Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers

Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with re...
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Autor*in:	Tian, Dan [verfasserIn] Teng, Chong [verfasserIn] Lv, Yanju [verfasserIn] Duan, Xiaozhuo [verfasserIn] Wang, Yi [verfasserIn] Song, Xiaowei [verfasserIn] Jiang, Qiuying [verfasserIn] Huang, Dayong [verfasserIn] Xin, Tao [verfasserIn] Yang, Yu [verfasserIn] Li, Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Cutaneous squamous cell carcinoma Intratumoral injection Photodynamic therapy Immunotherapy

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Discover oncology - Springer US, 2021, 15(2024), 1 vom: 04. Okt.
Übergeordnetes Werk:	volume:15 ; year:2024 ; number:1 ; day:04 ; month:10

Links:	Volltext

DOI / URN:	10.1007/s12672-024-01342-0

Katalog-ID:	SPR057671915

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allfields	10.1007/s12672-024-01342-0 doi (DE-627)SPR057671915 (SPR)s12672-024-01342-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ Tian, Dan verfasserin aut Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Teng, Chong verfasserin aut Lv, Yanju verfasserin aut Duan, Xiaozhuo verfasserin aut Wang, Yi verfasserin aut Song, Xiaowei verfasserin aut Jiang, Qiuying verfasserin aut Huang, Dayong verfasserin aut Xin, Tao verfasserin aut Yang, Yu verfasserin aut Li, Li verfasserin aut Enthalten in Discover oncology Springer US, 2021 15(2024), 1 vom: 04. Okt. Online-Ressource (DE-627)1753566347 (DE-600)3059869-2 2730-6011 nnns volume:15 year:2024 number:1 day:04 month:10 https://dx.doi.org/10.1007/s12672-024-01342-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 04 10
spelling	10.1007/s12672-024-01342-0 doi (DE-627)SPR057671915 (SPR)s12672-024-01342-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ Tian, Dan verfasserin aut Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Teng, Chong verfasserin aut Lv, Yanju verfasserin aut Duan, Xiaozhuo verfasserin aut Wang, Yi verfasserin aut Song, Xiaowei verfasserin aut Jiang, Qiuying verfasserin aut Huang, Dayong verfasserin aut Xin, Tao verfasserin aut Yang, Yu verfasserin aut Li, Li verfasserin aut Enthalten in Discover oncology Springer US, 2021 15(2024), 1 vom: 04. Okt. Online-Ressource (DE-627)1753566347 (DE-600)3059869-2 2730-6011 nnns volume:15 year:2024 number:1 day:04 month:10 https://dx.doi.org/10.1007/s12672-024-01342-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 04 10
allfields_unstemmed	10.1007/s12672-024-01342-0 doi (DE-627)SPR057671915 (SPR)s12672-024-01342-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ Tian, Dan verfasserin aut Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Teng, Chong verfasserin aut Lv, Yanju verfasserin aut Duan, Xiaozhuo verfasserin aut Wang, Yi verfasserin aut Song, Xiaowei verfasserin aut Jiang, Qiuying verfasserin aut Huang, Dayong verfasserin aut Xin, Tao verfasserin aut Yang, Yu verfasserin aut Li, Li verfasserin aut Enthalten in Discover oncology Springer US, 2021 15(2024), 1 vom: 04. Okt. Online-Ressource (DE-627)1753566347 (DE-600)3059869-2 2730-6011 nnns volume:15 year:2024 number:1 day:04 month:10 https://dx.doi.org/10.1007/s12672-024-01342-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 04 10
allfieldsGer	10.1007/s12672-024-01342-0 doi (DE-627)SPR057671915 (SPR)s12672-024-01342-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ Tian, Dan verfasserin aut Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Teng, Chong verfasserin aut Lv, Yanju verfasserin aut Duan, Xiaozhuo verfasserin aut Wang, Yi verfasserin aut Song, Xiaowei verfasserin aut Jiang, Qiuying verfasserin aut Huang, Dayong verfasserin aut Xin, Tao verfasserin aut Yang, Yu verfasserin aut Li, Li verfasserin aut Enthalten in Discover oncology Springer US, 2021 15(2024), 1 vom: 04. Okt. Online-Ressource (DE-627)1753566347 (DE-600)3059869-2 2730-6011 nnns volume:15 year:2024 number:1 day:04 month:10 https://dx.doi.org/10.1007/s12672-024-01342-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 04 10
