c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells
Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kawasaki, Hiroki [verfasserIn] Komai, Koichiro [verfasserIn] Ouyang, Zhufeng [verfasserIn] Murata, Miki [verfasserIn] Hikasa, Mari [verfasserIn] Ohgiri, Mami [verfasserIn] Shiozawa, Shunichi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2001 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 2001 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 20(2001), 16 vom: 15. Aug., Seite 4618-4627 |
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| Übergeordnetes Werk: |
volume:20 ; year:2001 ; number:16 ; day:15 ; month:08 ; pages:4618-4627 |
| Links: |
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| DOI / URN: |
10.1093/emboj/20.16.4618 |
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| Katalog-ID: |
SPR057853487 |
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| 100 | 1 | |a Kawasaki, Hiroki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
| 264 | 1 | |c 2001 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a © European Molecular Biology Organization 2001 | ||
| 520 | |a Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. | ||
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| 650 | 4 | |a c‐Fos |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a G |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a S phase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a mitotic cell division |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a wee1 kinase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Komai, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ouyang, Zhufeng |e verfasserin |4 aut | |
| 700 | 1 | |a Murata, Miki |e verfasserin |4 aut | |
| 700 | 1 | |a Hikasa, Mari |e verfasserin |4 aut | |
| 700 | 1 | |a Ohgiri, Mami |e verfasserin |4 aut | |
| 700 | 1 | |a Shiozawa, Shunichi |e verfasserin |4 aut | |
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| 952 | |d 20 |j 2001 |e 16 |b 15 |c 08 |h 4618-4627 | ||
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2001 |
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2001 |
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10.1093/emboj/20.16.4618 doi (DE-627)SPR057853487 (SPR)20.16.4618-e DE-627 ger DE-627 rakwb eng Kawasaki, Hiroki verfasserin aut c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 Komai, Koichiro verfasserin aut Ouyang, Zhufeng verfasserin aut Murata, Miki verfasserin aut Hikasa, Mari verfasserin aut Ohgiri, Mami verfasserin aut Shiozawa, Shunichi verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 16 vom: 15. Aug., Seite 4618-4627 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 https://dx.doi.org/10.1093/emboj/20.16.4618 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2001 16 15 08 4618-4627 |
| spelling |
10.1093/emboj/20.16.4618 doi (DE-627)SPR057853487 (SPR)20.16.4618-e DE-627 ger DE-627 rakwb eng Kawasaki, Hiroki verfasserin aut c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 Komai, Koichiro verfasserin aut Ouyang, Zhufeng verfasserin aut Murata, Miki verfasserin aut Hikasa, Mari verfasserin aut Ohgiri, Mami verfasserin aut Shiozawa, Shunichi verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 16 vom: 15. Aug., Seite 4618-4627 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 https://dx.doi.org/10.1093/emboj/20.16.4618 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2001 16 15 08 4618-4627 |
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10.1093/emboj/20.16.4618 doi (DE-627)SPR057853487 (SPR)20.16.4618-e DE-627 ger DE-627 rakwb eng Kawasaki, Hiroki verfasserin aut c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 Komai, Koichiro verfasserin aut Ouyang, Zhufeng verfasserin aut Murata, Miki verfasserin aut Hikasa, Mari verfasserin aut Ohgiri, Mami verfasserin aut Shiozawa, Shunichi verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 16 vom: 15. Aug., Seite 4618-4627 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 https://dx.doi.org/10.1093/emboj/20.16.4618 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2001 16 15 08 4618-4627 |
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10.1093/emboj/20.16.4618 doi (DE-627)SPR057853487 (SPR)20.16.4618-e DE-627 ger DE-627 rakwb eng Kawasaki, Hiroki verfasserin aut c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 Komai, Koichiro verfasserin aut Ouyang, Zhufeng verfasserin aut Murata, Miki verfasserin aut Hikasa, Mari verfasserin aut Ohgiri, Mami verfasserin aut Shiozawa, Shunichi verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 16 vom: 15. Aug., Seite 4618-4627 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 https://dx.doi.org/10.1093/emboj/20.16.4618 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2001 16 15 08 4618-4627 |
