A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems

Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses...
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Gespeichert in:

Autor*in:	Rani, Manju [verfasserIn] Chawla, Neha [verfasserIn] Wadhwa, Nitya [verfasserIn] Mathur, Roli [verfasserIn] Jinks, Timothy [verfasserIn] Das, Priyanka [verfasserIn] Rijal, Suman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Research ethics Ethical review/standards Ethics committees Research participants Ethics review systems Harmonization of research ethics review Clinical trial register

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Health research policy and systems - BioMed Central, 2003, 22(2024), 1 vom: 20. Sept.
Übergeordnetes Werk:	volume:22 ; year:2024 ; number:1 ; day:20 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s12961-024-01219-2

Katalog-ID:	SPR057407843

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allfields	10.1186/s12961-024-01219-2 doi (DE-627)SPR057407843 (SPR)s12961-024-01219-2-e DE-627 ger DE-627 rakwb eng 610 VZ Rani, Manju verfasserin aut A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213 Chawla, Neha verfasserin aut Wadhwa, Nitya verfasserin aut Mathur, Roli verfasserin aut Jinks, Timothy verfasserin aut Das, Priyanka verfasserin aut Rijal, Suman verfasserin aut Enthalten in Health research policy and systems BioMed Central, 2003 22(2024), 1 vom: 20. Sept. (DE-627)36277935X (DE-600)2101196-5 1478-4505 nnns volume:22 year:2024 number:1 day:20 month:09 https://dx.doi.org/10.1186/s12961-024-01219-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 20 09
spelling	10.1186/s12961-024-01219-2 doi (DE-627)SPR057407843 (SPR)s12961-024-01219-2-e DE-627 ger DE-627 rakwb eng 610 VZ Rani, Manju verfasserin aut A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213 Chawla, Neha verfasserin aut Wadhwa, Nitya verfasserin aut Mathur, Roli verfasserin aut Jinks, Timothy verfasserin aut Das, Priyanka verfasserin aut Rijal, Suman verfasserin aut Enthalten in Health research policy and systems BioMed Central, 2003 22(2024), 1 vom: 20. Sept. (DE-627)36277935X (DE-600)2101196-5 1478-4505 nnns volume:22 year:2024 number:1 day:20 month:09 https://dx.doi.org/10.1186/s12961-024-01219-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 20 09
allfields_unstemmed	10.1186/s12961-024-01219-2 doi (DE-627)SPR057407843 (SPR)s12961-024-01219-2-e DE-627 ger DE-627 rakwb eng 610 VZ Rani, Manju verfasserin aut A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213 Chawla, Neha verfasserin aut Wadhwa, Nitya verfasserin aut Mathur, Roli verfasserin aut Jinks, Timothy verfasserin aut Das, Priyanka verfasserin aut Rijal, Suman verfasserin aut Enthalten in Health research policy and systems BioMed Central, 2003 22(2024), 1 vom: 20. Sept. (DE-627)36277935X (DE-600)2101196-5 1478-4505 nnns volume:22 year:2024 number:1 day:20 month:09 https://dx.doi.org/10.1186/s12961-024-01219-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 20 09
allfieldsGer	10.1186/s12961-024-01219-2 doi (DE-627)SPR057407843 (SPR)s12961-024-01219-2-e DE-627 ger DE-627 rakwb eng 610 VZ Rani, Manju verfasserin aut A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213 Chawla, Neha verfasserin aut Wadhwa, Nitya verfasserin aut Mathur, Roli verfasserin aut Jinks, Timothy verfasserin aut Das, Priyanka verfasserin aut Rijal, Suman verfasserin aut Enthalten in Health research policy and systems BioMed Central, 2003 22(2024), 1 vom: 20. Sept. (DE-627)36277935X (DE-600)2101196-5 1478-4505 nnns volume:22 year:2024 number:1 day:20 month:09 https://dx.doi.org/10.1186/s12961-024-01219-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 20 09
allfieldsSound	10.1186/s12961-024-01219-2 doi (DE-627)SPR057407843 (SPR)s12961-024-01219-2-e DE-627 ger DE-627 rakwb eng 610 VZ Rani, Manju verfasserin aut A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213 Chawla, Neha verfasserin aut Wadhwa, Nitya verfasserin aut Mathur, Roli verfasserin aut Jinks, Timothy verfasserin aut Das, Priyanka verfasserin aut Rijal, Suman verfasserin aut Enthalten in Health research policy and systems BioMed Central, 2003 22(2024), 1 vom: 20. Sept. (DE-627)36277935X (DE-600)2101196-5 1478-4505 nnns volume:22 year:2024 number:1 day:20 month:09 https://dx.doi.org/10.1186/s12961-024-01219-2 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_375 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 22 2024 1 20 09
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author	Rani, Manju
spellingShingle	Rani, Manju ddc 610 misc Research ethics misc Ethical review/standards misc Ethics committees misc Research participants misc Ethics review systems misc Harmonization of research ethics review misc Clinical trial register A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems
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topic_title	610 VZ A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems Research ethics (dpeaa)DE-He213 Ethical review/standards (dpeaa)DE-He213 Ethics committees (dpeaa)DE-He213 Research participants (dpeaa)DE-He213 Ethics review systems (dpeaa)DE-He213 Harmonization of research ethics review (dpeaa)DE-He213 Clinical trial register (dpeaa)DE-He213
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title_sort	a transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems
title_auth	A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems
abstract	Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. © The Author(s) 2024
abstractGer	Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. © The Author(s) 2024
abstract_unstemmed	Abstract The current research ethics review systems are composed of isolated institutional Research Ethics Committees (RECs) that develop their own standard operating procedures (SOPs), templates and so on, with low adoption of digital solutions to manage submission and review processes. This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. To maximize benefits, concurrent efforts are needed to build researchers’ capacity and enhance the quality and efficiency of human reviews of the research proposals by REC. © The Author(s) 2024
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title_short	A transformative solution to build effective, transparent, and resilient “fit-for-purpose” national health research ethics systems
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author2	Chawla, Neha Wadhwa, Nitya Mathur, Roli Jinks, Timothy Das, Priyanka Rijal, Suman
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This poses several challenges, such as delays, higher costs, and hindering multi-site research. We propose an online national research ethics platform that all RECs can use, with common review processes and documentation requirements following national policy. The system will scale up adoption of digital solutions to all RECs. It will reduce administrative burden and harmonize review procedures. It will also obviate the need for separate and isolated interventions such as national REC registries or clinical trial registries, as these can be generated as transactional outputs of the system. The harmonized procedures and possibility of single submission will facilitate multi-site research. Sharing of resources and expertise among RECs on the platform will enhance resilience. An e-EC system developed in India and a Regional Health research portal developed by the WHO South-East Asia office offer proof of concepts to demonstrate the feasibility of developing and using such systems. The proposed solution is ambitious but feasible. Developing the proposed system will be a vital cost-effective investment in national health infrastructure to strengthen the research ecosystem and accelerate delivery of improved healthcare innovations by reducing unnecessary delays in conducting research. 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