Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy
Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma wh...
Ausführliche Beschreibung
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| Autor*in: |
Pensato, Umberto [verfasserIn] Pondrelli, Federica [verfasserIn] de Philippis, Chiara [verfasserIn] Asioli, Gian Maria [verfasserIn] Crespi, Alessandra [verfasserIn] Buizza, Alessandro [verfasserIn] Mannina, Daniele [verfasserIn] Casadei, Beatrice [verfasserIn] Maffini, Enrico [verfasserIn] Straffi, Laura [verfasserIn] Marcheselli, Simona [verfasserIn] Zinzani, Pier Luigi [verfasserIn] Bonifazi, Francesca [verfasserIn] Guarino, Maria [verfasserIn] Bramanti, Stefania [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2024. corrected publication 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Neurological sciences - Springer International Publishing, 2000, 45(2024), 8 vom: 21. März, Seite 4007-4014 |
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| Übergeordnetes Werk: |
volume:45 ; year:2024 ; number:8 ; day:21 ; month:03 ; pages:4007-4014 |
| Links: |
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| DOI / URN: |
10.1007/s10072-024-07481-0 |
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| Katalog-ID: |
SPR056621701 |
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| 245 | 1 | 0 | |a Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
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| 520 | |a Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. | ||
| 650 | 4 | |a Status epilepticus |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neurotoxicity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Electroencephalography (EEG) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immune effector-associated neurotoxicity syndrome (ICANS) |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-epileptic drugs |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cancer immunotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neurological complications |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-Hodgkin lymphoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cytokine storm-associated encephalopathy (CySE) |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pondrelli, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a de Philippis, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Asioli, Gian Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Crespi, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Buizza, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Mannina, Daniele |e verfasserin |4 aut | |
| 700 | 1 | |a Casadei, Beatrice |e verfasserin |4 aut | |
| 700 | 1 | |a Maffini, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Straffi, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Marcheselli, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Zinzani, Pier Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Bonifazi, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Guarino, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Bramanti, Stefania |e verfasserin |4 aut | |
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10.1007/s10072-024-07481-0 doi (DE-627)SPR056621701 (SPR)s10072-024-07481-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Pensato, Umberto verfasserin (orcid)0000-0002-4042-4735 aut Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 Pondrelli, Federica verfasserin aut de Philippis, Chiara verfasserin aut Asioli, Gian Maria verfasserin aut Crespi, Alessandra verfasserin aut Buizza, Alessandro verfasserin aut Mannina, Daniele verfasserin aut Casadei, Beatrice verfasserin aut Maffini, Enrico verfasserin aut Straffi, Laura verfasserin aut Marcheselli, Simona verfasserin aut Zinzani, Pier Luigi verfasserin aut Bonifazi, Francesca verfasserin aut Guarino, Maria verfasserin aut Bramanti, Stefania verfasserin aut Enthalten in Neurological sciences Springer International Publishing, 2000 45(2024), 8 vom: 21. März, Seite 4007-4014 (DE-627)300187025 (DE-600)1481772-X 1590-3478 nnns volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 https://dx.doi.org/10.1007/s10072-024-07481-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 VZ AR 45 2024 8 21 03 4007-4014 |
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10.1007/s10072-024-07481-0 doi (DE-627)SPR056621701 (SPR)s10072-024-07481-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Pensato, Umberto verfasserin (orcid)0000-0002-4042-4735 aut Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 Pondrelli, Federica verfasserin aut de Philippis, Chiara verfasserin aut Asioli, Gian Maria verfasserin aut Crespi, Alessandra verfasserin aut Buizza, Alessandro verfasserin aut Mannina, Daniele verfasserin aut Casadei, Beatrice verfasserin aut Maffini, Enrico verfasserin aut Straffi, Laura verfasserin aut Marcheselli, Simona verfasserin aut Zinzani, Pier Luigi verfasserin aut Bonifazi, Francesca verfasserin aut Guarino, Maria verfasserin aut Bramanti, Stefania verfasserin aut Enthalten in Neurological sciences Springer International Publishing, 2000 45(2024), 8 vom: 21. März, Seite 4007-4014 (DE-627)300187025 (DE-600)1481772-X 1590-3478 nnns volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 https://dx.doi.org/10.1007/s10072-024-07481-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 VZ AR 45 2024 8 21 03 4007-4014 |
