Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model
Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
dos Santos, Tabata Maruyama [verfasserIn] Righetti, Renato Fraga [verfasserIn] do Nascimento Camargo, Leandro [verfasserIn] Leick, Edna Aparecida [verfasserIn] Fukuzaki, Silvia [verfasserIn] de Campos, Elaine Cristina [verfasserIn] Galli, Thiago Tafarel [verfasserIn] Saraiva-Romanholo, Beatriz Mangueira [verfasserIn] da Silva, Luana Laura Sales [verfasserIn] Barbosa, Jéssica Anastácia Silva [verfasserIn] João, Juliana Morelli Lopes Gonçalves [verfasserIn] Prado, Carla Máximo [verfasserIn] de Rezende, Bianca Goulart [verfasserIn] Bourotte, Christine Laure Marie [verfasserIn] dos Santos Lopes, Fernanda Degobbi Tenorio Quirino [verfasserIn] de Arruda Martins, Milton [verfasserIn] Bensenor, Isabela M. [verfasserIn] de Oliveira Cirillo, João Vitor [verfasserIn] Bezerra, Suellen Karoline Moreira [verfasserIn] Silva, Fabio José Alencar [verfasserIn] Paulo, Marcela Souza Lima [verfasserIn] Lotufo, Paulo A. [verfasserIn] Lopes Calvo Tibério, Iolanda de Fátima [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Anmerkung: |
© The Author(s) 2024. corrected publication 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Journal of Inflammation - BioMed Central, 2004, 21(2024), 1 vom: 03. Juli |
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| Übergeordnetes Werk: |
volume:21 ; year:2024 ; number:1 ; day:03 ; month:07 |
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| DOI / URN: |
10.1186/s12950-024-00399-6 |
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| Katalog-ID: |
SPR056462875 |
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| 245 | 1 | 0 | |a Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model |
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| 520 | |a Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. | ||
| 650 | 4 | |a Asthma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acetylcholine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Particulate matter |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pollution |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Righetti, Renato Fraga |e verfasserin |4 aut | |
| 700 | 1 | |a do Nascimento Camargo, Leandro |e verfasserin |4 aut | |
| 700 | 1 | |a Leick, Edna Aparecida |e verfasserin |4 aut | |
| 700 | 1 | |a Fukuzaki, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a de Campos, Elaine Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Galli, Thiago Tafarel |e verfasserin |4 aut | |
| 700 | 1 | |a Saraiva-Romanholo, Beatriz Mangueira |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva, Luana Laura Sales |e verfasserin |4 aut | |
| 700 | 1 | |a Barbosa, Jéssica Anastácia Silva |e verfasserin |4 aut | |
| 700 | 1 | |a João, Juliana Morelli Lopes Gonçalves |e verfasserin |4 aut | |
| 700 | 1 | |a Prado, Carla Máximo |e verfasserin |4 aut | |
| 700 | 1 | |a de Rezende, Bianca Goulart |e verfasserin |4 aut | |
| 700 | 1 | |a Bourotte, Christine Laure Marie |e verfasserin |4 aut | |
| 700 | 1 | |a dos Santos Lopes, Fernanda Degobbi Tenorio Quirino |e verfasserin |4 aut | |
| 700 | 1 | |a de Arruda Martins, Milton |e verfasserin |4 aut | |
| 700 | 1 | |a Bensenor, Isabela M. |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira Cirillo, João Vitor |e verfasserin |4 aut | |
| 700 | 1 | |a Bezerra, Suellen Karoline Moreira |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Fabio José Alencar |e verfasserin |4 aut | |
| 700 | 1 | |a Paulo, Marcela Souza Lima |e verfasserin |4 aut | |
| 700 | 1 | |a Lotufo, Paulo A. |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes Calvo Tibério, Iolanda de Fátima |e verfasserin |4 aut | |
