Identification of neuromedin S and its possible role in the mammalian circadian oscillator system
Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TG...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mori, Kenji [verfasserIn] Miyazato, Mikiya [verfasserIn] Ida, Takanori [verfasserIn] Murakami, Noboru [verfasserIn] Serino, Ryota [verfasserIn] Ueta, Yoichi [verfasserIn] Kojima, Masayasu [verfasserIn] Kangawa, Kenji [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2005 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 2005 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 24(2005), 2 vom: 06. Jan., Seite 325-335 |
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| Übergeordnetes Werk: |
volume:24 ; year:2005 ; number:2 ; day:06 ; month:01 ; pages:325-335 |
| Links: |
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| DOI / URN: |
10.1038/sj.emboj.7600526 |
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| Katalog-ID: |
SPR057950652 |
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| 100 | 1 | |a Mori, Kenji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Identification of neuromedin S and its possible role in the mammalian circadian oscillator system |
| 264 | 1 | |c 2005 | |
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| 500 | |a © European Molecular Biology Organization 2005 | ||
| 520 | |a Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. | ||
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| 650 | 4 | |a endogenous ligand |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a neuropeptide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a orphan G protein‐coupled receptor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a suprachiasmatic nucleus |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Miyazato, Mikiya |e verfasserin |4 aut | |
| 700 | 1 | |a Ida, Takanori |e verfasserin |4 aut | |
| 700 | 1 | |a Murakami, Noboru |e verfasserin |4 aut | |
| 700 | 1 | |a Serino, Ryota |e verfasserin |4 aut | |
| 700 | 1 | |a Ueta, Yoichi |e verfasserin |4 aut | |
| 700 | 1 | |a Kojima, Masayasu |e verfasserin |4 aut | |
| 700 | 1 | |a Kangawa, Kenji |e verfasserin |4 aut | |
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10.1038/sj.emboj.7600526 doi (DE-627)SPR057950652 (SPR)sj.emboj.7600526-e DE-627 ger DE-627 rakwb eng Mori, Kenji verfasserin aut Identification of neuromedin S and its possible role in the mammalian circadian oscillator system 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2005 Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 Miyazato, Mikiya verfasserin aut Ida, Takanori verfasserin aut Murakami, Noboru verfasserin aut Serino, Ryota verfasserin aut Ueta, Yoichi verfasserin aut Kojima, Masayasu verfasserin aut Kangawa, Kenji verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 24(2005), 2 vom: 06. Jan., Seite 325-335 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:24 year:2005 number:2 day:06 month:01 pages:325-335 https://dx.doi.org/10.1038/sj.emboj.7600526 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 24 2005 2 06 01 325-335 |
| spelling |
10.1038/sj.emboj.7600526 doi (DE-627)SPR057950652 (SPR)sj.emboj.7600526-e DE-627 ger DE-627 rakwb eng Mori, Kenji verfasserin aut Identification of neuromedin S and its possible role in the mammalian circadian oscillator system 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2005 Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 Miyazato, Mikiya verfasserin aut Ida, Takanori verfasserin aut Murakami, Noboru verfasserin aut Serino, Ryota verfasserin aut Ueta, Yoichi verfasserin aut Kojima, Masayasu verfasserin aut Kangawa, Kenji verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 24(2005), 2 vom: 06. Jan., Seite 325-335 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:24 year:2005 number:2 day:06 month:01 pages:325-335 https://dx.doi.org/10.1038/sj.emboj.7600526 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 24 2005 2 06 01 325-335 |
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10.1038/sj.emboj.7600526 doi (DE-627)SPR057950652 (SPR)sj.emboj.7600526-e DE-627 ger DE-627 rakwb eng Mori, Kenji verfasserin aut Identification of neuromedin S and its possible role in the mammalian circadian oscillator system 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2005 Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 Miyazato, Mikiya verfasserin aut Ida, Takanori verfasserin aut Murakami, Noboru verfasserin aut Serino, Ryota verfasserin aut Ueta, Yoichi verfasserin aut Kojima, Masayasu verfasserin aut Kangawa, Kenji verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 24(2005), 2 vom: 06. Jan., Seite 325-335 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:24 year:2005 number:2 day:06 month:01 pages:325-335 https://dx.doi.org/10.1038/sj.emboj.7600526 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 24 2005 2 06 01 325-335 |
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10.1038/sj.emboj.7600526 doi (DE-627)SPR057950652 (SPR)sj.emboj.7600526-e DE-627 ger DE-627 rakwb eng Mori, Kenji verfasserin aut Identification of neuromedin S and its possible role in the mammalian circadian oscillator system 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2005 Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 Miyazato, Mikiya verfasserin aut Ida, Takanori verfasserin aut Murakami, Noboru verfasserin aut Serino, Ryota verfasserin aut Ueta, Yoichi verfasserin aut Kojima, Masayasu verfasserin aut Kangawa, Kenji verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 24(2005), 2 vom: 06. Jan., Seite 325-335 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:24 year:2005 number:2 day:06 month:01 pages:325-335 https://dx.doi.org/10.1038/sj.emboj.7600526 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 24 2005 2 06 01 325-335 |
