Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets

Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or al...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hong, Zihang [verfasserIn] Liu, Furong [verfasserIn] Zhang, Zhanguo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Cancer immunotherapy Ubiquitin Drug resistance

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Experimental hematology & oncology - BioMed Central, 2012, 13(2024), 1 vom: 30. Aug.
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:1 ; day:30 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s40164-024-00552-0

Katalog-ID:	SPR057188157

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spelling	10.1186/s40164-024-00552-0 doi (DE-627)SPR057188157 (SPR)s40164-024-00552-0-e DE-627 ger DE-627 rakwb eng 610 VZ Hong, Zihang verfasserin aut Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. Cancer immunotherapy (dpeaa)DE-He213 Ubiquitin (dpeaa)DE-He213 Drug resistance (dpeaa)DE-He213 Liu, Furong verfasserin aut Zhang, Zhanguo verfasserin aut Enthalten in Experimental hematology & oncology BioMed Central, 2012 13(2024), 1 vom: 30. Aug. (DE-627)718833341 (DE-600)2669066-4 2162-3619 nnns volume:13 year:2024 number:1 day:30 month:08 https://dx.doi.org/10.1186/s40164-024-00552-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 1 30 08
allfields_unstemmed	10.1186/s40164-024-00552-0 doi (DE-627)SPR057188157 (SPR)s40164-024-00552-0-e DE-627 ger DE-627 rakwb eng 610 VZ Hong, Zihang verfasserin aut Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. Cancer immunotherapy (dpeaa)DE-He213 Ubiquitin (dpeaa)DE-He213 Drug resistance (dpeaa)DE-He213 Liu, Furong verfasserin aut Zhang, Zhanguo verfasserin aut Enthalten in Experimental hematology & oncology BioMed Central, 2012 13(2024), 1 vom: 30. Aug. (DE-627)718833341 (DE-600)2669066-4 2162-3619 nnns volume:13 year:2024 number:1 day:30 month:08 https://dx.doi.org/10.1186/s40164-024-00552-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 1 30 08
allfieldsGer	10.1186/s40164-024-00552-0 doi (DE-627)SPR057188157 (SPR)s40164-024-00552-0-e DE-627 ger DE-627 rakwb eng 610 VZ Hong, Zihang verfasserin aut Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. Cancer immunotherapy (dpeaa)DE-He213 Ubiquitin (dpeaa)DE-He213 Drug resistance (dpeaa)DE-He213 Liu, Furong verfasserin aut Zhang, Zhanguo verfasserin aut Enthalten in Experimental hematology & oncology BioMed Central, 2012 13(2024), 1 vom: 30. Aug. (DE-627)718833341 (DE-600)2669066-4 2162-3619 nnns volume:13 year:2024 number:1 day:30 month:08 https://dx.doi.org/10.1186/s40164-024-00552-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 1 30 08
allfieldsSound	10.1186/s40164-024-00552-0 doi (DE-627)SPR057188157 (SPR)s40164-024-00552-0-e DE-627 ger DE-627 rakwb eng 610 VZ Hong, Zihang verfasserin aut Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. Cancer immunotherapy (dpeaa)DE-He213 Ubiquitin (dpeaa)DE-He213 Drug resistance (dpeaa)DE-He213 Liu, Furong verfasserin aut Zhang, Zhanguo verfasserin aut Enthalten in Experimental hematology & oncology BioMed Central, 2012 13(2024), 1 vom: 30. Aug. (DE-627)718833341 (DE-600)2669066-4 2162-3619 nnns volume:13 year:2024 number:1 day:30 month:08 https://dx.doi.org/10.1186/s40164-024-00552-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 1 30 08
language	English
source	Enthalten in Experimental hematology & oncology 13(2024), 1 vom: 30. Aug. volume:13 year:2024 number:1 day:30 month:08
sourceStr	Enthalten in Experimental hematology & oncology 13(2024), 1 vom: 30. Aug. volume:13 year:2024 number:1 day:30 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cancer immunotherapy Ubiquitin Drug resistance
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container_title	Experimental hematology & oncology
authorswithroles_txt_mv	Hong, Zihang @@aut@@ Liu, Furong @@aut@@ Zhang, Zhanguo @@aut@@
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author	Hong, Zihang
spellingShingle	Hong, Zihang ddc 610 misc Cancer immunotherapy misc Ubiquitin misc Drug resistance Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
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topic_title	610 VZ Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets Cancer immunotherapy (dpeaa)DE-He213 Ubiquitin (dpeaa)DE-He213 Drug resistance (dpeaa)DE-He213
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title	Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
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title_full	Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
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title_sort	ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
title_auth	Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
abstract	Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. © The Author(s) 2024
abstractGer	Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. © The Author(s) 2024
abstract_unstemmed	Abstract Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still limits its therapeutic effects. Ubiquitination modification is a mechanism that adds different types of ubiquitin chains to proteins, mediating protein degradation or altering their function, thereby affecting cellular signal transduction. Increasing evidence suggests that ubiquitination modification plays a crucial role in regulating the mechanisms of resistance to cancer immunotherapy. Drugs targeting ubiquitination modification pathways have been shown to inhibit tumor progression or enhance the efficacy of cancer immunotherapy. This review elaborates on the mechanisms by which tumor cells, immune cells, and the tumor microenvironment mediate resistance to cancer immunotherapy and the details of how ubiquitination modification regulates these mechanisms, providing a foundation for enhancing the efficacy of cancer immunotherapy by intervening in ubiquitination modification. © The Author(s) 2024
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title_short	Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
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