Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit
Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ahumada-Santos, Yesmi P. [verfasserIn] López-Angulo, Gabriela [verfasserIn] Pinto-González, Rebeca M. [verfasserIn] Clemente-Soto, Aldo F. [verfasserIn] López-Valenzuela, José A. [verfasserIn] Delgado-Vargas, Francisco [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Advances in traditional medicine - Springer Nature Singapore, 2020, 24(2024), 3 vom: 11. Jan., Seite 801-812 |
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| Übergeordnetes Werk: |
volume:24 ; year:2024 ; number:3 ; day:11 ; month:01 ; pages:801-812 |
| Links: |
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| DOI / URN: |
10.1007/s13596-023-00735-w |
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SPR05707643X |
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| 520 | |a Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. | ||
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| 650 | 4 | |a Cellular antioxidant activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunomodulatory activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antitumor activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antimutagenic activity |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Delgado-Vargas, Francisco |e verfasserin |0 (orcid)0000-0003-3369-5200 |4 aut | |
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10.1007/s13596-023-00735-w doi (DE-627)SPR05707643X (SPR)s13596-023-00735-w-e DE-627 ger DE-627 rakwb eng Ahumada-Santos, Yesmi P. verfasserin (orcid)0000-0002-4192-5152 aut Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 López-Angulo, Gabriela verfasserin (orcid)0000-0001-7498-5859 aut Pinto-González, Rebeca M. verfasserin (orcid)0009-0009-6345-7394 aut Clemente-Soto, Aldo F. verfasserin (orcid)0000-0002-3416-8915 aut López-Valenzuela, José A. verfasserin (orcid)0000-0002-9358-5030 aut Delgado-Vargas, Francisco verfasserin (orcid)0000-0003-3369-5200 aut Enthalten in Advances in traditional medicine Springer Nature Singapore, 2020 24(2024), 3 vom: 11. Jan., Seite 801-812 Online-Ressource (DE-627)1733544879 (DE-600)3038145-9 2662-4060 nnns volume:24 year:2024 number:3 day:11 month:01 pages:801-812 https://dx.doi.org/10.1007/s13596-023-00735-w X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2024 3 11 01 801-812 |
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10.1007/s13596-023-00735-w doi (DE-627)SPR05707643X (SPR)s13596-023-00735-w-e DE-627 ger DE-627 rakwb eng Ahumada-Santos, Yesmi P. verfasserin (orcid)0000-0002-4192-5152 aut Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 López-Angulo, Gabriela verfasserin (orcid)0000-0001-7498-5859 aut Pinto-González, Rebeca M. verfasserin (orcid)0009-0009-6345-7394 aut Clemente-Soto, Aldo F. verfasserin (orcid)0000-0002-3416-8915 aut López-Valenzuela, José A. verfasserin (orcid)0000-0002-9358-5030 aut Delgado-Vargas, Francisco verfasserin (orcid)0000-0003-3369-5200 aut Enthalten in Advances in traditional medicine Springer Nature Singapore, 2020 24(2024), 3 vom: 11. Jan., Seite 801-812 Online-Ressource (DE-627)1733544879 (DE-600)3038145-9 2662-4060 nnns volume:24 year:2024 number:3 day:11 month:01 pages:801-812 https://dx.doi.org/10.1007/s13596-023-00735-w X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2024 3 11 01 801-812 |
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10.1007/s13596-023-00735-w doi (DE-627)SPR05707643X (SPR)s13596-023-00735-w-e DE-627 ger DE-627 rakwb eng Ahumada-Santos, Yesmi P. verfasserin (orcid)0000-0002-4192-5152 aut Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 López-Angulo, Gabriela verfasserin (orcid)0000-0001-7498-5859 aut Pinto-González, Rebeca M. verfasserin (orcid)0009-0009-6345-7394 aut Clemente-Soto, Aldo F. verfasserin (orcid)0000-0002-3416-8915 aut López-Valenzuela, José A. verfasserin (orcid)0000-0002-9358-5030 aut Delgado-Vargas, Francisco verfasserin (orcid)0000-0003-3369-5200 aut Enthalten in Advances in traditional medicine Springer Nature Singapore, 2020 24(2024), 3 vom: 11. Jan., Seite 801-812 Online-Ressource (DE-627)1733544879 (DE-600)3038145-9 2662-4060 nnns volume:24 year:2024 number:3 day:11 month:01 pages:801-812 https://dx.doi.org/10.1007/s13596-023-00735-w X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2024 3 11 01 801-812 |