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10.1093/emboj/20.16.4618 doi (DE-627)SPR057853487 (SPR)20.16.4618-e DE-627 ger DE-627 rakwb eng Kawasaki, Hiroki verfasserin aut c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 Komai, Koichiro verfasserin aut Ouyang, Zhufeng verfasserin aut Murata, Miki verfasserin aut Hikasa, Mari verfasserin aut Ohgiri, Mami verfasserin aut Shiozawa, Shunichi verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 16 vom: 15. Aug., Seite 4618-4627 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 https://dx.doi.org/10.1093/emboj/20.16.4618 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 20 2001 16 15 08 4618-4627 |
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Enthalten in The EMBO Journal 20(2001), 16 vom: 15. Aug., Seite 4618-4627 volume:20 year:2001 number:16 day:15 month:08 pages:4618-4627 |
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Kawasaki, Hiroki @@aut@@ Komai, Koichiro @@aut@@ Ouyang, Zhufeng @@aut@@ Murata, Miki @@aut@@ Hikasa, Mari @@aut@@ Ohgiri, Mami @@aut@@ Shiozawa, Shunichi @@aut@@ |
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We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. 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Kawasaki, Hiroki |
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Kawasaki, Hiroki misc activator protein‐1 misc c‐Fos misc G misc S phase misc mitotic cell division misc wee1 kinase c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
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c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells activator protein‐1 (dpeaa)DE-He213 c‐Fos (dpeaa)DE-He213 G (dpeaa)DE-He213 S phase (dpeaa)DE-He213 mitotic cell division (dpeaa)DE-He213 wee1 kinase (dpeaa)DE-He213 |
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c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
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c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
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Kawasaki, Hiroki Komai, Koichiro Ouyang, Zhufeng Murata, Miki Hikasa, Mari Ohgiri, Mami Shiozawa, Shunichi |
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c‐fos/activator protein‐1 transactivates wee1 kinase at $ g_{1} $/s to inhibit premature mitosis in antigen‐specific th1 cells |
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c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
| abstract |
Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. © European Molecular Biology Organization 2001 |
| abstractGer |
Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. © European Molecular Biology Organization 2001 |
| abstract_unstemmed |
Abstract M‐phase promoting factor is a complex of cdc2 and cyclin B that is regulated positively by cdc25 phosphatase and negatively by wee1 kinase. We isolated the wee1 gene promoter and found that it contains one AP‐1 binding motif and is directly activated by the immediate early gene product c‐Fos at cellular $ G_{1} $/S phase. In antigen‐specific Th1 cells stimulated by antigen, transactivation of the c‐fos and wee1 kinase genes occurred sequentially at $ G_{1} $/S, and the substrate of wee1 kinase, cdc2‐Tyr15, was subsequently phosphorylated at late $ G_{1} $/S. Under prolonged expression of the c‐fos gene, however, the amount of wee1 kinase was increased and its target cdc2 molecule was constitutively phosphorylated on its tyrosine residue, where Th1 cells went into aberrant mitosis. Thus, an immediate early gene product, c‐Fos/AP‐1, directly transactivates the wee1 kinase gene at $ G_{1} $/S. The transient increase in c‐fos and wee1 kinase genes is likely to be responsible for preventing premature mitosis while the cells remain in the $ G_{1} $/S phase of the cell cycle. © European Molecular Biology Organization 2001 |
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16 |
| title_short |
c‐Fos/activator protein‐1 transactivates wee1 kinase at $ G_{1} $/S to inhibit premature mitosis in antigen‐specific Th1 cells |
| url |
https://dx.doi.org/10.1093/emboj/20.16.4618 |
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| author2 |
Komai, Koichiro Ouyang, Zhufeng Murata, Miki Hikasa, Mari Ohgiri, Mami Shiozawa, Shunichi |
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Komai, Koichiro Ouyang, Zhufeng Murata, Miki Hikasa, Mari Ohgiri, Mami Shiozawa, Shunichi |
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| doi_str |
10.1093/emboj/20.16.4618 |
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2024-10-18T04:52:35.890Z |
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|
| score |
7.40075 |