miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation
• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes prol...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Hong [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2021 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
Enthalten in: International immunopharmacology - Laupland, Kevin B. ELSEVIER, 2022, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:96 ; year:2021 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.intimp.2021.107587 |
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ELV054455073 |
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| 520 | |a • miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment. | ||
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miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation |
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• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment. |
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• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment. |
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• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV054455073</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230624211524.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210910s2021 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.intimp.2021.107587</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001877.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV054455073</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1567-5769(21)00223-X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.75</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wang, Hong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2021</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cell proliferation</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Psoriasis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Lipocalin-2</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">microRNA-383</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Keratinocyte</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">JAK/STAT</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Apoptosis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xu, Yangchun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jin, Meishan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Hongxia</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Shanshan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Laupland, Kevin B. 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