Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro
• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Erratico, Claudio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
12 |
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| Übergeordnetes Werk: |
Enthalten in: Toxicology letters - Chen, Yun-Ru ELSEVIER, 2019, an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:236 ; year:2015 ; number:2 ; day:16 ; month:07 ; pages:98-109 ; extent:12 |
| Links: |
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| DOI / URN: |
10.1016/j.toxlet.2015.05.003 |
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ELV034603573 |
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| 520 | |a • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. | ||
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| 650 | 7 | |a 2′-OH-BDE-118 |2 Elsevier | |
| 650 | 7 | |a 2′-OH-BDE-28 |2 Elsevier | |
| 650 | 7 | |a 5′-OH-BDE-99 |2 Elsevier | |
| 650 | 7 | |a 2,4,5-TBP |2 Elsevier | |
| 650 | 7 | |a Naphth-Gluc |2 Elsevier | |
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| 700 | 1 | |a Zheng, Xiaobo |4 oth | |
| 700 | 1 | |a Ryden, Andreas |4 oth | |
| 700 | 1 | |a Marsh, Goran |4 oth | |
| 700 | 1 | |a Maho, Walid |4 oth | |
| 700 | 1 | |a Covaci, Adrian |4 oth | |
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10.1016/j.toxlet.2015.05.003 doi GBVA2015012000029.pica (DE-627)ELV034603573 (ELSEVIER)S0378-4274(15)00163-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Erratico, Claudio verfasserin aut Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro 2015 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. 2,4-DBP Elsevier HLCYT Elsevier 5-OH-BDE-47 Elsevier 6′-OH-BDE-99 Elsevier 3-OH-BDE-47 Elsevier HLM Elsevier 4-NP-Sulf Elsevier 3′-OH-BDE-99 Elsevier PAPS Elsevier 3-OH-BDE-100 Elsevier 6-OH-BDE-99 Elsevier Indolyl-Sulf Elsevier 4′-OH-BDE-49 Elsevier 4-NP-Gluc Elsevier 4-OH-BDE-42 Elsevier 3-OH-BDE-99 Elsevier 2′-OH-BDE-118 Elsevier 2′-OH-BDE-28 Elsevier 5′-OH-BDE-99 Elsevier 2,4,5-TBP Elsevier Naphth-Gluc Elsevier 2′-OH-BDE-66 Elsevier UDPGA Elsevier 6-OH-BDE-47 Elsevier 4′-OH-BDE-17 Elsevier Zheng, Xiaobo oth Ryden, Andreas oth Marsh, Goran oth Maho, Walid oth Covaci, Adrian oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:236 year:2015 number:2 day:16 month:07 pages:98-109 extent:12 https://doi.org/10.1016/j.toxlet.2015.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 236 2015 2 16 0716 98-109 12 045F 570 |
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10.1016/j.toxlet.2015.05.003 doi GBVA2015012000029.pica (DE-627)ELV034603573 (ELSEVIER)S0378-4274(15)00163-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Erratico, Claudio verfasserin aut Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro 2015 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. 2,4-DBP Elsevier HLCYT Elsevier 5-OH-BDE-47 Elsevier 6′-OH-BDE-99 Elsevier 3-OH-BDE-47 Elsevier HLM Elsevier 4-NP-Sulf Elsevier 3′-OH-BDE-99 Elsevier PAPS Elsevier 3-OH-BDE-100 Elsevier 6-OH-BDE-99 Elsevier Indolyl-Sulf Elsevier 4′-OH-BDE-49 Elsevier 4-NP-Gluc Elsevier 4-OH-BDE-42 Elsevier 3-OH-BDE-99 Elsevier 2′-OH-BDE-118 Elsevier 2′-OH-BDE-28 Elsevier 5′-OH-BDE-99 Elsevier 2,4,5-TBP Elsevier Naphth-Gluc Elsevier 2′-OH-BDE-66 Elsevier UDPGA Elsevier 6-OH-BDE-47 Elsevier 4′-OH-BDE-17 Elsevier Zheng, Xiaobo oth Ryden, Andreas oth Marsh, Goran oth Maho, Walid oth Covaci, Adrian oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:236 year:2015 number:2 day:16 month:07 pages:98-109 extent:12 https://doi.org/10.1016/j.toxlet.2015.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 236 2015 2 16 0716 98-109 12 045F 570 |
