Transcriptional repression by MYB3R proteins regulates plant organ growth
Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitoti...
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| Autor*in: |
Kobayashi, Kosuke [verfasserIn] Suzuki, Toshiya [verfasserIn] Iwata, Eriko [verfasserIn] Nakamichi, Norihito [verfasserIn] Suzuki, Takamasa [verfasserIn] Chen, Poyu [verfasserIn] Ohtani, Misato [verfasserIn] Ishida, Takashi [verfasserIn] Hosoya, Hanako [verfasserIn] Müller, Sabine [verfasserIn] Leviczky, Tünde [verfasserIn] Pettkó‐Szandtner, Aladár [verfasserIn] Darula, Zsuzsanna [verfasserIn] Iwamoto, Akitoshi [verfasserIn] Nomoto, Mika [verfasserIn] Tada, Yasuomi [verfasserIn] Higashiyama, Tetsuya [verfasserIn] Demura, Taku [verfasserIn] Doonan, John H [verfasserIn] Hauser, Marie‐Theres [verfasserIn] Sugimoto, Keiko [verfasserIn] Umeda, Masaaki [verfasserIn] Magyar, Zoltán [verfasserIn] Bögre, László [verfasserIn] Ito, Masaki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© The Authors 2015 |
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| Übergeordnetes Werk: |
Enthalten in: The EMBO Journal - Nature Publishing Group UK, 2023, 34(2015), 15 vom: 09. Juni, Seite 1992-2007 |
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| Übergeordnetes Werk: |
volume:34 ; year:2015 ; number:15 ; day:09 ; month:06 ; pages:1992-2007 |
| Links: |
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| DOI / URN: |
10.15252/embj.201490899 |
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| Katalog-ID: |
SPR058063064 |
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| 100 | 1 | |a Kobayashi, Kosuke |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Transcriptional repression by MYB3R proteins regulates plant organ growth |
| 264 | 1 | |c 2015 | |
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| 520 | |a Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. | ||
| 520 | |a Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. | ||
| 520 | |a Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. | ||
| 650 | 4 | |a cell cycle regulation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a cell differentiation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a DREAM complex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a G2/M phase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MYB transcription factors |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Suzuki, Toshiya |e verfasserin |4 aut | |
| 700 | 1 | |a Iwata, Eriko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamichi, Norihito |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Poyu |e verfasserin |4 aut | |
| 700 | 1 | |a Ohtani, Misato |e verfasserin |4 aut | |
| 700 | 1 | |a Ishida, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Hosoya, Hanako |e verfasserin |4 aut | |
| 700 | 1 | |a Müller, Sabine |e verfasserin |4 aut | |
| 700 | 1 | |a Leviczky, Tünde |e verfasserin |4 aut | |
| 700 | 1 | |a Pettkó‐Szandtner, Aladár |e verfasserin |4 aut | |
| 700 | 1 | |a Darula, Zsuzsanna |e verfasserin |4 aut | |
| 700 | 1 | |a Iwamoto, Akitoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Nomoto, Mika |e verfasserin |4 aut | |
| 700 | 1 | |a Tada, Yasuomi |e verfasserin |4 aut | |
| 700 | 1 | |a Higashiyama, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Demura, Taku |e verfasserin |4 aut | |
| 700 | 1 | |a Doonan, John H |e verfasserin |4 aut | |
| 700 | 1 | |a Hauser, Marie‐Theres |e verfasserin |4 aut | |
| 700 | 1 | |a Sugimoto, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Umeda, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Magyar, Zoltán |e verfasserin |4 aut | |
| 700 | 1 | |a Bögre, László |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Masaki |e verfasserin |4 aut | |
