Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial

Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Snooks, Helen A. [verfasserIn] Jones, Jenna K. [verfasserIn] Bell, Fiona B. [verfasserIn] Benger, Jonathon R. [verfasserIn] Black, Sarah L. [verfasserIn] Dixon, Simon [verfasserIn] Edwards, Adrian [verfasserIn] Emery, Helena [verfasserIn] Evans, Bridie A. [verfasserIn] Fuller, Gordon W. [verfasserIn] Goodacre, Steve [verfasserIn] Hoskins, Rebecca [verfasserIn] Hughes, Jane [verfasserIn] John, Ann [verfasserIn] Johnston, Sasha [verfasserIn] Jones, Matthew B. [verfasserIn] Moore, Chris R. [verfasserIn] Parab, Rakshita [verfasserIn] Pilbery, Richard [verfasserIn] Sampson, Fiona C. [verfasserIn] Watkins, Alan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Naloxone Opioid-Related Disorders Randomised controlled trial Feasibility study Emergency medical services

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC emergency medicine - BioMed Central, 2001, 24(2024), 1 vom: 29. Aug.
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:29 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12873-024-01061-3

Katalog-ID:	SPR057127646

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520			\|a Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018).
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allfields	10.1186/s12873-024-01061-3 doi (DE-627)SPR057127646 (SPR)s12873-024-01061-3-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Snooks, Helen A. verfasserin aut Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213 Jones, Jenna K. verfasserin aut Bell, Fiona B. verfasserin aut Benger, Jonathon R. verfasserin aut Black, Sarah L. verfasserin aut Dixon, Simon verfasserin aut Edwards, Adrian verfasserin aut Emery, Helena verfasserin aut Evans, Bridie A. verfasserin aut Fuller, Gordon W. verfasserin aut Goodacre, Steve verfasserin aut Hoskins, Rebecca verfasserin aut Hughes, Jane verfasserin aut John, Ann verfasserin aut Johnston, Sasha verfasserin aut Jones, Matthew B. verfasserin aut Moore, Chris R. verfasserin aut Parab, Rakshita verfasserin aut Pilbery, Richard verfasserin aut Sampson, Fiona C. verfasserin aut Watkins, Alan verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Aug. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:08 https://dx.doi.org/10.1186/s12873-024-01061-3 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 08
spelling	10.1186/s12873-024-01061-3 doi (DE-627)SPR057127646 (SPR)s12873-024-01061-3-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Snooks, Helen A. verfasserin aut Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213 Jones, Jenna K. verfasserin aut Bell, Fiona B. verfasserin aut Benger, Jonathon R. verfasserin aut Black, Sarah L. verfasserin aut Dixon, Simon verfasserin aut Edwards, Adrian verfasserin aut Emery, Helena verfasserin aut Evans, Bridie A. verfasserin aut Fuller, Gordon W. verfasserin aut Goodacre, Steve verfasserin aut Hoskins, Rebecca verfasserin aut Hughes, Jane verfasserin aut John, Ann verfasserin aut Johnston, Sasha verfasserin aut Jones, Matthew B. verfasserin aut Moore, Chris R. verfasserin aut Parab, Rakshita verfasserin aut Pilbery, Richard verfasserin aut Sampson, Fiona C. verfasserin aut Watkins, Alan verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Aug. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:08 https://dx.doi.org/10.1186/s12873-024-01061-3 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 08
allfields_unstemmed	10.1186/s12873-024-01061-3 doi (DE-627)SPR057127646 (SPR)s12873-024-01061-3-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Snooks, Helen A. verfasserin aut Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213 Jones, Jenna K. verfasserin aut Bell, Fiona B. verfasserin aut Benger, Jonathon R. verfasserin aut Black, Sarah L. verfasserin aut Dixon, Simon verfasserin aut Edwards, Adrian verfasserin aut Emery, Helena verfasserin aut Evans, Bridie A. verfasserin aut Fuller, Gordon W. verfasserin aut Goodacre, Steve verfasserin aut Hoskins, Rebecca verfasserin aut Hughes, Jane verfasserin aut John, Ann verfasserin aut Johnston, Sasha verfasserin aut Jones, Matthew B. verfasserin aut Moore, Chris R. verfasserin aut Parab, Rakshita verfasserin aut Pilbery, Richard verfasserin aut Sampson, Fiona C. verfasserin aut Watkins, Alan verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Aug. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:08 https://dx.doi.org/10.1186/s12873-024-01061-3 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 08