allfieldsSound	10.1007/s12672-024-01342-0 doi (DE-627)SPR057671915 (SPR)s12672-024-01342-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ Tian, Dan verfasserin aut Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Teng, Chong verfasserin aut Lv, Yanju verfasserin aut Duan, Xiaozhuo verfasserin aut Wang, Yi verfasserin aut Song, Xiaowei verfasserin aut Jiang, Qiuying verfasserin aut Huang, Dayong verfasserin aut Xin, Tao verfasserin aut Yang, Yu verfasserin aut Li, Li verfasserin aut Enthalten in Discover oncology Springer US, 2021 15(2024), 1 vom: 04. Okt. Online-Ressource (DE-627)1753566347 (DE-600)3059869-2 2730-6011 nnns volume:15 year:2024 number:1 day:04 month:10 https://dx.doi.org/10.1007/s12672-024-01342-0 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2119 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 04 10
language	English
source	Enthalten in Discover oncology 15(2024), 1 vom: 04. Okt. volume:15 year:2024 number:1 day:04 month:10
sourceStr	Enthalten in Discover oncology 15(2024), 1 vom: 04. Okt. volume:15 year:2024 number:1 day:04 month:10
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institution	findex.gbv.de
topic_facet	Cutaneous squamous cell carcinoma Intratumoral injection Photodynamic therapy Immunotherapy
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container_title	Discover oncology
authorswithroles_txt_mv	Tian, Dan @@aut@@ Teng, Chong @@aut@@ Lv, Yanju @@aut@@ Duan, Xiaozhuo @@aut@@ Wang, Yi @@aut@@ Song, Xiaowei @@aut@@ Jiang, Qiuying @@aut@@ Huang, Dayong @@aut@@ Xin, Tao @@aut@@ Yang, Yu @@aut@@ Li, Li @@aut@@
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author	Tian, Dan
spellingShingle	Tian, Dan ddc 610 misc Cutaneous squamous cell carcinoma misc Intratumoral injection misc Photodynamic therapy misc Immunotherapy Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
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topic_title	610 VZ Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers Cutaneous squamous cell carcinoma (dpeaa)DE-He213 Intratumoral injection (dpeaa)DE-He213 Photodynamic therapy (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213
topic	ddc 610 misc Cutaneous squamous cell carcinoma misc Intratumoral injection misc Photodynamic therapy misc Immunotherapy
topic_unstemmed	ddc 610 misc Cutaneous squamous cell carcinoma misc Intratumoral injection misc Photodynamic therapy misc Immunotherapy
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title	Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
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title_full	Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
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author_browse	Tian, Dan Teng, Chong Lv, Yanju Duan, Xiaozhuo Wang, Yi Song, Xiaowei Jiang, Qiuying Huang, Dayong Xin, Tao Yang, Yu Li, Li
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title_sort	photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
title_auth	Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
abstract	Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. © The Author(s) 2024
abstractGer	Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. © The Author(s) 2024
abstract_unstemmed	Abstract Cutaneous squamous cell carcinoma (CSCC) is common among the elderly, typically treated with surgery. However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. HpD-PDT combined with immunotherapy is promising for treating CSCC, particularly with malignant ulcers. © The Author(s) 2024
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title_short	Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers
url	https://dx.doi.org/10.1007/s12672-024-01342-0
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author2	Teng, Chong Lv, Yanju Duan, Xiaozhuo Wang, Yi Song, Xiaowei Jiang, Qiuying Huang, Dayong Xin, Tao Yang, Yu Li, Li
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up_date	2024-10-05T07:44:23.676Z
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However, for surgery-ineligible patients or those with non-healing wounds progressing to malignant ulcers, non-surgical local treatments are viable. This case details an 80-year-old with recurrent back CSCC and intractable malignant ulcers post-radiotherapy and chemotherapy. Treatment involved Hematoporphyrin Derivative (HpD) Photodynamic Therapy (PDT) with low-dose cindilimab immunotherapy (intravenous and intralesional). Two cycles achieved lesion remission, altering peripheral immune cell counts. 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Photodynamic therapy with intratumoral injection of photosensitizers combined with immunotherapy brings hope to patients with refractory cutaneous malignant ulcers

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