COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study

Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Pietroluongo, Erica [verfasserIn] Peddio, Annarita [verfasserIn] De Placido, Pietro [verfasserIn] Tortora, Marianna [verfasserIn] Ottaviano, Margaret [verfasserIn] Gelzo, Monica [verfasserIn] Cernera, Gustavo [verfasserIn] Foggia, Maria [verfasserIn] Buonomo, Antonio Riccardo [verfasserIn] Pinchera, Biagio [verfasserIn] Zappulo, Emanuela [verfasserIn] Mercinelli, Simona [verfasserIn] Cattaneo, Letizia [verfasserIn] Sardanelli, Alessia [verfasserIn] Viceconte, Giulio [verfasserIn] Scotto, Riccardo [verfasserIn] Schiano Moriello, Nicola [verfasserIn] Servetto, Alberto [verfasserIn] De Angelis, Carmine [verfasserIn] Arpino, Grazia [verfasserIn] Palmieri, Giovannella [verfasserIn] De Placido, Sabino [verfasserIn] Bianco, Roberto [verfasserIn] Castaldo, Giuseppe [verfasserIn] Gentile, Ivan [verfasserIn] Giuliano, Mario [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	SARS-CoV-2 COVID-19, thymic epithelial tumors Good’s syndrome

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC cancer - BioMed Central, 2001, 24(2024), 1 vom: 19. Juni
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:19 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s12885-024-12405-4

Katalog-ID:	SPR056297254

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520			\|a Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols.
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allfields	10.1186/s12885-024-12405-4 doi (DE-627)SPR056297254 (SPR)s12885-024-12405-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pietroluongo, Erica verfasserin aut COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. SARS-CoV-2 (dpeaa)DE-He213 COVID-19, thymic epithelial tumors (dpeaa)DE-He213 Good’s syndrome (dpeaa)DE-He213 Peddio, Annarita verfasserin aut De Placido, Pietro verfasserin aut Tortora, Marianna verfasserin aut Ottaviano, Margaret verfasserin aut Gelzo, Monica verfasserin aut Cernera, Gustavo verfasserin aut Foggia, Maria verfasserin aut Buonomo, Antonio Riccardo verfasserin aut Pinchera, Biagio verfasserin aut Zappulo, Emanuela verfasserin aut Mercinelli, Simona verfasserin aut Cattaneo, Letizia verfasserin aut Sardanelli, Alessia verfasserin aut Viceconte, Giulio verfasserin aut Scotto, Riccardo verfasserin aut Schiano Moriello, Nicola verfasserin aut Servetto, Alberto verfasserin aut De Angelis, Carmine verfasserin aut Arpino, Grazia verfasserin aut Palmieri, Giovannella verfasserin aut De Placido, Sabino verfasserin aut Bianco, Roberto verfasserin aut Castaldo, Giuseppe verfasserin aut Gentile, Ivan verfasserin aut Giuliano, Mario verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 19. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:19 month:06 https://dx.doi.org/10.1186/s12885-024-12405-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 19 06
spelling	10.1186/s12885-024-12405-4 doi (DE-627)SPR056297254 (SPR)s12885-024-12405-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pietroluongo, Erica verfasserin aut COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. SARS-CoV-2 (dpeaa)DE-He213 COVID-19, thymic epithelial tumors (dpeaa)DE-He213 Good’s syndrome (dpeaa)DE-He213 Peddio, Annarita verfasserin aut De Placido, Pietro verfasserin aut Tortora, Marianna verfasserin aut Ottaviano, Margaret verfasserin aut Gelzo, Monica verfasserin aut Cernera, Gustavo verfasserin aut Foggia, Maria verfasserin aut Buonomo, Antonio Riccardo verfasserin aut Pinchera, Biagio verfasserin aut Zappulo, Emanuela verfasserin aut Mercinelli, Simona verfasserin aut Cattaneo, Letizia verfasserin aut Sardanelli, Alessia verfasserin aut Viceconte, Giulio verfasserin aut Scotto, Riccardo verfasserin aut Schiano Moriello, Nicola verfasserin aut Servetto, Alberto verfasserin aut De Angelis, Carmine verfasserin aut Arpino, Grazia verfasserin aut Palmieri, Giovannella verfasserin aut De Placido, Sabino verfasserin aut Bianco, Roberto verfasserin aut Castaldo, Giuseppe verfasserin aut Gentile, Ivan verfasserin aut Giuliano, Mario verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 19. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:19 month:06 https://dx.doi.org/10.1186/s12885-024-12405-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 19 06
