Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation
Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Proepper, Christian [verfasserIn] Johannsen, Svenja [verfasserIn] Liebau, Stefan [verfasserIn] Dahl, Janine [verfasserIn] Vaida, Bianca [verfasserIn] Bockmann, Juergen [verfasserIn] Kreutz, Michael R [verfasserIn] Gundelfinger, Eckart D [verfasserIn] Boeckers, Tobias M [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2007 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 2007 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 26(2007), 5 vom: 15. Feb., Seite 1397-1409 |
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| Übergeordnetes Werk: |
volume:26 ; year:2007 ; number:5 ; day:15 ; month:02 ; pages:1397-1409 |
| Links: |
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| DOI / URN: |
10.1038/sj.emboj.7601569 |
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| Katalog-ID: |
SPR057858284 |
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| 100 | 1 | |a Proepper, Christian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
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| 520 | |a Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. | ||
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| 650 | 4 | |a Shank3 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a synapse |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Johannsen, Svenja |e verfasserin |4 aut | |
| 700 | 1 | |a Liebau, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Dahl, Janine |e verfasserin |4 aut | |
| 700 | 1 | |a Vaida, Bianca |e verfasserin |4 aut | |
| 700 | 1 | |a Bockmann, Juergen |e verfasserin |4 aut | |
| 700 | 1 | |a Kreutz, Michael R |e verfasserin |4 aut | |
| 700 | 1 | |a Gundelfinger, Eckart D |e verfasserin |4 aut | |
| 700 | 1 | |a Boeckers, Tobias M |e verfasserin |4 aut | |
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10.1038/sj.emboj.7601569 doi (DE-627)SPR057858284 (SPR)sj.emboj.7601569-e DE-627 ger DE-627 rakwb eng Proepper, Christian verfasserin aut Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 Johannsen, Svenja verfasserin aut Liebau, Stefan verfasserin aut Dahl, Janine verfasserin aut Vaida, Bianca verfasserin aut Bockmann, Juergen verfasserin aut Kreutz, Michael R verfasserin aut Gundelfinger, Eckart D verfasserin aut Boeckers, Tobias M verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 5 vom: 15. Feb., Seite 1397-1409 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 https://dx.doi.org/10.1038/sj.emboj.7601569 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 5 15 02 1397-1409 |
| spelling |
10.1038/sj.emboj.7601569 doi (DE-627)SPR057858284 (SPR)sj.emboj.7601569-e DE-627 ger DE-627 rakwb eng Proepper, Christian verfasserin aut Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 Johannsen, Svenja verfasserin aut Liebau, Stefan verfasserin aut Dahl, Janine verfasserin aut Vaida, Bianca verfasserin aut Bockmann, Juergen verfasserin aut Kreutz, Michael R verfasserin aut Gundelfinger, Eckart D verfasserin aut Boeckers, Tobias M verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 5 vom: 15. Feb., Seite 1397-1409 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 https://dx.doi.org/10.1038/sj.emboj.7601569 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 5 15 02 1397-1409 |
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10.1038/sj.emboj.7601569 doi (DE-627)SPR057858284 (SPR)sj.emboj.7601569-e DE-627 ger DE-627 rakwb eng Proepper, Christian verfasserin aut Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 Johannsen, Svenja verfasserin aut Liebau, Stefan verfasserin aut Dahl, Janine verfasserin aut Vaida, Bianca verfasserin aut Bockmann, Juergen verfasserin aut Kreutz, Michael R verfasserin aut Gundelfinger, Eckart D verfasserin aut Boeckers, Tobias M verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 5 vom: 15. Feb., Seite 1397-1409 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 https://dx.doi.org/10.1038/sj.emboj.7601569 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 5 15 02 1397-1409 |
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10.1038/sj.emboj.7601569 doi (DE-627)SPR057858284 (SPR)sj.emboj.7601569-e DE-627 ger DE-627 rakwb eng Proepper, Christian verfasserin aut Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 Johannsen, Svenja verfasserin aut Liebau, Stefan verfasserin aut Dahl, Janine verfasserin aut Vaida, Bianca verfasserin aut Bockmann, Juergen verfasserin aut Kreutz, Michael R verfasserin aut Gundelfinger, Eckart D verfasserin aut Boeckers, Tobias M verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 5 vom: 15. Feb., Seite 1397-1409 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 https://dx.doi.org/10.1038/sj.emboj.7601569 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 5 15 02 1397-1409 |
