High‐resolution definition of humoral immune response correlates of effective immunity against HIV
Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alter, Galit [verfasserIn] Dowell, Karen G [verfasserIn] Brown, Eric P [verfasserIn] Suscovich, Todd J [verfasserIn] Mikhailova, Anastassia [verfasserIn] Mahan, Alison E [verfasserIn] Walker, Bruce D [verfasserIn] Nimmerjahn, Falk [verfasserIn] Bailey‐Kellogg, Chris [verfasserIn] Ackerman, Margaret E [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2018 |
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| Übergeordnetes Werk: |
Enthalten in: Molecular Systems Biology - Nature Publishing Group UK, 2023, 14(2018), 3 vom: 26. März |
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| Übergeordnetes Werk: |
volume:14 ; year:2018 ; number:3 ; day:26 ; month:03 |
| Links: |
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| DOI / URN: |
10.15252/msb.20177881 |
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| Katalog-ID: |
SPR05809282X |
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| 245 | 1 | 0 | |a High‐resolution definition of humoral immune response correlates of effective immunity against HIV |
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| 520 | |a Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. | ||
| 520 | |a Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. | ||
| 520 | |a Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. | ||
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| 700 | 1 | |a Brown, Eric P |e verfasserin |4 aut | |
| 700 | 1 | |a Suscovich, Todd J |e verfasserin |4 aut | |
| 700 | 1 | |a Mikhailova, Anastassia |e verfasserin |4 aut | |
| 700 | 1 | |a Mahan, Alison E |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Bruce D |e verfasserin |4 aut | |
| 700 | 1 | |a Nimmerjahn, Falk |e verfasserin |4 aut | |
| 700 | 1 | |a Bailey‐Kellogg, Chris |e verfasserin |4 aut | |
| 700 | 1 | |a Ackerman, Margaret E |e verfasserin |0 (orcid)0000-0002-4253-3476 |4 aut | |
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10.15252/msb.20177881 doi (DE-627)SPR05809282X (SPR)msb.20177881-e DE-627 ger DE-627 rakwb eng Alter, Galit verfasserin aut High‐resolution definition of humoral immune response correlates of effective immunity against HIV 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 Dowell, Karen G verfasserin aut Brown, Eric P verfasserin aut Suscovich, Todd J verfasserin aut Mikhailova, Anastassia verfasserin aut Mahan, Alison E verfasserin aut Walker, Bruce D verfasserin aut Nimmerjahn, Falk verfasserin aut Bailey‐Kellogg, Chris verfasserin aut Ackerman, Margaret E verfasserin (orcid)0000-0002-4253-3476 aut Enthalten in Molecular Systems Biology Nature Publishing Group UK, 2023 14(2018), 3 vom: 26. März (DE-627)490536905 (DE-600)2193510-5 1744-4292 nnns volume:14 year:2018 number:3 day:26 month:03 https://dx.doi.org/10.15252/msb.20177881 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 14 2018 3 26 03 |
| spelling |
10.15252/msb.20177881 doi (DE-627)SPR05809282X (SPR)msb.20177881-e DE-627 ger DE-627 rakwb eng Alter, Galit verfasserin aut High‐resolution definition of humoral immune response correlates of effective immunity against HIV 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 Dowell, Karen G verfasserin aut Brown, Eric P verfasserin aut Suscovich, Todd J verfasserin aut Mikhailova, Anastassia verfasserin aut Mahan, Alison E verfasserin aut Walker, Bruce D verfasserin aut Nimmerjahn, Falk verfasserin aut Bailey‐Kellogg, Chris verfasserin aut Ackerman, Margaret E verfasserin (orcid)0000-0002-4253-3476 aut Enthalten in Molecular Systems Biology Nature Publishing Group UK, 2023 14(2018), 3 vom: 26. März (DE-627)490536905 (DE-600)2193510-5 1744-4292 nnns volume:14 year:2018 number:3 day:26 month:03 https://dx.doi.org/10.15252/msb.20177881 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 14 2018 3 26 03 |
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10.15252/msb.20177881 doi (DE-627)SPR05809282X (SPR)msb.20177881-e DE-627 ger DE-627 rakwb eng Alter, Galit verfasserin aut High‐resolution definition of humoral immune response correlates of effective immunity against HIV 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 Dowell, Karen G verfasserin aut Brown, Eric P verfasserin aut Suscovich, Todd J verfasserin aut Mikhailova, Anastassia verfasserin aut Mahan, Alison E verfasserin aut Walker, Bruce D verfasserin aut Nimmerjahn, Falk verfasserin aut Bailey‐Kellogg, Chris verfasserin aut Ackerman, Margaret E verfasserin (orcid)0000-0002-4253-3476 aut Enthalten in Molecular Systems Biology Nature Publishing Group UK, 2023 14(2018), 3 vom: 26. März (DE-627)490536905 (DE-600)2193510-5 1744-4292 nnns volume:14 year:2018 number:3 day:26 month:03 https://dx.doi.org/10.15252/msb.20177881 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 14 2018 3 26 03 |
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10.15252/msb.20177881 doi (DE-627)SPR05809282X (SPR)msb.20177881-e DE-627 ger DE-627 rakwb eng Alter, Galit verfasserin aut High‐resolution definition of humoral immune response correlates of effective immunity against HIV 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 Dowell, Karen G verfasserin aut Brown, Eric P verfasserin aut Suscovich, Todd J verfasserin aut Mikhailova, Anastassia verfasserin aut Mahan, Alison E verfasserin aut Walker, Bruce D verfasserin aut Nimmerjahn, Falk verfasserin aut Bailey‐Kellogg, Chris verfasserin aut Ackerman, Margaret E verfasserin (orcid)0000-0002-4253-3476 aut Enthalten in Molecular Systems Biology Nature Publishing Group UK, 2023 14(2018), 3 vom: 26. März (DE-627)490536905 (DE-600)2193510-5 1744-4292 nnns volume:14 year:2018 number:3 day:26 month:03 https://dx.doi.org/10.15252/msb.20177881 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 14 2018 3 26 03 |
