A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers
Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two hum...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bischoff, James R. [verfasserIn] Anderson, Lee [verfasserIn] Zhu, Yingfang [verfasserIn] Mossie, Kevin [verfasserIn] Ng, Lelia [verfasserIn] Souza, Brian [verfasserIn] Schryver, Brian [verfasserIn] Flanagan, Peter [verfasserIn] Clairvoyant, Felix [verfasserIn] Ginther, Charles [verfasserIn] Chan, Clarence S.M. [verfasserIn] Novotny, Mike [verfasserIn] Slamon, Dennis J. [verfasserIn] Plowman, Gregory D. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 1998 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 17(1998), 11 vom: 01. Juni, Seite 3052-3065 |
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| Übergeordnetes Werk: |
volume:17 ; year:1998 ; number:11 ; day:01 ; month:06 ; pages:3052-3065 |
| Links: |
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| DOI / URN: |
10.1093/emboj/17.11.3052 |
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| Katalog-ID: |
SPR05780589X |
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| 100 | 1 | |a Bischoff, James R. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
| 264 | 1 | |c 1998 | |
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| 500 | |a © European Molecular Biology Organization 1998 | ||
| 520 | |a Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. | ||
| 650 | 4 | |a 20q13 amplicon |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a centrosome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a colon cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a oncogene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a serine‐threonine kinase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Anderson, Lee |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Yingfang |e verfasserin |4 aut | |
| 700 | 1 | |a Mossie, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Lelia |e verfasserin |4 aut | |
| 700 | 1 | |a Souza, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Schryver, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Flanagan, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Clairvoyant, Felix |e verfasserin |4 aut | |
| 700 | 1 | |a Ginther, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Clarence S.M. |e verfasserin |4 aut | |
| 700 | 1 | |a Novotny, Mike |e verfasserin |4 aut | |
| 700 | 1 | |a Slamon, Dennis J. |e verfasserin |4 aut | |
| 700 | 1 | |a Plowman, Gregory D. |e verfasserin |4 aut | |
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1998 |
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1998 |
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10.1093/emboj/17.11.3052 doi (DE-627)SPR05780589X (SPR)17.11.3052-e DE-627 ger DE-627 rakwb eng Bischoff, James R. verfasserin aut A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1998 Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 Anderson, Lee verfasserin aut Zhu, Yingfang verfasserin aut Mossie, Kevin verfasserin aut Ng, Lelia verfasserin aut Souza, Brian verfasserin aut Schryver, Brian verfasserin aut Flanagan, Peter verfasserin aut Clairvoyant, Felix verfasserin aut Ginther, Charles verfasserin aut Chan, Clarence S.M. verfasserin aut Novotny, Mike verfasserin aut Slamon, Dennis J. verfasserin aut Plowman, Gregory D. verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 17(1998), 11 vom: 01. Juni, Seite 3052-3065 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:17 year:1998 number:11 day:01 month:06 pages:3052-3065 https://dx.doi.org/10.1093/emboj/17.11.3052 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 1998 11 01 06 3052-3065 |
| spelling |
10.1093/emboj/17.11.3052 doi (DE-627)SPR05780589X (SPR)17.11.3052-e DE-627 ger DE-627 rakwb eng Bischoff, James R. verfasserin aut A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1998 Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 Anderson, Lee verfasserin aut Zhu, Yingfang verfasserin aut Mossie, Kevin verfasserin aut Ng, Lelia verfasserin aut Souza, Brian verfasserin aut Schryver, Brian verfasserin aut Flanagan, Peter verfasserin aut Clairvoyant, Felix verfasserin aut Ginther, Charles verfasserin aut Chan, Clarence S.M. verfasserin aut Novotny, Mike verfasserin aut Slamon, Dennis J. verfasserin aut Plowman, Gregory D. verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 17(1998), 11 vom: 01. Juni, Seite 3052-3065 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:17 year:1998 number:11 day:01 month:06 pages:3052-3065 https://dx.doi.org/10.1093/emboj/17.11.3052 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 1998 11 01 06 3052-3065 |
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10.1093/emboj/17.11.3052 doi (DE-627)SPR05780589X (SPR)17.11.3052-e DE-627 ger DE-627 rakwb eng Bischoff, James R. verfasserin aut A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1998 Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 Anderson, Lee verfasserin aut Zhu, Yingfang verfasserin aut Mossie, Kevin verfasserin aut Ng, Lelia verfasserin aut Souza, Brian verfasserin aut Schryver, Brian verfasserin aut Flanagan, Peter verfasserin aut Clairvoyant, Felix verfasserin aut Ginther, Charles verfasserin aut Chan, Clarence S.M. verfasserin aut Novotny, Mike verfasserin aut Slamon, Dennis J. verfasserin aut Plowman, Gregory D. verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 17(1998), 11 vom: 01. Juni, Seite 3052-3065 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:17 year:1998 number:11 day:01 month:06 pages:3052-3065 https://dx.doi.org/10.1093/emboj/17.11.3052 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 1998 11 01 06 3052-3065 |
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10.1093/emboj/17.11.3052 doi (DE-627)SPR05780589X (SPR)17.11.3052-e DE-627 ger DE-627 rakwb eng Bischoff, James R. verfasserin aut A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1998 Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 Anderson, Lee verfasserin aut Zhu, Yingfang verfasserin aut Mossie, Kevin verfasserin aut Ng, Lelia verfasserin aut Souza, Brian verfasserin aut Schryver, Brian verfasserin aut Flanagan, Peter verfasserin aut Clairvoyant, Felix verfasserin aut Ginther, Charles verfasserin aut Chan, Clarence S.M. verfasserin aut Novotny, Mike verfasserin aut Slamon, Dennis J. verfasserin aut Plowman, Gregory D. verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 17(1998), 11 vom: 01. Juni, Seite 3052-3065 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:17 year:1998 number:11 day:01 month:06 pages:3052-3065 https://dx.doi.org/10.1093/emboj/17.11.3052 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 1998 11 01 06 3052-3065 |
