Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities
A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully cha...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mahmoud, Walaa H. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
14 |
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| Übergeordnetes Werk: |
Enthalten in: The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial - Li, Chenglong ELSEVIER, 2019, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:848 ; year:2017 ; day:15 ; month:10 ; pages:288-301 ; extent:14 |
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| DOI / URN: |
10.1016/j.jorganchem.2017.08.001 |
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| Katalog-ID: |
ELV036207446 |
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| 245 | 1 | 0 | |a Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities |
| 264 | 1 | |c 2017transfer abstract | |
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| 520 | |a A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). | ||
| 520 | |a A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). | ||
| 650 | 7 | |a Pathogenic strains |2 Elsevier | |
| 650 | 7 | |a SEM |2 Elsevier | |
| 650 | 7 | |a Ferrocene Schiff base complexes |2 Elsevier | |
| 650 | 7 | |a Molecular docking |2 Elsevier | |
| 700 | 1 | |a Mahmoud, Nessma F. |4 oth | |
| 700 | 1 | |a Mohamed, Gehad G. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Li, Chenglong ELSEVIER |t The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial |d 2019 |g New York, NY [u.a.] |w (DE-627)ELV002971518 |
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10.1016/j.jorganchem.2017.08.001 doi GBV00000000000318_01.pica (DE-627)ELV036207446 (ELSEVIER)S0022-328X(17)30477-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl 44.66 bkl Mahmoud, Walaa H. verfasserin aut Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities 2017transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). Pathogenic strains Elsevier SEM Elsevier Ferrocene Schiff base complexes Elsevier Molecular docking Elsevier Mahmoud, Nessma F. oth Mohamed, Gehad G. oth Enthalten in Elsevier Li, Chenglong ELSEVIER The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial 2019 New York, NY [u.a.] (DE-627)ELV002971518 volume:848 year:2017 day:15 month:10 pages:288-301 extent:14 https://doi.org/10.1016/j.jorganchem.2017.08.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.66 Anästhesiologie VZ AR 848 2017 15 1015 288-301 14 |
| spelling |
10.1016/j.jorganchem.2017.08.001 doi GBV00000000000318_01.pica (DE-627)ELV036207446 (ELSEVIER)S0022-328X(17)30477-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl 44.66 bkl Mahmoud, Walaa H. verfasserin aut Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities 2017transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). Pathogenic strains Elsevier SEM Elsevier Ferrocene Schiff base complexes Elsevier Molecular docking Elsevier Mahmoud, Nessma F. oth Mohamed, Gehad G. oth Enthalten in Elsevier Li, Chenglong ELSEVIER The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial 2019 New York, NY [u.a.] (DE-627)ELV002971518 volume:848 year:2017 day:15 month:10 pages:288-301 extent:14 https://doi.org/10.1016/j.jorganchem.2017.08.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.66 Anästhesiologie VZ AR 848 2017 15 1015 288-301 14 |
| allfields_unstemmed |
10.1016/j.jorganchem.2017.08.001 doi GBV00000000000318_01.pica (DE-627)ELV036207446 (ELSEVIER)S0022-328X(17)30477-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl 44.66 bkl Mahmoud, Walaa H. verfasserin aut Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities 2017transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). Pathogenic strains Elsevier SEM Elsevier Ferrocene Schiff base complexes Elsevier Molecular docking Elsevier Mahmoud, Nessma F. oth Mohamed, Gehad G. oth Enthalten in Elsevier Li, Chenglong ELSEVIER The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial 2019 New York, NY [u.a.] (DE-627)ELV002971518 volume:848 year:2017 day:15 month:10 pages:288-301 extent:14 https://doi.org/10.1016/j.jorganchem.2017.08.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.66 Anästhesiologie VZ AR 848 2017 15 1015 288-301 14 |
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10.1016/j.jorganchem.2017.08.001 doi GBV00000000000318_01.pica (DE-627)ELV036207446 (ELSEVIER)S0022-328X(17)30477-1 DE-627 ger DE-627 rakwb eng 610 VZ 44.85 bkl 44.66 bkl Mahmoud, Walaa H. verfasserin aut Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities 2017transfer abstract 14 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). Pathogenic strains Elsevier SEM Elsevier Ferrocene Schiff base complexes Elsevier Molecular docking Elsevier Mahmoud, Nessma F. oth Mohamed, Gehad G. oth Enthalten in Elsevier Li, Chenglong ELSEVIER The Effect of Simultaneous Renal Replacement Therapy on Extracorporeal Membrane Oxygenation Support for Postcardiotomy Patients with Cardiogenic Shock: A Pilot Randomized Controlled Trial 2019 New York, NY [u.a.] (DE-627)ELV002971518 volume:848 year:2017 day:15 month:10 pages:288-301 extent:14 https://doi.org/10.1016/j.jorganchem.2017.08.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.66 Anästhesiologie VZ AR 848 2017 15 1015 288-301 14 |
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mixed ligand complexes of the novel nanoferrocene based schiff base ligand (hl): synthesis, spectroscopic characterization, moe studies and antimicrobial/anticancer activities |
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Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities |
| abstract |
A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). |
| abstractGer |
A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). |
| abstract_unstemmed |
A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). |
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| title_short |
Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities |
| url |
https://doi.org/10.1016/j.jorganchem.2017.08.001 |
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Mahmoud, Nessma F. Mohamed, Gehad G. |
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10.1016/j.jorganchem.2017.08.001 |
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2024-07-06T19:35:22.585Z |
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