Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction
Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic va...
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| Autor*in: |
Abou Kamar, S. [verfasserIn] Aga, Y. S. [verfasserIn] de Bakker, M. [verfasserIn] van den Berg, V. J. [verfasserIn] Strachinaru, M. [verfasserIn] Bowen, D. [verfasserIn] Frowijn, R. [verfasserIn] Akkerhuis, K. M. [verfasserIn] Brugts, J. J. [verfasserIn] Manintveld, O. [verfasserIn] Umans, V. [verfasserIn] Geleijnse, M. [verfasserIn] de Boer, R. A. [verfasserIn] Boersma, E. [verfasserIn] Kardys, I. [verfasserIn] van Dalen, B. M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© Crown 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Clinical research in cardiology - Springer Berlin Heidelberg, 2006, 113(2023), 9 vom: 13. Juni, Seite 1306-1316 |
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| Übergeordnetes Werk: |
volume:113 ; year:2023 ; number:9 ; day:13 ; month:06 ; pages:1306-1316 |
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| DOI / URN: |
10.1007/s00392-023-02244-x |
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| Katalog-ID: |
SPR057192383 |
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| 100 | 1 | |a Abou Kamar, S. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
| 264 | 1 | |c 2023 | |
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| 520 | |a Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract | ||
| 650 | 4 | |a Left atrial reservoir strain |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart failure with reduced ejection fraction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Longitudinal studies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Repeated measurements |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Aga, Y. S. |e verfasserin |4 aut | |
| 700 | 1 | |a de Bakker, M. |e verfasserin |4 aut | |
| 700 | 1 | |a van den Berg, V. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Strachinaru, M. |e verfasserin |4 aut | |
| 700 | 1 | |a Bowen, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Frowijn, R. |e verfasserin |4 aut | |
| 700 | 1 | |a Akkerhuis, K. M. |e verfasserin |4 aut | |
| 700 | 1 | |a Brugts, J. J. |e verfasserin |4 aut | |
| 700 | 1 | |a Manintveld, O. |e verfasserin |4 aut | |
| 700 | 1 | |a Umans, V. |e verfasserin |4 aut | |
| 700 | 1 | |a Geleijnse, M. |e verfasserin |4 aut | |
| 700 | 1 | |a de Boer, R. A. |e verfasserin |4 aut | |
| 700 | 1 | |a Boersma, E. |e verfasserin |4 aut | |
| 700 | 1 | |a Kardys, I. |e verfasserin |4 aut | |
| 700 | 1 | |a van Dalen, B. M. |e verfasserin |4 aut | |
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10.1007/s00392-023-02244-x doi (DE-627)SPR057192383 (SPR)s00392-023-02244-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Abou Kamar, S. verfasserin aut Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Crown 2023 Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 Aga, Y. S. verfasserin aut de Bakker, M. verfasserin aut van den Berg, V. J. verfasserin aut Strachinaru, M. verfasserin aut Bowen, D. verfasserin aut Frowijn, R. verfasserin aut Akkerhuis, K. M. verfasserin aut Brugts, J. J. verfasserin aut Manintveld, O. verfasserin aut Umans, V. verfasserin aut Geleijnse, M. verfasserin aut de Boer, R. A. verfasserin aut Boersma, E. verfasserin aut Kardys, I. verfasserin aut van Dalen, B. M. verfasserin aut Enthalten in Clinical research in cardiology Springer Berlin Heidelberg, 2006 113(2023), 9 vom: 13. Juni, Seite 1306-1316 Online-Ressource (DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 1861-0692 nnns volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 https://dx.doi.org/10.1007/s00392-023-02244-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 113 2023 9 13 06 1306-1316 |
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10.1007/s00392-023-02244-x doi (DE-627)SPR057192383 (SPR)s00392-023-02244-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Abou Kamar, S. verfasserin aut Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Crown 2023 Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 Aga, Y. S. verfasserin aut de Bakker, M. verfasserin aut van den Berg, V. J. verfasserin aut Strachinaru, M. verfasserin aut Bowen, D. verfasserin aut Frowijn, R. verfasserin aut Akkerhuis, K. M. verfasserin aut Brugts, J. J. verfasserin aut Manintveld, O. verfasserin aut Umans, V. verfasserin aut Geleijnse, M. verfasserin aut de Boer, R. A. verfasserin aut Boersma, E. verfasserin aut Kardys, I. verfasserin aut van Dalen, B. M. verfasserin aut Enthalten in Clinical research in cardiology Springer Berlin Heidelberg, 2006 113(2023), 9 vom: 13. Juni, Seite 1306-1316 Online-Ressource (DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 1861-0692 nnns volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 https://dx.doi.org/10.1007/s00392-023-02244-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 113 2023 9 13 06 1306-1316 |
| allfields_unstemmed |
