The global emergence of a novel Streptococcus suis clade associated with human infections
Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virule...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dong, Xingxing [verfasserIn] Chao, Yanjie [verfasserIn] Zhou, Yang [verfasserIn] Zhou, Rui [verfasserIn] Zhang, Wei [verfasserIn] Fischetti, Vincent A. [verfasserIn] Wang, Xiaohong [verfasserIn] Feng, Ye [verfasserIn] Li, Jinquan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2021 |
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| Übergeordnetes Werk: |
Enthalten in: EMBO Molecular Medicine - Nature Publishing Group UK, 2023, 13(2021), 7 vom: 17. Juni |
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| Übergeordnetes Werk: |
volume:13 ; year:2021 ; number:7 ; day:17 ; month:06 |
| Links: |
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| DOI / URN: |
10.15252/emmm.202013810 |
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| Katalog-ID: |
SPR058031731 |
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| 520 | |a Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. | ||
| 520 | |a SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. | ||
| 520 | |a Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. | ||
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10.15252/emmm.202013810 doi (DE-627)SPR058031731 (SPR)emmm.202013810-e DE-627 ger DE-627 rakwb eng Dong, Xingxing verfasserin aut The global emergence of a novel Streptococcus suis clade associated with human infections 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 Chao, Yanjie verfasserin (orcid)0000-0002-5735-7954 aut Zhou, Yang verfasserin aut Zhou, Rui verfasserin aut Zhang, Wei verfasserin aut Fischetti, Vincent A. verfasserin aut Wang, Xiaohong verfasserin aut Feng, Ye verfasserin (orcid)0000-0002-6551-1560 aut Li, Jinquan verfasserin (orcid)0000-0001-8971-7582 aut Enthalten in EMBO Molecular Medicine Nature Publishing Group UK, 2023 13(2021), 7 vom: 17. Juni (DE-627)594772761 (DE-600)2485479-7 1757-4684 nnns volume:13 year:2021 number:7 day:17 month:06 https://dx.doi.org/10.15252/emmm.202013810 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2021 7 17 06 |
| spelling |
10.15252/emmm.202013810 doi (DE-627)SPR058031731 (SPR)emmm.202013810-e DE-627 ger DE-627 rakwb eng Dong, Xingxing verfasserin aut The global emergence of a novel Streptococcus suis clade associated with human infections 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 Chao, Yanjie verfasserin (orcid)0000-0002-5735-7954 aut Zhou, Yang verfasserin aut Zhou, Rui verfasserin aut Zhang, Wei verfasserin aut Fischetti, Vincent A. verfasserin aut Wang, Xiaohong verfasserin aut Feng, Ye verfasserin (orcid)0000-0002-6551-1560 aut Li, Jinquan verfasserin (orcid)0000-0001-8971-7582 aut Enthalten in EMBO Molecular Medicine Nature Publishing Group UK, 2023 13(2021), 7 vom: 17. Juni (DE-627)594772761 (DE-600)2485479-7 1757-4684 nnns volume:13 year:2021 number:7 day:17 month:06 https://dx.doi.org/10.15252/emmm.202013810 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2021 7 17 06 |
| allfields_unstemmed |
10.15252/emmm.202013810 doi (DE-627)SPR058031731 (SPR)emmm.202013810-e DE-627 ger DE-627 rakwb eng Dong, Xingxing verfasserin aut The global emergence of a novel Streptococcus suis clade associated with human infections 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 Chao, Yanjie verfasserin (orcid)0000-0002-5735-7954 aut Zhou, Yang verfasserin aut Zhou, Rui verfasserin aut Zhang, Wei verfasserin aut Fischetti, Vincent A. verfasserin aut Wang, Xiaohong verfasserin aut Feng, Ye verfasserin (orcid)0000-0002-6551-1560 aut Li, Jinquan verfasserin (orcid)0000-0001-8971-7582 aut Enthalten in EMBO Molecular Medicine Nature Publishing Group UK, 2023 13(2021), 7 vom: 17. Juni (DE-627)594772761 (DE-600)2485479-7 1757-4684 nnns volume:13 year:2021 number:7 day:17 month:06 https://dx.doi.org/10.15252/emmm.202013810 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2021 7 17 06 |
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10.15252/emmm.202013810 doi (DE-627)SPR058031731 (SPR)emmm.202013810-e DE-627 ger DE-627 rakwb eng Dong, Xingxing verfasserin aut The global emergence of a novel Streptococcus suis clade associated with human infections 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 Chao, Yanjie verfasserin (orcid)0000-0002-5735-7954 aut Zhou, Yang verfasserin aut Zhou, Rui verfasserin aut Zhang, Wei verfasserin aut Fischetti, Vincent A. verfasserin aut Wang, Xiaohong verfasserin aut Feng, Ye verfasserin (orcid)0000-0002-6551-1560 aut Li, Jinquan verfasserin (orcid)0000-0001-8971-7582 aut Enthalten in EMBO Molecular Medicine Nature Publishing Group UK, 2023 13(2021), 7 vom: 17. Juni (DE-627)594772761 (DE-600)2485479-7 1757-4684 nnns volume:13 year:2021 number:7 day:17 month:06 https://dx.doi.org/10.15252/emmm.202013810 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2021 7 17 06 |