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10.1093/emboj/17.11.3052 doi (DE-627)SPR05780589X (SPR)17.11.3052-e DE-627 ger DE-627 rakwb eng Bischoff, James R. verfasserin aut A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1998 Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 Anderson, Lee verfasserin aut Zhu, Yingfang verfasserin aut Mossie, Kevin verfasserin aut Ng, Lelia verfasserin aut Souza, Brian verfasserin aut Schryver, Brian verfasserin aut Flanagan, Peter verfasserin aut Clairvoyant, Felix verfasserin aut Ginther, Charles verfasserin aut Chan, Clarence S.M. verfasserin aut Novotny, Mike verfasserin aut Slamon, Dennis J. verfasserin aut Plowman, Gregory D. verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 17(1998), 11 vom: 01. Juni, Seite 3052-3065 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:17 year:1998 number:11 day:01 month:06 pages:3052-3065 https://dx.doi.org/10.1093/emboj/17.11.3052 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 17 1998 11 01 06 3052-3065 |
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Bischoff, James R. @@aut@@ Anderson, Lee @@aut@@ Zhu, Yingfang @@aut@@ Mossie, Kevin @@aut@@ Ng, Lelia @@aut@@ Souza, Brian @@aut@@ Schryver, Brian @@aut@@ Flanagan, Peter @@aut@@ Clairvoyant, Felix @@aut@@ Ginther, Charles @@aut@@ Chan, Clarence S.M. @@aut@@ Novotny, Mike @@aut@@ Slamon, Dennis J. @@aut@@ Plowman, Gregory D. @@aut@@ |
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|
| author |
Bischoff, James R. |
| spellingShingle |
Bischoff, James R. misc 20q13 amplicon misc centrosome misc colon cancer misc oncogene misc serine‐threonine kinase A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
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1460-2075 |
| topic_title |
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers 20q13 amplicon (dpeaa)DE-He213 centrosome (dpeaa)DE-He213 colon cancer (dpeaa)DE-He213 oncogene (dpeaa)DE-He213 serine‐threonine kinase (dpeaa)DE-He213 |
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misc 20q13 amplicon misc centrosome misc colon cancer misc oncogene misc serine‐threonine kinase |
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misc 20q13 amplicon misc centrosome misc colon cancer misc oncogene misc serine‐threonine kinase |
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misc 20q13 amplicon misc centrosome misc colon cancer misc oncogene misc serine‐threonine kinase |
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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
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| title_full |
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
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Bischoff, James R. |
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Bischoff, James R. Anderson, Lee Zhu, Yingfang Mossie, Kevin Ng, Lelia Souza, Brian Schryver, Brian Flanagan, Peter Clairvoyant, Felix Ginther, Charles Chan, Clarence S.M. Novotny, Mike Slamon, Dennis J. Plowman, Gregory D. |
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17 |
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Elektronische Aufsätze |
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Bischoff, James R. |
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10.1093/emboj/17.11.3052 |
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verfasserin |
| title_sort |
a homologue of drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
| title_auth |
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
| abstract |
Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. © European Molecular Biology Organization 1998 |
| abstractGer |
Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. © European Molecular Biology Organization 1998 |
| abstract_unstemmed |
Abstract Genetic and biochemical studies in lower eukaryotes have identified several proteins that ensure accurate segregation of chromosomes. These include the Drosophila aurora and yeast Ipl1 kinases that are required for centrosome maturation and chromosome segregation. We have identified two human homologues of these genes, termed aurora1 and aurora2, that encode cell‐cycle‐regulated serine/threonine kinases. Here we demonstrate that the aurora2 gene maps to chromosome 20q13, a region amplified in a variety of human cancers, including a significant number of colorectal malignancies. We propose that aurora2 may be a target of this amplicon since its DNA is amplified and its RNA overexpressed, in more than 50% of primary colorectal cancers. Furthermore, overexpression of aurora2 transforms rodent fibroblasts. These observations implicate aurora2 as a potential oncogene in many colon, breast and other solid tumors, and identify centrosome‐associated proteins as novel targets for cancer therapy. © European Molecular Biology Organization 1998 |
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| title_short |
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers |
| url |
https://dx.doi.org/10.1093/emboj/17.11.3052 |
| remote_bool |
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| author2 |
Anderson, Lee Zhu, Yingfang Mossie, Kevin Ng, Lelia Souza, Brian Schryver, Brian Flanagan, Peter Clairvoyant, Felix Ginther, Charles Chan, Clarence S.M. Novotny, Mike Slamon, Dennis J. Plowman, Gregory D. |
| author2Str |
Anderson, Lee Zhu, Yingfang Mossie, Kevin Ng, Lelia Souza, Brian Schryver, Brian Flanagan, Peter Clairvoyant, Felix Ginther, Charles Chan, Clarence S.M. Novotny, Mike Slamon, Dennis J. Plowman, Gregory D. |
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| doi_str |
10.1093/emboj/17.11.3052 |
| up_date |
2024-10-16T04:51:00.031Z |
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| score |
7.40149 |