10.1007/s00392-023-02244-x doi (DE-627)SPR057192383 (SPR)s00392-023-02244-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Abou Kamar, S. verfasserin aut Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Crown 2023 Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 Aga, Y. S. verfasserin aut de Bakker, M. verfasserin aut van den Berg, V. J. verfasserin aut Strachinaru, M. verfasserin aut Bowen, D. verfasserin aut Frowijn, R. verfasserin aut Akkerhuis, K. M. verfasserin aut Brugts, J. J. verfasserin aut Manintveld, O. verfasserin aut Umans, V. verfasserin aut Geleijnse, M. verfasserin aut de Boer, R. A. verfasserin aut Boersma, E. verfasserin aut Kardys, I. verfasserin aut van Dalen, B. M. verfasserin aut Enthalten in Clinical research in cardiology Springer Berlin Heidelberg, 2006 113(2023), 9 vom: 13. Juni, Seite 1306-1316 Online-Ressource (DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 1861-0692 nnns volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 https://dx.doi.org/10.1007/s00392-023-02244-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 113 2023 9 13 06 1306-1316 |
| allfieldsGer |
10.1007/s00392-023-02244-x doi (DE-627)SPR057192383 (SPR)s00392-023-02244-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Abou Kamar, S. verfasserin aut Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Crown 2023 Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 Aga, Y. S. verfasserin aut de Bakker, M. verfasserin aut van den Berg, V. J. verfasserin aut Strachinaru, M. verfasserin aut Bowen, D. verfasserin aut Frowijn, R. verfasserin aut Akkerhuis, K. M. verfasserin aut Brugts, J. J. verfasserin aut Manintveld, O. verfasserin aut Umans, V. verfasserin aut Geleijnse, M. verfasserin aut de Boer, R. A. verfasserin aut Boersma, E. verfasserin aut Kardys, I. verfasserin aut van Dalen, B. M. verfasserin aut Enthalten in Clinical research in cardiology Springer Berlin Heidelberg, 2006 113(2023), 9 vom: 13. Juni, Seite 1306-1316 Online-Ressource (DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 1861-0692 nnns volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 https://dx.doi.org/10.1007/s00392-023-02244-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 113 2023 9 13 06 1306-1316 |
| allfieldsSound |
10.1007/s00392-023-02244-x doi (DE-627)SPR057192383 (SPR)s00392-023-02244-x-e DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl Abou Kamar, S. verfasserin aut Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Crown 2023 Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 Aga, Y. S. verfasserin aut de Bakker, M. verfasserin aut van den Berg, V. J. verfasserin aut Strachinaru, M. verfasserin aut Bowen, D. verfasserin aut Frowijn, R. verfasserin aut Akkerhuis, K. M. verfasserin aut Brugts, J. J. verfasserin aut Manintveld, O. verfasserin aut Umans, V. verfasserin aut Geleijnse, M. verfasserin aut de Boer, R. A. verfasserin aut Boersma, E. verfasserin aut Kardys, I. verfasserin aut van Dalen, B. M. verfasserin aut Enthalten in Clinical research in cardiology Springer Berlin Heidelberg, 2006 113(2023), 9 vom: 13. Juni, Seite 1306-1316 Online-Ressource (DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 1861-0692 nnns volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 https://dx.doi.org/10.1007/s00392-023-02244-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 Kardiologie Angiologie VZ AR 113 2023 9 13 06 1306-1316 |
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Enthalten in Clinical research in cardiology 113(2023), 9 vom: 13. Juni, Seite 1306-1316 volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 |
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Enthalten in Clinical research in cardiology 113(2023), 9 vom: 13. Juni, Seite 1306-1316 volume:113 year:2023 number:9 day:13 month:06 pages:1306-1316 |
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Left atrial reservoir strain Heart failure with reduced ejection fraction Longitudinal studies Repeated measurements |
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Abou Kamar, S. @@aut@@ Aga, Y. S. @@aut@@ de Bakker, M. @@aut@@ van den Berg, V. J. @@aut@@ Strachinaru, M. @@aut@@ Bowen, D. @@aut@@ Frowijn, R. @@aut@@ Akkerhuis, K. M. @@aut@@ Brugts, J. J. @@aut@@ Manintveld, O. @@aut@@ Umans, V. @@aut@@ Geleijnse, M. @@aut@@ de Boer, R. A. @@aut@@ Boersma, E. @@aut@@ Kardys, I. @@aut@@ van Dalen, B. M. @@aut@@ |
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Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. 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| author |
Abou Kamar, S. |
| spellingShingle |
Abou Kamar, S. ddc 610 bkl 44.85 misc Left atrial reservoir strain misc Heart failure with reduced ejection fraction misc Longitudinal studies misc Repeated measurements Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
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Abou Kamar, S. |
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1861-0692 |
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610 VZ 44.85 bkl Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction Left atrial reservoir strain (dpeaa)DE-He213 Heart failure with reduced ejection fraction (dpeaa)DE-He213 Longitudinal studies (dpeaa)DE-He213 Repeated measurements (dpeaa)DE-He213 |
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ddc 610 bkl 44.85 misc Left atrial reservoir strain misc Heart failure with reduced ejection fraction misc Longitudinal studies misc Repeated measurements |
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ddc 610 bkl 44.85 misc Left atrial reservoir strain misc Heart failure with reduced ejection fraction misc Longitudinal studies misc Repeated measurements |
