Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes
Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activ...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ikeda, Fumiyo [verfasserIn] Hecker, Christina Maria [verfasserIn] Rozenknop, Alexis [verfasserIn] Nordmeier, Rolf Dietrich [verfasserIn] Rogov, Vladimir [verfasserIn] Hofmann, Kay [verfasserIn] Akira, Shizuo [verfasserIn] Dötsch, Volker [verfasserIn] Dikic, Ivan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 2007 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 26(2007), 14 vom: 28. Juni, Seite 3451-3462 |
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| Übergeordnetes Werk: |
volume:26 ; year:2007 ; number:14 ; day:28 ; month:06 ; pages:3451-3462 |
| Links: |
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| DOI / URN: |
10.1038/sj.emboj.7601773 |
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| Katalog-ID: |
SPR057856869 |
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| 024 | 7 | |a 10.1038/sj.emboj.7601773 |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Ikeda, Fumiyo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
| 264 | 1 | |c 2007 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a © European Molecular Biology Organization 2007 | ||
| 520 | |a Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. | ||
| 650 | 4 | |a innate immunity signal |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a interferon‐inducible gene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TANK‐binding kinase 1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ubiquitin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ubiquitin‐like domain |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hecker, Christina Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Rozenknop, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Nordmeier, Rolf Dietrich |e verfasserin |4 aut | |
| 700 | 1 | |a Rogov, Vladimir |e verfasserin |4 aut | |
| 700 | 1 | |a Hofmann, Kay |e verfasserin |4 aut | |
| 700 | 1 | |a Akira, Shizuo |e verfasserin |4 aut | |
| 700 | 1 | |a Dötsch, Volker |e verfasserin |4 aut | |
| 700 | 1 | |a Dikic, Ivan |e verfasserin |4 aut | |
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| 912 | |a GBV_ILN_2050 | ||
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| 912 | |a GBV_ILN_2056 | ||
| 912 | |a GBV_ILN_2057 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
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| 952 | |d 26 |j 2007 |e 14 |b 28 |c 06 |h 3451-3462 | ||
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10.1038/sj.emboj.7601773 doi (DE-627)SPR057856869 (SPR)sj.emboj.7601773-e DE-627 ger DE-627 rakwb eng Ikeda, Fumiyo verfasserin aut Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 Hecker, Christina Maria verfasserin aut Rozenknop, Alexis verfasserin aut Nordmeier, Rolf Dietrich verfasserin aut Rogov, Vladimir verfasserin aut Hofmann, Kay verfasserin aut Akira, Shizuo verfasserin aut Dötsch, Volker verfasserin aut Dikic, Ivan verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 14 vom: 28. Juni, Seite 3451-3462 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 https://dx.doi.org/10.1038/sj.emboj.7601773 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 14 28 06 3451-3462 |
| spelling |
10.1038/sj.emboj.7601773 doi (DE-627)SPR057856869 (SPR)sj.emboj.7601773-e DE-627 ger DE-627 rakwb eng Ikeda, Fumiyo verfasserin aut Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 Hecker, Christina Maria verfasserin aut Rozenknop, Alexis verfasserin aut Nordmeier, Rolf Dietrich verfasserin aut Rogov, Vladimir verfasserin aut Hofmann, Kay verfasserin aut Akira, Shizuo verfasserin aut Dötsch, Volker verfasserin aut Dikic, Ivan verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 14 vom: 28. Juni, Seite 3451-3462 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 https://dx.doi.org/10.1038/sj.emboj.7601773 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 14 28 06 3451-3462 |
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10.1038/sj.emboj.7601773 doi (DE-627)SPR057856869 (SPR)sj.emboj.7601773-e DE-627 ger DE-627 rakwb eng Ikeda, Fumiyo verfasserin aut Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 Hecker, Christina Maria verfasserin aut Rozenknop, Alexis verfasserin aut Nordmeier, Rolf Dietrich verfasserin aut Rogov, Vladimir verfasserin aut Hofmann, Kay verfasserin aut Akira, Shizuo verfasserin aut Dötsch, Volker verfasserin aut Dikic, Ivan verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 14 vom: 28. Juni, Seite 3451-3462 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 https://dx.doi.org/10.1038/sj.emboj.7601773 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 14 28 06 3451-3462 |
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10.1038/sj.emboj.7601773 doi (DE-627)SPR057856869 (SPR)sj.emboj.7601773-e DE-627 ger DE-627 rakwb eng Ikeda, Fumiyo verfasserin aut Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 Hecker, Christina Maria verfasserin aut Rozenknop, Alexis verfasserin aut Nordmeier, Rolf Dietrich verfasserin aut Rogov, Vladimir verfasserin aut Hofmann, Kay verfasserin aut Akira, Shizuo verfasserin aut Dötsch, Volker verfasserin aut Dikic, Ivan verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 14 vom: 28. Juni, Seite 3451-3462 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 https://dx.doi.org/10.1038/sj.emboj.7601773 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 14 28 06 3451-3462 |
