Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation

Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed...
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Autor*in:	Kong, Xin [verfasserIn] Xu, Ziyi [verfasserIn] Wu, Yanjun [verfasserIn] Tang, Xiaowen [verfasserIn] Xue, Shengli [verfasserIn] Miao, Miao [verfasserIn] Han, Yue [verfasserIn] Wang, Ying [verfasserIn] Chen, Suning [verfasserIn] Sun, Aining [verfasserIn] Qiu, Huiying [verfasserIn] Wu, Depei [verfasserIn] Zhao, Ye [verfasserIn] Chen, Feng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Hematopoietic stem cell transplantation Epstein-Barr virus Cytomegalovirus Letermovir Prophylaxis

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Journal of hematology & oncology - BioMed Central, 2008, 17(2024), 1 vom: 12. Okt.
Übergeordnetes Werk:	volume:17 ; year:2024 ; number:1 ; day:12 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s13045-024-01612-y

Katalog-ID:	SPR057764271

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245	1	0	\|a Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
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520			\|a Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT.
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allfields	10.1186/s13045-024-01612-y doi (DE-627)SPR057764271 (SPR)s13045-024-01612-y-e DE-627 ger DE-627 rakwb eng 610 VZ Kong, Xin verfasserin aut Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213 Xu, Ziyi verfasserin aut Wu, Yanjun verfasserin aut Tang, Xiaowen verfasserin aut Xue, Shengli verfasserin aut Miao, Miao verfasserin aut Han, Yue verfasserin aut Wang, Ying verfasserin aut Chen, Suning verfasserin aut Sun, Aining verfasserin aut Qiu, Huiying verfasserin aut Wu, Depei verfasserin aut Zhao, Ye verfasserin aut Chen, Feng verfasserin aut Enthalten in Journal of hematology & oncology BioMed Central, 2008 17(2024), 1 vom: 12. Okt. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:17 year:2024 number:1 day:12 month:10 https://dx.doi.org/10.1186/s13045-024-01612-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 12 10
spelling	10.1186/s13045-024-01612-y doi (DE-627)SPR057764271 (SPR)s13045-024-01612-y-e DE-627 ger DE-627 rakwb eng 610 VZ Kong, Xin verfasserin aut Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213 Xu, Ziyi verfasserin aut Wu, Yanjun verfasserin aut Tang, Xiaowen verfasserin aut Xue, Shengli verfasserin aut Miao, Miao verfasserin aut Han, Yue verfasserin aut Wang, Ying verfasserin aut Chen, Suning verfasserin aut Sun, Aining verfasserin aut Qiu, Huiying verfasserin aut Wu, Depei verfasserin aut Zhao, Ye verfasserin aut Chen, Feng verfasserin aut Enthalten in Journal of hematology & oncology BioMed Central, 2008 17(2024), 1 vom: 12. Okt. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:17 year:2024 number:1 day:12 month:10 https://dx.doi.org/10.1186/s13045-024-01612-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 12 10
allfields_unstemmed	10.1186/s13045-024-01612-y doi (DE-627)SPR057764271 (SPR)s13045-024-01612-y-e DE-627 ger DE-627 rakwb eng 610 VZ Kong, Xin verfasserin aut Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213 Xu, Ziyi verfasserin aut Wu, Yanjun verfasserin aut Tang, Xiaowen verfasserin aut Xue, Shengli verfasserin aut Miao, Miao verfasserin aut Han, Yue verfasserin aut Wang, Ying verfasserin aut Chen, Suning verfasserin aut Sun, Aining verfasserin aut Qiu, Huiying verfasserin aut Wu, Depei verfasserin aut Zhao, Ye verfasserin aut Chen, Feng verfasserin aut Enthalten in Journal of hematology & oncology BioMed Central, 2008 17(2024), 1 vom: 12. Okt. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:17 year:2024 number:1 day:12 month:10 https://dx.doi.org/10.1186/s13045-024-01612-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 12 10
allfieldsGer	10.1186/s13045-024-01612-y doi (DE-627)SPR057764271 (SPR)s13045-024-01612-y-e DE-627 ger DE-627 rakwb eng 610 VZ Kong, Xin verfasserin aut Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213 Xu, Ziyi verfasserin aut Wu, Yanjun verfasserin aut Tang, Xiaowen verfasserin aut Xue, Shengli verfasserin aut Miao, Miao verfasserin aut Han, Yue verfasserin aut Wang, Ying verfasserin aut Chen, Suning verfasserin aut Sun, Aining verfasserin aut Qiu, Huiying verfasserin aut Wu, Depei verfasserin aut Zhao, Ye verfasserin aut Chen, Feng verfasserin aut Enthalten in Journal of hematology & oncology BioMed Central, 2008 17(2024), 1 vom: 12. Okt. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:17 year:2024 number:1 day:12 month:10 https://dx.doi.org/10.1186/s13045-024-01612-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 12 10
allfieldsSound	10.1186/s13045-024-01612-y doi (DE-627)SPR057764271 (SPR)s13045-024-01612-y-e DE-627 ger DE-627 rakwb eng 610 VZ Kong, Xin verfasserin aut Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213 Xu, Ziyi verfasserin aut Wu, Yanjun verfasserin aut Tang, Xiaowen verfasserin aut Xue, Shengli verfasserin aut Miao, Miao verfasserin aut Han, Yue verfasserin aut Wang, Ying verfasserin aut Chen, Suning verfasserin aut Sun, Aining verfasserin aut Qiu, Huiying verfasserin aut Wu, Depei verfasserin aut Zhao, Ye verfasserin aut Chen, Feng verfasserin aut Enthalten in Journal of hematology & oncology BioMed Central, 2008 17(2024), 1 vom: 12. Okt. (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:17 year:2024 number:1 day:12 month:10 https://dx.doi.org/10.1186/s13045-024-01612-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 12 10
