[18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer
Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies...
Ausführliche Beschreibung
Autor*in: |
Backhaus, Philipp [verfasserIn] Pentlow, Keith S. [verfasserIn] Ho, Alan L [verfasserIn] Mauguen, Audrey [verfasserIn] Fagin, James A [verfasserIn] Pillarsetty, Naga Vara Kishore [verfasserIn] Lyashchenko, Serge K. [verfasserIn] Burnazi, Eva [verfasserIn] Ghossein, Ronald A. [verfasserIn] Chhabra, Shalini [verfasserIn] Abusamra, Murad [verfasserIn] Larson, Steven M. [verfasserIn] Schöder, Heiko [verfasserIn] O’Donoghue, Joseph [verfasserIn] Weber, Wolfgang [verfasserIn] Grewal, Ravinder K. [verfasserIn] |
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E-Artikel |
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Englisch |
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2024 |
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Anmerkung: |
© The Author(s) 2024 |
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Übergeordnetes Werk: |
Enthalten in: EJNMMI Research - Springer Berlin Heidelberg, 2011, 14(2024), 1 vom: 08. Okt. |
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Übergeordnetes Werk: |
volume:14 ; year:2024 ; number:1 ; day:08 ; month:10 |
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DOI / URN: |
10.1186/s13550-024-01138-x |
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Katalog-ID: |
SPR057717109 |
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245 | 1 | 0 | |a [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
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520 | |a Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. | ||
650 | 4 | |a Thyroid cancer |7 (dpeaa)DE-He213 | |
650 | 4 | |a PET/CT |7 (dpeaa)DE-He213 | |
650 | 4 | |a [ |7 (dpeaa)DE-He213 | |
650 | 4 | |a F]TFB |7 (dpeaa)DE-He213 | |
650 | 4 | |a [ |7 (dpeaa)DE-He213 | |
650 | 4 | |a I]iodine |7 (dpeaa)DE-He213 | |
650 | 4 | |a Redifferentiation |7 (dpeaa)DE-He213 | |
700 | 1 | |a Pentlow, Keith S. |e verfasserin |4 aut | |
700 | 1 | |a Ho, Alan L |e verfasserin |4 aut | |
700 | 1 | |a Mauguen, Audrey |e verfasserin |4 aut | |
700 | 1 | |a Fagin, James A |e verfasserin |4 aut | |
700 | 1 | |a Pillarsetty, Naga Vara Kishore |e verfasserin |4 aut | |
700 | 1 | |a Lyashchenko, Serge K. |e verfasserin |4 aut | |
700 | 1 | |a Burnazi, Eva |e verfasserin |4 aut | |
700 | 1 | |a Ghossein, Ronald A. |e verfasserin |4 aut | |
700 | 1 | |a Chhabra, Shalini |e verfasserin |4 aut | |
700 | 1 | |a Abusamra, Murad |e verfasserin |4 aut | |
700 | 1 | |a Larson, Steven M. |e verfasserin |4 aut | |
700 | 1 | |a Schöder, Heiko |e verfasserin |4 aut | |
700 | 1 | |a O’Donoghue, Joseph |e verfasserin |4 aut | |
700 | 1 | |a Weber, Wolfgang |e verfasserin |4 aut | |
700 | 1 | |a Grewal, Ravinder K. |e verfasserin |4 aut | |
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10.1186/s13550-024-01138-x doi (DE-627)SPR057717109 (SPR)s13550-024-01138-x-e DE-627 ger DE-627 rakwb eng 610 VZ Backhaus, Philipp verfasserin (orcid)0000-0003-4164-4104 aut [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 [ (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 [ (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 Pentlow, Keith S. verfasserin aut Ho, Alan L verfasserin aut Mauguen, Audrey verfasserin aut Fagin, James A verfasserin aut Pillarsetty, Naga Vara Kishore verfasserin aut Lyashchenko, Serge K. verfasserin aut Burnazi, Eva verfasserin aut Ghossein, Ronald A. verfasserin aut Chhabra, Shalini verfasserin aut Abusamra, Murad verfasserin aut Larson, Steven M. verfasserin aut Schöder, Heiko verfasserin aut O’Donoghue, Joseph verfasserin aut Weber, Wolfgang verfasserin aut Grewal, Ravinder K. verfasserin aut Enthalten in EJNMMI Research Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 08. Okt. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:14 year:2024 number:1 day:08 month:10 https://dx.doi.org/10.1186/s13550-024-01138-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 08 10 |
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10.1186/s13550-024-01138-x doi (DE-627)SPR057717109 (SPR)s13550-024-01138-x-e DE-627 ger DE-627 rakwb eng 610 VZ Backhaus, Philipp verfasserin (orcid)0000-0003-4164-4104 aut [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 [ (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 [ (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 Pentlow, Keith S. verfasserin aut Ho, Alan L verfasserin aut Mauguen, Audrey verfasserin aut Fagin, James A verfasserin aut Pillarsetty, Naga Vara Kishore verfasserin aut Lyashchenko, Serge K. verfasserin aut Burnazi, Eva verfasserin aut Ghossein, Ronald A. verfasserin aut Chhabra, Shalini verfasserin aut Abusamra, Murad verfasserin aut Larson, Steven M. verfasserin aut Schöder, Heiko verfasserin aut O’Donoghue, Joseph verfasserin aut Weber, Wolfgang verfasserin aut Grewal, Ravinder K. verfasserin aut Enthalten in EJNMMI Research Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 08. Okt. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:14 year:2024 number:1 day:08 month:10 https://dx.doi.org/10.1186/s13550-024-01138-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 08 10 |