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10.15252/msb.20177881 doi (DE-627)SPR05809282X (SPR)msb.20177881-e DE-627 ger DE-627 rakwb eng Alter, Galit verfasserin aut High‐resolution definition of humoral immune response correlates of effective immunity against HIV 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 Dowell, Karen G verfasserin aut Brown, Eric P verfasserin aut Suscovich, Todd J verfasserin aut Mikhailova, Anastassia verfasserin aut Mahan, Alison E verfasserin aut Walker, Bruce D verfasserin aut Nimmerjahn, Falk verfasserin aut Bailey‐Kellogg, Chris verfasserin aut Ackerman, Margaret E verfasserin (orcid)0000-0002-4253-3476 aut Enthalten in Molecular Systems Biology Nature Publishing Group UK, 2023 14(2018), 3 vom: 26. März (DE-627)490536905 (DE-600)2193510-5 1744-4292 nnns volume:14 year:2018 number:3 day:26 month:03 https://dx.doi.org/10.15252/msb.20177881 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_72 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4029 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4116 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4155 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4311 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4315 GBV_ILN_4318 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4598 GBV_ILN_4700 AR 14 2018 3 26 03 |
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Enthalten in Molecular Systems Biology 14(2018), 3 vom: 26. März volume:14 year:2018 number:3 day:26 month:03 |
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We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antibody</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">effector function</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HIV</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">systems serology</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dowell, Karen G</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, Eric P</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Suscovich, Todd J</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mikhailova, Anastassia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mahan, Alison E</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Walker, Bruce D</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nimmerjahn, Falk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bailey‐Kellogg, Chris</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ackerman, Margaret E</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-4253-3476</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Molecular Systems Biology</subfield><subfield code="d">Nature Publishing Group UK, 2023</subfield><subfield code="g">14(2018), 3 vom: 26. 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High‐resolution definition of humoral immune response correlates of effective immunity against HIV antibody (dpeaa)DE-He213 effector function (dpeaa)DE-He213 HIV (dpeaa)DE-He213 systems serology (dpeaa)DE-He213 |
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high‐resolution definition of humoral immune response correlates of effective immunity against hiv |
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High‐resolution definition of humoral immune response correlates of effective immunity against HIV |
| abstract |
Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. © The Author(s) 2018 |
| abstractGer |
Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. © The Author(s) 2018 |
| abstract_unstemmed |
Abstract Defining correlates of immunity by comprehensively interrogating the extensive biological diversity in naturally or experimentally protected subjects may provide insights critical for guiding the development of effective vaccines and antibody‐based therapies. We report advances in a humoral immunoprofiling approach and its application to elucidate hallmarks of effective HIV‐1 viral control. Systematic serological analysis for a cohort of HIV‐infected subjects with varying viral control was conducted using both a high‐resolution, high‐throughput biophysical antibody profiling approach, providing unbiased dissection of the humoral response, along with functional antibody assays, characterizing antibody‐directed effector functions such as complement fixation and phagocytosis that are central to protective immunity. Profiles of subjects with varying viral control were computationally analyzed and modeled in order to deconvolute relationships among IgG Fab properties, Fc characteristics, and effector functions and to identify humoral correlates of potent antiviral antibody‐directed effector activity and effective viral suppression. The resulting models reveal multifaceted and coordinated contributions of polyclonal antibodies to diverse antiviral responses, and suggest key biophysical features predictive of viral control. Synopsis Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. High resolution profiling of antibody features and effector functions is used to evaluate immune responses in HIV infection.Humoral responses associated with spontaneous viral suppression are modeled.Features of antibodies associated with potent effector function are defined.The identified antibody markers of HIV viral suppression and potent effector function may be useful for benchmarking HIV vaccines. Graphical Abstract Interrogation and systematic analysis of the humoral immune response define correlates of antibody effector function and humoral responses associated with spontaneous HIV‐1 suppression, indicating new metrics, which may be relevant for HIV vaccine trials. © The Author(s) 2018 |
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High‐resolution definition of humoral immune response correlates of effective immunity against HIV |
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https://dx.doi.org/10.15252/msb.20177881 |
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Dowell, Karen G Brown, Eric P Suscovich, Todd J Mikhailova, Anastassia Mahan, Alison E Walker, Bruce D Nimmerjahn, Falk Bailey‐Kellogg, Chris Ackerman, Margaret E |
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Dowell, Karen G Brown, Eric P Suscovich, Todd J Mikhailova, Anastassia Mahan, Alison E Walker, Bruce D Nimmerjahn, Falk Bailey‐Kellogg, Chris Ackerman, Margaret E |
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| doi_str |
10.15252/msb.20177881 |
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2024-10-25T04:56:21.141Z |
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| score |
7.402916 |