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10.1186/s12950-024-00399-6 doi (DE-627)SPR056462875 (SPR)s12950-024-00399-6-e DE-627 ger DE-627 rakwb eng 610 VZ dos Santos, Tabata Maruyama verfasserin aut Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Righetti, Renato Fraga verfasserin aut do Nascimento Camargo, Leandro verfasserin aut Leick, Edna Aparecida verfasserin aut Fukuzaki, Silvia verfasserin aut de Campos, Elaine Cristina verfasserin aut Galli, Thiago Tafarel verfasserin aut Saraiva-Romanholo, Beatriz Mangueira verfasserin aut da Silva, Luana Laura Sales verfasserin aut Barbosa, Jéssica Anastácia Silva verfasserin aut João, Juliana Morelli Lopes Gonçalves verfasserin aut Prado, Carla Máximo verfasserin aut de Rezende, Bianca Goulart verfasserin aut Bourotte, Christine Laure Marie verfasserin aut dos Santos Lopes, Fernanda Degobbi Tenorio Quirino verfasserin aut de Arruda Martins, Milton verfasserin aut Bensenor, Isabela M. verfasserin aut de Oliveira Cirillo, João Vitor verfasserin aut Bezerra, Suellen Karoline Moreira verfasserin aut Silva, Fabio José Alencar verfasserin aut Paulo, Marcela Souza Lima verfasserin aut Lotufo, Paulo A. verfasserin aut Lopes Calvo Tibério, Iolanda de Fátima verfasserin aut Enthalten in Journal of Inflammation BioMed Central, 2004 21(2024), 1 vom: 03. Juli (DE-627)461908018 (DE-600)2164385-4 1476-9255 nnns volume:21 year:2024 number:1 day:03 month:07 https://dx.doi.org/10.1186/s12950-024-00399-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 03 07 |
| spelling |
10.1186/s12950-024-00399-6 doi (DE-627)SPR056462875 (SPR)s12950-024-00399-6-e DE-627 ger DE-627 rakwb eng 610 VZ dos Santos, Tabata Maruyama verfasserin aut Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Righetti, Renato Fraga verfasserin aut do Nascimento Camargo, Leandro verfasserin aut Leick, Edna Aparecida verfasserin aut Fukuzaki, Silvia verfasserin aut de Campos, Elaine Cristina verfasserin aut Galli, Thiago Tafarel verfasserin aut Saraiva-Romanholo, Beatriz Mangueira verfasserin aut da Silva, Luana Laura Sales verfasserin aut Barbosa, Jéssica Anastácia Silva verfasserin aut João, Juliana Morelli Lopes Gonçalves verfasserin aut Prado, Carla Máximo verfasserin aut de Rezende, Bianca Goulart verfasserin aut Bourotte, Christine Laure Marie verfasserin aut dos Santos Lopes, Fernanda Degobbi Tenorio Quirino verfasserin aut de Arruda Martins, Milton verfasserin aut Bensenor, Isabela M. verfasserin aut de Oliveira Cirillo, João Vitor verfasserin aut Bezerra, Suellen Karoline Moreira verfasserin aut Silva, Fabio José Alencar verfasserin aut Paulo, Marcela Souza Lima verfasserin aut Lotufo, Paulo A. verfasserin aut Lopes Calvo Tibério, Iolanda de Fátima verfasserin aut Enthalten in Journal of Inflammation BioMed Central, 2004 21(2024), 1 vom: 03. Juli (DE-627)461908018 (DE-600)2164385-4 1476-9255 nnns volume:21 year:2024 number:1 day:03 month:07 https://dx.doi.org/10.1186/s12950-024-00399-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 03 07 |
| allfields_unstemmed |
10.1186/s12950-024-00399-6 doi (DE-627)SPR056462875 (SPR)s12950-024-00399-6-e DE-627 ger DE-627 rakwb eng 610 VZ dos Santos, Tabata Maruyama verfasserin aut Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Righetti, Renato Fraga verfasserin aut do Nascimento Camargo, Leandro verfasserin aut Leick, Edna Aparecida verfasserin aut Fukuzaki, Silvia verfasserin aut de Campos, Elaine Cristina verfasserin aut Galli, Thiago Tafarel verfasserin aut Saraiva-Romanholo, Beatriz Mangueira verfasserin aut da Silva, Luana Laura Sales verfasserin aut Barbosa, Jéssica Anastácia Silva verfasserin aut João, Juliana Morelli Lopes Gonçalves verfasserin aut Prado, Carla Máximo verfasserin aut de Rezende, Bianca Goulart verfasserin aut Bourotte, Christine Laure Marie verfasserin aut dos Santos Lopes, Fernanda Degobbi Tenorio Quirino verfasserin aut de Arruda Martins, Milton verfasserin aut Bensenor, Isabela M. verfasserin aut de Oliveira Cirillo, João Vitor verfasserin aut Bezerra, Suellen Karoline Moreira verfasserin aut Silva, Fabio José Alencar verfasserin aut Paulo, Marcela Souza Lima verfasserin aut Lotufo, Paulo A. verfasserin aut Lopes Calvo Tibério, Iolanda de Fátima verfasserin aut Enthalten in Journal of Inflammation BioMed Central, 2004 21(2024), 1 vom: 03. Juli (DE-627)461908018 (DE-600)2164385-4 1476-9255 nnns volume:21 year:2024 number:1 day:03 month:07 https://dx.doi.org/10.1186/s12950-024-00399-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 03 07 |