allfields_unstemmed	10.1186/s12885-024-12405-4 doi (DE-627)SPR056297254 (SPR)s12885-024-12405-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pietroluongo, Erica verfasserin aut COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. SARS-CoV-2 (dpeaa)DE-He213 COVID-19, thymic epithelial tumors (dpeaa)DE-He213 Good’s syndrome (dpeaa)DE-He213 Peddio, Annarita verfasserin aut De Placido, Pietro verfasserin aut Tortora, Marianna verfasserin aut Ottaviano, Margaret verfasserin aut Gelzo, Monica verfasserin aut Cernera, Gustavo verfasserin aut Foggia, Maria verfasserin aut Buonomo, Antonio Riccardo verfasserin aut Pinchera, Biagio verfasserin aut Zappulo, Emanuela verfasserin aut Mercinelli, Simona verfasserin aut Cattaneo, Letizia verfasserin aut Sardanelli, Alessia verfasserin aut Viceconte, Giulio verfasserin aut Scotto, Riccardo verfasserin aut Schiano Moriello, Nicola verfasserin aut Servetto, Alberto verfasserin aut De Angelis, Carmine verfasserin aut Arpino, Grazia verfasserin aut Palmieri, Giovannella verfasserin aut De Placido, Sabino verfasserin aut Bianco, Roberto verfasserin aut Castaldo, Giuseppe verfasserin aut Gentile, Ivan verfasserin aut Giuliano, Mario verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 19. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:19 month:06 https://dx.doi.org/10.1186/s12885-024-12405-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 19 06
allfieldsGer	10.1186/s12885-024-12405-4 doi (DE-627)SPR056297254 (SPR)s12885-024-12405-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pietroluongo, Erica verfasserin aut COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. SARS-CoV-2 (dpeaa)DE-He213 COVID-19, thymic epithelial tumors (dpeaa)DE-He213 Good’s syndrome (dpeaa)DE-He213 Peddio, Annarita verfasserin aut De Placido, Pietro verfasserin aut Tortora, Marianna verfasserin aut Ottaviano, Margaret verfasserin aut Gelzo, Monica verfasserin aut Cernera, Gustavo verfasserin aut Foggia, Maria verfasserin aut Buonomo, Antonio Riccardo verfasserin aut Pinchera, Biagio verfasserin aut Zappulo, Emanuela verfasserin aut Mercinelli, Simona verfasserin aut Cattaneo, Letizia verfasserin aut Sardanelli, Alessia verfasserin aut Viceconte, Giulio verfasserin aut Scotto, Riccardo verfasserin aut Schiano Moriello, Nicola verfasserin aut Servetto, Alberto verfasserin aut De Angelis, Carmine verfasserin aut Arpino, Grazia verfasserin aut Palmieri, Giovannella verfasserin aut De Placido, Sabino verfasserin aut Bianco, Roberto verfasserin aut Castaldo, Giuseppe verfasserin aut Gentile, Ivan verfasserin aut Giuliano, Mario verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 19. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:19 month:06 https://dx.doi.org/10.1186/s12885-024-12405-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 19 06
allfieldsSound	10.1186/s12885-024-12405-4 doi (DE-627)SPR056297254 (SPR)s12885-024-12405-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Pietroluongo, Erica verfasserin aut COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. SARS-CoV-2 (dpeaa)DE-He213 COVID-19, thymic epithelial tumors (dpeaa)DE-He213 Good’s syndrome (dpeaa)DE-He213 Peddio, Annarita verfasserin aut De Placido, Pietro verfasserin aut Tortora, Marianna verfasserin aut Ottaviano, Margaret verfasserin aut Gelzo, Monica verfasserin aut Cernera, Gustavo verfasserin aut Foggia, Maria verfasserin aut Buonomo, Antonio Riccardo verfasserin aut Pinchera, Biagio verfasserin aut Zappulo, Emanuela verfasserin aut Mercinelli, Simona verfasserin aut Cattaneo, Letizia verfasserin aut Sardanelli, Alessia verfasserin aut Viceconte, Giulio verfasserin aut Scotto, Riccardo verfasserin aut Schiano Moriello, Nicola verfasserin aut Servetto, Alberto verfasserin aut De Angelis, Carmine verfasserin aut Arpino, Grazia verfasserin aut Palmieri, Giovannella verfasserin aut De Placido, Sabino verfasserin aut Bianco, Roberto verfasserin aut Castaldo, Giuseppe verfasserin aut Gentile, Ivan verfasserin aut Giuliano, Mario verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 19. Juni (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:19 month:06 https://dx.doi.org/10.1186/s12885-024-12405-4 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 19 06
language	English
source	Enthalten in BMC cancer 24(2024), 1 vom: 19. Juni volume:24 year:2024 number:1 day:19 month:06
sourceStr	Enthalten in BMC cancer 24(2024), 1 vom: 19. Juni volume:24 year:2024 number:1 day:19 month:06
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SARS-CoV-2 COVID-19, thymic epithelial tumors Good’s syndrome
dewey-raw	610
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container_title	BMC cancer
authorswithroles_txt_mv	Pietroluongo, Erica @@aut@@ Peddio, Annarita @@aut@@ De Placido, Pietro @@aut@@ Tortora, Marianna @@aut@@ Ottaviano, Margaret @@aut@@ Gelzo, Monica @@aut@@ Cernera, Gustavo @@aut@@ Foggia, Maria @@aut@@ Buonomo, Antonio Riccardo @@aut@@ Pinchera, Biagio @@aut@@ Zappulo, Emanuela @@aut@@ Mercinelli, Simona @@aut@@ Cattaneo, Letizia @@aut@@ Sardanelli, Alessia @@aut@@ Viceconte, Giulio @@aut@@ Scotto, Riccardo @@aut@@ Schiano Moriello, Nicola @@aut@@ Servetto, Alberto @@aut@@ De Angelis, Carmine @@aut@@ Arpino, Grazia @@aut@@ Palmieri, Giovannella @@aut@@ De Placido, Sabino @@aut@@ Bianco, Roberto @@aut@@ Castaldo, Giuseppe @@aut@@ Gentile, Ivan @@aut@@ Giuliano, Mario @@aut@@
