Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development
Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We h...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gauthier, Karine [verfasserIn] Chassande, Olivier [verfasserIn] Plateroti, Michela [verfasserIn] Roux, Jean‐Paul [verfasserIn] Legrand, Claude [verfasserIn] Pain, Bertrand [verfasserIn] Rousset, Bernard [verfasserIn] Weiss, Roy [verfasserIn] Trouillas, Jacqueline [verfasserIn] Samarut, Jacques [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1999 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 1999 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 18(1999), 3 vom: 01. Feb., Seite 623-631 |
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| Übergeordnetes Werk: |
volume:18 ; year:1999 ; number:3 ; day:01 ; month:02 ; pages:623-631 |
| Links: |
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| DOI / URN: |
10.1093/emboj/18.3.623 |
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SPR057894655 |
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| 100 | 1 | |a Gauthier, Karine |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
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| 520 | |a Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. | ||
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| 700 | 1 | |a Chassande, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Plateroti, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Roux, Jean‐Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Legrand, Claude |e verfasserin |4 aut | |
| 700 | 1 | |a Pain, Bertrand |e verfasserin |4 aut | |
| 700 | 1 | |a Rousset, Bernard |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Roy |e verfasserin |4 aut | |
| 700 | 1 | |a Trouillas, Jacqueline |e verfasserin |4 aut | |
| 700 | 1 | |a Samarut, Jacques |e verfasserin |4 aut | |
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1999 |
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1999 |
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10.1093/emboj/18.3.623 doi (DE-627)SPR057894655 (SPR)18.3.623-e DE-627 ger DE-627 rakwb eng Gauthier, Karine verfasserin aut Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development 1999 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1999 Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 Chassande, Olivier verfasserin aut Plateroti, Michela verfasserin aut Roux, Jean‐Paul verfasserin aut Legrand, Claude verfasserin aut Pain, Bertrand verfasserin aut Rousset, Bernard verfasserin aut Weiss, Roy verfasserin aut Trouillas, Jacqueline verfasserin aut Samarut, Jacques verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 18(1999), 3 vom: 01. Feb., Seite 623-631 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:18 year:1999 number:3 day:01 month:02 pages:623-631 https://dx.doi.org/10.1093/emboj/18.3.623 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 1999 3 01 02 623-631 |
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10.1093/emboj/18.3.623 doi (DE-627)SPR057894655 (SPR)18.3.623-e DE-627 ger DE-627 rakwb eng Gauthier, Karine verfasserin aut Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development 1999 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1999 Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 Chassande, Olivier verfasserin aut Plateroti, Michela verfasserin aut Roux, Jean‐Paul verfasserin aut Legrand, Claude verfasserin aut Pain, Bertrand verfasserin aut Rousset, Bernard verfasserin aut Weiss, Roy verfasserin aut Trouillas, Jacqueline verfasserin aut Samarut, Jacques verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 18(1999), 3 vom: 01. Feb., Seite 623-631 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:18 year:1999 number:3 day:01 month:02 pages:623-631 https://dx.doi.org/10.1093/emboj/18.3.623 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 1999 3 01 02 623-631 |
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10.1093/emboj/18.3.623 doi (DE-627)SPR057894655 (SPR)18.3.623-e DE-627 ger DE-627 rakwb eng Gauthier, Karine verfasserin aut Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development 1999 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1999 Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 Chassande, Olivier verfasserin aut Plateroti, Michela verfasserin aut Roux, Jean‐Paul verfasserin aut Legrand, Claude verfasserin aut Pain, Bertrand verfasserin aut Rousset, Bernard verfasserin aut Weiss, Roy verfasserin aut Trouillas, Jacqueline verfasserin aut Samarut, Jacques verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 18(1999), 3 vom: 01. Feb., Seite 623-631 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:18 year:1999 number:3 day:01 month:02 pages:623-631 https://dx.doi.org/10.1093/emboj/18.3.623 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 1999 3 01 02 623-631 |
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10.1093/emboj/18.3.623 doi (DE-627)SPR057894655 (SPR)18.3.623-e DE-627 ger DE-627 rakwb eng Gauthier, Karine verfasserin aut Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development 1999 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1999 Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 Chassande, Olivier verfasserin aut Plateroti, Michela verfasserin aut Roux, Jean‐Paul verfasserin aut Legrand, Claude verfasserin aut Pain, Bertrand verfasserin aut Rousset, Bernard verfasserin aut Weiss, Roy verfasserin aut Trouillas, Jacqueline verfasserin aut Samarut, Jacques verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 18(1999), 3 vom: 01. Feb., Seite 623-631 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:18 year:1999 number:3 day:01 month:02 pages:623-631 https://dx.doi.org/10.1093/emboj/18.3.623 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 1999 3 01 02 623-631 |