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10.15252/emmm.202013810 doi (DE-627)SPR058031731 (SPR)emmm.202013810-e DE-627 ger DE-627 rakwb eng Dong, Xingxing verfasserin aut The global emergence of a novel Streptococcus suis clade associated with human infections 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2021 Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 Chao, Yanjie verfasserin (orcid)0000-0002-5735-7954 aut Zhou, Yang verfasserin aut Zhou, Rui verfasserin aut Zhang, Wei verfasserin aut Fischetti, Vincent A. verfasserin aut Wang, Xiaohong verfasserin aut Feng, Ye verfasserin (orcid)0000-0002-6551-1560 aut Li, Jinquan verfasserin (orcid)0000-0001-8971-7582 aut Enthalten in EMBO Molecular Medicine Nature Publishing Group UK, 2023 13(2021), 7 vom: 17. Juni (DE-627)594772761 (DE-600)2485479-7 1757-4684 nnns volume:13 year:2021 number:7 day:17 month:06 https://dx.doi.org/10.15252/emmm.202013810 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 13 2021 7 17 06 |
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Enthalten in EMBO Molecular Medicine 13(2021), 7 vom: 17. Juni volume:13 year:2021 number:7 day:17 month:06 |
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Dong, Xingxing @@aut@@ Chao, Yanjie @@aut@@ Zhou, Yang @@aut@@ Zhou, Rui @@aut@@ Zhang, Wei @@aut@@ Fischetti, Vincent A. @@aut@@ Wang, Xiaohong @@aut@@ Feng, Ye @@aut@@ Li, Jinquan @@aut@@ |
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The global emergence of a novel Streptococcus suis clade associated with human infections human pathogen (dpeaa)DE-He213 population genomics (dpeaa)DE-He213 ST1 (dpeaa)DE-He213 ST7 (dpeaa)DE-He213 |
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the global emergence of a novel streptococcus suis clade associated with human infections |
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The global emergence of a novel Streptococcus suis clade associated with human infections |
| abstract |
Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. © The Author(s) 2021 |
| abstractGer |
Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. © The Author(s) 2021 |
| abstract_unstemmed |
Abstract Streptococcus suis, a ubiquitous bacterial colonizer in pigs, has recently extended host range to humans, leading to a global surge of deadly human infections and three large outbreaks since 1998. To better understand the mechanisms for the emergence of cross‐species transmission and virulence in human, we have sequenced 366 S. suis human and pig isolates from 2005 to 2016 and performed a large‐scale phylogenomic analysis on 1,634 isolates from 14 countries over 36 years. We show the formation of a novel human‐associated clade (HAC) diversified from swine S. suis isolates. Phylogeographic analysis identified Europe as the origin of HAC, coinciding with the exportation of European swine breeds between 1960s and 1970s. HAC is composed of three sub‐lineages and contains several healthy‐pig isolates that display high virulence in experimental infections, suggesting healthy‐pig carriers as a potential source for human infection. New HAC‐specific genes are identified as promising markers for pathogen detection and surveillance. Our discovery of a human‐associated S. suis clade provides insights into the evolution of this emerging human pathogen and extend our understanding of S. suis epidemics worldwide. SYNOPSIS The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. Large‐scale genomic analysis on clinical strains from human patients and pigs have revealed three distinct bacterial clades, i.e. healthy‐pig clade, disease‐pig clade, and human‐associated clade (HAC).HAC isolates displayed high virulence potential in animal models. Several HAC strains were isolated from healthy‐pigs, suggesting these healthy‐pig carriers might be a potential source for human infection.The origin of HAC was pointed to West Europe, with subsequent spread to other continents, including South America, North America, Africa and Asia.The discriminative markers identified for HAC are useful diagnostic tools for routine surveillance of S. suis in environments and animals, including asymptomatic livestock. Graphical Abstract The increasing incidences of human infections caused by Streptococcus suis indicate that this bacterium may undergo adaptive evolution in humans. In this study, a novel clade of S. suis strongly associated with human infections was identified. © The Author(s) 2021 |
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The global emergence of a novel Streptococcus suis clade associated with human infections |
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Chao, Yanjie Zhou, Yang Zhou, Rui Zhang, Wei Fischetti, Vincent A. Wang, Xiaohong Feng, Ye Li, Jinquan |
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10.15252/emmm.202013810 |
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| score |
7.402895 |