li, Yu Pan, Jie Li, Feiwu Zha, Cuifang Miao, Kai Ben, Lukuyu Saleemi, Muhammad Kashif Zhu, Yongwen Ye, Hui Yang, Lin Wang, Wence
ppnlink	363772340
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1186/s11658-024-00603-8
up_date	2024-07-03T21:07:24.752Z
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