allfieldsGer	10.1186/s12873-024-01061-3 doi (DE-627)SPR057127646 (SPR)s12873-024-01061-3-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Snooks, Helen A. verfasserin aut Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213 Jones, Jenna K. verfasserin aut Bell, Fiona B. verfasserin aut Benger, Jonathon R. verfasserin aut Black, Sarah L. verfasserin aut Dixon, Simon verfasserin aut Edwards, Adrian verfasserin aut Emery, Helena verfasserin aut Evans, Bridie A. verfasserin aut Fuller, Gordon W. verfasserin aut Goodacre, Steve verfasserin aut Hoskins, Rebecca verfasserin aut Hughes, Jane verfasserin aut John, Ann verfasserin aut Johnston, Sasha verfasserin aut Jones, Matthew B. verfasserin aut Moore, Chris R. verfasserin aut Parab, Rakshita verfasserin aut Pilbery, Richard verfasserin aut Sampson, Fiona C. verfasserin aut Watkins, Alan verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Aug. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:08 https://dx.doi.org/10.1186/s12873-024-01061-3 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 08
allfieldsSound	10.1186/s12873-024-01061-3 doi (DE-627)SPR057127646 (SPR)s12873-024-01061-3-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Snooks, Helen A. verfasserin aut Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213 Jones, Jenna K. verfasserin aut Bell, Fiona B. verfasserin aut Benger, Jonathon R. verfasserin aut Black, Sarah L. verfasserin aut Dixon, Simon verfasserin aut Edwards, Adrian verfasserin aut Emery, Helena verfasserin aut Evans, Bridie A. verfasserin aut Fuller, Gordon W. verfasserin aut Goodacre, Steve verfasserin aut Hoskins, Rebecca verfasserin aut Hughes, Jane verfasserin aut John, Ann verfasserin aut Johnston, Sasha verfasserin aut Jones, Matthew B. verfasserin aut Moore, Chris R. verfasserin aut Parab, Rakshita verfasserin aut Pilbery, Richard verfasserin aut Sampson, Fiona C. verfasserin aut Watkins, Alan verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Aug. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:08 https://dx.doi.org/10.1186/s12873-024-01061-3 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 08
language	English
source	Enthalten in BMC emergency medicine 24(2024), 1 vom: 29. Aug. volume:24 year:2024 number:1 day:29 month:08
sourceStr	Enthalten in BMC emergency medicine 24(2024), 1 vom: 29. Aug. volume:24 year:2024 number:1 day:29 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Naloxone Opioid-Related Disorders Randomised controlled trial Feasibility study Emergency medical services
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC emergency medicine
authorswithroles_txt_mv	Snooks, Helen A. @@aut@@ Jones, Jenna K. @@aut@@ Bell, Fiona B. @@aut@@ Benger, Jonathon R. @@aut@@ Black, Sarah L. @@aut@@ Dixon, Simon @@aut@@ Edwards, Adrian @@aut@@ Emery, Helena @@aut@@ Evans, Bridie A. @@aut@@ Fuller, Gordon W. @@aut@@ Goodacre, Steve @@aut@@ Hoskins, Rebecca @@aut@@ Hughes, Jane @@aut@@ John, Ann @@aut@@ Johnston, Sasha @@aut@@ Jones, Matthew B. @@aut@@ Moore, Chris R. @@aut@@ Parab, Rakshita @@aut@@ Pilbery, Richard @@aut@@ Sampson, Fiona C. @@aut@@ Watkins, Alan @@aut@@
publishDateDaySort_date	2024-08-29T00:00:00Z
hierarchy_top_id	33101873X
dewey-sort	3610
id	SPR057127646
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR057127646</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240829064751.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240829s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12873-024-01061-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR057127646</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12873-024-01061-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Snooks, Helen A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. 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author	Snooks, Helen A.
spellingShingle	Snooks, Helen A. ddc 610 bkl 44.00 misc Naloxone misc Opioid-Related Disorders misc Randomised controlled trial misc Feasibility study misc Emergency medical services Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
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topic_title	610 VZ 44.00 bkl Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial Naloxone (dpeaa)DE-He213 Opioid-Related Disorders (dpeaa)DE-He213 Randomised controlled trial (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Emergency medical services (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Naloxone misc Opioid-Related Disorders misc Randomised controlled trial misc Feasibility study misc Emergency medical services
