The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans

Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 tra...
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Gespeichert in:

Autor*in:	Wang, Shanping [verfasserIn] Kimble, Judith [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2001

Schlagwörter:	sex determination TRA‐1 TRA‐2

Anmerkung:	© European Molecular Biology Organization 2001

Übergeordnetes Werk:	Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 20(2001), 6 vom: 15. März, Seite 1363-1372
Übergeordnetes Werk:	volume:20 ; year:2001 ; number:6 ; day:15 ; month:03 ; pages:1363-1372

Links:	Volltext

DOI / URN:	10.1093/emboj/20.6.1363

Katalog-ID:	SPR058006397

Internformat


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520			\|a Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination.
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publishDate	2001
allfields	10.1093/emboj/20.6.1363 doi (DE-627)SPR058006397 (SPR)20.6.1363-e DE-627 ger DE-627 rakwb eng Wang, Shanping verfasserin aut The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213 Kimble, Judith verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 6 vom: 15. März, Seite 1363-1372 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372 https://dx.doi.org/10.1093/emboj/20.6.1363 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 20 2001 6 15 03 1363-1372
spelling	10.1093/emboj/20.6.1363 doi (DE-627)SPR058006397 (SPR)20.6.1363-e DE-627 ger DE-627 rakwb eng Wang, Shanping verfasserin aut The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213 Kimble, Judith verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 6 vom: 15. März, Seite 1363-1372 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372 https://dx.doi.org/10.1093/emboj/20.6.1363 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 20 2001 6 15 03 1363-1372
allfields_unstemmed	10.1093/emboj/20.6.1363 doi (DE-627)SPR058006397 (SPR)20.6.1363-e DE-627 ger DE-627 rakwb eng Wang, Shanping verfasserin aut The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213 Kimble, Judith verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 6 vom: 15. März, Seite 1363-1372 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372 https://dx.doi.org/10.1093/emboj/20.6.1363 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 20 2001 6 15 03 1363-1372
allfieldsGer	10.1093/emboj/20.6.1363 doi (DE-627)SPR058006397 (SPR)20.6.1363-e DE-627 ger DE-627 rakwb eng Wang, Shanping verfasserin aut The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213 Kimble, Judith verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 6 vom: 15. März, Seite 1363-1372 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372 https://dx.doi.org/10.1093/emboj/20.6.1363 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 20 2001 6 15 03 1363-1372
allfieldsSound	10.1093/emboj/20.6.1363 doi (DE-627)SPR058006397 (SPR)20.6.1363-e DE-627 ger DE-627 rakwb eng Wang, Shanping verfasserin aut The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2001 Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213 Kimble, Judith verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 20(2001), 6 vom: 15. März, Seite 1363-1372 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372 https://dx.doi.org/10.1093/emboj/20.6.1363 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 20 2001 6 15 03 1363-1372
language	English
source	Enthalten in The EMBO Journal 20(2001), 6 vom: 15. März, Seite 1363-1372 volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372
sourceStr	Enthalten in The EMBO Journal 20(2001), 6 vom: 15. März, Seite 1363-1372 volume:20 year:2001 number:6 day:15 month:03 pages:1363-1372
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	sex determination TRA‐1 TRA‐2
isfreeaccess_bool	false
container_title	The EMBO Journal
authorswithroles_txt_mv	Wang, Shanping @@aut@@ Kimble, Judith @@aut@@
publishDateDaySort_date	2001-03-15T00:00:00Z
hierarchy_top_id	266022529
id	SPR058006397
language_de	englisch
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author	Wang, Shanping
spellingShingle	Wang, Shanping misc sex determination misc TRA‐1 misc TRA‐2 The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans
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topic_title	The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans sex determination (dpeaa)DE-He213 TRA‐1 (dpeaa)DE-He213 TRA‐2 (dpeaa)DE-He213
topic	misc sex determination misc TRA‐1 misc TRA‐2
topic_unstemmed	misc sex determination misc TRA‐1 misc TRA‐2
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title	The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans
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title_full	The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans
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doi_str_mv	10.1093/emboj/20.6.1363
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title_sort	the tra‐1 transcription factor binds tra‐2 to regulate sexual fates in caenorhabditis elegans
title_auth	The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans
abstract	Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. © European Molecular Biology Organization 2001
abstractGer	Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. © European Molecular Biology Organization 2001
abstract_unstemmed	Abstract The tra‐1 and tra‐2 sex‐determining genes promote female fates in Caenorhabditis elegans. Classical genetic studies placed tra‐1 as the terminal regulator of the pathway with tra‐2 acting upstream as a regulator of regulators of tra‐1. Here we report the surprising result that the TRA‐1 transcription factor binds the intracellular domain of the TRA‐2 membrane protein. This binding is dependent on the MX regulatory domain, a region of the TRA‐2 intracellular domain shown previously to be critical for the onset of hermaphrodite spermatogenesis. The functional importance of the TRA‐1–TRA‐2 physical interaction is supported by genetic interactions between tra‐1(0) and tra‐2(mx) mutations: a reduction of tra‐1 gene dose from two copies to one copy enhances the tra‐2(mx) feminization phenotype, but has no apparent somatic effect. In Caenorhabditis briggsae, we also find an MX‐dependent interaction between Cb‐TRA‐1 and Cb‐TRA‐2, but intriguingly, no cross‐species interactions are seen. The conservation of the TRA‐1–TRA‐2 interaction underscores its importance in sex determination. © European Molecular Biology Organization 2001
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title_short	The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans
url	https://dx.doi.org/10.1093/emboj/20.6.1363
remote_bool	true
author2	Kimble, Judith
author2Str	Kimble, Judith
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doi_str	10.1093/emboj/20.6.1363
up_date	2024-10-24T04:56:14.515Z
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The TRA‐1 transcription factor binds TRA‐2 to regulate sexual fates in Caenorhabditis elegans

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