allfields_unstemmed |
10.1186/s13550-024-01138-x doi (DE-627)SPR057717109 (SPR)s13550-024-01138-x-e DE-627 ger DE-627 rakwb eng 610 VZ Backhaus, Philipp verfasserin (orcid)0000-0003-4164-4104 aut [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 [ (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 [ (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 Pentlow, Keith S. verfasserin aut Ho, Alan L verfasserin aut Mauguen, Audrey verfasserin aut Fagin, James A verfasserin aut Pillarsetty, Naga Vara Kishore verfasserin aut Lyashchenko, Serge K. verfasserin aut Burnazi, Eva verfasserin aut Ghossein, Ronald A. verfasserin aut Chhabra, Shalini verfasserin aut Abusamra, Murad verfasserin aut Larson, Steven M. verfasserin aut Schöder, Heiko verfasserin aut O’Donoghue, Joseph verfasserin aut Weber, Wolfgang verfasserin aut Grewal, Ravinder K. verfasserin aut Enthalten in EJNMMI Research Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 08. Okt. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:14 year:2024 number:1 day:08 month:10 https://dx.doi.org/10.1186/s13550-024-01138-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 08 10 |
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10.1186/s13550-024-01138-x doi (DE-627)SPR057717109 (SPR)s13550-024-01138-x-e DE-627 ger DE-627 rakwb eng 610 VZ Backhaus, Philipp verfasserin (orcid)0000-0003-4164-4104 aut [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 [ (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 [ (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 Pentlow, Keith S. verfasserin aut Ho, Alan L verfasserin aut Mauguen, Audrey verfasserin aut Fagin, James A verfasserin aut Pillarsetty, Naga Vara Kishore verfasserin aut Lyashchenko, Serge K. verfasserin aut Burnazi, Eva verfasserin aut Ghossein, Ronald A. verfasserin aut Chhabra, Shalini verfasserin aut Abusamra, Murad verfasserin aut Larson, Steven M. verfasserin aut Schöder, Heiko verfasserin aut O’Donoghue, Joseph verfasserin aut Weber, Wolfgang verfasserin aut Grewal, Ravinder K. verfasserin aut Enthalten in EJNMMI Research Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 08. Okt. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:14 year:2024 number:1 day:08 month:10 https://dx.doi.org/10.1186/s13550-024-01138-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 08 10 |
allfieldsSound |
10.1186/s13550-024-01138-x doi (DE-627)SPR057717109 (SPR)s13550-024-01138-x-e DE-627 ger DE-627 rakwb eng 610 VZ Backhaus, Philipp verfasserin (orcid)0000-0003-4164-4104 aut [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 [ (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 [ (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 Pentlow, Keith S. verfasserin aut Ho, Alan L verfasserin aut Mauguen, Audrey verfasserin aut Fagin, James A verfasserin aut Pillarsetty, Naga Vara Kishore verfasserin aut Lyashchenko, Serge K. verfasserin aut Burnazi, Eva verfasserin aut Ghossein, Ronald A. verfasserin aut Chhabra, Shalini verfasserin aut Abusamra, Murad verfasserin aut Larson, Steven M. verfasserin aut Schöder, Heiko verfasserin aut O’Donoghue, Joseph verfasserin aut Weber, Wolfgang verfasserin aut Grewal, Ravinder K. verfasserin aut Enthalten in EJNMMI Research Springer Berlin Heidelberg, 2011 14(2024), 1 vom: 08. Okt. (DE-627)664970265 (DE-600)2619892-7 2191-219X nnns volume:14 year:2024 number:1 day:08 month:10 https://dx.doi.org/10.1186/s13550-024-01138-x X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 08 10 |
language |
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Enthalten in EJNMMI Research 14(2024), 1 vom: 08. Okt. volume:14 year:2024 number:1 day:08 month:10 |
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Enthalten in EJNMMI Research 14(2024), 1 vom: 08. Okt. volume:14 year:2024 number:1 day:08 month:10 |
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Thyroid cancer PET/CT [ F]TFB I]iodine Redifferentiation |