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ddc 610 bkl 44.85 misc Left atrial reservoir strain misc Heart failure with reduced ejection fraction misc Longitudinal studies misc Repeated measurements |
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Clinical research in cardiology |
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610 - Medicine & health |
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Clinical research in cardiology |
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(DE-627)506287343 (DE-600)2218331-0 (DE-576)251097692 |
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Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
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(DE-627)SPR057192383 (SPR)s00392-023-02244-x-e |
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Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
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Abou Kamar, S. |
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Clinical research in cardiology |
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Clinical research in cardiology |
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eng |
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600 - Technology |
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2023 |
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Abou Kamar, S. Aga, Y. S. de Bakker, M. van den Berg, V. J. Strachinaru, M. Bowen, D. Frowijn, R. Akkerhuis, K. M. Brugts, J. J. Manintveld, O. Umans, V. Geleijnse, M. de Boer, R. A. Boersma, E. Kardys, I. van Dalen, B. M. |
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610 VZ 44.85 bkl |
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Elektronische Aufsätze |
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Abou Kamar, S. |
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10.1007/s00392-023-02244-x |
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610 |
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verfasserin |
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prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
| title_auth |
Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
| abstract |
Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract © Crown 2023 |
| abstractGer |
Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract © Crown 2023 |
| abstract_unstemmed |
Background We investigated whether repeatedly measured left atrial reservoir strain (LASr) in heart failure with reduced ejection fraction (HFrEF) patients provides incremental prognostic value over a single baseline LASr value, and whether temporal patterns of LASr provide incremental prognostic value over temporal patterns of other echocardiographic markers and NT-proBNP. Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. Although LASr was persistently lower over time in patients with PEP, temporal trajectories did not diverge in patients with versus without the PEP as the PEP approached. Conclusion LASr was associated with adverse events in HFrEF patients, independent of baseline and repeated other echo-parameters and NT-proBNP. Temporal trajectories of LASr showed decreased but stable values in patients with the PEP, and do not provide incremental prognostic value for clinical practice compared to single measurements of LASr. Graphical abstract © Crown 2023 |
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Prognostic value of temporal patterns of left atrial reservoir strain in patients with heart failure with reduced ejection fraction |
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https://dx.doi.org/10.1007/s00392-023-02244-x |
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Aga, Y. S. de Bakker, M. van den Berg, V. J. Strachinaru, M. Bowen, D. Frowijn, R. Akkerhuis, K. M. Brugts, J. J. Manintveld, O. Umans, V. Geleijnse, M. de Boer, R. A. Boersma, E. Kardys, I. van Dalen, B. M. |
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Aga, Y. S. de Bakker, M. van den Berg, V. J. Strachinaru, M. Bowen, D. Frowijn, R. Akkerhuis, K. M. Brugts, J. J. Manintveld, O. Umans, V. Geleijnse, M. de Boer, R. A. Boersma, E. Kardys, I. van Dalen, B. M. |
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10.1007/s00392-023-02244-x |
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2024-09-04T05:56:25.128Z |
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Methods In this prospective observational study, 153 patients underwent 6-monthly echocardiography, during a median follow-up of 2.5 years. Speckle tracking echocardiography was used to measure LASr. Hazard ratios (HRs) were calculated for LASr from Cox models (baseline) and joint models (repeated measurements). The primary endpoint (PEP) comprised HF hospitalization, left ventricular assist device, heart transplantation, and cardiovascular death. Results Mean age was 58 ± 11 years, 76% were men, 82% were in NYHA class I/II, mean LASr was 20.9% ± 11.3%, and mean LVEF was 29% ± 10%. PEP was reached by 50 patients. Baseline and repeated measurements of LASr (HR per SD change (95% CI) 0.20 (0.10–0.41) and (0.13 (0.10–0.29), respectively) were both significantly associated with the PEP, independent of both baseline and repeated measurements of other echo-parameters and NT-proBNP. 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| score |
7.4018145 |