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10.1016/j.toxlet.2015.05.003 doi GBVA2015012000029.pica (DE-627)ELV034603573 (ELSEVIER)S0378-4274(15)00163-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Erratico, Claudio verfasserin aut Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro 2015 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. 2,4-DBP Elsevier HLCYT Elsevier 5-OH-BDE-47 Elsevier 6′-OH-BDE-99 Elsevier 3-OH-BDE-47 Elsevier HLM Elsevier 4-NP-Sulf Elsevier 3′-OH-BDE-99 Elsevier PAPS Elsevier 3-OH-BDE-100 Elsevier 6-OH-BDE-99 Elsevier Indolyl-Sulf Elsevier 4′-OH-BDE-49 Elsevier 4-NP-Gluc Elsevier 4-OH-BDE-42 Elsevier 3-OH-BDE-99 Elsevier 2′-OH-BDE-118 Elsevier 2′-OH-BDE-28 Elsevier 5′-OH-BDE-99 Elsevier 2,4,5-TBP Elsevier Naphth-Gluc Elsevier 2′-OH-BDE-66 Elsevier UDPGA Elsevier 6-OH-BDE-47 Elsevier 4′-OH-BDE-17 Elsevier Zheng, Xiaobo oth Ryden, Andreas oth Marsh, Goran oth Maho, Walid oth Covaci, Adrian oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:236 year:2015 number:2 day:16 month:07 pages:98-109 extent:12 https://doi.org/10.1016/j.toxlet.2015.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 236 2015 2 16 0716 98-109 12 045F 570 |
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10.1016/j.toxlet.2015.05.003 doi GBVA2015012000029.pica (DE-627)ELV034603573 (ELSEVIER)S0378-4274(15)00163-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Erratico, Claudio verfasserin aut Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro 2015 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. 2,4-DBP Elsevier HLCYT Elsevier 5-OH-BDE-47 Elsevier 6′-OH-BDE-99 Elsevier 3-OH-BDE-47 Elsevier HLM Elsevier 4-NP-Sulf Elsevier 3′-OH-BDE-99 Elsevier PAPS Elsevier 3-OH-BDE-100 Elsevier 6-OH-BDE-99 Elsevier Indolyl-Sulf Elsevier 4′-OH-BDE-49 Elsevier 4-NP-Gluc Elsevier 4-OH-BDE-42 Elsevier 3-OH-BDE-99 Elsevier 2′-OH-BDE-118 Elsevier 2′-OH-BDE-28 Elsevier 5′-OH-BDE-99 Elsevier 2,4,5-TBP Elsevier Naphth-Gluc Elsevier 2′-OH-BDE-66 Elsevier UDPGA Elsevier 6-OH-BDE-47 Elsevier 4′-OH-BDE-17 Elsevier Zheng, Xiaobo oth Ryden, Andreas oth Marsh, Goran oth Maho, Walid oth Covaci, Adrian oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:236 year:2015 number:2 day:16 month:07 pages:98-109 extent:12 https://doi.org/10.1016/j.toxlet.2015.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 236 2015 2 16 0716 98-109 12 045F 570 |
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10.1016/j.toxlet.2015.05.003 doi GBVA2015012000029.pica (DE-627)ELV034603573 (ELSEVIER)S0378-4274(15)00163-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Erratico, Claudio verfasserin aut Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro 2015 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. 2,4-DBP Elsevier HLCYT Elsevier 5-OH-BDE-47 Elsevier 6′-OH-BDE-99 Elsevier 3-OH-BDE-47 Elsevier HLM Elsevier 4-NP-Sulf Elsevier 3′-OH-BDE-99 Elsevier PAPS Elsevier 3-OH-BDE-100 Elsevier 6-OH-BDE-99 Elsevier Indolyl-Sulf Elsevier 4′-OH-BDE-49 Elsevier 4-NP-Gluc Elsevier 4-OH-BDE-42 Elsevier 3-OH-BDE-99 Elsevier 2′-OH-BDE-118 Elsevier 2′-OH-BDE-28 Elsevier 5′-OH-BDE-99 Elsevier 2,4,5-TBP Elsevier Naphth-Gluc Elsevier 2′-OH-BDE-66 Elsevier UDPGA Elsevier 6-OH-BDE-47 Elsevier 4′-OH-BDE-17 Elsevier Zheng, Xiaobo oth Ryden, Andreas oth Marsh, Goran oth Maho, Walid oth Covaci, Adrian oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:236 year:2015 number:2 day:16 month:07 pages:98-109 extent:12 https://doi.org/10.1016/j.toxlet.2015.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 236 2015 2 16 0716 98-109 12 045F 570 |
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Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro |
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• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. |
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• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. |
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• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. |
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