Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2
• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pace-Asciak, Cecil R. [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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5 |
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| Übergeordnetes Werk: |
Enthalten in: Radial growth response of trees to seasonal soil humidity in a subtropical forest - Gheyret, Gheyur ELSEVIER, 2021, an international journal, New York, NY |
|---|---|
| Übergeordnetes Werk: |
volume:107 ; year:2013 ; pages:43-47 ; extent:5 |
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| DOI / URN: |
10.1016/j.prostaglandins.2013.03.004 |
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| 520 | |a • We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. | ||
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10.1016/j.prostaglandins.2013.03.004 doi GBVA2013017000009.pica (DE-627)ELV017054753 (ELSEVIER)S1098-8823(13)00022-1 DE-627 ger DE-627 rakwb eng 590 580 610 590 DE-600 580 DE-600 610 DE-600 570 VZ BIODIV DE-30 fid Pace-Asciak, Cecil R. verfasserin aut Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. Hepoxilins Elsevier Phospholipase Elsevier Tumours Elsevier LCMSMS Elsevier Eicosanoids Elsevier Antagonists Elsevier Li, Xiang oth Reynaud, Denis oth Qiao, Na oth Demin, Peter oth Abdelhaleem, Mohamed oth Enthalten in Elsevier Gheyret, Gheyur ELSEVIER Radial growth response of trees to seasonal soil humidity in a subtropical forest 2021 an international journal New York, NY (DE-627)ELV006560792 volume:107 year:2013 pages:43-47 extent:5 https://doi.org/10.1016/j.prostaglandins.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 107 2013 43-47 5 045F 590 |
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10.1016/j.prostaglandins.2013.03.004 doi GBVA2013017000009.pica (DE-627)ELV017054753 (ELSEVIER)S1098-8823(13)00022-1 DE-627 ger DE-627 rakwb eng 590 580 610 590 DE-600 580 DE-600 610 DE-600 570 VZ BIODIV DE-30 fid Pace-Asciak, Cecil R. verfasserin aut Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. Hepoxilins Elsevier Phospholipase Elsevier Tumours Elsevier LCMSMS Elsevier Eicosanoids Elsevier Antagonists Elsevier Li, Xiang oth Reynaud, Denis oth Qiao, Na oth Demin, Peter oth Abdelhaleem, Mohamed oth Enthalten in Elsevier Gheyret, Gheyur ELSEVIER Radial growth response of trees to seasonal soil humidity in a subtropical forest 2021 an international journal New York, NY (DE-627)ELV006560792 volume:107 year:2013 pages:43-47 extent:5 https://doi.org/10.1016/j.prostaglandins.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 107 2013 43-47 5 045F 590 |
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10.1016/j.prostaglandins.2013.03.004 doi GBVA2013017000009.pica (DE-627)ELV017054753 (ELSEVIER)S1098-8823(13)00022-1 DE-627 ger DE-627 rakwb eng 590 580 610 590 DE-600 580 DE-600 610 DE-600 570 VZ BIODIV DE-30 fid Pace-Asciak, Cecil R. verfasserin aut Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. Hepoxilins Elsevier Phospholipase Elsevier Tumours Elsevier LCMSMS Elsevier Eicosanoids Elsevier Antagonists Elsevier Li, Xiang oth Reynaud, Denis oth Qiao, Na oth Demin, Peter oth Abdelhaleem, Mohamed oth Enthalten in Elsevier Gheyret, Gheyur ELSEVIER Radial growth response of trees to seasonal soil humidity in a subtropical forest 2021 an international journal New York, NY (DE-627)ELV006560792 volume:107 year:2013 pages:43-47 extent:5 https://doi.org/10.1016/j.prostaglandins.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 107 2013 43-47 5 045F 590 |
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10.1016/j.prostaglandins.2013.03.004 doi GBVA2013017000009.pica (DE-627)ELV017054753 (ELSEVIER)S1098-8823(13)00022-1 DE-627 ger DE-627 rakwb eng 590 580 610 590 DE-600 580 DE-600 610 DE-600 570 VZ BIODIV DE-30 fid Pace-Asciak, Cecil R. verfasserin aut Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 2013 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. Hepoxilins Elsevier Phospholipase Elsevier Tumours Elsevier LCMSMS Elsevier Eicosanoids Elsevier Antagonists Elsevier Li, Xiang oth Reynaud, Denis oth Qiao, Na oth Demin, Peter oth Abdelhaleem, Mohamed oth Enthalten in Elsevier Gheyret, Gheyur ELSEVIER Radial growth response of trees to seasonal soil humidity in a subtropical forest 2021 an international journal New York, NY (DE-627)ELV006560792 volume:107 year:2013 pages:43-47 extent:5 https://doi.org/10.1016/j.prostaglandins.2013.03.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 107 2013 43-47 5 045F 590 |
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alterations in eicosanoid levels during u937 bcl-xl tumour growth suppression and recovery in nu/nu mice in vivo—involvement of phospholipase a2 |
| title_auth |
Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 |
| abstract |
• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. |
| abstractGer |
• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. |
| abstract_unstemmed |
• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA |
| title_short |
Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2 |
| url |
https://doi.org/10.1016/j.prostaglandins.2013.03.004 |
| remote_bool |
true |
| author2 |
Li, Xiang Reynaud, Denis Qiao, Na Demin, Peter Abdelhaleem, Mohamed |
| author2Str |
Li, Xiang Reynaud, Denis Qiao, Na Demin, Peter Abdelhaleem, Mohamed |
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| doi_str |
10.1016/j.prostaglandins.2013.03.004 |
| up_date |
2024-07-06T21:00:41.294Z |
| _version_ |
1803864916670545920 |
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7.401888 |