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10.15252/embj.201490899 doi (DE-627)SPR058063064 (SPR)embj.201490899-e DE-627 ger DE-627 rakwb eng Kobayashi, Kosuke verfasserin aut Transcriptional repression by MYB3R proteins regulates plant organ growth 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Authors 2015 Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 Suzuki, Toshiya verfasserin aut Iwata, Eriko verfasserin aut Nakamichi, Norihito verfasserin aut Suzuki, Takamasa verfasserin aut Chen, Poyu verfasserin aut Ohtani, Misato verfasserin aut Ishida, Takashi verfasserin aut Hosoya, Hanako verfasserin aut Müller, Sabine verfasserin aut Leviczky, Tünde verfasserin aut Pettkó‐Szandtner, Aladár verfasserin aut Darula, Zsuzsanna verfasserin aut Iwamoto, Akitoshi verfasserin aut Nomoto, Mika verfasserin aut Tada, Yasuomi verfasserin aut Higashiyama, Tetsuya verfasserin aut Demura, Taku verfasserin aut Doonan, John H verfasserin aut Hauser, Marie‐Theres verfasserin aut Sugimoto, Keiko verfasserin aut Umeda, Masaaki verfasserin aut Magyar, Zoltán verfasserin aut Bögre, László verfasserin aut Ito, Masaki verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 34(2015), 15 vom: 09. Juni, Seite 1992-2007 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:34 year:2015 number:15 day:09 month:06 pages:1992-2007 https://dx.doi.org/10.15252/embj.201490899 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 34 2015 15 09 06 1992-2007 |
| spelling |
10.15252/embj.201490899 doi (DE-627)SPR058063064 (SPR)embj.201490899-e DE-627 ger DE-627 rakwb eng Kobayashi, Kosuke verfasserin aut Transcriptional repression by MYB3R proteins regulates plant organ growth 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Authors 2015 Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 Suzuki, Toshiya verfasserin aut Iwata, Eriko verfasserin aut Nakamichi, Norihito verfasserin aut Suzuki, Takamasa verfasserin aut Chen, Poyu verfasserin aut Ohtani, Misato verfasserin aut Ishida, Takashi verfasserin aut Hosoya, Hanako verfasserin aut Müller, Sabine verfasserin aut Leviczky, Tünde verfasserin aut Pettkó‐Szandtner, Aladár verfasserin aut Darula, Zsuzsanna verfasserin aut Iwamoto, Akitoshi verfasserin aut Nomoto, Mika verfasserin aut Tada, Yasuomi verfasserin aut Higashiyama, Tetsuya verfasserin aut Demura, Taku verfasserin aut Doonan, John H verfasserin aut Hauser, Marie‐Theres verfasserin aut Sugimoto, Keiko verfasserin aut Umeda, Masaaki verfasserin aut Magyar, Zoltán verfasserin aut Bögre, László verfasserin aut Ito, Masaki verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 34(2015), 15 vom: 09. Juni, Seite 1992-2007 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:34 year:2015 number:15 day:09 month:06 pages:1992-2007 https://dx.doi.org/10.15252/embj.201490899 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 34 2015 15 09 06 1992-2007 |
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10.15252/embj.201490899 doi (DE-627)SPR058063064 (SPR)embj.201490899-e DE-627 ger DE-627 rakwb eng Kobayashi, Kosuke verfasserin aut Transcriptional repression by MYB3R proteins regulates plant organ growth 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Authors 2015 Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 Suzuki, Toshiya verfasserin aut Iwata, Eriko verfasserin aut Nakamichi, Norihito verfasserin aut Suzuki, Takamasa verfasserin aut Chen, Poyu verfasserin aut Ohtani, Misato verfasserin aut Ishida, Takashi verfasserin aut Hosoya, Hanako verfasserin aut Müller, Sabine verfasserin aut Leviczky, Tünde verfasserin aut Pettkó‐Szandtner, Aladár verfasserin aut Darula, Zsuzsanna verfasserin aut Iwamoto, Akitoshi verfasserin aut Nomoto, Mika verfasserin aut Tada, Yasuomi verfasserin aut Higashiyama, Tetsuya verfasserin aut Demura, Taku verfasserin aut Doonan, John H verfasserin aut Hauser, Marie‐Theres verfasserin aut Sugimoto, Keiko verfasserin aut Umeda, Masaaki verfasserin aut Magyar, Zoltán verfasserin aut Bögre, László verfasserin aut Ito, Masaki verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 34(2015), 15 vom: 09. Juni, Seite 1992-2007 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:34 year:2015 number:15 day:09 month:06 pages:1992-2007 https://dx.doi.org/10.15252/embj.201490899 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 34 2015 15 09 06 1992-2007 |