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10.1093/emboj/18.3.623 doi (DE-627)SPR057894655 (SPR)18.3.623-e DE-627 ger DE-627 rakwb eng Gauthier, Karine verfasserin aut Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development 1999 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 1999 Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 Chassande, Olivier verfasserin aut Plateroti, Michela verfasserin aut Roux, Jean‐Paul verfasserin aut Legrand, Claude verfasserin aut Pain, Bertrand verfasserin aut Rousset, Bernard verfasserin aut Weiss, Roy verfasserin aut Trouillas, Jacqueline verfasserin aut Samarut, Jacques verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 18(1999), 3 vom: 01. Feb., Seite 623-631 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:18 year:1999 number:3 day:01 month:02 pages:623-631 https://dx.doi.org/10.1093/emboj/18.3.623 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 18 1999 3 01 02 623-631 |
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English |
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Enthalten in The EMBO Journal 18(1999), 3 vom: 01. Feb., Seite 623-631 volume:18 year:1999 number:3 day:01 month:02 pages:623-631 |
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Enthalten in The EMBO Journal 18(1999), 3 vom: 01. Feb., Seite 623-631 volume:18 year:1999 number:3 day:01 month:02 pages:623-631 |
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bone intestine knockout thyroid hormone receptor TSH |
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Gauthier, Karine @@aut@@ Chassande, Olivier @@aut@@ Plateroti, Michela @@aut@@ Roux, Jean‐Paul @@aut@@ Legrand, Claude @@aut@@ Pain, Bertrand @@aut@@ Rousset, Bernard @@aut@@ Weiss, Roy @@aut@@ Trouillas, Jacqueline @@aut@@ Samarut, Jacques @@aut@@ |
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The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. 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|
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Gauthier, Karine |
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Gauthier, Karine misc bone misc intestine misc knockout misc thyroid hormone receptor misc TSH Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
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Gauthier, Karine |
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1460-2075 |
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Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development bone (dpeaa)DE-He213 intestine (dpeaa)DE-He213 knockout (dpeaa)DE-He213 thyroid hormone receptor (dpeaa)DE-He213 TSH (dpeaa)DE-He213 |
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misc bone misc intestine misc knockout misc thyroid hormone receptor misc TSH |
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misc bone misc intestine misc knockout misc thyroid hormone receptor misc TSH |
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Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
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Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
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Gauthier, Karine |
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1999 |
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Gauthier, Karine Chassande, Olivier Plateroti, Michela Roux, Jean‐Paul Legrand, Claude Pain, Bertrand Rousset, Bernard Weiss, Roy Trouillas, Jacqueline Samarut, Jacques |
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Gauthier, Karine |
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10.1093/emboj/18.3.623 |
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verfasserin |
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different functions for the thyroid hormone receptors trα and trβ in the control of thyroid hormone production and post‐natal development |
| title_auth |
Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
| abstract |
Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. © European Molecular Biology Organization 1999 |
| abstractGer |
Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. © European Molecular Biology Organization 1999 |
| abstract_unstemmed |
Abstract The biological activities of thyroid hormones are thought to be mediated by receptors generated by the TRα and TRβ loci. The existence of several receptor isoforms suggests that different functions are mediated by specific isoforms and raises the possibility of functional redundancies. We have inactivated both TRα and TRβ genes by homologous recombination in the mouse and compared the phenotypes of wild‐type, and single and double mutant mice. We show by this method that the TRβ receptors are the most potent regulators of the production of thyroid stimulating hormone (TSH). However, in the absence of TRβ, the products of the TRα gene can fulfill this function as, in the absence of any receptors, TSH and thyroid hormone concentrations reach very high levels. We also show that TRβ, in contrast to TRα, is dispensable for the normal development of bone and intestine. In bone, the disruption of both TRα and TRβ genes does not modify the maturation delay observed in TRα−/− mice. In the ileum, the absence of any receptor results in a much more severe impairment than that observed in TRα−/− animals. We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions. © European Molecular Biology Organization 1999 |
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Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post‐natal development |
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https://dx.doi.org/10.1093/emboj/18.3.623 |
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Chassande, Olivier Plateroti, Michela Roux, Jean‐Paul Legrand, Claude Pain, Bertrand Rousset, Bernard Weiss, Roy Trouillas, Jacqueline Samarut, Jacques |
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Chassande, Olivier Plateroti, Michela Roux, Jean‐Paul Legrand, Claude Pain, Bertrand Rousset, Bernard Weiss, Roy Trouillas, Jacqueline Samarut, Jacques |
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10.1093/emboj/18.3.623 |
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| score |
7.4013395 |