CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study
Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of thes...
Ausführliche Beschreibung
Autor*in: |
Enomoto, Noriyuki [verfasserIn] Nakai, Shogo [verfasserIn] Yazawa, Shusuke [verfasserIn] Mochizuka, Yasutaka [verfasserIn] Fukada, Atsuki [verfasserIn] Tanaka, Yuko [verfasserIn] Naoi, Hyogo [verfasserIn] Inoue, Yusuke [verfasserIn] Yasui, Hideki [verfasserIn] Karayama, Masato [verfasserIn] Suzuki, Yuzo [verfasserIn] Hozumi, Hironao [verfasserIn] Furuhashi, Kazuki [verfasserIn] Toyoshima, Mikio [verfasserIn] Kono, Masato [verfasserIn] Imokawa, Shiro [verfasserIn] Fujii, Masato [verfasserIn] Akamatsu, Taisuke [verfasserIn] Koshimizu, Naoki [verfasserIn] Yokomura, Koshi [verfasserIn] Matsuda, Hiroyuki [verfasserIn] Kaida, Yusuke [verfasserIn] Nakamura, Yutaro [verfasserIn] Shirai, Masahiro [verfasserIn] Mori, Kazutaka [verfasserIn] Masuda, Masafumi [verfasserIn] Fujisawa, Tomoyuki [verfasserIn] Inui, Naoki [verfasserIn] Sugiura, Hiroaki [verfasserIn] Sumikawa, Hiromitsu [verfasserIn] Kitani, Masashi [verfasserIn] Tabata, Kazuhiro [verfasserIn] Ogawa, Noriyoshi [verfasserIn] Suda, Takafumi [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Schlagwörter: |
Interstitial pneumonia with autoimmune features Idiopathic interstitial pneumonia |
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Anmerkung: |
© The Author(s) 2024 |
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Übergeordnetes Werk: |
Enthalten in: Respiratory research - BioMed Central, 2001, 25(2024), 1 vom: 28. Sept. |
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Übergeordnetes Werk: |
volume:25 ; year:2024 ; number:1 ; day:28 ; month:09 |
Links: |
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DOI / URN: |
10.1186/s12931-024-02982-0 |
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Katalog-ID: |
SPR057514453 |
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245 | 1 | 0 | |a CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
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520 | |a Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. | ||
650 | 4 | |a Interstitial pneumonia with autoimmune features |7 (dpeaa)DE-He213 | |
650 | 4 | |a Idiopathic interstitial pneumonia |7 (dpeaa)DE-He213 | |
650 | 4 | |a Nonspecific interstitial pneumonia |7 (dpeaa)DE-He213 | |
650 | 4 | |a Organizing pneumonia |7 (dpeaa)DE-He213 | |
650 | 4 | |a C-X-C motif chemokine 10 |7 (dpeaa)DE-He213 | |
700 | 1 | |a Nakai, Shogo |e verfasserin |4 aut | |
700 | 1 | |a Yazawa, Shusuke |e verfasserin |4 aut | |
700 | 1 | |a Mochizuka, Yasutaka |e verfasserin |4 aut | |
700 | 1 | |a Fukada, Atsuki |e verfasserin |4 aut | |
700 | 1 | |a Tanaka, Yuko |e verfasserin |4 aut | |
700 | 1 | |a Naoi, Hyogo |e verfasserin |4 aut | |
700 | 1 | |a Inoue, Yusuke |e verfasserin |4 aut | |
700 | 1 | |a Yasui, Hideki |e verfasserin |4 aut | |
700 | 1 | |a Karayama, Masato |e verfasserin |4 aut | |
700 | 1 | |a Suzuki, Yuzo |e verfasserin |4 aut | |
700 | 1 | |a Hozumi, Hironao |e verfasserin |4 aut | |
700 | 1 | |a Furuhashi, Kazuki |e verfasserin |4 aut | |
700 | 1 | |a Toyoshima, Mikio |e verfasserin |4 aut | |
700 | 1 | |a Kono, Masato |e verfasserin |4 aut | |
700 | 1 | |a Imokawa, Shiro |e verfasserin |4 aut | |
700 | 1 | |a Fujii, Masato |e verfasserin |4 aut | |
700 | 1 | |a Akamatsu, Taisuke |e verfasserin |4 aut | |
700 | 1 | |a Koshimizu, Naoki |e verfasserin |4 aut | |
700 | 1 | |a Yokomura, Koshi |e verfasserin |4 aut | |
