Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae

Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involve...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Coïc, Eric [verfasserIn] Gluck, Laurence [verfasserIn] Fabre, Francis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2000

Schlagwörter:	gene conversion mismatch repair short‐patch mismatch repair

Anmerkung:	© European Molecular Biology Organization 2000

Übergeordnetes Werk:	Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 19(2000), 13 vom: 03. Juli, Seite 3408-3417
Übergeordnetes Werk:	volume:19 ; year:2000 ; number:13 ; day:03 ; month:07 ; pages:3408-3417

Links:	Volltext

DOI / URN:	10.1093/emboj/19.13.3408

Katalog-ID:	SPR057830142

Internformat


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245	1	0	\|a Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
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520			\|a Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe.
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912			\|a GBV_ILN_224
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912			\|a GBV_ILN_252
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912			\|a GBV_ILN_285
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2153
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912			\|a GBV_ILN_4035
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4046
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matchkey_str	article:14602075:2000----::vdneosotacmsacrpiischr
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publishDate	2000
allfields	10.1093/emboj/19.13.3408 doi (DE-627)SPR057830142 (SPR)19.13.3408-e DE-627 ger DE-627 rakwb eng Coïc, Eric verfasserin aut Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2000 Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213 Gluck, Laurence verfasserin aut Fabre, Francis verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 19(2000), 13 vom: 03. Juli, Seite 3408-3417 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417 https://dx.doi.org/10.1093/emboj/19.13.3408 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2000 13 03 07 3408-3417
spelling	10.1093/emboj/19.13.3408 doi (DE-627)SPR057830142 (SPR)19.13.3408-e DE-627 ger DE-627 rakwb eng Coïc, Eric verfasserin aut Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2000 Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213 Gluck, Laurence verfasserin aut Fabre, Francis verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 19(2000), 13 vom: 03. Juli, Seite 3408-3417 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417 https://dx.doi.org/10.1093/emboj/19.13.3408 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2000 13 03 07 3408-3417
allfields_unstemmed	10.1093/emboj/19.13.3408 doi (DE-627)SPR057830142 (SPR)19.13.3408-e DE-627 ger DE-627 rakwb eng Coïc, Eric verfasserin aut Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2000 Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213 Gluck, Laurence verfasserin aut Fabre, Francis verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 19(2000), 13 vom: 03. Juli, Seite 3408-3417 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417 https://dx.doi.org/10.1093/emboj/19.13.3408 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2000 13 03 07 3408-3417
allfieldsGer	10.1093/emboj/19.13.3408 doi (DE-627)SPR057830142 (SPR)19.13.3408-e DE-627 ger DE-627 rakwb eng Coïc, Eric verfasserin aut Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2000 Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213 Gluck, Laurence verfasserin aut Fabre, Francis verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 19(2000), 13 vom: 03. Juli, Seite 3408-3417 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417 https://dx.doi.org/10.1093/emboj/19.13.3408 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2000 13 03 07 3408-3417
allfieldsSound	10.1093/emboj/19.13.3408 doi (DE-627)SPR057830142 (SPR)19.13.3408-e DE-627 ger DE-627 rakwb eng Coïc, Eric verfasserin aut Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae 2000 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2000 Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213 Gluck, Laurence verfasserin aut Fabre, Francis verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 19(2000), 13 vom: 03. Juli, Seite 3408-3417 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417 https://dx.doi.org/10.1093/emboj/19.13.3408 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2000 13 03 07 3408-3417
language	English
source	Enthalten in The EMBO Journal 19(2000), 13 vom: 03. Juli, Seite 3408-3417 volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417
sourceStr	Enthalten in The EMBO Journal 19(2000), 13 vom: 03. Juli, Seite 3408-3417 volume:19 year:2000 number:13 day:03 month:07 pages:3408-3417
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	gene conversion mismatch repair short‐patch mismatch repair
isfreeaccess_bool	false
container_title	The EMBO Journal
authorswithroles_txt_mv	Coïc, Eric @@aut@@ Gluck, Laurence @@aut@@ Fabre, Francis @@aut@@
publishDateDaySort_date	2000-07-03T00:00:00Z
hierarchy_top_id	266022529
id	SPR057830142
language_de	englisch
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author	Coïc, Eric
spellingShingle	Coïc, Eric misc gene conversion misc mismatch repair misc short‐patch mismatch repair Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
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topic_title	Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae gene conversion (dpeaa)DE-He213 mismatch repair (dpeaa)DE-He213 short‐patch mismatch repair (dpeaa)DE-He213
topic	misc gene conversion misc mismatch repair misc short‐patch mismatch repair
topic_unstemmed	misc gene conversion misc mismatch repair misc short‐patch mismatch repair
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title	Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
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title_full	Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
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title_sort	evidence for short‐patch mismatch repair in saccharomyces cerevisiae
title_auth	Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
abstract	Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. © European Molecular Biology Organization 2000
abstractGer	Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. © European Molecular Biology Organization 2000
abstract_unstemmed	Abstract Recombination events between non‐identical sequences most often involve heteroduplex DNA intermediates that are subjected to mismatch repair. The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. We show that this activity does not depend on genes required for nucleotide excision repair and thus differs from the short‐patch mismatch repair described in Schizosaccharomyces pombe. © European Molecular Biology Organization 2000
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title_short	Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae
url	https://dx.doi.org/10.1093/emboj/19.13.3408
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up_date	2024-10-17T04:51:14.484Z
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The well‐characterized long‐patch mismatch repair process, controlled in eukaryotes by bacterial MutS and MutL orthologs, is the major system involved in repair of mispaired bases. Here we present evidence for an alternative short‐patch mismatch repair pathway that operates on a broad spectrum of mismatches. In msh2 mutants lacking the long‐patch repair system, sequence analysis of recombination tracts resulting from exchanges between similar but non‐identical (homeologous) parental DNAs showed the occurrence of short‐patch repair events that can involve <12 nucleotides. Such events were detected both in mitotic and in meiotic recombinants. Confirming the existence of a distinct short‐patch repair activity, we found in a recombination assay involving homologous alleles that closely spaced mismatches are repaired independently with high efficiency in cells lacking MSH2 or PMS1. 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Evidence for short‐patch mismatch repair in Saccharomyces cerevisiae

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