Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation
Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
He, Jun [verfasserIn] Xu, Qing [verfasserIn] Jing, Yi [verfasserIn] Agani, Faton [verfasserIn] Qian, Xu [verfasserIn] Carpenter, Richard [verfasserIn] Li, Qi [verfasserIn] Wang, Xin‐Ru [verfasserIn] Peiper, Stephen S [verfasserIn] Lu, Zhimin [verfasserIn] Liu, Ling‐Zhi [verfasserIn] Jiang, Bing‐Hua [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© European Molecular Biology Organization 2012 |
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| Übergeordnetes Werk: |
Enthalten in: EMBO Reports - Nature Publishing Group UK, 2023, 13(2012), 12 vom: 13. Nov., Seite 1116-1122 |
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| Übergeordnetes Werk: |
volume:13 ; year:2012 ; number:12 ; day:13 ; month:11 ; pages:1116-1122 |
| Links: |
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| DOI / URN: |
10.1038/embor.2012.162 |
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| Katalog-ID: |
SPR058022511 |
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| 245 | 1 | 0 | |a Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation |
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| 520 | |a Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. | ||
| 520 | |a Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. | ||
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| 700 | 1 | |a Qian, Xu |e verfasserin |4 aut | |
| 700 | 1 | |a Carpenter, Richard |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xin‐Ru |e verfasserin |4 aut | |
| 700 | 1 | |a Peiper, Stephen S |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Zhimin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ling‐Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Bing‐Hua |e verfasserin |4 aut | |
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2012 |
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10.1038/embor.2012.162 doi (DE-627)SPR058022511 (SPR)embor.2012.162-e DE-627 ger DE-627 rakwb eng He, Jun verfasserin aut Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2012 Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Xu, Qing verfasserin aut Jing, Yi verfasserin aut Agani, Faton verfasserin aut Qian, Xu verfasserin aut Carpenter, Richard verfasserin aut Li, Qi verfasserin aut Wang, Xin‐Ru verfasserin aut Peiper, Stephen S verfasserin aut Lu, Zhimin verfasserin aut Liu, Ling‐Zhi verfasserin aut Jiang, Bing‐Hua verfasserin aut Enthalten in EMBO Reports Nature Publishing Group UK, 2023 13(2012), 12 vom: 13. Nov., Seite 1116-1122 (DE-627)320645622 (DE-600)2025376-X 1469-3178 nnns volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 https://dx.doi.org/10.1038/embor.2012.162 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2012 12 13 11 1116-1122 |
| spelling |
10.1038/embor.2012.162 doi (DE-627)SPR058022511 (SPR)embor.2012.162-e DE-627 ger DE-627 rakwb eng He, Jun verfasserin aut Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2012 Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Xu, Qing verfasserin aut Jing, Yi verfasserin aut Agani, Faton verfasserin aut Qian, Xu verfasserin aut Carpenter, Richard verfasserin aut Li, Qi verfasserin aut Wang, Xin‐Ru verfasserin aut Peiper, Stephen S verfasserin aut Lu, Zhimin verfasserin aut Liu, Ling‐Zhi verfasserin aut Jiang, Bing‐Hua verfasserin aut Enthalten in EMBO Reports Nature Publishing Group UK, 2023 13(2012), 12 vom: 13. Nov., Seite 1116-1122 (DE-627)320645622 (DE-600)2025376-X 1469-3178 nnns volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 https://dx.doi.org/10.1038/embor.2012.162 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2012 12 13 11 1116-1122 |
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10.1038/embor.2012.162 doi (DE-627)SPR058022511 (SPR)embor.2012.162-e DE-627 ger DE-627 rakwb eng He, Jun verfasserin aut Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2012 Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Xu, Qing verfasserin aut Jing, Yi verfasserin aut Agani, Faton verfasserin aut Qian, Xu verfasserin aut Carpenter, Richard verfasserin aut Li, Qi verfasserin aut Wang, Xin‐Ru verfasserin aut Peiper, Stephen S verfasserin aut Lu, Zhimin verfasserin aut Liu, Ling‐Zhi verfasserin aut Jiang, Bing‐Hua verfasserin aut Enthalten in EMBO Reports Nature Publishing Group UK, 2023 13(2012), 12 vom: 13. Nov., Seite 1116-1122 (DE-627)320645622 (DE-600)2025376-X 1469-3178 nnns volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 https://dx.doi.org/10.1038/embor.2012.162 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2012 12 13 11 1116-1122 |