700 | 1 | |a Matsuda, Hiroyuki |e verfasserin |4 aut | |
700 | 1 | |a Kaida, Yusuke |e verfasserin |4 aut | |
700 | 1 | |a Nakamura, Yutaro |e verfasserin |4 aut | |
700 | 1 | |a Shirai, Masahiro |e verfasserin |4 aut | |
700 | 1 | |a Mori, Kazutaka |e verfasserin |4 aut | |
700 | 1 | |a Masuda, Masafumi |e verfasserin |4 aut | |
700 | 1 | |a Fujisawa, Tomoyuki |e verfasserin |4 aut | |
700 | 1 | |a Inui, Naoki |e verfasserin |4 aut | |
700 | 1 | |a Sugiura, Hiroaki |e verfasserin |4 aut | |
700 | 1 | |a Sumikawa, Hiromitsu |e verfasserin |4 aut | |
700 | 1 | |a Kitani, Masashi |e verfasserin |4 aut | |
700 | 1 | |a Tabata, Kazuhiro |e verfasserin |4 aut | |
700 | 1 | |a Ogawa, Noriyoshi |e verfasserin |4 aut | |
700 | 1 | |a Suda, Takafumi |e verfasserin |4 aut | |
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10.1186/s12931-024-02982-0 doi (DE-627)SPR057514453 (SPR)s12931-024-02982-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Enomoto, Noriyuki verfasserin aut CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 Nakai, Shogo verfasserin aut Yazawa, Shusuke verfasserin aut Mochizuka, Yasutaka verfasserin aut Fukada, Atsuki verfasserin aut Tanaka, Yuko verfasserin aut Naoi, Hyogo verfasserin aut Inoue, Yusuke verfasserin aut Yasui, Hideki verfasserin aut Karayama, Masato verfasserin aut Suzuki, Yuzo verfasserin aut Hozumi, Hironao verfasserin aut Furuhashi, Kazuki verfasserin aut Toyoshima, Mikio verfasserin aut Kono, Masato verfasserin aut Imokawa, Shiro verfasserin aut Fujii, Masato verfasserin aut Akamatsu, Taisuke verfasserin aut Koshimizu, Naoki verfasserin aut Yokomura, Koshi verfasserin aut Matsuda, Hiroyuki verfasserin aut Kaida, Yusuke verfasserin aut Nakamura, Yutaro verfasserin aut Shirai, Masahiro verfasserin aut Mori, Kazutaka verfasserin aut Masuda, Masafumi verfasserin aut Fujisawa, Tomoyuki verfasserin aut Inui, Naoki verfasserin aut Sugiura, Hiroaki verfasserin aut Sumikawa, Hiromitsu verfasserin aut Kitani, Masashi verfasserin aut Tabata, Kazuhiro verfasserin aut Ogawa, Noriyoshi verfasserin aut Suda, Takafumi verfasserin aut Enthalten in Respiratory research BioMed Central, 2001 25(2024), 1 vom: 28. Sept. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:25 year:2024 number:1 day:28 month:09 https://dx.doi.org/10.1186/s12931-024-02982-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 25 2024 1 28 09 |
spelling |
10.1186/s12931-024-02982-0 doi (DE-627)SPR057514453 (SPR)s12931-024-02982-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Enomoto, Noriyuki verfasserin aut CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 Nakai, Shogo verfasserin aut Yazawa, Shusuke verfasserin aut Mochizuka, Yasutaka verfasserin aut Fukada, Atsuki verfasserin aut Tanaka, Yuko verfasserin aut Naoi, Hyogo verfasserin aut Inoue, Yusuke verfasserin aut Yasui, Hideki verfasserin aut Karayama, Masato verfasserin aut Suzuki, Yuzo verfasserin aut Hozumi, Hironao verfasserin aut Furuhashi, Kazuki verfasserin aut Toyoshima, Mikio verfasserin aut Kono, Masato verfasserin aut Imokawa, Shiro verfasserin aut Fujii, Masato verfasserin aut Akamatsu, Taisuke verfasserin aut Koshimizu, Naoki verfasserin aut Yokomura, Koshi verfasserin aut Matsuda, Hiroyuki verfasserin aut Kaida, Yusuke verfasserin aut Nakamura, Yutaro verfasserin aut Shirai, Masahiro verfasserin aut Mori, Kazutaka verfasserin aut Masuda, Masafumi verfasserin aut Fujisawa, Tomoyuki verfasserin aut Inui, Naoki verfasserin aut Sugiura, Hiroaki verfasserin aut Sumikawa, Hiromitsu verfasserin aut Kitani, Masashi verfasserin aut Tabata, Kazuhiro verfasserin aut Ogawa, Noriyoshi verfasserin aut Suda, Takafumi verfasserin aut Enthalten in Respiratory research BioMed Central, 2001 25(2024), 1 vom: 28. Sept. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:25 year:2024 number:1 day:28 month:09 https://dx.doi.org/10.1186/s12931-024-02982-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 25 2024 1 28 09 |
