In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus
• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Muniz, Débora Feitosa [verfasserIn] dos Santos Barbosa, Cristina Rodrigues de Menezes, Irwin Rose Alencar de Morais Oliveira-Tintino, Cícera Datiane |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn - Yurtseven, H. ELSEVIER, 2018, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:337 ; year:2021 ; day:1 ; month:02 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1016/j.foodchem.2020.127776 |
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| 520 | |a • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. | ||
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10.1016/j.foodchem.2020.127776 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001155.pica (DE-627)ELV05158400X (ELSEVIER)S0308-8146(20)31638-1 DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Muniz, Débora Feitosa verfasserin aut In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus 2021 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Eugenol derivatives Elsevier Efflux pump inhibitors Elsevier Antibiotic resistance Elsevier Staphylococcus aureus Elsevier dos Santos Barbosa, Cristina Rodrigues oth de Menezes, Irwin Rose Alencar oth de Sousa, Erlânio Oliveira oth Pereira, Raimundo Luiz Silva oth Júnior, João Tavares Calixto oth Pereira, Pedro Silvino oth de Matos, Yedda M.L.S. oth da Costa, Roger H.S. oth de Morais Oliveira-Tintino, Cícera Datiane oth Coutinho, Henrique Douglas Melo oth Filho, José Maria Barbosa oth Ribeiro de Sousa, Gabriela oth Filho, Jaime Ribeiro oth Siqueira-Junior, José Pinto oth Tintino, Saulo Relison oth Enthalten in Elsevier Yurtseven, H. ELSEVIER Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn 2018 New York, NY [u.a.] (DE-627)ELV000463221 volume:337 year:2021 day:1 month:02 pages:0 https://doi.org/10.1016/j.foodchem.2020.127776 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 337 2021 1 0201 0 |
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10.1016/j.foodchem.2020.127776 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001155.pica (DE-627)ELV05158400X (ELSEVIER)S0308-8146(20)31638-1 DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Muniz, Débora Feitosa verfasserin aut In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus 2021 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Eugenol derivatives Elsevier Efflux pump inhibitors Elsevier Antibiotic resistance Elsevier Staphylococcus aureus Elsevier dos Santos Barbosa, Cristina Rodrigues oth de Menezes, Irwin Rose Alencar oth de Sousa, Erlânio Oliveira oth Pereira, Raimundo Luiz Silva oth Júnior, João Tavares Calixto oth Pereira, Pedro Silvino oth de Matos, Yedda M.L.S. oth da Costa, Roger H.S. oth de Morais Oliveira-Tintino, Cícera Datiane oth Coutinho, Henrique Douglas Melo oth Filho, José Maria Barbosa oth Ribeiro de Sousa, Gabriela oth Filho, Jaime Ribeiro oth Siqueira-Junior, José Pinto oth Tintino, Saulo Relison oth Enthalten in Elsevier Yurtseven, H. ELSEVIER Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn 2018 New York, NY [u.a.] (DE-627)ELV000463221 volume:337 year:2021 day:1 month:02 pages:0 https://doi.org/10.1016/j.foodchem.2020.127776 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 337 2021 1 0201 0 |
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10.1016/j.foodchem.2020.127776 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001155.pica (DE-627)ELV05158400X (ELSEVIER)S0308-8146(20)31638-1 DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Muniz, Débora Feitosa verfasserin aut In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus 2021 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Eugenol derivatives Elsevier Efflux pump inhibitors Elsevier Antibiotic resistance Elsevier Staphylococcus aureus Elsevier dos Santos Barbosa, Cristina Rodrigues oth de Menezes, Irwin Rose Alencar oth de Sousa, Erlânio Oliveira oth Pereira, Raimundo Luiz Silva oth Júnior, João Tavares Calixto oth Pereira, Pedro Silvino oth de Matos, Yedda M.L.S. oth da Costa, Roger H.S. oth de Morais Oliveira-Tintino, Cícera Datiane oth Coutinho, Henrique Douglas Melo oth Filho, José Maria Barbosa oth Ribeiro de Sousa, Gabriela oth Filho, Jaime Ribeiro oth Siqueira-Junior, José Pinto oth Tintino, Saulo Relison oth Enthalten in Elsevier Yurtseven, H. ELSEVIER Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn 2018 New York, NY [u.a.] (DE-627)ELV000463221 volume:337 year:2021 day:1 month:02 pages:0 https://doi.org/10.1016/j.foodchem.2020.127776 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 337 2021 1 0201 0 |
| allfieldsGer |