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10.1038/embor.2012.162 doi (DE-627)SPR058022511 (SPR)embor.2012.162-e DE-627 ger DE-627 rakwb eng He, Jun verfasserin aut Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2012 Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Xu, Qing verfasserin aut Jing, Yi verfasserin aut Agani, Faton verfasserin aut Qian, Xu verfasserin aut Carpenter, Richard verfasserin aut Li, Qi verfasserin aut Wang, Xin‐Ru verfasserin aut Peiper, Stephen S verfasserin aut Lu, Zhimin verfasserin aut Liu, Ling‐Zhi verfasserin aut Jiang, Bing‐Hua verfasserin aut Enthalten in EMBO Reports Nature Publishing Group UK, 2023 13(2012), 12 vom: 13. Nov., Seite 1116-1122 (DE-627)320645622 (DE-600)2025376-X 1469-3178 nnns volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 https://dx.doi.org/10.1038/embor.2012.162 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2012 12 13 11 1116-1122 |
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10.1038/embor.2012.162 doi (DE-627)SPR058022511 (SPR)embor.2012.162-e DE-627 ger DE-627 rakwb eng He, Jun verfasserin aut Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Molecular Biology Organization 2012 Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 Xu, Qing verfasserin aut Jing, Yi verfasserin aut Agani, Faton verfasserin aut Qian, Xu verfasserin aut Carpenter, Richard verfasserin aut Li, Qi verfasserin aut Wang, Xin‐Ru verfasserin aut Peiper, Stephen S verfasserin aut Lu, Zhimin verfasserin aut Liu, Ling‐Zhi verfasserin aut Jiang, Bing‐Hua verfasserin aut Enthalten in EMBO Reports Nature Publishing Group UK, 2023 13(2012), 12 vom: 13. Nov., Seite 1116-1122 (DE-627)320645622 (DE-600)2025376-X 1469-3178 nnns volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 https://dx.doi.org/10.1038/embor.2012.162 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2012 12 13 11 1116-1122 |
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Enthalten in EMBO Reports 13(2012), 12 vom: 13. Nov., Seite 1116-1122 volume:13 year:2012 number:12 day:13 month:11 pages:1116-1122 |
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He, Jun @@aut@@ Xu, Qing @@aut@@ Jing, Yi @@aut@@ Agani, Faton @@aut@@ Qian, Xu @@aut@@ Carpenter, Richard @@aut@@ Li, Qi @@aut@@ Wang, Xin‐Ru @@aut@@ Peiper, Stephen S @@aut@@ Lu, Zhimin @@aut@@ Liu, Ling‐Zhi @@aut@@ Jiang, Bing‐Hua @@aut@@ |
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He, Jun |
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Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation miR‐199a (dpeaa)DE-He213 miR‐125b (dpeaa)DE-He213 ERBB2/3 (dpeaa)DE-He213 ROS (dpeaa)DE-He213 DNA methylation (dpeaa)DE-He213 |
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He, Jun Xu, Qing Jing, Yi Agani, Faton Qian, Xu Carpenter, Richard Li, Qi Wang, Xin‐Ru Peiper, Stephen S Lu, Zhimin Liu, Ling‐Zhi Jiang, Bing‐Hua |
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reactive oxygen species regulate erbb2 and erbb3 expression via mir‐199a/125b and dna methylation |
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Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR‐199a/125b and DNA methylation |
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Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. © European Molecular Biology Organization 2012 |
| abstractGer |
Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. © European Molecular Biology Organization 2012 |
| abstract_unstemmed |
Abstract Overexpression of ERBB2 or ERBB3 is associated with cancer development and poor prognosis. In this study, we show that reactive oxygen species (ROS) induce both ERBB2 and ERBB3 expression in vitro and in vivo. We also identify that miR‐199a and miR‐125b target ERBB2 and/or ERBB3 in ovarian cancer cells, and demonstrate that ROS inhibit miR‐199a and miR‐125b expression through increasing the promoter methylation of the miR‐199a and miR‐125b genes by DNA methyltransferase 1. These findings reveal that ERBB2 and ERBB3 expression is regulated by ROS via miR‐199a and miR‐125b downregulation and DNA hypermethylation. Abstract High ROS levels in cancer cells inhibit miR‐199a and miR‐125b expression by increasing DNMT1‐mediated methylation of the miR promoters. miR‐199a and miR‐125b repression leads to activation of their direct targets ERBB2 and ERBB3 that induce tumor growth. © European Molecular Biology Organization 2012 |
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| score |
7.4003916 |