Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds
• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on...
Ausführliche Beschreibung
Autor*in: |
Søfteland, Liv [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Umfang: |
18 |
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Übergeordnetes Werk: |
Enthalten in: Numerical simulations on static Vertical Axis Wind Turbine blade icing - Manatbayev, Rustem ELSEVIER, 2021, New York, NY [u.a.] |
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Übergeordnetes Werk: |
volume:73 ; year:2014 ; pages:157-174 ; extent:18 |
Links: |
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DOI / URN: |
10.1016/j.fct.2014.08.008 |
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Katalog-ID: |
ELV01744831X |
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520 | |a • Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. | ||
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10.1016/j.fct.2014.08.008 doi GBVA2014009000019.pica (DE-627)ELV01744831X (ELSEVIER)S0278-6915(14)00380-9 DE-627 ger DE-627 rakwb eng 630 640 610 630 DE-600 640 DE-600 610 DE-600 530 620 VZ 52.56 bkl Søfteland, Liv verfasserin aut Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds 2014 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. RTG-2 Elsevier RT Elsevier RTgill-W1 Elsevier DMSO Elsevier MNE Elsevier POPs Elsevier VTG Elsevier FS Elsevier nac Elsevier MAP1LC3B Elsevier QC Elsevier CYP1A Elsevier ANOVA Elsevier RT-PCR Elsevier sEH Elsevier KEGG Elsevier PFP Elsevier ntc Elsevier SOX4 Elsevier R 2 Elsevier GH Elsevier EROD Elsevier CI Elsevier AhR Elsevier PLS-DA Elsevier PPARα Elsevier ER Elsevier real-time qPCR Elsevier RTL-W1 Elsevier cGRASP Elsevier PPARγ Elsevier PCA Elsevier THF-diols Elsevier CT Elsevier NMR Elsevier FABP4 Elsevier Q 2 Elsevier NCI Elsevier SIM Elsevier PMTs Elsevier PAHs Elsevier TAG Elsevier EF1AB Elsevier FC Elsevier ARP Elsevier Kirwan, Jennifer A. oth Hori, Tiago S.F. oth Størseth, Trond R. oth Sommer, Ulf oth Berntssen, Marc H.G. oth Viant, Mark R. oth Rise, Matthew L. oth Waagbø, Rune oth Torstensen, Bente E. oth Booman, Marije oth Olsvik, Pål A. oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:73 year:2014 pages:157-174 extent:18 https://doi.org/10.1016/j.fct.2014.08.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 73 2014 157-174 18 045F 630 |
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10.1016/j.fct.2014.08.008 doi GBVA2014009000019.pica (DE-627)ELV01744831X (ELSEVIER)S0278-6915(14)00380-9 DE-627 ger DE-627 rakwb eng 630 640 610 630 DE-600 640 DE-600 610 DE-600 530 620 VZ 52.56 bkl Søfteland, Liv verfasserin aut Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds 2014 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. RTG-2 Elsevier RT Elsevier RTgill-W1 Elsevier DMSO Elsevier MNE Elsevier POPs Elsevier VTG Elsevier FS Elsevier nac Elsevier MAP1LC3B Elsevier QC Elsevier CYP1A Elsevier ANOVA Elsevier RT-PCR Elsevier sEH Elsevier KEGG Elsevier PFP Elsevier ntc Elsevier SOX4 Elsevier R 2 Elsevier GH Elsevier EROD Elsevier CI Elsevier AhR Elsevier PLS-DA Elsevier PPARα Elsevier ER Elsevier real-time qPCR Elsevier RTL-W1 Elsevier cGRASP Elsevier PPARγ Elsevier PCA Elsevier THF-diols Elsevier CT Elsevier NMR Elsevier FABP4 Elsevier Q 2 Elsevier NCI Elsevier SIM Elsevier PMTs Elsevier PAHs Elsevier TAG Elsevier EF1AB Elsevier FC Elsevier ARP Elsevier Kirwan, Jennifer A. oth Hori, Tiago S.F. oth Størseth, Trond R. oth Sommer, Ulf oth Berntssen, Marc H.G. oth Viant, Mark R. oth Rise, Matthew L. oth Waagbø, Rune oth Torstensen, Bente E. oth Booman, Marije oth Olsvik, Pål A. oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:73 year:2014 pages:157-174 extent:18 https://doi.org/10.1016/j.fct.2014.08.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 73 2014 157-174 18 045F 630 |
