DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study

Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH...
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Autor*in:	Dou, Yanyun [verfasserIn] Liao, Guangfu [verfasserIn] Lu, Ruichao [verfasserIn] Su, Lingsong [verfasserIn] Lan, Ke [verfasserIn] Meng, Zhihao [verfasserIn] Qin, Shanfang [verfasserIn] Huang, Wei [verfasserIn] Xu, Yuanlong [verfasserIn] Lv, Yu [verfasserIn] Wen, Yuhong [verfasserIn] Lan, Shuanglai [verfasserIn] Zuo, Yong [verfasserIn] Zhang, Yong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Dolutegravir Lamivudine Dual therapy HIV

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC infectious diseases - BioMed Central, 2001, 24(2024), 1 vom: 22. Juli
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:22 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12879-024-09624-2

Katalog-ID:	SPR056683014

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520			\|a Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH.
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allfields	10.1186/s12879-024-09624-2 doi (DE-627)SPR056683014 (SPR)s12879-024-09624-2-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Dou, Yanyun verfasserin aut DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Liao, Guangfu verfasserin aut Lu, Ruichao verfasserin aut Su, Lingsong verfasserin aut Lan, Ke verfasserin aut Meng, Zhihao verfasserin aut Qin, Shanfang verfasserin aut Huang, Wei verfasserin aut Xu, Yuanlong verfasserin aut Lv, Yu verfasserin aut Wen, Yuhong verfasserin aut Lan, Shuanglai verfasserin aut Zuo, Yong verfasserin aut Zhang, Yong verfasserin aut Enthalten in BMC infectious diseases BioMed Central, 2001 24(2024), 1 vom: 22. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:24 year:2024 number:1 day:22 month:07 https://dx.doi.org/10.1186/s12879-024-09624-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 22 07
spelling	10.1186/s12879-024-09624-2 doi (DE-627)SPR056683014 (SPR)s12879-024-09624-2-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Dou, Yanyun verfasserin aut DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Liao, Guangfu verfasserin aut Lu, Ruichao verfasserin aut Su, Lingsong verfasserin aut Lan, Ke verfasserin aut Meng, Zhihao verfasserin aut Qin, Shanfang verfasserin aut Huang, Wei verfasserin aut Xu, Yuanlong verfasserin aut Lv, Yu verfasserin aut Wen, Yuhong verfasserin aut Lan, Shuanglai verfasserin aut Zuo, Yong verfasserin aut Zhang, Yong verfasserin aut Enthalten in BMC infectious diseases BioMed Central, 2001 24(2024), 1 vom: 22. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:24 year:2024 number:1 day:22 month:07 https://dx.doi.org/10.1186/s12879-024-09624-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 22 07
allfields_unstemmed	10.1186/s12879-024-09624-2 doi (DE-627)SPR056683014 (SPR)s12879-024-09624-2-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Dou, Yanyun verfasserin aut DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Liao, Guangfu verfasserin aut Lu, Ruichao verfasserin aut Su, Lingsong verfasserin aut Lan, Ke verfasserin aut Meng, Zhihao verfasserin aut Qin, Shanfang verfasserin aut Huang, Wei verfasserin aut Xu, Yuanlong verfasserin aut Lv, Yu verfasserin aut Wen, Yuhong verfasserin aut Lan, Shuanglai verfasserin aut Zuo, Yong verfasserin aut Zhang, Yong verfasserin aut Enthalten in BMC infectious diseases BioMed Central, 2001 24(2024), 1 vom: 22. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:24 year:2024 number:1 day:22 month:07 https://dx.doi.org/10.1186/s12879-024-09624-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 22 07
allfieldsGer	10.1186/s12879-024-09624-2 doi (DE-627)SPR056683014 (SPR)s12879-024-09624-2-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Dou, Yanyun verfasserin aut DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Liao, Guangfu verfasserin aut Lu, Ruichao verfasserin aut Su, Lingsong verfasserin aut Lan, Ke verfasserin aut Meng, Zhihao verfasserin aut Qin, Shanfang verfasserin aut Huang, Wei verfasserin aut Xu, Yuanlong verfasserin aut Lv, Yu verfasserin aut Wen, Yuhong verfasserin aut Lan, Shuanglai verfasserin aut Zuo, Yong verfasserin aut Zhang, Yong verfasserin aut Enthalten in BMC infectious diseases BioMed Central, 2001 24(2024), 1 vom: 22. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:24 year:2024 number:1 day:22 month:07 https://dx.doi.org/10.1186/s12879-024-09624-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 22 07