| allfields_unstemmed |
10.1007/s10072-024-07481-0 doi (DE-627)SPR056621701 (SPR)s10072-024-07481-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Pensato, Umberto verfasserin (orcid)0000-0002-4042-4735 aut Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 Pondrelli, Federica verfasserin aut de Philippis, Chiara verfasserin aut Asioli, Gian Maria verfasserin aut Crespi, Alessandra verfasserin aut Buizza, Alessandro verfasserin aut Mannina, Daniele verfasserin aut Casadei, Beatrice verfasserin aut Maffini, Enrico verfasserin aut Straffi, Laura verfasserin aut Marcheselli, Simona verfasserin aut Zinzani, Pier Luigi verfasserin aut Bonifazi, Francesca verfasserin aut Guarino, Maria verfasserin aut Bramanti, Stefania verfasserin aut Enthalten in Neurological sciences Springer International Publishing, 2000 45(2024), 8 vom: 21. März, Seite 4007-4014 (DE-627)300187025 (DE-600)1481772-X 1590-3478 nnns volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 https://dx.doi.org/10.1007/s10072-024-07481-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 VZ AR 45 2024 8 21 03 4007-4014 |
| allfieldsGer |
10.1007/s10072-024-07481-0 doi (DE-627)SPR056621701 (SPR)s10072-024-07481-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Pensato, Umberto verfasserin (orcid)0000-0002-4042-4735 aut Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 Pondrelli, Federica verfasserin aut de Philippis, Chiara verfasserin aut Asioli, Gian Maria verfasserin aut Crespi, Alessandra verfasserin aut Buizza, Alessandro verfasserin aut Mannina, Daniele verfasserin aut Casadei, Beatrice verfasserin aut Maffini, Enrico verfasserin aut Straffi, Laura verfasserin aut Marcheselli, Simona verfasserin aut Zinzani, Pier Luigi verfasserin aut Bonifazi, Francesca verfasserin aut Guarino, Maria verfasserin aut Bramanti, Stefania verfasserin aut Enthalten in Neurological sciences Springer International Publishing, 2000 45(2024), 8 vom: 21. März, Seite 4007-4014 (DE-627)300187025 (DE-600)1481772-X 1590-3478 nnns volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 https://dx.doi.org/10.1007/s10072-024-07481-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 VZ AR 45 2024 8 21 03 4007-4014 |
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10.1007/s10072-024-07481-0 doi (DE-627)SPR056621701 (SPR)s10072-024-07481-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Pensato, Umberto verfasserin (orcid)0000-0002-4042-4735 aut Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024. corrected publication 2024 Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 Pondrelli, Federica verfasserin aut de Philippis, Chiara verfasserin aut Asioli, Gian Maria verfasserin aut Crespi, Alessandra verfasserin aut Buizza, Alessandro verfasserin aut Mannina, Daniele verfasserin aut Casadei, Beatrice verfasserin aut Maffini, Enrico verfasserin aut Straffi, Laura verfasserin aut Marcheselli, Simona verfasserin aut Zinzani, Pier Luigi verfasserin aut Bonifazi, Francesca verfasserin aut Guarino, Maria verfasserin aut Bramanti, Stefania verfasserin aut Enthalten in Neurological sciences Springer International Publishing, 2000 45(2024), 8 vom: 21. März, Seite 4007-4014 (DE-627)300187025 (DE-600)1481772-X 1590-3478 nnns volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 https://dx.doi.org/10.1007/s10072-024-07481-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 VZ AR 45 2024 8 21 03 4007-4014 |
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Enthalten in Neurological sciences 45(2024), 8 vom: 21. März, Seite 4007-4014 volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 |
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Enthalten in Neurological sciences 45(2024), 8 vom: 21. März, Seite 4007-4014 volume:45 year:2024 number:8 day:21 month:03 pages:4007-4014 |
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findex.gbv.de |
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Status epilepticus Neurotoxicity Electroencephalography (EEG) Immune effector-associated neurotoxicity syndrome (ICANS) Anti-epileptic drugs Cancer immunotherapy Neurological complications Non-Hodgkin lymphoma Cytokine storm-associated encephalopathy (CySE) |
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Neurological sciences |
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Pensato, Umberto @@aut@@ Pondrelli, Federica @@aut@@ de Philippis, Chiara @@aut@@ Asioli, Gian Maria @@aut@@ Crespi, Alessandra @@aut@@ Buizza, Alessandro @@aut@@ Mannina, Daniele @@aut@@ Casadei, Beatrice @@aut@@ Maffini, Enrico @@aut@@ Straffi, Laura @@aut@@ Marcheselli, Simona @@aut@@ Zinzani, Pier Luigi @@aut@@ Bonifazi, Francesca @@aut@@ Guarino, Maria @@aut@@ Bramanti, Stefania @@aut@@ |
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2024-03-21T00:00:00Z |
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Pensato, Umberto |
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Pensato, Umberto ddc 610 bkl 44.90 misc Status epilepticus misc Neurotoxicity misc Electroencephalography (EEG) misc Immune effector-associated neurotoxicity syndrome (ICANS) misc Anti-epileptic drugs misc Cancer immunotherapy misc Neurological complications misc Non-Hodgkin lymphoma misc Cytokine storm-associated encephalopathy (CySE) Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
