Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy

Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated i...
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Autor*in:	Zoto Mustafayev, Teuta [verfasserIn] Turna, Menekse [verfasserIn] Bolukbasi, Yasemin [verfasserIn] Tezcanli, Evrim [verfasserIn] Guney, Yildiz [verfasserIn] Dincbas, Fazilet Oner [verfasserIn] Atasoy, Beste Melek [verfasserIn] Ugurluer, Gamze [verfasserIn] Caglar, Hale Basak [verfasserIn] Atalar, Banu [verfasserIn] Ozyar, Enis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Radiation induced toxicity Brain metastasis Stereotactic radiosurgery Bevacizumab

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC cancer - BioMed Central, 2001, 24(2024), 1 vom: 30. Juli
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:30 ; month:07

Links:	Volltext

DOI / URN:	10.1186/s12885-024-12643-6

Katalog-ID:	SPR056788436

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520			\|a Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies.
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allfields	10.1186/s12885-024-12643-6 doi (DE-627)SPR056788436 (SPR)s12885-024-12643-6-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Zoto Mustafayev, Teuta verfasserin aut Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Turna, Menekse verfasserin aut Bolukbasi, Yasemin verfasserin aut Tezcanli, Evrim verfasserin aut Guney, Yildiz verfasserin aut Dincbas, Fazilet Oner verfasserin aut Atasoy, Beste Melek verfasserin aut Ugurluer, Gamze verfasserin aut Caglar, Hale Basak verfasserin aut Atalar, Banu verfasserin aut Ozyar, Enis verfasserin (orcid)0000-0002-9497-7976 aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 30. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12885-024-12643-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 30 07
spelling	10.1186/s12885-024-12643-6 doi (DE-627)SPR056788436 (SPR)s12885-024-12643-6-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Zoto Mustafayev, Teuta verfasserin aut Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Turna, Menekse verfasserin aut Bolukbasi, Yasemin verfasserin aut Tezcanli, Evrim verfasserin aut Guney, Yildiz verfasserin aut Dincbas, Fazilet Oner verfasserin aut Atasoy, Beste Melek verfasserin aut Ugurluer, Gamze verfasserin aut Caglar, Hale Basak verfasserin aut Atalar, Banu verfasserin aut Ozyar, Enis verfasserin (orcid)0000-0002-9497-7976 aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 30. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12885-024-12643-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 30 07
allfields_unstemmed	10.1186/s12885-024-12643-6 doi (DE-627)SPR056788436 (SPR)s12885-024-12643-6-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Zoto Mustafayev, Teuta verfasserin aut Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Turna, Menekse verfasserin aut Bolukbasi, Yasemin verfasserin aut Tezcanli, Evrim verfasserin aut Guney, Yildiz verfasserin aut Dincbas, Fazilet Oner verfasserin aut Atasoy, Beste Melek verfasserin aut Ugurluer, Gamze verfasserin aut Caglar, Hale Basak verfasserin aut Atalar, Banu verfasserin aut Ozyar, Enis verfasserin (orcid)0000-0002-9497-7976 aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 30. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12885-024-12643-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 30 07
allfieldsGer	10.1186/s12885-024-12643-6 doi (DE-627)SPR056788436 (SPR)s12885-024-12643-6-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Zoto Mustafayev, Teuta verfasserin aut Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Turna, Menekse verfasserin aut Bolukbasi, Yasemin verfasserin aut Tezcanli, Evrim verfasserin aut Guney, Yildiz verfasserin aut Dincbas, Fazilet Oner verfasserin aut Atasoy, Beste Melek verfasserin aut Ugurluer, Gamze verfasserin aut Caglar, Hale Basak verfasserin aut Atalar, Banu verfasserin aut Ozyar, Enis verfasserin (orcid)0000-0002-9497-7976 aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 30. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12885-024-12643-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 30 07
allfieldsSound	10.1186/s12885-024-12643-6 doi (DE-627)SPR056788436 (SPR)s12885-024-12643-6-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Zoto Mustafayev, Teuta verfasserin aut Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Turna, Menekse verfasserin aut Bolukbasi, Yasemin verfasserin aut Tezcanli, Evrim verfasserin aut Guney, Yildiz verfasserin aut Dincbas, Fazilet Oner verfasserin aut Atasoy, Beste Melek verfasserin aut Ugurluer, Gamze verfasserin aut Caglar, Hale Basak verfasserin aut Atalar, Banu verfasserin aut Ozyar, Enis verfasserin (orcid)0000-0002-9497-7976 aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 30. Juli (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:30 month:07 https://dx.doi.org/10.1186/s12885-024-12643-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 30 07