allfields_unstemmed |
10.1186/s12931-024-02982-0 doi (DE-627)SPR057514453 (SPR)s12931-024-02982-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Enomoto, Noriyuki verfasserin aut CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 Nakai, Shogo verfasserin aut Yazawa, Shusuke verfasserin aut Mochizuka, Yasutaka verfasserin aut Fukada, Atsuki verfasserin aut Tanaka, Yuko verfasserin aut Naoi, Hyogo verfasserin aut Inoue, Yusuke verfasserin aut Yasui, Hideki verfasserin aut Karayama, Masato verfasserin aut Suzuki, Yuzo verfasserin aut Hozumi, Hironao verfasserin aut Furuhashi, Kazuki verfasserin aut Toyoshima, Mikio verfasserin aut Kono, Masato verfasserin aut Imokawa, Shiro verfasserin aut Fujii, Masato verfasserin aut Akamatsu, Taisuke verfasserin aut Koshimizu, Naoki verfasserin aut Yokomura, Koshi verfasserin aut Matsuda, Hiroyuki verfasserin aut Kaida, Yusuke verfasserin aut Nakamura, Yutaro verfasserin aut Shirai, Masahiro verfasserin aut Mori, Kazutaka verfasserin aut Masuda, Masafumi verfasserin aut Fujisawa, Tomoyuki verfasserin aut Inui, Naoki verfasserin aut Sugiura, Hiroaki verfasserin aut Sumikawa, Hiromitsu verfasserin aut Kitani, Masashi verfasserin aut Tabata, Kazuhiro verfasserin aut Ogawa, Noriyoshi verfasserin aut Suda, Takafumi verfasserin aut Enthalten in Respiratory research BioMed Central, 2001 25(2024), 1 vom: 28. Sept. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:25 year:2024 number:1 day:28 month:09 https://dx.doi.org/10.1186/s12931-024-02982-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 25 2024 1 28 09 |
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10.1186/s12931-024-02982-0 doi (DE-627)SPR057514453 (SPR)s12931-024-02982-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Enomoto, Noriyuki verfasserin aut CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 Nakai, Shogo verfasserin aut Yazawa, Shusuke verfasserin aut Mochizuka, Yasutaka verfasserin aut Fukada, Atsuki verfasserin aut Tanaka, Yuko verfasserin aut Naoi, Hyogo verfasserin aut Inoue, Yusuke verfasserin aut Yasui, Hideki verfasserin aut Karayama, Masato verfasserin aut Suzuki, Yuzo verfasserin aut Hozumi, Hironao verfasserin aut Furuhashi, Kazuki verfasserin aut Toyoshima, Mikio verfasserin aut Kono, Masato verfasserin aut Imokawa, Shiro verfasserin aut Fujii, Masato verfasserin aut Akamatsu, Taisuke verfasserin aut Koshimizu, Naoki verfasserin aut Yokomura, Koshi verfasserin aut Matsuda, Hiroyuki verfasserin aut Kaida, Yusuke verfasserin aut Nakamura, Yutaro verfasserin aut Shirai, Masahiro verfasserin aut Mori, Kazutaka verfasserin aut Masuda, Masafumi verfasserin aut Fujisawa, Tomoyuki verfasserin aut Inui, Naoki verfasserin aut Sugiura, Hiroaki verfasserin aut Sumikawa, Hiromitsu verfasserin aut Kitani, Masashi verfasserin aut Tabata, Kazuhiro verfasserin aut Ogawa, Noriyoshi verfasserin aut Suda, Takafumi verfasserin aut Enthalten in Respiratory research BioMed Central, 2001 25(2024), 1 vom: 28. Sept. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:25 year:2024 number:1 day:28 month:09 https://dx.doi.org/10.1186/s12931-024-02982-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 25 2024 1 28 09 |