10.1016/j.foodchem.2020.127776 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001155.pica (DE-627)ELV05158400X (ELSEVIER)S0308-8146(20)31638-1 DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Muniz, Débora Feitosa verfasserin aut In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus 2021 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Eugenol derivatives Elsevier Efflux pump inhibitors Elsevier Antibiotic resistance Elsevier Staphylococcus aureus Elsevier dos Santos Barbosa, Cristina Rodrigues oth de Menezes, Irwin Rose Alencar oth de Sousa, Erlânio Oliveira oth Pereira, Raimundo Luiz Silva oth Júnior, João Tavares Calixto oth Pereira, Pedro Silvino oth de Matos, Yedda M.L.S. oth da Costa, Roger H.S. oth de Morais Oliveira-Tintino, Cícera Datiane oth Coutinho, Henrique Douglas Melo oth Filho, José Maria Barbosa oth Ribeiro de Sousa, Gabriela oth Filho, Jaime Ribeiro oth Siqueira-Junior, José Pinto oth Tintino, Saulo Relison oth Enthalten in Elsevier Yurtseven, H. ELSEVIER Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn 2018 New York, NY [u.a.] (DE-627)ELV000463221 volume:337 year:2021 day:1 month:02 pages:0 https://doi.org/10.1016/j.foodchem.2020.127776 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 337 2021 1 0201 0 |
| allfieldsSound |
10.1016/j.foodchem.2020.127776 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001155.pica (DE-627)ELV05158400X (ELSEVIER)S0308-8146(20)31638-1 DE-627 ger DE-627 rakwb eng 540 VZ 35.00 bkl Muniz, Débora Feitosa verfasserin aut In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus 2021 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Eugenol derivatives Elsevier Efflux pump inhibitors Elsevier Antibiotic resistance Elsevier Staphylococcus aureus Elsevier dos Santos Barbosa, Cristina Rodrigues oth de Menezes, Irwin Rose Alencar oth de Sousa, Erlânio Oliveira oth Pereira, Raimundo Luiz Silva oth Júnior, João Tavares Calixto oth Pereira, Pedro Silvino oth de Matos, Yedda M.L.S. oth da Costa, Roger H.S. oth de Morais Oliveira-Tintino, Cícera Datiane oth Coutinho, Henrique Douglas Melo oth Filho, José Maria Barbosa oth Ribeiro de Sousa, Gabriela oth Filho, Jaime Ribeiro oth Siqueira-Junior, José Pinto oth Tintino, Saulo Relison oth Enthalten in Elsevier Yurtseven, H. ELSEVIER Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn 2018 New York, NY [u.a.] (DE-627)ELV000463221 volume:337 year:2021 day:1 month:02 pages:0 https://doi.org/10.1016/j.foodchem.2020.127776 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 337 2021 1 0201 0 |
| language |
English |
| source |
Enthalten in Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn New York, NY [u.a.] volume:337 year:2021 day:1 month:02 pages:0 |
| sourceStr |
Enthalten in Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn New York, NY [u.a.] volume:337 year:2021 day:1 month:02 pages:0 |
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Eugenol derivatives Efflux pump inhibitors Antibiotic resistance Staphylococcus aureus |
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Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn |
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Muniz, Débora Feitosa @@aut@@ dos Santos Barbosa, Cristina Rodrigues @@oth@@ de Menezes, Irwin Rose Alencar @@oth@@ de Sousa, Erlânio Oliveira @@oth@@ Pereira, Raimundo Luiz Silva @@oth@@ Júnior, João Tavares Calixto @@oth@@ Pereira, Pedro Silvino @@oth@@ de Matos, Yedda M.L.S. @@oth@@ da Costa, Roger H.S. @@oth@@ de Morais Oliveira-Tintino, Cícera Datiane @@oth@@ Coutinho, Henrique Douglas Melo @@oth@@ Filho, José Maria Barbosa @@oth@@ Ribeiro de Sousa, Gabriela @@oth@@ Filho, Jaime Ribeiro @@oth@@ Siqueira-Junior, José Pinto @@oth@@ Tintino, Saulo Relison @@oth@@ |
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Temperature and the field dependence of the magnetization close to order–disorder phase transitions in DMMn and the chromium-doped DMMn |
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in vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the nora efflux pump in staphylococcus aureus |
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In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus |
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• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. |
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• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. |
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• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. |
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In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus |
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