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10.1186/s12950-024-00399-6 doi (DE-627)SPR056462875 (SPR)s12950-024-00399-6-e DE-627 ger DE-627 rakwb eng 610 VZ dos Santos, Tabata Maruyama verfasserin aut Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Righetti, Renato Fraga verfasserin aut do Nascimento Camargo, Leandro verfasserin aut Leick, Edna Aparecida verfasserin aut Fukuzaki, Silvia verfasserin aut de Campos, Elaine Cristina verfasserin aut Galli, Thiago Tafarel verfasserin aut Saraiva-Romanholo, Beatriz Mangueira verfasserin aut da Silva, Luana Laura Sales verfasserin aut Barbosa, Jéssica Anastácia Silva verfasserin aut João, Juliana Morelli Lopes Gonçalves verfasserin aut Prado, Carla Máximo verfasserin aut de Rezende, Bianca Goulart verfasserin aut Bourotte, Christine Laure Marie verfasserin aut dos Santos Lopes, Fernanda Degobbi Tenorio Quirino verfasserin aut de Arruda Martins, Milton verfasserin aut Bensenor, Isabela M. verfasserin aut de Oliveira Cirillo, João Vitor verfasserin aut Bezerra, Suellen Karoline Moreira verfasserin aut Silva, Fabio José Alencar verfasserin aut Paulo, Marcela Souza Lima verfasserin aut Lotufo, Paulo A. verfasserin aut Lopes Calvo Tibério, Iolanda de Fátima verfasserin aut Enthalten in Journal of Inflammation BioMed Central, 2004 21(2024), 1 vom: 03. Juli (DE-627)461908018 (DE-600)2164385-4 1476-9255 nnns volume:21 year:2024 number:1 day:03 month:07 https://dx.doi.org/10.1186/s12950-024-00399-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 03 07 |
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10.1186/s12950-024-00399-6 doi (DE-627)SPR056462875 (SPR)s12950-024-00399-6-e DE-627 ger DE-627 rakwb eng 610 VZ dos Santos, Tabata Maruyama verfasserin aut Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Righetti, Renato Fraga verfasserin aut do Nascimento Camargo, Leandro verfasserin aut Leick, Edna Aparecida verfasserin aut Fukuzaki, Silvia verfasserin aut de Campos, Elaine Cristina verfasserin aut Galli, Thiago Tafarel verfasserin aut Saraiva-Romanholo, Beatriz Mangueira verfasserin aut da Silva, Luana Laura Sales verfasserin aut Barbosa, Jéssica Anastácia Silva verfasserin aut João, Juliana Morelli Lopes Gonçalves verfasserin aut Prado, Carla Máximo verfasserin aut de Rezende, Bianca Goulart verfasserin aut Bourotte, Christine Laure Marie verfasserin aut dos Santos Lopes, Fernanda Degobbi Tenorio Quirino verfasserin aut de Arruda Martins, Milton verfasserin aut Bensenor, Isabela M. verfasserin aut de Oliveira Cirillo, João Vitor verfasserin aut Bezerra, Suellen Karoline Moreira verfasserin aut Silva, Fabio José Alencar verfasserin aut Paulo, Marcela Souza Lima verfasserin aut Lotufo, Paulo A. verfasserin aut Lopes Calvo Tibério, Iolanda de Fátima verfasserin aut Enthalten in Journal of Inflammation BioMed Central, 2004 21(2024), 1 vom: 03. Juli (DE-627)461908018 (DE-600)2164385-4 1476-9255 nnns volume:21 year:2024 number:1 day:03 month:07 https://dx.doi.org/10.1186/s12950-024-00399-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 03 07 |
| language |
English |
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Enthalten in Journal of Inflammation 21(2024), 1 vom: 03. Juli volume:21 year:2024 number:1 day:03 month:07 |
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Enthalten in Journal of Inflammation 21(2024), 1 vom: 03. Juli volume:21 year:2024 number:1 day:03 month:07 |
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Article |
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findex.gbv.de |
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Asthma Acetylcholine Particulate matter Pollution Inflammation |
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610 |
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Journal of Inflammation |
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dos Santos, Tabata Maruyama @@aut@@ Righetti, Renato Fraga @@aut@@ do Nascimento Camargo, Leandro @@aut@@ Leick, Edna Aparecida @@aut@@ Fukuzaki, Silvia @@aut@@ de Campos, Elaine Cristina @@aut@@ Galli, Thiago Tafarel @@aut@@ Saraiva-Romanholo, Beatriz Mangueira @@aut@@ da Silva, Luana Laura Sales @@aut@@ Barbosa, Jéssica Anastácia Silva @@aut@@ João, Juliana Morelli Lopes Gonçalves @@aut@@ Prado, Carla Máximo @@aut@@ de Rezende, Bianca Goulart @@aut@@ Bourotte, Christine Laure Marie @@aut@@ dos Santos Lopes, Fernanda Degobbi Tenorio Quirino @@aut@@ de Arruda Martins, Milton @@aut@@ Bensenor, Isabela M. @@aut@@ de Oliveira Cirillo, João Vitor @@aut@@ Bezerra, Suellen Karoline Moreira @@aut@@ Silva, Fabio José Alencar @@aut@@ Paulo, Marcela Souza Lima @@aut@@ Lotufo, Paulo A. @@aut@@ Lopes Calvo Tibério, Iolanda de Fátima @@aut@@ |