allfieldsSound |
10.1186/s12931-024-02982-0 doi (DE-627)SPR057514453 (SPR)s12931-024-02982-0-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Enomoto, Noriyuki verfasserin aut CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 Nakai, Shogo verfasserin aut Yazawa, Shusuke verfasserin aut Mochizuka, Yasutaka verfasserin aut Fukada, Atsuki verfasserin aut Tanaka, Yuko verfasserin aut Naoi, Hyogo verfasserin aut Inoue, Yusuke verfasserin aut Yasui, Hideki verfasserin aut Karayama, Masato verfasserin aut Suzuki, Yuzo verfasserin aut Hozumi, Hironao verfasserin aut Furuhashi, Kazuki verfasserin aut Toyoshima, Mikio verfasserin aut Kono, Masato verfasserin aut Imokawa, Shiro verfasserin aut Fujii, Masato verfasserin aut Akamatsu, Taisuke verfasserin aut Koshimizu, Naoki verfasserin aut Yokomura, Koshi verfasserin aut Matsuda, Hiroyuki verfasserin aut Kaida, Yusuke verfasserin aut Nakamura, Yutaro verfasserin aut Shirai, Masahiro verfasserin aut Mori, Kazutaka verfasserin aut Masuda, Masafumi verfasserin aut Fujisawa, Tomoyuki verfasserin aut Inui, Naoki verfasserin aut Sugiura, Hiroaki verfasserin aut Sumikawa, Hiromitsu verfasserin aut Kitani, Masashi verfasserin aut Tabata, Kazuhiro verfasserin aut Ogawa, Noriyoshi verfasserin aut Suda, Takafumi verfasserin aut Enthalten in Respiratory research BioMed Central, 2001 25(2024), 1 vom: 28. Sept. (DE-627)326646485 (DE-600)2041675-1 1465-993X nnns volume:25 year:2024 number:1 day:28 month:09 https://dx.doi.org/10.1186/s12931-024-02982-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 25 2024 1 28 09 |
language |
English |
source |
Enthalten in Respiratory research 25(2024), 1 vom: 28. Sept. volume:25 year:2024 number:1 day:28 month:09 |
sourceStr |
Enthalten in Respiratory research 25(2024), 1 vom: 28. Sept. volume:25 year:2024 number:1 day:28 month:09 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Interstitial pneumonia with autoimmune features Idiopathic interstitial pneumonia Nonspecific interstitial pneumonia Organizing pneumonia C-X-C motif chemokine 10 |
dewey-raw |
610 |
isfreeaccess_bool |
true |
container_title |
Respiratory research |
authorswithroles_txt_mv |
Enomoto, Noriyuki @@aut@@ Nakai, Shogo @@aut@@ Yazawa, Shusuke @@aut@@ Mochizuka, Yasutaka @@aut@@ Fukada, Atsuki @@aut@@ Tanaka, Yuko @@aut@@ Naoi, Hyogo @@aut@@ Inoue, Yusuke @@aut@@ Yasui, Hideki @@aut@@ Karayama, Masato @@aut@@ Suzuki, Yuzo @@aut@@ Hozumi, Hironao @@aut@@ Furuhashi, Kazuki @@aut@@ Toyoshima, Mikio @@aut@@ Kono, Masato @@aut@@ Imokawa, Shiro @@aut@@ Fujii, Masato @@aut@@ Akamatsu, Taisuke @@aut@@ Koshimizu, Naoki @@aut@@ Yokomura, Koshi @@aut@@ Matsuda, Hiroyuki @@aut@@ Kaida, Yusuke @@aut@@ Nakamura, Yutaro @@aut@@ Shirai, Masahiro @@aut@@ Mori, Kazutaka @@aut@@ Masuda, Masafumi @@aut@@ Fujisawa, Tomoyuki @@aut@@ Inui, Naoki @@aut@@ Sugiura, Hiroaki @@aut@@ Sumikawa, Hiromitsu @@aut@@ Kitani, Masashi @@aut@@ Tabata, Kazuhiro @@aut@@ Ogawa, Noriyoshi @@aut@@ Suda, Takafumi @@aut@@ |
publishDateDaySort_date |
2024-09-28T00:00:00Z |
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3610 |
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language_de |
englisch |
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However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. 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Enomoto, Noriyuki |