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610 VZ 44.90 bkl Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy Status epilepticus (dpeaa)DE-He213 Neurotoxicity (dpeaa)DE-He213 Electroencephalography (EEG) (dpeaa)DE-He213 Immune effector-associated neurotoxicity syndrome (ICANS) (dpeaa)DE-He213 Anti-epileptic drugs (dpeaa)DE-He213 Cancer immunotherapy (dpeaa)DE-He213 Neurological complications (dpeaa)DE-He213 Non-Hodgkin lymphoma (dpeaa)DE-He213 Cytokine storm-associated encephalopathy (CySE) (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Status epilepticus misc Neurotoxicity misc Electroencephalography (EEG) misc Immune effector-associated neurotoxicity syndrome (ICANS) misc Anti-epileptic drugs misc Cancer immunotherapy misc Neurological complications misc Non-Hodgkin lymphoma misc Cytokine storm-associated encephalopathy (CySE) |
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ddc 610 bkl 44.90 misc Status epilepticus misc Neurotoxicity misc Electroencephalography (EEG) misc Immune effector-associated neurotoxicity syndrome (ICANS) misc Anti-epileptic drugs misc Cancer immunotherapy misc Neurological complications misc Non-Hodgkin lymphoma misc Cytokine storm-associated encephalopathy (CySE) |
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ddc 610 bkl 44.90 misc Status epilepticus misc Neurotoxicity misc Electroencephalography (EEG) misc Immune effector-associated neurotoxicity syndrome (ICANS) misc Anti-epileptic drugs misc Cancer immunotherapy misc Neurological complications misc Non-Hodgkin lymphoma misc Cytokine storm-associated encephalopathy (CySE) |
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Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
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Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
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Pensato, Umberto Pondrelli, Federica de Philippis, Chiara Asioli, Gian Maria Crespi, Alessandra Buizza, Alessandro Mannina, Daniele Casadei, Beatrice Maffini, Enrico Straffi, Laura Marcheselli, Simona Zinzani, Pier Luigi Bonifazi, Francesca Guarino, Maria Bramanti, Stefania |
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Pensato, Umberto |
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primary vs. pre-emptive anti-seizure medication prophylaxis in anti-cd19 car t-cell therapy |
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Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
| abstract |
Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. © The Author(s) 2024. corrected publication 2024 |
| abstractGer |
Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. © The Author(s) 2024. corrected publication 2024 |
| abstract_unstemmed |
Introduction Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated. Methods Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols. ASM was started either as a primary prophylaxis (PP-group) before CAR T-cells infusion or as a pre-emptive therapy (PET-group) only upon the onset of neurotoxicity development. Results One hundred fifty-six patients were included (PP-group = 88, PET-group = 66). Overall, neurotoxicity and severe neurotoxicity occurred in 45 (29%) and 20 (13%) patients, respectively, equally distributed between the two groups. Five patients experienced epileptic events (PET-group = 3 [4%]; PP-group = 2 [2%]). For all the PET-group patients, seizure/status epilepticus occurred in the absence of overt CAR-T-related neurotoxicity, whereas patients in the PP-group experienced brief seizures only in the context of critical neurotoxicity with progressive severe encephalopathy. ASMs were well-tolerated by all patients, even without titration. No patients developed epilepsy or required long-term ASMs. Conclusion Our data suggest that both primary and pre-emptive anti-seizure prophylaxis are safe and effective in anti-CD19 CAR T-cell recipients. Clinical rationale suggests a possible more favourable profile of primary prophylaxis, yet no definitive conclusion of superiority between the two ASM strategies can be drawn from our study. © The Author(s) 2024. corrected publication 2024 |
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Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy |
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https://dx.doi.org/10.1007/s10072-024-07481-0 |
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Pondrelli, Federica de Philippis, Chiara Asioli, Gian Maria Crespi, Alessandra Buizza, Alessandro Mannina, Daniele Casadei, Beatrice Maffini, Enrico Straffi, Laura Marcheselli, Simona Zinzani, Pier Luigi Bonifazi, Francesca Guarino, Maria Bramanti, Stefania |
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Pondrelli, Federica de Philippis, Chiara Asioli, Gian Maria Crespi, Alessandra Buizza, Alessandro Mannina, Daniele Casadei, Beatrice Maffini, Enrico Straffi, Laura Marcheselli, Simona Zinzani, Pier Luigi Bonifazi, Francesca Guarino, Maria Bramanti, Stefania |
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10.1007/s10072-024-07481-0 |
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2024-07-18T04:49:29.647Z |
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| score |
7.3995514 |