language	English
source	Enthalten in BMC cancer 24(2024), 1 vom: 30. Juli volume:24 year:2024 number:1 day:30 month:07
sourceStr	Enthalten in BMC cancer 24(2024), 1 vom: 30. Juli volume:24 year:2024 number:1 day:30 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Radiation induced toxicity Brain metastasis Stereotactic radiosurgery Bevacizumab
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Zoto Mustafayev, Teuta @@aut@@ Turna, Menekse @@aut@@ Bolukbasi, Yasemin @@aut@@ Tezcanli, Evrim @@aut@@ Guney, Yildiz @@aut@@ Dincbas, Fazilet Oner @@aut@@ Atasoy, Beste Melek @@aut@@ Ugurluer, Gamze @@aut@@ Caglar, Hale Basak @@aut@@ Atalar, Banu @@aut@@ Ozyar, Enis @@aut@@
publishDateDaySort_date	2024-07-30T00:00:00Z
hierarchy_top_id	326643710
dewey-sort	3610
id	SPR056788436
language_de	englisch
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Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). 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author	Zoto Mustafayev, Teuta
spellingShingle	Zoto Mustafayev, Teuta ddc 610 bkl 44.00 misc Radiation induced toxicity misc Brain metastasis misc Stereotactic radiosurgery misc Bevacizumab Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
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topic_title	610 VZ 44.00 bkl Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy Radiation induced toxicity (dpeaa)DE-He213 Brain metastasis (dpeaa)DE-He213 Stereotactic radiosurgery (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Radiation induced toxicity misc Brain metastasis misc Stereotactic radiosurgery misc Bevacizumab
topic_unstemmed	ddc 610 bkl 44.00 misc Radiation induced toxicity misc Brain metastasis misc Stereotactic radiosurgery misc Bevacizumab
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title	Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
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title_full	Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
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author_browse	Zoto Mustafayev, Teuta Turna, Menekse Bolukbasi, Yasemin Tezcanli, Evrim Guney, Yildiz Dincbas, Fazilet Oner Atasoy, Beste Melek Ugurluer, Gamze Caglar, Hale Basak Atalar, Banu Ozyar, Enis
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title_sort	clinical and radiological effects of bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
title_auth	Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
abstract	Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. © The Author(s) 2024
abstractGer	Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. © The Author(s) 2024
abstract_unstemmed	Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. The clinical response to BV treatment was categorized as follows: complete (no additional treatment required), partial (requiring either steroids or repeat BV), and unresponsive (requiring surgery). The radiological features of brain RN were analyzed in 10 patients whose serial MRI scans were available after corticosteroid and BV treatments. Results BV was used as a first line treatment in 11 (27.5%) and as a second line treatment in 29 (72.5%) of patients. The neurological symptoms regressed in 77.5% of patients after treatment with BV (45% complete response, 32.5% partial response). The median edema volume increased from 75.9 cc (range: 5.9-125.8 cc) at RN to 113.65 cc (range: 1.5-382.1 cc) after use of corticosteroids, representing a rate of 39.8% increase (p = 0.074). However, after BV treatment the median volume of edema decreased to 19.5 cc (range: 0-163.3 cc) which represents a difference of 62.2% (p = 0.041) from RN. Conclusion The use of BV caused clinical response rate of 77.5% and a good radiological response in corticosteroid unresponsive patients. The role of BV should be further investigated in prospective studies. © The Author(s) 2024
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title_short	Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy
url	https://dx.doi.org/10.1186/s12885-024-12643-6
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author2	Turna, Menekse Bolukbasi, Yasemin Tezcanli, Evrim Guney, Yildiz Dincbas, Fazilet Oner Atasoy, Beste Melek Ugurluer, Gamze Caglar, Hale Basak Atalar, Banu Ozyar, Enis
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Clinical and radiological effects of Bevacizumab for the treatment of radionecrosis after stereotactic brain radiotherapy

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