Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy

Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develo...
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Autor*in:	Su, Xin [verfasserIn] Li, Jian [verfasserIn] Xu, Xiao [verfasserIn] Ye, Youbao [verfasserIn] Wang, Cailiu [verfasserIn] Pang, Guanglong [verfasserIn] Liu, Wenxiu [verfasserIn] Liu, Ang [verfasserIn] Zhao, Changchun [verfasserIn] Hao, Xiangyong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Immune checkpoint inhibitors Immunotherapy Combination therapy Tumor microenvironment Cancer therapy

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Journal of translational medicine - BioMed Central, 2003, 22(2024), 1 vom: 09. Aug.
Übergeordnetes Werk:	volume:22 ; year:2024 ; number:1 ; day:09 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12967-024-05552-6

Katalog-ID:	SPR056915357

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allfields	10.1186/s12967-024-05552-6 doi (DE-627)SPR056915357 (SPR)s12967-024-05552-6-e DE-627 ger DE-627 rakwb eng 610 VZ Su, Xin verfasserin aut Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213 Li, Jian verfasserin aut Xu, Xiao verfasserin aut Ye, Youbao verfasserin aut Wang, Cailiu verfasserin aut Pang, Guanglong verfasserin aut Liu, Wenxiu verfasserin aut Liu, Ang verfasserin aut Zhao, Changchun verfasserin aut Hao, Xiangyong verfasserin (orcid)0000-0003-4419-7047 aut Enthalten in Journal of translational medicine BioMed Central, 2003 22(2024), 1 vom: 09. Aug. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:22 year:2024 number:1 day:09 month:08 https://dx.doi.org/10.1186/s12967-024-05552-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 09 08
spelling	10.1186/s12967-024-05552-6 doi (DE-627)SPR056915357 (SPR)s12967-024-05552-6-e DE-627 ger DE-627 rakwb eng 610 VZ Su, Xin verfasserin aut Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213 Li, Jian verfasserin aut Xu, Xiao verfasserin aut Ye, Youbao verfasserin aut Wang, Cailiu verfasserin aut Pang, Guanglong verfasserin aut Liu, Wenxiu verfasserin aut Liu, Ang verfasserin aut Zhao, Changchun verfasserin aut Hao, Xiangyong verfasserin (orcid)0000-0003-4419-7047 aut Enthalten in Journal of translational medicine BioMed Central, 2003 22(2024), 1 vom: 09. Aug. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:22 year:2024 number:1 day:09 month:08 https://dx.doi.org/10.1186/s12967-024-05552-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 09 08
allfields_unstemmed	10.1186/s12967-024-05552-6 doi (DE-627)SPR056915357 (SPR)s12967-024-05552-6-e DE-627 ger DE-627 rakwb eng 610 VZ Su, Xin verfasserin aut Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213 Li, Jian verfasserin aut Xu, Xiao verfasserin aut Ye, Youbao verfasserin aut Wang, Cailiu verfasserin aut Pang, Guanglong verfasserin aut Liu, Wenxiu verfasserin aut Liu, Ang verfasserin aut Zhao, Changchun verfasserin aut Hao, Xiangyong verfasserin (orcid)0000-0003-4419-7047 aut Enthalten in Journal of translational medicine BioMed Central, 2003 22(2024), 1 vom: 09. Aug. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:22 year:2024 number:1 day:09 month:08 https://dx.doi.org/10.1186/s12967-024-05552-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 09 08
allfieldsGer	10.1186/s12967-024-05552-6 doi (DE-627)SPR056915357 (SPR)s12967-024-05552-6-e DE-627 ger DE-627 rakwb eng 610 VZ Su, Xin verfasserin aut Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213 Li, Jian verfasserin aut Xu, Xiao verfasserin aut Ye, Youbao verfasserin aut Wang, Cailiu verfasserin aut Pang, Guanglong verfasserin aut Liu, Wenxiu verfasserin aut Liu, Ang verfasserin aut Zhao, Changchun verfasserin aut Hao, Xiangyong verfasserin (orcid)0000-0003-4419-7047 aut Enthalten in Journal of translational medicine BioMed Central, 2003 22(2024), 1 vom: 09. Aug. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:22 year:2024 number:1 day:09 month:08 https://dx.doi.org/10.1186/s12967-024-05552-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 09 08
allfieldsSound	10.1186/s12967-024-05552-6 doi (DE-627)SPR056915357 (SPR)s12967-024-05552-6-e DE-627 ger DE-627 rakwb eng 610 VZ Su, Xin verfasserin aut Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213 Li, Jian verfasserin aut Xu, Xiao verfasserin aut Ye, Youbao verfasserin aut Wang, Cailiu verfasserin aut Pang, Guanglong verfasserin aut Liu, Wenxiu verfasserin aut Liu, Ang verfasserin aut Zhao, Changchun verfasserin aut Hao, Xiangyong verfasserin (orcid)0000-0003-4419-7047 aut Enthalten in Journal of translational medicine BioMed Central, 2003 22(2024), 1 vom: 09. Aug. (DE-627)369084136 (DE-600)2118570-0 1479-5876 nnns volume:22 year:2024 number:1 day:09 month:08 https://dx.doi.org/10.1186/s12967-024-05552-6 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 09 08
language	English
source	Enthalten in Journal of translational medicine 22(2024), 1 vom: 09. Aug. volume:22 year:2024 number:1 day:09 month:08
sourceStr	Enthalten in Journal of translational medicine 22(2024), 1 vom: 09. Aug. volume:22 year:2024 number:1 day:09 month:08
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topic_facet	Immune checkpoint inhibitors Immunotherapy Combination therapy Tumor microenvironment Cancer therapy
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container_title	Journal of translational medicine
authorswithroles_txt_mv	Su, Xin @@aut@@ Li, Jian @@aut@@ Xu, Xiao @@aut@@ Ye, Youbao @@aut@@ Wang, Cailiu @@aut@@ Pang, Guanglong @@aut@@ Liu, Wenxiu @@aut@@ Liu, Ang @@aut@@ Zhao, Changchun @@aut@@ Hao, Xiangyong @@aut@@
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author	Su, Xin
spellingShingle	Su, Xin ddc 610 misc Immune checkpoint inhibitors misc Immunotherapy misc Combination therapy misc Tumor microenvironment misc Cancer therapy Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy
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topic_title	610 VZ Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy Immune checkpoint inhibitors (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Combination therapy (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Cancer therapy (dpeaa)DE-He213
topic	ddc 610 misc Immune checkpoint inhibitors misc Immunotherapy misc Combination therapy misc Tumor microenvironment misc Cancer therapy
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title_sort	strategies to enhance the therapeutic efficacy of anti-pd-1 antibody, anti-pd-l1 antibody and anti-ctla-4 antibody in cancer therapy
title_auth	Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy
abstract	Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. © The Author(s) 2024
abstractGer	Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. © The Author(s) 2024
abstract_unstemmed	Abstract Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy. © The Author(s) 2024
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title_short	Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy
url	https://dx.doi.org/10.1186/s12967-024-05552-6
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up_date	2024-08-10T04:50:07.763Z
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Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy

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