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2024-07-03T00:00:00Z |
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461908018 |
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3610 |
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englisch |
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The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. 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dos Santos, Tabata Maruyama |
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dos Santos, Tabata Maruyama ddc 610 misc Asthma misc Acetylcholine misc Particulate matter misc Pollution misc Inflammation Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model |
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610 VZ Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model Asthma (dpeaa)DE-He213 Acetylcholine (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Pollution (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 |
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dos Santos, Tabata Maruyama Righetti, Renato Fraga do Nascimento Camargo, Leandro Leick, Edna Aparecida Fukuzaki, Silvia de Campos, Elaine Cristina Galli, Thiago Tafarel Saraiva-Romanholo, Beatriz Mangueira da Silva, Luana Laura Sales Barbosa, Jéssica Anastácia Silva João, Juliana Morelli Lopes Gonçalves Prado, Carla Máximo de Rezende, Bianca Goulart Bourotte, Christine Laure Marie dos Santos Lopes, Fernanda Degobbi Tenorio Quirino de Arruda Martins, Milton Bensenor, Isabela M. de Oliveira Cirillo, João Vitor Bezerra, Suellen Karoline Moreira Silva, Fabio José Alencar Paulo, Marcela Souza Lima Lotufo, Paulo A. Lopes Calvo Tibério, Iolanda de Fátima |
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effect of vacht reduction on lung alterations induced by exposure to iron particles in an asthma model |
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Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model |
| abstract |
Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. © The Author(s) 2024. corrected publication 2024 |
| abstractGer |
Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. © The Author(s) 2024. corrected publication 2024 |
| abstract_unstemmed |
Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling. © The Author(s) 2024. corrected publication 2024 |
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Righetti, Renato Fraga do Nascimento Camargo, Leandro Leick, Edna Aparecida Fukuzaki, Silvia de Campos, Elaine Cristina Galli, Thiago Tafarel Saraiva-Romanholo, Beatriz Mangueira da Silva, Luana Laura Sales Barbosa, Jéssica Anastácia Silva João, Juliana Morelli Lopes Gonçalves Prado, Carla Máximo de Rezende, Bianca Goulart Bourotte, Christine Laure Marie dos Santos Lopes, Fernanda Degobbi Tenorio Quirino de Arruda Martins, Milton Bensenor, Isabela M. de Oliveira Cirillo, João Vitor Bezerra, Suellen Karoline Moreira Silva, Fabio José Alencar Paulo, Marcela Souza Lima Lotufo, Paulo A. Lopes Calvo Tibério, Iolanda de Fátima |
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Righetti, Renato Fraga do Nascimento Camargo, Leandro Leick, Edna Aparecida Fukuzaki, Silvia de Campos, Elaine Cristina Galli, Thiago Tafarel Saraiva-Romanholo, Beatriz Mangueira da Silva, Luana Laura Sales Barbosa, Jéssica Anastácia Silva João, Juliana Morelli Lopes Gonçalves Prado, Carla Máximo de Rezende, Bianca Goulart Bourotte, Christine Laure Marie dos Santos Lopes, Fernanda Degobbi Tenorio Quirino de Arruda Martins, Milton Bensenor, Isabela M. de Oliveira Cirillo, João Vitor Bezerra, Suellen Karoline Moreira Silva, Fabio José Alencar Paulo, Marcela Souza Lima Lotufo, Paulo A. Lopes Calvo Tibério, Iolanda de Fátima |
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The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. 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