LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival

Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse...
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Autor*in:	James R. Bayrer [verfasserIn] Hongtao Wang [verfasserIn] Roy Nattiv [verfasserIn] Miyuki Suzawa [verfasserIn] Hazel S. Escusa [verfasserIn] Robert J. Fletterick [verfasserIn] Ophir D. Klein [verfasserIn] David D. Moore [verfasserIn] Holly A. Ingraham [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 9(2018), 1, Seite 10
Übergeordnetes Werk:	volume:9 ; year:2018 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-018-06137-w

Katalog-ID:	DOAJ066649536

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spelling	10.1038/s41467-018-06137-w doi (DE-627)DOAJ066649536 (DE-599)DOAJ90369e6a41a144aa93dc643e36748685 DE-627 ger DE-627 rakwb eng James R. Bayrer verfasserin aut LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model. Science Q Hongtao Wang verfasserin aut Roy Nattiv verfasserin aut Miyuki Suzawa verfasserin aut Hazel S. Escusa verfasserin aut Robert J. Fletterick verfasserin aut Ophir D. Klein verfasserin aut David D. Moore verfasserin aut Holly A. Ingraham verfasserin aut In Nature Communications Nature Portfolio, 2016 9(2018), 1, Seite 10 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:9 year:2018 number:1 pages:10 https://doi.org/10.1038/s41467-018-06137-w kostenfrei https://doaj.org/article/90369e6a41a144aa93dc643e36748685 kostenfrei https://doi.org/10.1038/s41467-018-06137-w kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018 1 10
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author	James R. Bayrer
spellingShingle	James R. Bayrer misc Science misc Q LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
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topic_title	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
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title	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
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title_full	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
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author_browse	James R. Bayrer Hongtao Wang Roy Nattiv Miyuki Suzawa Hazel S. Escusa Robert J. Fletterick Ophir D. Klein David D. Moore Holly A. Ingraham
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title_sort	lrh-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
title_auth	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
abstract	Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.
abstractGer	Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.
abstract_unstemmed	Inflammatory bowel disease is characterised by epithelial dysfunction. Here the authors show that loss of the nuclear receptor LRH-1 leads to epithelial disruption by altering Notch signaling in mouse intestinal organoids, and that LRH-1 overexpression ameliorates immune-mediated colitis in a mouse model.
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title_short	LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival
url	https://doi.org/10.1038/s41467-018-06137-w https://doaj.org/article/90369e6a41a144aa93dc643e36748685 https://doaj.org/toc/2041-1723
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