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10.1007/s13596-023-00735-w doi (DE-627)SPR05707643X (SPR)s13596-023-00735-w-e DE-627 ger DE-627 rakwb eng Ahumada-Santos, Yesmi P. verfasserin (orcid)0000-0002-4192-5152 aut Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 López-Angulo, Gabriela verfasserin (orcid)0000-0001-7498-5859 aut Pinto-González, Rebeca M. verfasserin (orcid)0009-0009-6345-7394 aut Clemente-Soto, Aldo F. verfasserin (orcid)0000-0002-3416-8915 aut López-Valenzuela, José A. verfasserin (orcid)0000-0002-9358-5030 aut Delgado-Vargas, Francisco verfasserin (orcid)0000-0003-3369-5200 aut Enthalten in Advances in traditional medicine Springer Nature Singapore, 2020 24(2024), 3 vom: 11. Jan., Seite 801-812 Online-Ressource (DE-627)1733544879 (DE-600)3038145-9 2662-4060 nnns volume:24 year:2024 number:3 day:11 month:01 pages:801-812 https://dx.doi.org/10.1007/s13596-023-00735-w X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2024 3 11 01 801-812 |
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10.1007/s13596-023-00735-w doi (DE-627)SPR05707643X (SPR)s13596-023-00735-w-e DE-627 ger DE-627 rakwb eng Ahumada-Santos, Yesmi P. verfasserin (orcid)0000-0002-4192-5152 aut Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 López-Angulo, Gabriela verfasserin (orcid)0000-0001-7498-5859 aut Pinto-González, Rebeca M. verfasserin (orcid)0009-0009-6345-7394 aut Clemente-Soto, Aldo F. verfasserin (orcid)0000-0002-3416-8915 aut López-Valenzuela, José A. verfasserin (orcid)0000-0002-9358-5030 aut Delgado-Vargas, Francisco verfasserin (orcid)0000-0003-3369-5200 aut Enthalten in Advances in traditional medicine Springer Nature Singapore, 2020 24(2024), 3 vom: 11. Jan., Seite 801-812 Online-Ressource (DE-627)1733544879 (DE-600)3038145-9 2662-4060 nnns volume:24 year:2024 number:3 day:11 month:01 pages:801-812 https://dx.doi.org/10.1007/s13596-023-00735-w X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2024 3 11 01 801-812 |
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Ahumada-Santos, Yesmi P. @@aut@@ López-Angulo, Gabriela @@aut@@ Pinto-González, Rebeca M. @@aut@@ Clemente-Soto, Aldo F. @@aut@@ López-Valenzuela, José A. @@aut@@ Delgado-Vargas, Francisco @@aut@@ |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. 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Ahumada-Santos, Yesmi P. |
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Ahumada-Santos, Yesmi P. misc Antibiofilm activity misc Cellular antioxidant activity misc Immunomodulatory activity misc Antitumor activity misc Antimutagenic activity Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit |
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Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit Antibiofilm activity (dpeaa)DE-He213 Cellular antioxidant activity (dpeaa)DE-He213 Immunomodulatory activity (dpeaa)DE-He213 Antitumor activity (dpeaa)DE-He213 Antimutagenic activity (dpeaa)DE-He213 |
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Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit |
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Ahumada-Santos, Yesmi P. López-Angulo, Gabriela Pinto-González, Rebeca M. Clemente-Soto, Aldo F. López-Valenzuela, José A. Delgado-Vargas, Francisco |
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antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from randia echinocarpa fruit |
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Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit |
| abstract |
Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Abstract Melanins are widely distributed biopolymers that exhibit important biological activities. However, fruit melanins have been scarcely studied. In this work, the antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins (SMs) isolated from the Randia echinocarpa fruit (papache) were evaluated. The SMs inhibited biofilm formation in Staphylococcus aureus MDR and ATCC 43300 up to 60% at 1000 µg/mL; they presented a cellular antioxidant activity (60.02%) at 50 µg/mL, were immunomodulatory by increasing the peripheral blood mononuclear cells (PBMC) proliferation index (1.09 at 50 μg/mL), and inhibited HeLa cell proliferation by 77.39% ($ IC_{50} $ = 9.34 µg/mL). SMs were neither toxic nor mutagenic in the Salmonella Typhimurium YG1024 strain and inhibited the 1-nitropyrene mutagenicity by 30.2%. The biological activities of papache SMs support their potential to be used in nutraceutical and pharmaceutical formulations. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Antibiofilm, cellular antioxidant, anti-inflammatory, immunomodulatory, cytotoxic, and antimutagenic activities of soluble melanins from Randia echinocarpa fruit |
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López-Angulo, Gabriela Pinto-González, Rebeca M. Clemente-Soto, Aldo F. López-Valenzuela, José A. Delgado-Vargas, Francisco |
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López-Angulo, Gabriela Pinto-González, Rebeca M. Clemente-Soto, Aldo F. López-Valenzuela, José A. Delgado-Vargas, Francisco |
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| score |
7.3999414 |