allfieldsSound	10.1186/s12879-024-09624-2 doi (DE-627)SPR056683014 (SPR)s12879-024-09624-2-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Dou, Yanyun verfasserin aut DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Liao, Guangfu verfasserin aut Lu, Ruichao verfasserin aut Su, Lingsong verfasserin aut Lan, Ke verfasserin aut Meng, Zhihao verfasserin aut Qin, Shanfang verfasserin aut Huang, Wei verfasserin aut Xu, Yuanlong verfasserin aut Lv, Yu verfasserin aut Wen, Yuhong verfasserin aut Lan, Shuanglai verfasserin aut Zuo, Yong verfasserin aut Zhang, Yong verfasserin aut Enthalten in BMC infectious diseases BioMed Central, 2001 24(2024), 1 vom: 22. Juli (DE-627)326645381 (DE-600)2041550-3 1471-2334 nnns volume:24 year:2024 number:1 day:22 month:07 https://dx.doi.org/10.1186/s12879-024-09624-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 22 07
language	English
source	Enthalten in BMC infectious diseases 24(2024), 1 vom: 22. Juli volume:24 year:2024 number:1 day:22 month:07
sourceStr	Enthalten in BMC infectious diseases 24(2024), 1 vom: 22. Juli volume:24 year:2024 number:1 day:22 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dolutegravir Lamivudine Dual therapy HIV
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC infectious diseases
authorswithroles_txt_mv	Dou, Yanyun @@aut@@ Liao, Guangfu @@aut@@ Lu, Ruichao @@aut@@ Su, Lingsong @@aut@@ Lan, Ke @@aut@@ Meng, Zhihao @@aut@@ Qin, Shanfang @@aut@@ Huang, Wei @@aut@@ Xu, Yuanlong @@aut@@ Lv, Yu @@aut@@ Wen, Yuhong @@aut@@ Lan, Shuanglai @@aut@@ Zuo, Yong @@aut@@ Zhang, Yong @@aut@@
publishDateDaySort_date	2024-07-22T00:00:00Z
hierarchy_top_id	326645381
dewey-sort	3610
id	SPR056683014
language_de	englisch
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author	Dou, Yanyun
spellingShingle	Dou, Yanyun ddc 610 bkl 44.00 misc Dolutegravir misc Lamivudine misc Dual therapy misc HIV DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
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topic_title	610 VZ 44.00 bkl DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study Dolutegravir (dpeaa)DE-He213 Lamivudine (dpeaa)DE-He213 Dual therapy (dpeaa)DE-He213 HIV (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Dolutegravir misc Lamivudine misc Dual therapy misc HIV
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title	DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
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title_full	DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
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author_browse	Dou, Yanyun Liao, Guangfu Lu, Ruichao Su, Lingsong Lan, Ke Meng, Zhihao Qin, Shanfang Huang, Wei Xu, Yuanlong Lv, Yu Wen, Yuhong Lan, Shuanglai Zuo, Yong Zhang, Yong
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title_sort	dtg + 3tc dual therapy for the treatment naïve patients with viral load exceeding 500,000 copies/ml: a retrospective study
title_auth	DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
abstract	Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. © The Author(s) 2024
abstractGer	Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. © The Author(s) 2024
abstract_unstemmed	Background Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens. Methods A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed. Results The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported. Conclusions DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH. © The Author(s) 2024
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title_short	DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
url	https://dx.doi.org/10.1186/s12879-024-09624-2
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author2	Liao, Guangfu Lu, Ruichao Su, Lingsong Lan, Ke Meng, Zhihao Qin, Shanfang Huang, Wei Xu, Yuanlong Lv, Yu Wen, Yuhong Lan, Shuanglai Zuo, Yong Zhang, Yong
author2Str	Liao, Guangfu Lu, Ruichao Su, Lingsong Lan, Ke Meng, Zhihao Qin, Shanfang Huang, Wei Xu, Yuanlong Lv, Yu Wen, Yuhong Lan, Shuanglai Zuo, Yong Zhang, Yong
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up_date	2024-07-23T04:49:50.091Z
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