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10.15252/embj.201490899 doi (DE-627)SPR058063064 (SPR)embj.201490899-e DE-627 ger DE-627 rakwb eng Kobayashi, Kosuke verfasserin aut Transcriptional repression by MYB3R proteins regulates plant organ growth 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Authors 2015 Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 Suzuki, Toshiya verfasserin aut Iwata, Eriko verfasserin aut Nakamichi, Norihito verfasserin aut Suzuki, Takamasa verfasserin aut Chen, Poyu verfasserin aut Ohtani, Misato verfasserin aut Ishida, Takashi verfasserin aut Hosoya, Hanako verfasserin aut Müller, Sabine verfasserin aut Leviczky, Tünde verfasserin aut Pettkó‐Szandtner, Aladár verfasserin aut Darula, Zsuzsanna verfasserin aut Iwamoto, Akitoshi verfasserin aut Nomoto, Mika verfasserin aut Tada, Yasuomi verfasserin aut Higashiyama, Tetsuya verfasserin aut Demura, Taku verfasserin aut Doonan, John H verfasserin aut Hauser, Marie‐Theres verfasserin aut Sugimoto, Keiko verfasserin aut Umeda, Masaaki verfasserin aut Magyar, Zoltán verfasserin aut Bögre, László verfasserin aut Ito, Masaki verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 34(2015), 15 vom: 09. Juni, Seite 1992-2007 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:34 year:2015 number:15 day:09 month:06 pages:1992-2007 https://dx.doi.org/10.15252/embj.201490899 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 34 2015 15 09 06 1992-2007 |
| allfieldsSound |
10.15252/embj.201490899 doi (DE-627)SPR058063064 (SPR)embj.201490899-e DE-627 ger DE-627 rakwb eng Kobayashi, Kosuke verfasserin aut Transcriptional repression by MYB3R proteins regulates plant organ growth 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Authors 2015 Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 Suzuki, Toshiya verfasserin aut Iwata, Eriko verfasserin aut Nakamichi, Norihito verfasserin aut Suzuki, Takamasa verfasserin aut Chen, Poyu verfasserin aut Ohtani, Misato verfasserin aut Ishida, Takashi verfasserin aut Hosoya, Hanako verfasserin aut Müller, Sabine verfasserin aut Leviczky, Tünde verfasserin aut Pettkó‐Szandtner, Aladár verfasserin aut Darula, Zsuzsanna verfasserin aut Iwamoto, Akitoshi verfasserin aut Nomoto, Mika verfasserin aut Tada, Yasuomi verfasserin aut Higashiyama, Tetsuya verfasserin aut Demura, Taku verfasserin aut Doonan, John H verfasserin aut Hauser, Marie‐Theres verfasserin aut Sugimoto, Keiko verfasserin aut Umeda, Masaaki verfasserin aut Magyar, Zoltán verfasserin aut Bögre, László verfasserin aut Ito, Masaki verfasserin aut Enthalten in The EMBO Journal Nature Publishing Group UK, 2023 34(2015), 15 vom: 09. Juni, Seite 1992-2007 (DE-627)266022529 (DE-600)1467419-1 1460-2075 nnns volume:34 year:2015 number:15 day:09 month:06 pages:1992-2007 https://dx.doi.org/10.15252/embj.201490899 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_252 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 34 2015 15 09 06 1992-2007 |
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The EMBO Journal |
| authorswithroles_txt_mv |
Kobayashi, Kosuke @@aut@@ Suzuki, Toshiya @@aut@@ Iwata, Eriko @@aut@@ Nakamichi, Norihito @@aut@@ Suzuki, Takamasa @@aut@@ Chen, Poyu @@aut@@ Ohtani, Misato @@aut@@ Ishida, Takashi @@aut@@ Hosoya, Hanako @@aut@@ Müller, Sabine @@aut@@ Leviczky, Tünde @@aut@@ Pettkó‐Szandtner, Aladár @@aut@@ Darula, Zsuzsanna @@aut@@ Iwamoto, Akitoshi @@aut@@ Nomoto, Mika @@aut@@ Tada, Yasuomi @@aut@@ Higashiyama, Tetsuya @@aut@@ Demura, Taku @@aut@@ Doonan, John H @@aut@@ Hauser, Marie‐Theres @@aut@@ Sugimoto, Keiko @@aut@@ Umeda, Masaaki @@aut@@ Magyar, Zoltán @@aut@@ Bögre, László @@aut@@ Ito, Masaki @@aut@@ |