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10.1038/sj.emboj.7600526 doi (DE-627)SPR057950652 (SPR)sj.emboj.7600526-e DE-627 ger DE-627 rakwb eng Mori, Kenji verfasserin aut Identification of neuromedin S and its possible role in the mammalian circadian oscillator system 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2005 Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 Miyazato, Mikiya verfasserin aut Ida, Takanori verfasserin aut Murakami, Noboru verfasserin aut Serino, Ryota verfasserin aut Ueta, Yoichi verfasserin aut Kojima, Masayasu verfasserin aut Kangawa, Kenji verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 24(2005), 2 vom: 06. Jan., Seite 325-335 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:24 year:2005 number:2 day:06 month:01 pages:325-335 https://dx.doi.org/10.1038/sj.emboj.7600526 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 24 2005 2 06 01 325-335 |
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Enthalten in The EMBO Journal 24(2005), 2 vom: 06. Jan., Seite 325-335 volume:24 year:2005 number:2 day:06 month:01 pages:325-335 |
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Enthalten in The EMBO Journal 24(2005), 2 vom: 06. Jan., Seite 325-335 volume:24 year:2005 number:2 day:06 month:01 pages:325-335 |
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Mori, Kenji @@aut@@ Miyazato, Mikiya @@aut@@ Ida, Takanori @@aut@@ Murakami, Noboru @@aut@@ Serino, Ryota @@aut@@ Ueta, Yoichi @@aut@@ Kojima, Masayasu @@aut@@ Kangawa, Kenji @@aut@@ |
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Mori, Kenji |
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Mori, Kenji misc circadian rhythm misc endogenous ligand misc neuropeptide misc orphan G protein‐coupled receptor misc suprachiasmatic nucleus Identification of neuromedin S and its possible role in the mammalian circadian oscillator system |
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Identification of neuromedin S and its possible role in the mammalian circadian oscillator system circadian rhythm (dpeaa)DE-He213 endogenous ligand (dpeaa)DE-He213 neuropeptide (dpeaa)DE-He213 orphan G protein‐coupled receptor (dpeaa)DE-He213 suprachiasmatic nucleus (dpeaa)DE-He213 |
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misc circadian rhythm misc endogenous ligand misc neuropeptide misc orphan G protein‐coupled receptor misc suprachiasmatic nucleus |
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Identification of neuromedin S and its possible role in the mammalian circadian oscillator system |
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Mori, Kenji Miyazato, Mikiya Ida, Takanori Murakami, Noboru Serino, Ryota Ueta, Yoichi Kojima, Masayasu Kangawa, Kenji |
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identification of neuromedin s and its possible role in the mammalian circadian oscillator system |
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Identification of neuromedin S and its possible role in the mammalian circadian oscillator system |
| abstract |
Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. © European Molecular Biology Organization 2005 |
| abstractGer |
Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. © European Molecular Biology Organization 2005 |
| abstract_unstemmed |
Abstract The discovery of neuropeptides has resulted in an increased understanding of novel regulatory mechanisms of certain physiological phenomena. Here we identify a novel neuropeptide of 36 amino‐acid residues in rat brain as an endogenous ligand for the orphan G protein‐coupled receptor FM‐4/TGR‐1, which was identified to date as the neuromedin U (NMU) receptor, and designate this peptide ‘neuromedin S (NMS)’ because it is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS shares a C‐terminal core structure with NMU. The NMS precursor contains another novel peptide. NMS mRNA is highly expressed in the central nervous system, spleen and testis. In rat brain, NMS expression is restricted to the core of the SCN and has a diurnal peak under light/dark cycling, but remains stable under constant darkness. Intracerebroventricular administration of NMS in rats activates SCN neurons and induces nonphotic type phase shifts in the circadian rhythm of locomotor activity. These findings suggest that NMS in the SCN is implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions. © European Molecular Biology Organization 2005 |
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| title_short |
Identification of neuromedin S and its possible role in the mammalian circadian oscillator system |
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https://dx.doi.org/10.1038/sj.emboj.7600526 |
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| author2 |
Miyazato, Mikiya Ida, Takanori Murakami, Noboru Serino, Ryota Ueta, Yoichi Kojima, Masayasu Kangawa, Kenji |
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Miyazato, Mikiya Ida, Takanori Murakami, Noboru Serino, Ryota Ueta, Yoichi Kojima, Masayasu Kangawa, Kenji |
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10.1038/sj.emboj.7600526 |
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| score |
7.400302 |