spellingShingle |
Enomoto, Noriyuki ddc 610 bkl 44.00 misc Interstitial pneumonia with autoimmune features misc Idiopathic interstitial pneumonia misc Nonspecific interstitial pneumonia misc Organizing pneumonia misc C-X-C motif chemokine 10 CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
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610 VZ 44.00 bkl CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study Interstitial pneumonia with autoimmune features (dpeaa)DE-He213 Idiopathic interstitial pneumonia (dpeaa)DE-He213 Nonspecific interstitial pneumonia (dpeaa)DE-He213 Organizing pneumonia (dpeaa)DE-He213 C-X-C motif chemokine 10 (dpeaa)DE-He213 |
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ddc 610 bkl 44.00 misc Interstitial pneumonia with autoimmune features misc Idiopathic interstitial pneumonia misc Nonspecific interstitial pneumonia misc Organizing pneumonia misc C-X-C motif chemokine 10 |
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ddc 610 bkl 44.00 misc Interstitial pneumonia with autoimmune features misc Idiopathic interstitial pneumonia misc Nonspecific interstitial pneumonia misc Organizing pneumonia misc C-X-C motif chemokine 10 |
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CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
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CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
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Enomoto, Noriyuki |
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Respiratory research |
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Enomoto, Noriyuki Nakai, Shogo Yazawa, Shusuke Mochizuka, Yasutaka Fukada, Atsuki Tanaka, Yuko Naoi, Hyogo Inoue, Yusuke Yasui, Hideki Karayama, Masato Suzuki, Yuzo Hozumi, Hironao Furuhashi, Kazuki Toyoshima, Mikio Kono, Masato Imokawa, Shiro Fujii, Masato Akamatsu, Taisuke Koshimizu, Naoki Yokomura, Koshi Matsuda, Hiroyuki Kaida, Yusuke Nakamura, Yutaro Shirai, Masahiro Mori, Kazutaka Masuda, Masafumi Fujisawa, Tomoyuki Inui, Naoki Sugiura, Hiroaki Sumikawa, Hiromitsu Kitani, Masashi Tabata, Kazuhiro Ogawa, Noriyoshi Suda, Takafumi |
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Elektronische Aufsätze |
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Enomoto, Noriyuki |
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10.1186/s12931-024-02982-0 |
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610 |
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verfasserin |
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cxcl10 predicts autoimmune features and a favorable clinical course in patients with iip: post hoc analysis of a prospective and multicenter cohort study |
title_auth |
CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
abstract |
Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. © The Author(s) 2024 |
abstractGer |
Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. © The Author(s) 2024 |
abstract_unstemmed |
