Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids
Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosp...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Brown, Michael L. [verfasserIn] Marshall, Lisa A. [verfasserIn] Johnston, Patricia V. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1984 |
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Online-Ressource |
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2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 43(1984), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:43 ; year:1984 ; number:5 ; pages:0 |
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| DOI / URN: |
10.1111/j.1471-4159.1984.tb05399.x |
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| 520 | |a Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. | ||
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10.1111/j.1471-4159.1984.tb05399.x doi (DE-627)NLEJ240302591 DE-627 ger DE-627 rakwb Brown, Michael L. verfasserin aut Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Essential fatty acids Marshall, Lisa A. verfasserin aut Johnston, Patricia V. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 43(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:43 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 1984 5 0 |
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10.1111/j.1471-4159.1984.tb05399.x doi (DE-627)NLEJ240302591 DE-627 ger DE-627 rakwb Brown, Michael L. verfasserin aut Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Essential fatty acids Marshall, Lisa A. verfasserin aut Johnston, Patricia V. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 43(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:43 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 1984 5 0 |
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10.1111/j.1471-4159.1984.tb05399.x doi (DE-627)NLEJ240302591 DE-627 ger DE-627 rakwb Brown, Michael L. verfasserin aut Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Essential fatty acids Marshall, Lisa A. verfasserin aut Johnston, Patricia V. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 43(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:43 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 1984 5 0 |
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10.1111/j.1471-4159.1984.tb05399.x doi (DE-627)NLEJ240302591 DE-627 ger DE-627 rakwb Brown, Michael L. verfasserin aut Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Essential fatty acids Marshall, Lisa A. verfasserin aut Johnston, Patricia V. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 43(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:43 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 1984 5 0 |
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10.1111/j.1471-4159.1984.tb05399.x doi (DE-627)NLEJ240302591 DE-627 ger DE-627 rakwb Brown, Michael L. verfasserin aut Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Essential fatty acids Marshall, Lisa A. verfasserin aut Johnston, Patricia V. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 43(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:43 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 1984 5 0 |
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Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. |
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Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ240302591</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707105904.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1984 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1471-4159.1984.tb05399.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ240302591</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Brown, Michael L.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Alterations in Cerebral and Microvascular Prostaglandin Synthesis by Manipulation of Dietary Essential Fatty Acids</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1984</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract: Sprague-Dawley rats were fed one of three purified diets—10% corn oil, 10% hydrogenated coconut oil, or 10% linseed oil—through two generations. At 60–80 days of age the animals were sacrificed. The fatty acyl composition of phosphatidylcholine, phosphatidyletha-nolamine, plasmalogen phosphatidylethanolamine, and combined phosphatidylinositol/phosphatidylserine from cerebral cortex and isolated cerebral microvessels was determined. Brain slice prostaglandin F2α or microvas-cular prostacyclin synthesis was also measured. Major changes were noted in the fatty acid profiles, most dramatically in the phosphatidylethanolamine and ethanol-amine plasmalogen fractions, with an active rise in docosahexaenoic acid resulting from linseed oil feeding. A depression in prostaglandin F2α synthesis was seen in brain slices of hydrogenated coconut oil-and linseed oil-fed rats. Such a depression was also observed in micro-vascular prostaglandin synthesis at basal and stimulated levels but not in control incubations. The potential importance of these findings to cerebral microcirculation and hemostasis is discussed.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Essential fatty acids</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marshall, Lisa A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Johnston, Patricia V.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of neurochemistry</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1956</subfield><subfield code="g">43(1984), 5, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927584</subfield><subfield code="w">(DE-600)2020528-4</subfield><subfield code="x">1471-4159</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:43</subfield><subfield code="g">year:1984</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1471-4159.1984.tb05399.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">43</subfield><subfield code="j">1984</subfield><subfield code="e">5</subfield><subfield code="h">0</subfield></datafield></record></collection>
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