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Backhaus, Philipp @@aut@@ Pentlow, Keith S. @@aut@@ Ho, Alan L @@aut@@ Mauguen, Audrey @@aut@@ Fagin, James A @@aut@@ Pillarsetty, Naga Vara Kishore @@aut@@ Lyashchenko, Serge K. @@aut@@ Burnazi, Eva @@aut@@ Ghossein, Ronald A. @@aut@@ Chhabra, Shalini @@aut@@ Abusamra, Murad @@aut@@ Larson, Steven M. @@aut@@ Schöder, Heiko @@aut@@ O’Donoghue, Joseph @@aut@@ Weber, Wolfgang @@aut@@ Grewal, Ravinder K. @@aut@@ |
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2024-10-08T00:00:00Z |
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In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. 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Backhaus, Philipp ddc 610 misc Thyroid cancer misc PET/CT misc [ misc F]TFB misc I]iodine misc Redifferentiation [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
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610 VZ [18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer Thyroid cancer (dpeaa)DE-He213 PET/CT (dpeaa)DE-He213 (dpeaa)DE-He213 F]TFB (dpeaa)DE-He213 I]iodine (dpeaa)DE-He213 Redifferentiation (dpeaa)DE-He213 |
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[18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
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Backhaus, Philipp Pentlow, Keith S. Ho, Alan L Mauguen, Audrey Fagin, James A Pillarsetty, Naga Vara Kishore Lyashchenko, Serge K. Burnazi, Eva Ghossein, Ronald A. Chhabra, Shalini Abusamra, Murad Larson, Steven M. Schöder, Heiko O’Donoghue, Joseph Weber, Wolfgang Grewal, Ravinder K. |
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[18f]tfb pet/ct misses intense [124i]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
title_auth |
[18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
abstract |
Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. © The Author(s) 2024 |
abstractGer |
Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. © The Author(s) 2024 |
abstract_unstemmed |
Background Fluorine 18-labelled tetrafluoroborate ([18F]TFB) is a substrate for the sodium/iodide symporter. In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. Trial registration number NCT03196518, registered on June 22, 2017. © The Author(s) 2024 |
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[18F]TFB PET/CT misses intense [124I]iodine-avid metastases after redifferentiation therapy in metastatic thyroid cancer |
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Pentlow, Keith S. Ho, Alan L Mauguen, Audrey Fagin, James A Pillarsetty, Naga Vara Kishore Lyashchenko, Serge K. Burnazi, Eva Ghossein, Ronald A. Chhabra, Shalini Abusamra, Murad Larson, Steven M. Schöder, Heiko O’Donoghue, Joseph Weber, Wolfgang Grewal, Ravinder K. |
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Pentlow, Keith S. Ho, Alan L Mauguen, Audrey Fagin, James A Pillarsetty, Naga Vara Kishore Lyashchenko, Serge K. Burnazi, Eva Ghossein, Ronald A. Chhabra, Shalini Abusamra, Murad Larson, Steven M. Schöder, Heiko O’Donoghue, Joseph Weber, Wolfgang Grewal, Ravinder K. |
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In thyroid cancer, [18F]TFB-PET/CT may be an alternative to iodine imaging to evaluate the extent of disease, eligibility for radioiodine treatment, and success of redifferentiation therapies. We report the results of a pilot study to determine tumor uptake of [18F]TFB and compare its properties to [124I]IodinePET/CT in patients with metastatic thyroid cancer. Methods Five patients were included in a prospective study. All patients received PET/CT 1 h after injection of 356 ± 12 MBq [18F]TFB and were given 230 ± 9 MBq [124I]Iodine orally on the same day, followed by PET/CT after 48 h. Before redifferentiation therapy, patients underwent an additional baseline [124I]Iodine PET/CT. Cases were analyzed by two board-certified specialists. Detection rates and Spearman correlation for [18F]TFB and [124I]Iodine were calculated. Results Three patients had poorly differentiated thyroid cancer and received trametinib in a redifferentiation trial. Two patients had papillary thyroid cancer and did not receive redifferentiation therapy. Of the 33 lesions seen before/without redifferentiation therapy, 19 (58%) were visible on [18F]TFB and 30 (91%) on [124I]Iodine imaging. In the patients who underwent redifferentiation therapy, 48 lesions were newly seen on [124I]Iodine PET/CT with a median $ SUV_{max} $ of 3.3 (range, 0.4–285.0). All of these lesions were [18F]TFB-negative. Conclusion [18F]TFB failed to predict radioactive iodine uptake in patients with poorly differentiated thyroid cancer who underwent redifferentiation therapy with trametinib. It is unclear whether such discrepancies may also occur in other redifferentiation therapies or may even be encountered in redifferentiation-naïve thyroid cancer. 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