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10.1016/j.fct.2014.08.008 doi GBVA2014009000019.pica (DE-627)ELV01744831X (ELSEVIER)S0278-6915(14)00380-9 DE-627 ger DE-627 rakwb eng 630 640 610 630 DE-600 640 DE-600 610 DE-600 530 620 VZ 52.56 bkl Søfteland, Liv verfasserin aut Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds 2014 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. RTG-2 Elsevier RT Elsevier RTgill-W1 Elsevier DMSO Elsevier MNE Elsevier POPs Elsevier VTG Elsevier FS Elsevier nac Elsevier MAP1LC3B Elsevier QC Elsevier CYP1A Elsevier ANOVA Elsevier RT-PCR Elsevier sEH Elsevier KEGG Elsevier PFP Elsevier ntc Elsevier SOX4 Elsevier R 2 Elsevier GH Elsevier EROD Elsevier CI Elsevier AhR Elsevier PLS-DA Elsevier PPARα Elsevier ER Elsevier real-time qPCR Elsevier RTL-W1 Elsevier cGRASP Elsevier PPARγ Elsevier PCA Elsevier THF-diols Elsevier CT Elsevier NMR Elsevier FABP4 Elsevier Q 2 Elsevier NCI Elsevier SIM Elsevier PMTs Elsevier PAHs Elsevier TAG Elsevier EF1AB Elsevier FC Elsevier ARP Elsevier Kirwan, Jennifer A. oth Hori, Tiago S.F. oth Størseth, Trond R. oth Sommer, Ulf oth Berntssen, Marc H.G. oth Viant, Mark R. oth Rise, Matthew L. oth Waagbø, Rune oth Torstensen, Bente E. oth Booman, Marije oth Olsvik, Pål A. oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:73 year:2014 pages:157-174 extent:18 https://doi.org/10.1016/j.fct.2014.08.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 73 2014 157-174 18 045F 630 |
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10.1016/j.fct.2014.08.008 doi GBVA2014009000019.pica (DE-627)ELV01744831X (ELSEVIER)S0278-6915(14)00380-9 DE-627 ger DE-627 rakwb eng 630 640 610 630 DE-600 640 DE-600 610 DE-600 530 620 VZ 52.56 bkl Søfteland, Liv verfasserin aut Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds 2014 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. RTG-2 Elsevier RT Elsevier RTgill-W1 Elsevier DMSO Elsevier MNE Elsevier POPs Elsevier VTG Elsevier FS Elsevier nac Elsevier MAP1LC3B Elsevier QC Elsevier CYP1A Elsevier ANOVA Elsevier RT-PCR Elsevier sEH Elsevier KEGG Elsevier PFP Elsevier ntc Elsevier SOX4 Elsevier R 2 Elsevier GH Elsevier EROD Elsevier CI Elsevier AhR Elsevier PLS-DA Elsevier PPARα Elsevier ER Elsevier real-time qPCR Elsevier RTL-W1 Elsevier cGRASP Elsevier PPARγ Elsevier PCA Elsevier THF-diols Elsevier CT Elsevier NMR Elsevier FABP4 Elsevier Q 2 Elsevier NCI Elsevier SIM Elsevier PMTs Elsevier PAHs Elsevier TAG Elsevier EF1AB Elsevier FC Elsevier ARP Elsevier Kirwan, Jennifer A. oth Hori, Tiago S.F. oth Størseth, Trond R. oth Sommer, Ulf oth Berntssen, Marc H.G. oth Viant, Mark R. oth Rise, Matthew L. oth Waagbø, Rune oth Torstensen, Bente E. oth Booman, Marije oth Olsvik, Pål A. oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:73 year:2014 pages:157-174 extent:18 https://doi.org/10.1016/j.fct.2014.08.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 73 2014 157-174 18 045F 630 |
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Numerical simulations on static Vertical Axis Wind Turbine blade icing |
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Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds |
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• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. |
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• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. |
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• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. |
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