Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications
The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Singh, Maninder [verfasserIn] Gill, Amoljit Singh [verfasserIn] Deol, Parneet Kaur [verfasserIn] Agrawal, Anupam [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Journal of materials research - Springer International Publishing, 1986, 39(2024), 11 vom: 10. Apr., Seite 1644-1660 |
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| Übergeordnetes Werk: |
volume:39 ; year:2024 ; number:11 ; day:10 ; month:04 ; pages:1644-1660 |
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| DOI / URN: |
10.1557/s43578-024-01335-3 |
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| Katalog-ID: |
SPR056255047 |
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| 520 | |a The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract | ||
| 650 | 4 | |a Ti6Al4V |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Graded porous structures |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Powder metallurgy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Orthopedic implants |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Drug delivery |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sodium alginate |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gill, Amoljit Singh |e verfasserin |0 (orcid)0000-0002-6821-5804 |4 aut | |
| 700 | 1 | |a Deol, Parneet Kaur |e verfasserin |4 aut | |
| 700 | 1 | |a Agrawal, Anupam |e verfasserin |4 aut | |
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10.1557/s43578-024-01335-3 doi (DE-627)SPR056255047 (SPR)s43578-024-01335-3-e DE-627 ger DE-627 rakwb eng 670 VZ 51.00 bkl Singh, Maninder verfasserin aut Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract Ti6Al4V (dpeaa)DE-He213 Graded porous structures (dpeaa)DE-He213 Powder metallurgy (dpeaa)DE-He213 Orthopedic implants (dpeaa)DE-He213 Drug delivery (dpeaa)DE-He213 Sodium alginate (dpeaa)DE-He213 Gill, Amoljit Singh verfasserin (orcid)0000-0002-6821-5804 aut Deol, Parneet Kaur verfasserin aut Agrawal, Anupam verfasserin aut Enthalten in Journal of materials research Springer International Publishing, 1986 39(2024), 11 vom: 10. Apr., Seite 1644-1660 (DE-627)320527026 (DE-600)2015297-8 2044-5326 nnns volume:39 year:2024 number:11 day:10 month:04 pages:1644-1660 https://dx.doi.org/10.1557/s43578-024-01335-3 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 VZ AR 39 2024 11 10 04 1644-1660 |
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10.1557/s43578-024-01335-3 doi (DE-627)SPR056255047 (SPR)s43578-024-01335-3-e DE-627 ger DE-627 rakwb eng 670 VZ 51.00 bkl Singh, Maninder verfasserin aut Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract Ti6Al4V (dpeaa)DE-He213 Graded porous structures (dpeaa)DE-He213 Powder metallurgy (dpeaa)DE-He213 Orthopedic implants (dpeaa)DE-He213 Drug delivery (dpeaa)DE-He213 Sodium alginate (dpeaa)DE-He213 Gill, Amoljit Singh verfasserin (orcid)0000-0002-6821-5804 aut Deol, Parneet Kaur verfasserin aut Agrawal, Anupam verfasserin aut Enthalten in Journal of materials research Springer International Publishing, 1986 39(2024), 11 vom: 10. Apr., Seite 1644-1660 (DE-627)320527026 (DE-600)2015297-8 2044-5326 nnns volume:39 year:2024 number:11 day:10 month:04 pages:1644-1660 https://dx.doi.org/10.1557/s43578-024-01335-3 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 VZ AR 39 2024 11 10 04 1644-1660 |
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10.1557/s43578-024-01335-3 doi (DE-627)SPR056255047 (SPR)s43578-024-01335-3-e DE-627 ger DE-627 rakwb eng 670 VZ 51.00 bkl Singh, Maninder verfasserin aut Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract Ti6Al4V (dpeaa)DE-He213 Graded porous structures (dpeaa)DE-He213 Powder metallurgy (dpeaa)DE-He213 Orthopedic implants (dpeaa)DE-He213 Drug delivery (dpeaa)DE-He213 Sodium alginate (dpeaa)DE-He213 Gill, Amoljit Singh verfasserin (orcid)0000-0002-6821-5804 aut Deol, Parneet Kaur verfasserin aut Agrawal, Anupam verfasserin aut Enthalten in Journal of materials research Springer International Publishing, 1986 39(2024), 11 vom: 10. Apr., Seite 1644-1660 (DE-627)320527026 (DE-600)2015297-8 2044-5326 nnns volume:39 year:2024 number:11 day:10 month:04 pages:1644-1660 https://dx.doi.org/10.1557/s43578-024-01335-3 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 VZ AR 39 2024 11 10 04 1644-1660 |