language	English
source	Enthalten in Journal of hematology & oncology 17(2024), 1 vom: 12. Okt. volume:17 year:2024 number:1 day:12 month:10
sourceStr	Enthalten in Journal of hematology & oncology 17(2024), 1 vom: 12. Okt. volume:17 year:2024 number:1 day:12 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hematopoietic stem cell transplantation Epstein-Barr virus Cytomegalovirus Letermovir Prophylaxis
dewey-raw	610
isfreeaccess_bool	true
container_title	Journal of hematology & oncology
authorswithroles_txt_mv	Kong, Xin @@aut@@ Xu, Ziyi @@aut@@ Wu, Yanjun @@aut@@ Tang, Xiaowen @@aut@@ Xue, Shengli @@aut@@ Miao, Miao @@aut@@ Han, Yue @@aut@@ Wang, Ying @@aut@@ Chen, Suning @@aut@@ Sun, Aining @@aut@@ Qiu, Huiying @@aut@@ Wu, Depei @@aut@@ Zhao, Ye @@aut@@ Chen, Feng @@aut@@
publishDateDaySort_date	2024-10-12T00:00:00Z
hierarchy_top_id	568914813
dewey-sort	3610
id	SPR057764271
language_de	englisch
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author	Kong, Xin
spellingShingle	Kong, Xin ddc 610 misc Hematopoietic stem cell transplantation misc Epstein-Barr virus misc Cytomegalovirus misc Letermovir misc Prophylaxis Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
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topic_title	610 VZ Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation Hematopoietic stem cell transplantation (dpeaa)DE-He213 Epstein-Barr virus (dpeaa)DE-He213 Cytomegalovirus (dpeaa)DE-He213 Letermovir (dpeaa)DE-He213 Prophylaxis (dpeaa)DE-He213
topic	ddc 610 misc Hematopoietic stem cell transplantation misc Epstein-Barr virus misc Cytomegalovirus misc Letermovir misc Prophylaxis
topic_unstemmed	ddc 610 misc Hematopoietic stem cell transplantation misc Epstein-Barr virus misc Cytomegalovirus misc Letermovir misc Prophylaxis
topic_browse	ddc 610 misc Hematopoietic stem cell transplantation misc Epstein-Barr virus misc Cytomegalovirus misc Letermovir misc Prophylaxis
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title	Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
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title_full	Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
author_sort	Kong, Xin
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author_browse	Kong, Xin Xu, Ziyi Wu, Yanjun Tang, Xiaowen Xue, Shengli Miao, Miao Han, Yue Wang, Ying Chen, Suning Sun, Aining Qiu, Huiying Wu, Depei Zhao, Ye Chen, Feng
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title_sort	increased epstein‒barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
title_auth	Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
abstract	Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. © The Author(s) 2024
abstractGer	Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. © The Author(s) 2024
abstract_unstemmed	Abstract Letermovir (LTV) prophylaxis is effective in reducing the incidence of clinically significant cytomegalovirus (CMV) infection (cs CMVi) after allogeneic haematopoietic stem cell transplantation (allo-HSCT). Since our centre began administering LTV prophylaxis in June 2022, we have observed a certain increase in the incidence of Epstein–Barr virus (EBV) reactivation after haploidentical HSCT. We retrospectively analysed 230 consecutive patients who underwent haploidentical HSCT with rabbit anti-thymocyte globulin (ATG) from October 2022 to June 2023. The LTV group included 133 patients who received LTV prophylaxis, and the control group included 97 patients who did not receive LTV prophylaxis. At 1 year after HSCT, EBV reactivation was observed in 36 patients (27%) in the LTV group and 13 patients (13%) in the control group (p = 0.012). All patients with EBV reactivation had EBV-DNAemia, and one patient in each group developed EBV-associated posttransplantation lymphoproliferative disorder (PTLD). The proportion of patients with low EBV-DNA loads (> 5 × $ 10^{2} $ to < 1 × $ 10^{4} $ copies/mL) was greater in the LTV group than in the control group (23% vs. 10%, p = 0.01). The proportion of patients with CMV reactivation was lower in the LTV group than in the control group (35% vs. 56%, p = 0.002). There was no significant difference between the groups in terms of neutrophil and platelet count recovery, the cumulative incidence of acute/chronic graft-versus-host disease, overall survival, cumulative relapse rate or nonrelapse mortality. Our results show that the increased incidence of EBV reactivation may be associated with LTV prophylaxis for CMV after haploidentical HSCT. © The Author(s) 2024
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container_issue	1
title_short	Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation
url	https://dx.doi.org/10.1186/s13045-024-01612-y
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author2	Xu, Ziyi Wu, Yanjun Tang, Xiaowen Xue, Shengli Miao, Miao Han, Yue Wang, Ying Chen, Suning Sun, Aining Qiu, Huiying Wu, Depei Zhao, Ye Chen, Feng
author2Str	Xu, Ziyi Wu, Yanjun Tang, Xiaowen Xue, Shengli Miao, Miao Han, Yue Wang, Ying Chen, Suning Sun, Aining Qiu, Huiying Wu, Depei Zhao, Ye Chen, Feng
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up_date	2024-10-13T04:47:46.141Z
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Increased Epstein‒Barr virus reactivation following prophylaxis for cytomegalovirus infection after haploidentical haematopoietic stem cell transplantation

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