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Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. 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author	Pietroluongo, Erica
spellingShingle	Pietroluongo, Erica ddc 610 bkl 44.00 misc SARS-CoV-2 misc COVID-19, thymic epithelial tumors misc Good’s syndrome COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study
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title	COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study
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author_browse	Pietroluongo, Erica Peddio, Annarita De Placido, Pietro Tortora, Marianna Ottaviano, Margaret Gelzo, Monica Cernera, Gustavo Foggia, Maria Buonomo, Antonio Riccardo Pinchera, Biagio Zappulo, Emanuela Mercinelli, Simona Cattaneo, Letizia Sardanelli, Alessia Viceconte, Giulio Scotto, Riccardo Schiano Moriello, Nicola Servetto, Alberto De Angelis, Carmine Arpino, Grazia Palmieri, Giovannella De Placido, Sabino Bianco, Roberto Castaldo, Giuseppe Gentile, Ivan Giuliano, Mario
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title_sort	covid-19 in patients with thymic epithelial tumors with or without good’s syndrome: a single-center retrospective study
title_auth	COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study
abstract	Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. © The Author(s) 2024
abstractGer	Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. © The Author(s) 2024
abstract_unstemmed	Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients with Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, are at a high risk of mortality due to infectious diseases. This study aims to examine COVID-19 occurrence and severity in TET patients, with or without GS. Methods Clinical records of TET patients referred to the Regional Coordinating Center for Rare Tumors of Campania Region were retrospectively collected. During the observation period, elapsing from March 2020 to April 2023, the following data were collected: occurrence of SARS-CoV-2 infection; COVID-19 severity, according to the National Institute of Health (NIH) illness categories; COVID-19 treatment. COVID-19 occurrence and severity were assessed in the overall population and correlated with the presence of GS and/or other immune-related dysregulations. Results Overall, 47 TET patients were included in the study; 27 of these (57.4%) had GS. All participants had received a full cycle of mRNA vaccine for SARS-CoV2., Thirty-one patients (66.0%) experienced COVID-19, of whom 18 (58.0%) had previously received a diagnosis of GS. No significant association of GS and/or other immune-related dysregulations with SARS-CoV-2 infection occurrence was detected (Fisher’s exact test p = 1 and p = 0.3587, respectively). Among patients with GS, 8 (45.0%) reported a COVID-19 severity score of ≥ 3; whereas, only 1 of the 13 patients without GS (7.7%) had a severity score of ≥ 3. The correlation between presence of GS and COVID-19 severity (score 1 or 2 vs. ≥ 3) was statistically significant (p = 0.0448). No statistically significant association between COVID-19 severity and other immune-related syndromes were found (p = 1). Of note, all the hospitalized patients for NIH 4 and 5 COVID-19 had GS. Conclusions Our data suggest that TET patients, especially those with GS, require a careful multidisciplinary monitoring for SARS-CoV-2 infection, in order to establish tailored treatments and prophylactic protocols. © The Author(s) 2024
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container_issue	1
title_short	COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study
url	https://dx.doi.org/10.1186/s12885-024-12405-4
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author2	Peddio, Annarita De Placido, Pietro Tortora, Marianna Ottaviano, Margaret Gelzo, Monica Cernera, Gustavo Foggia, Maria Buonomo, Antonio Riccardo Pinchera, Biagio Zappulo, Emanuela Mercinelli, Simona Cattaneo, Letizia Sardanelli, Alessia Viceconte, Giulio Scotto, Riccardo Schiano Moriello, Nicola Servetto, Alberto De Angelis, Carmine Arpino, Grazia Palmieri, Giovannella De Placido, Sabino Bianco, Roberto Castaldo, Giuseppe Gentile, Ivan Giuliano, Mario
author2Str	Peddio, Annarita De Placido, Pietro Tortora, Marianna Ottaviano, Margaret Gelzo, Monica Cernera, Gustavo Foggia, Maria Buonomo, Antonio Riccardo Pinchera, Biagio Zappulo, Emanuela Mercinelli, Simona Cattaneo, Letizia Sardanelli, Alessia Viceconte, Giulio Scotto, Riccardo Schiano Moriello, Nicola Servetto, Alberto De Angelis, Carmine Arpino, Grazia Palmieri, Giovannella De Placido, Sabino Bianco, Roberto Castaldo, Giuseppe Gentile, Ivan Giuliano, Mario
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doi_str	10.1186/s12885-024-12405-4
up_date	2024-07-03T21:29:30.139Z
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