Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors

Abstract The clinical response to immune checkpoint inhibitors may vary by tumor type and many tumors present with either primary or acquired resistance to immunotherapy. Improved understanding of the molecular and immunologic mechanisms underlying immunotherapy resistance is essential for developin...
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Gespeichert in:

Autor*in:	Malhotra, Jyoti [verfasserIn] De, Subhajyoti [verfasserIn] Nguyen, Kim [verfasserIn] Lee, Percy [verfasserIn] Villaflor, Victoria [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Molecular Genomic Primary resistance Immunotherapy

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Cancer immunology immunotherapy - Springer Berlin Heidelberg, 1976, 73(2024), 11 vom: 13. Sept.
Übergeordnetes Werk:	volume:73 ; year:2024 ; number:11 ; day:13 ; month:09

Links:	Volltext

DOI / URN:	10.1007/s00262-024-03825-z

Katalog-ID:	SPR057315639

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language	English
source	Enthalten in Cancer immunology immunotherapy 73(2024), 11 vom: 13. Sept. volume:73 year:2024 number:11 day:13 month:09
sourceStr	Enthalten in Cancer immunology immunotherapy 73(2024), 11 vom: 13. Sept. volume:73 year:2024 number:11 day:13 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Molecular Genomic Primary resistance Immunotherapy
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isfreeaccess_bool	true
container_title	Cancer immunology immunotherapy
authorswithroles_txt_mv	Malhotra, Jyoti @@aut@@ De, Subhajyoti @@aut@@ Nguyen, Kim @@aut@@ Lee, Percy @@aut@@ Villaflor, Victoria @@aut@@
publishDateDaySort_date	2024-09-13T00:00:00Z
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author	Malhotra, Jyoti
spellingShingle	Malhotra, Jyoti ddc 610 bkl 44.81 bkl 44.45 misc Molecular misc Genomic misc Primary resistance misc Immunotherapy Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
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title	Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
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title_sort	genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
title_auth	Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
abstract	Abstract The clinical response to immune checkpoint inhibitors may vary by tumor type and many tumors present with either primary or acquired resistance to immunotherapy. Improved understanding of the molecular and immunologic mechanisms underlying immunotherapy resistance is essential for developing biomarkers and for guiding the optimum approach to selecting treatment regimens and sequencing. This is increasingly important for tumors with primary resistance as effective biomarkers in this setting can guide clinicians about appropriate treatment regimen selection in the first-line setting. Multiple potential biological mechanisms of primary resistance have been proposed but most are yet to be validated in prospective clinical cohorts. Individual biomarkers have poor specificity and sensitivity, and the development of validated and integrated predictive models may guide which patient will benefit from monotherapy versus combination therapy. In this review, we discuss the emerging data identifying the molecular mechanisms of primary resistance to immunotherapy and explore potential therapeutic strategies to target these. © The Author(s) 2024
abstractGer	Abstract The clinical response to immune checkpoint inhibitors may vary by tumor type and many tumors present with either primary or acquired resistance to immunotherapy. Improved understanding of the molecular and immunologic mechanisms underlying immunotherapy resistance is essential for developing biomarkers and for guiding the optimum approach to selecting treatment regimens and sequencing. This is increasingly important for tumors with primary resistance as effective biomarkers in this setting can guide clinicians about appropriate treatment regimen selection in the first-line setting. Multiple potential biological mechanisms of primary resistance have been proposed but most are yet to be validated in prospective clinical cohorts. Individual biomarkers have poor specificity and sensitivity, and the development of validated and integrated predictive models may guide which patient will benefit from monotherapy versus combination therapy. In this review, we discuss the emerging data identifying the molecular mechanisms of primary resistance to immunotherapy and explore potential therapeutic strategies to target these. © The Author(s) 2024
abstract_unstemmed	Abstract The clinical response to immune checkpoint inhibitors may vary by tumor type and many tumors present with either primary or acquired resistance to immunotherapy. Improved understanding of the molecular and immunologic mechanisms underlying immunotherapy resistance is essential for developing biomarkers and for guiding the optimum approach to selecting treatment regimens and sequencing. This is increasingly important for tumors with primary resistance as effective biomarkers in this setting can guide clinicians about appropriate treatment regimen selection in the first-line setting. Multiple potential biological mechanisms of primary resistance have been proposed but most are yet to be validated in prospective clinical cohorts. Individual biomarkers have poor specificity and sensitivity, and the development of validated and integrated predictive models may guide which patient will benefit from monotherapy versus combination therapy. In this review, we discuss the emerging data identifying the molecular mechanisms of primary resistance to immunotherapy and explore potential therapeutic strategies to target these. © The Author(s) 2024
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title_short	Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors
url	https://dx.doi.org/10.1007/s00262-024-03825-z
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Genomic and molecular alterations associated with primary resistance to immune checkpoint inhibitors

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