| publishDateDaySort_date |
2015-06-09T00:00:00Z |
| hierarchy_top_id |
266022529 |
| id |
SPR058063064 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR058063064</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20241025065051.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">241025s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.15252/embj.201490899</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR058063064</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)embj.201490899-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kobayashi, Kosuke</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Transcriptional repression by MYB3R proteins regulates plant organ growth</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Authors 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cell cycle regulation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cell differentiation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " 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Kobayashi, Kosuke misc cell cycle regulation misc cell differentiation misc DREAM complex misc G2/M phase misc MYB transcription factors Transcriptional repression by MYB3R proteins regulates plant organ growth |
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Transcriptional repression by MYB3R proteins regulates plant organ growth cell cycle regulation (dpeaa)DE-He213 cell differentiation (dpeaa)DE-He213 DREAM complex (dpeaa)DE-He213 G2/M phase (dpeaa)DE-He213 MYB transcription factors (dpeaa)DE-He213 |
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Kobayashi, Kosuke Suzuki, Toshiya Iwata, Eriko Nakamichi, Norihito Suzuki, Takamasa Chen, Poyu Ohtani, Misato Ishida, Takashi Hosoya, Hanako Müller, Sabine Leviczky, Tünde Pettkó‐Szandtner, Aladár Darula, Zsuzsanna Iwamoto, Akitoshi Nomoto, Mika Tada, Yasuomi Higashiyama, Tetsuya Demura, Taku Doonan, John H Hauser, Marie‐Theres Sugimoto, Keiko Umeda, Masaaki Magyar, Zoltán Bögre, László Ito, Masaki |
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transcriptional repression by myb3r proteins regulates plant organ growth |
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Transcriptional repression by MYB3R proteins regulates plant organ growth |
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Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. © The Authors 2015 |
| abstractGer |
Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. © The Authors 2015 |
| abstract_unstemmed |
Abstract In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post‐mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor‐type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome‐wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M‐specific genes and to E2F target genes. MYB3R3 associates with the repressor‐type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post‐mitotic quiescent state determining organ size. Synopsis Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. R1R2R3‐Mybs with repressor functions maintain G2/M‐specific genes repressed in post‐mitotic cells and restrict mitotic gene expression in proliferating cells.Transcriptional cell cycle regulation at G2/M impacts on plant organ growth.R1R2R3‐Myb activators and repressors form distinct multi‐protein complexes.Repressive R1R2R3‐Mybs are similar to the DREAM/dREAM complexes in human and fly. Graphical Abstract Activator and DREAM‐like repressor R1R2R3‐Myb transcription factors act coordinately to regulate mitotic target genes and organ growth in Arabidopsis thaliana. © The Authors 2015 |
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