Background Interstitial pneumonia with autoimmune features (IPAF), which does not meet any of the criteria for connective tissue diseases (CTD), has been attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, the biomarkers that reflect the clinical course of these patients have not been fully elucidated. Objective To identify useful serum biomarkers reflecting CTD-related features and favorable prognoses in patients with IIP. Methods This was a post hoc analysis of a prospective and multicenter cohort study between 2015 and 2020. Newly diagnosed patients with IIP were consecutively enrolled, and 74 autoimmune features and autoantibodies were comprehensively checked during IIP diagnosis. Serum levels of CXCL10, CXCL1, CCL2, BAFF, angiopoietin-2, and leptin were evaluated at the time of IIP diagnosis. Results Two hundred twenty-two patients (159 men and 63 women) with IIP were enrolled. The median observation duration was 36 months. The median age was 71 years old, and median %forced vital capacity (FVC) was 84.1% at the time of IIP diagnosis. The proportion of patients who met the classification criteria for IPAF was 11.7%. In patients with high serum CXCL10, changes in both %FVC and %diffusion lung capacity for carbon monoxide at one year were significantly higher than those in patients with low CXCL10 (p = 0.014 and p = 0.009, respectively), whereas these changes were not significant for other chemokines and cytokines. High CXCL10 levels were associated with acute/subacute onset (p < 0.001) and the diagnosis of nonspecific interstitial pneumonia with organizing pneumonia overlap (p = 0.003). High CXCL10 levels were related to a higher classification of IPAF (relative risk for IPAF was 3.320, 95%CI: 1.571–7.019, p = 0.003) and lower classification of progressive pulmonary fibrosis (PPF; relative risk for PPF was 0.309, 95%CI: 0.100-0.953, p = 0.027) compared to those with low CXCL10. Finally, survival was higher in patients with IPF and high CXCL10 (p = 0.044), and high CXCL10 was a significant prognostic factor in multivariate Cox proportional hazards models (hazard ratio 0.368, p = 0.005). Conclusions High serum levels of CXCL10 are associated with CTD-related features, the favorable clinical course, and survival in patients with IIP, especially IPF. Clinical trial number Not applicable. © The Author(s) 2024 |
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container_issue |
1 |
title_short |
CXCL10 predicts autoimmune features and a favorable clinical course in patients with IIP: post hoc analysis of a prospective and multicenter cohort study |
url |
https://dx.doi.org/10.1186/s12931-024-02982-0 |
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Nakai, Shogo Yazawa, Shusuke Mochizuka, Yasutaka Fukada, Atsuki Tanaka, Yuko Naoi, Hyogo Inoue, Yusuke Yasui, Hideki Karayama, Masato Suzuki, Yuzo Hozumi, Hironao Furuhashi, Kazuki Toyoshima, Mikio Kono, Masato Imokawa, Shiro Fujii, Masato Akamatsu, Taisuke Koshimizu, Naoki Yokomura, Koshi Matsuda, Hiroyuki Kaida, Yusuke Nakamura, Yutaro Shirai, Masahiro Mori, Kazutaka Masuda, Masafumi Fujisawa, Tomoyuki Inui, Naoki Sugiura, Hiroaki Sumikawa, Hiromitsu Kitani, Masashi Tabata, Kazuhiro Ogawa, Noriyoshi Suda, Takafumi |
author2Str |
Nakai, Shogo Yazawa, Shusuke Mochizuka, Yasutaka Fukada, Atsuki Tanaka, Yuko Naoi, Hyogo Inoue, Yusuke Yasui, Hideki Karayama, Masato Suzuki, Yuzo Hozumi, Hironao Furuhashi, Kazuki Toyoshima, Mikio Kono, Masato Imokawa, Shiro Fujii, Masato Akamatsu, Taisuke Koshimizu, Naoki Yokomura, Koshi Matsuda, Hiroyuki Kaida, Yusuke Nakamura, Yutaro Shirai, Masahiro Mori, Kazutaka Masuda, Masafumi Fujisawa, Tomoyuki Inui, Naoki Sugiura, Hiroaki Sumikawa, Hiromitsu Kitani, Masashi Tabata, Kazuhiro Ogawa, Noriyoshi Suda, Takafumi |
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10.1186/s12931-024-02982-0 |
up_date |
2024-09-29T04:48:21.313Z |
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|
score |
7.400275 |