topic_unstemmed	ddc 610 bkl 44.00 misc Naloxone misc Opioid-Related Disorders misc Randomised controlled trial misc Feasibility study misc Emergency medical services
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title	Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
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title_full	Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
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author_browse	Snooks, Helen A. Jones, Jenna K. Bell, Fiona B. Benger, Jonathon R. Black, Sarah L. Dixon, Simon Edwards, Adrian Emery, Helena Evans, Bridie A. Fuller, Gordon W. Goodacre, Steve Hoskins, Rebecca Hughes, Jane John, Ann Johnston, Sasha Jones, Matthew B. Moore, Chris R. Parab, Rakshita Pilbery, Richard Sampson, Fiona C. Watkins, Alan
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title_sort	take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
title_auth	Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
abstract	Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). © The Author(s) 2024
abstractGer	Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). © The Author(s) 2024
abstract_unstemmed	Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. Trial Registration ISRCTN13232859 (Registered 16/02/2018). © The Author(s) 2024
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title_short	Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial
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author2	Jones, Jenna K. Bell, Fiona B. Benger, Jonathon R. Black, Sarah L. Dixon, Simon Edwards, Adrian Emery, Helena Evans, Bridie A. Fuller, Gordon W. Goodacre, Steve Hoskins, Rebecca Hughes, Jane John, Ann Johnston, Sasha Jones, Matthew B. Moore, Chris R. Parab, Rakshita Pilbery, Richard Sampson, Fiona C. Watkins, Alan
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up_date	2024-08-29T04:50:11.748Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR057127646</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240829064751.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240829s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12873-024-01061-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR057127646</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12873-024-01061-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Snooks, Helen A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Opioids kill more people than any other class of drug. Naloxone is an opioid antagonist which can be distributed in kits for peer administration. We assessed the feasibility of implementing a Take-home Naloxone (THN) intervention in emergency settings, as part of designing a definitive randomised controlled trial (RCT). Methods We undertook a clustered RCT on sites pairing UK Emergency Departments (ED) and ambulance services. At intervention sites, we recruited emergency healthcare practitioners to supply THN to patients presenting with opioid overdose or related condition, with recruitment across 2019–2021. We assessed feasibility of intervention implementation against four predetermined progression criteria covering site sign up and staff training; identification of eligible patients; issue of THN kits and Serious Adverse Events. Results At two intervention sites, randomly selected from 4, 299/687 (43.5%) clinical staff were trained (ED1 = 107, AS1 = 121, ED2 = 25, AS2 = 46). Sixty THN kits were supplied to eligible patients (21.7%) (n: ED1 = 36, AS1 = 4, ED2 = 16, AS2 = 4). Across sites, kits were not issued to eligible patients on a further 164 occasions, with reasons reported including: staff forgot (n = 136), staff too busy (n = 15), and suspected intentional overdose (n = 3), no kit available (n = 2), already given by drugs nurse (n = 4), other (n = 4). Staff recorded 626 other patients as ineligible but considered for inclusion, with reasons listed as: patient admitted to hospital (n = 194), patient absconded (n = 161) already recruited (n = 64), uncooperative or abusive (n = 55), staff not trained (n = 43), reduced consciousness level (n = 41), lack of capacity (n = 35), patient in custody (n = 21), other (n = 12). No adverse events were reported. Conclusion Staff and patient recruitment were low and varied widely by site. This feasibility study did not meet progression criteria; a fully powered RCT is not planned. 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Take-home naloxone administered in emergency settings: feasibility of intervention implementation in a cluster randomized trial

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