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10.1557/s43578-024-01335-3 doi (DE-627)SPR056255047 (SPR)s43578-024-01335-3-e DE-627 ger DE-627 rakwb eng 670 VZ 51.00 bkl Singh, Maninder verfasserin aut Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract Ti6Al4V (dpeaa)DE-He213 Graded porous structures (dpeaa)DE-He213 Powder metallurgy (dpeaa)DE-He213 Orthopedic implants (dpeaa)DE-He213 Drug delivery (dpeaa)DE-He213 Sodium alginate (dpeaa)DE-He213 Gill, Amoljit Singh verfasserin (orcid)0000-0002-6821-5804 aut Deol, Parneet Kaur verfasserin aut Agrawal, Anupam verfasserin aut Enthalten in Journal of materials research Springer International Publishing, 1986 39(2024), 11 vom: 10. Apr., Seite 1644-1660 (DE-627)320527026 (DE-600)2015297-8 2044-5326 nnns volume:39 year:2024 number:11 day:10 month:04 pages:1644-1660 https://dx.doi.org/10.1557/s43578-024-01335-3 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 VZ AR 39 2024 11 10 04 1644-1660 |
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10.1557/s43578-024-01335-3 doi (DE-627)SPR056255047 (SPR)s43578-024-01335-3-e DE-627 ger DE-627 rakwb eng 670 VZ 51.00 bkl Singh, Maninder verfasserin aut Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract Ti6Al4V (dpeaa)DE-He213 Graded porous structures (dpeaa)DE-He213 Powder metallurgy (dpeaa)DE-He213 Orthopedic implants (dpeaa)DE-He213 Drug delivery (dpeaa)DE-He213 Sodium alginate (dpeaa)DE-He213 Gill, Amoljit Singh verfasserin (orcid)0000-0002-6821-5804 aut Deol, Parneet Kaur verfasserin aut Agrawal, Anupam verfasserin aut Enthalten in Journal of materials research Springer International Publishing, 1986 39(2024), 11 vom: 10. Apr., Seite 1644-1660 (DE-627)320527026 (DE-600)2015297-8 2044-5326 nnns volume:39 year:2024 number:11 day:10 month:04 pages:1644-1660 https://dx.doi.org/10.1557/s43578-024-01335-3 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 51.00 VZ AR 39 2024 11 10 04 1644-1660 |
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Singh, Maninder |
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Singh, Maninder ddc 670 bkl 51.00 misc Ti6Al4V misc Graded porous structures misc Powder metallurgy misc Orthopedic implants misc Drug delivery misc Sodium alginate Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications |
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fabrication of drug-loaded graded porous ti6al4v structures for load-bearing biomedical applications |
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Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications |
| abstract |
The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
The present study investigated drug-loaded, titanium alloy (Ti6Al4V) graded porous structure with desired mechanical properties for implant-based local drug delivery application. The fabricated graded porous metallic structures displayed compressive yield strength in a range of 110.8–283.8 MPa, open porosity 30.2–69.4% and Young’s modulus 2.2–12.1 GPa. These characteristics resemble the range for human bone tissue. The electrochemical corrosion behaviour of the fabricated structures was found satisfactory even though comparatively higher corrosion rate was observed in porous samples. The analysis showed the formation of protective passive layer on the exposed surface of the porous samples. The micrographs confirmed the presence of well-distributed interconnected pores in the peripheral region of the samples which were used to load drug (simvastatin) using different dispersion media. It was found that by varying the later, the in vitro release of loaded drug can be prolonged to as long as 14 days. Graphical abstract © The Author(s), under exclusive licence to The Materials Research Society 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Fabrication of drug-loaded graded porous Ti6Al4V structures for load-bearing biomedical applications |
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https://dx.doi.org/10.1557/s43578-024-01335-3 |
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Gill, Amoljit Singh Deol, Parneet Kaur Agrawal, Anupam |
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10.1557/s43578-024-01335-3 |
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2024-07-03T21:11:38.294Z |
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| score |
7.401908 |