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10.1038/sj.emboj.7601773 doi (DE-627)SPR057856869 (SPR)sj.emboj.7601773-e DE-627 ger DE-627 rakwb eng Ikeda, Fumiyo verfasserin aut Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 Hecker, Christina Maria verfasserin aut Rozenknop, Alexis verfasserin aut Nordmeier, Rolf Dietrich verfasserin aut Rogov, Vladimir verfasserin aut Hofmann, Kay verfasserin aut Akira, Shizuo verfasserin aut Dötsch, Volker verfasserin aut Dikic, Ivan verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 14 vom: 28. Juni, Seite 3451-3462 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 https://dx.doi.org/10.1038/sj.emboj.7601773 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 14 28 06 3451-3462 |
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Enthalten in The EMBO Journal 26(2007), 14 vom: 28. Juni, Seite 3451-3462 volume:26 year:2007 number:14 day:28 month:06 pages:3451-3462 |
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Ikeda, Fumiyo @@aut@@ Hecker, Christina Maria @@aut@@ Rozenknop, Alexis @@aut@@ Nordmeier, Rolf Dietrich @@aut@@ Rogov, Vladimir @@aut@@ Hofmann, Kay @@aut@@ Akira, Shizuo @@aut@@ Dötsch, Volker @@aut@@ Dikic, Ivan @@aut@@ |
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Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. 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|
| author |
Ikeda, Fumiyo |
| spellingShingle |
Ikeda, Fumiyo misc innate immunity signal misc interferon‐inducible gene misc TANK‐binding kinase 1 misc ubiquitin misc ubiquitin‐like domain Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
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Ikeda, Fumiyo |
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Not Illustrated |
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1460-2075 |
| topic_title |
Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes innate immunity signal (dpeaa)DE-He213 interferon‐inducible gene (dpeaa)DE-He213 TANK‐binding kinase 1 (dpeaa)DE-He213 ubiquitin (dpeaa)DE-He213 ubiquitin‐like domain (dpeaa)DE-He213 |
| topic |
misc innate immunity signal misc interferon‐inducible gene misc TANK‐binding kinase 1 misc ubiquitin misc ubiquitin‐like domain |
| topic_unstemmed |
misc innate immunity signal misc interferon‐inducible gene misc TANK‐binding kinase 1 misc ubiquitin misc ubiquitin‐like domain |
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misc innate immunity signal misc interferon‐inducible gene misc TANK‐binding kinase 1 misc ubiquitin misc ubiquitin‐like domain |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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| title |
Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
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(DE-627)SPR057856869 (SPR)sj.emboj.7601773-e |
| title_full |
Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
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Ikeda, Fumiyo |
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The EMBO Journal |
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Ikeda, Fumiyo Hecker, Christina Maria Rozenknop, Alexis Nordmeier, Rolf Dietrich Rogov, Vladimir Hofmann, Kay Akira, Shizuo Dötsch, Volker Dikic, Ivan |
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26 |
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Elektronische Aufsätze |
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Ikeda, Fumiyo |
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10.1038/sj.emboj.7601773 |
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verfasserin |
| title_sort |
involvement of the ubiquitin‐like domain of tbk1/ikk‐i kinases in regulation of ifn‐inducible genes |
| title_auth |
Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
| abstract |
Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. © European Molecular Biology Organization 2007 |
| abstractGer |
Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. © European Molecular Biology Organization 2007 |
| abstract_unstemmed |
Abstract TANK‐binding kinase 1 (TBK1/NAK/T2K) and I‐κB Kinase (IKK‐i/IKK‐ε) play important roles in the regulation of interferon (IFN)‐inducible genes during the immune response to bacterial and viral infections. Cell stimulation with ssRNA virus, dsDNA virus or gram‐negative bacteria leads to activation of TBK1 or IKK‐i, which in turn phosphorylates the transcription factors, IFN‐regulatory factor (IRF) 3 and IRF7, promoting their translocation in the nucleus. To understand the molecular basis of activation of TBK1, we analyzed the sequence of TBK1 and IKK‐i and identified a ubiquitin‐like domain (ULD) adjacent to their kinase domains. Deletion or mutations of the ULD in TBK1 or IKK‐i impaired activation of respective kinases, failed to induce IRF3 phosphorylation and nuclear localization and to activate IFN‐β or RANTES promoters. The importance of the ULD of TBK1 in LPS‐ or poly(I:C)‐stimulated IFN‐β production was demonstrated by reconstitution experiments in TBK1‐IKK‐i‐deficient cells. We propose that the ULD is a regulatory component of the TBK1/IKK‐i kinases involved in the control of the kinase activation, substrate presentation and downstream signaling pathways. © European Molecular Biology Organization 2007 |
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| title_short |
Involvement of the ubiquitin‐like domain of TBK1/IKK‐i kinases in regulation of IFN‐inducible genes |
| url |
https://dx.doi.org/10.1038/sj.emboj.7601773 |
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| author2 |
Hecker, Christina Maria Rozenknop, Alexis Nordmeier, Rolf Dietrich Rogov, Vladimir Hofmann, Kay Akira, Shizuo Dötsch, Volker Dikic, Ivan |
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Hecker, Christina Maria Rozenknop, Alexis Nordmeier, Rolf Dietrich Rogov, Vladimir Hofmann, Kay Akira, Shizuo Dötsch, Volker Dikic, Ivan |
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|
| score |
7.401078 |