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10.1038/sj.emboj.7601569 doi (DE-627)SPR057858284 (SPR)sj.emboj.7601569-e DE-627 ger DE-627 rakwb eng Proepper, Christian verfasserin aut Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2007 Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 Johannsen, Svenja verfasserin aut Liebau, Stefan verfasserin aut Dahl, Janine verfasserin aut Vaida, Bianca verfasserin aut Bockmann, Juergen verfasserin aut Kreutz, Michael R verfasserin aut Gundelfinger, Eckart D verfasserin aut Boeckers, Tobias M verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 26(2007), 5 vom: 15. Feb., Seite 1397-1409 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 https://dx.doi.org/10.1038/sj.emboj.7601569 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 26 2007 5 15 02 1397-1409 |
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Enthalten in The EMBO Journal 26(2007), 5 vom: 15. Feb., Seite 1397-1409 volume:26 year:2007 number:5 day:15 month:02 pages:1397-1409 |
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Proepper, Christian @@aut@@ Johannsen, Svenja @@aut@@ Liebau, Stefan @@aut@@ Dahl, Janine @@aut@@ Vaida, Bianca @@aut@@ Bockmann, Juergen @@aut@@ Kreutz, Michael R @@aut@@ Gundelfinger, Eckart D @@aut@@ Boeckers, Tobias M @@aut@@ |
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We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. 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Proepper, Christian |
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Proepper, Christian misc actin misc ProSAP2 misc PSD misc Shank3 misc synapse Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation actin (dpeaa)DE-He213 ProSAP2 (dpeaa)DE-He213 PSD (dpeaa)DE-He213 Shank3 (dpeaa)DE-He213 synapse (dpeaa)DE-He213 |
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misc actin misc ProSAP2 misc PSD misc Shank3 misc synapse |
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misc actin misc ProSAP2 misc PSD misc Shank3 misc synapse |
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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
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Proepper, Christian Johannsen, Svenja Liebau, Stefan Dahl, Janine Vaida, Bianca Bockmann, Juergen Kreutz, Michael R Gundelfinger, Eckart D Boeckers, Tobias M |
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abelson interacting protein 1 (abi‐1) is essential for dendrite morphogenesis and synapse formation |
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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
| abstract |
Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. © European Molecular Biology Organization 2007 |
| abstractGer |
Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. © European Molecular Biology Organization 2007 |
| abstract_unstemmed |
Abstract Synaptogenesis and synaptic plasticity depend crucially on the dynamic and locally specific regulation of the actin cytoskeleton. We identified an important component for controlled actin assembly, abelson interacting protein‐1 (Abi‐1), as a binding partner for the postsynaptic density (PSD) protein ProSAP2/Shank3. During early neuronal development, Abi‐1 is localized in neurites and growth cones; at later stages, the protein is enriched in dendritic spines and PSDs, as are components of a trimeric complex consisting of Abi‐1, Eps8 and Sos‐1. Abi‐1 translocates upon NMDA application from PSDs to nuclei. Nuclear entry depends on abelson kinase activity. Abi‐1 co‐immunoprecipitates with the transcription factor complex of Myc/Max proteins and enhances E‐box‐regulated gene transcription. Downregulation of Abi‐1 by small interfering RNA results in excessive dendrite branching, immature spine and synapse morphology and a reduction of synapses, whereas overexpression of Abi‐1 has the opposite effect. Data show that Abi‐1 can act as a specific synapto‐nuclear messenger and is essentially involved in dendrite and synapse formation. © European Molecular Biology Organization 2007 |
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Abelson interacting protein 1 (Abi‐1) is essential for dendrite morphogenesis and synapse formation |
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https://dx.doi.org/10.1038/sj.emboj.7601569 |
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Johannsen, Svenja Liebau, Stefan Dahl, Janine Vaida, Bianca Bockmann, Juergen Kreutz, Michael R Gundelfinger, Eckart D Boeckers, Tobias M |
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Johannsen, Svenja Liebau, Stefan Dahl, Janine Vaida, Bianca Bockmann, Juergen Kreutz, Michael R Gundelfinger, Eckart D Boeckers, Tobias M |
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| score |
7.4005365 |