Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity
Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, JinFeng [verfasserIn] Zhao, JiuLong [verfasserIn] Chen, YongKang [verfasserIn] Zheng, YuTing [verfasserIn] Zhou, LingLing [verfasserIn] Zhao, JiaYan [verfasserIn] Liu, YiYun [verfasserIn] Liu, XiuYing [verfasserIn] Wang, ShiGe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Science in China - Heidelberg : Springer, 1997, 63(2020), 11 vom: 14. Aug., Seite 2403-2412 |
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| Übergeordnetes Werk: |
volume:63 ; year:2020 ; number:11 ; day:14 ; month:08 ; pages:2403-2412 |
| Links: |
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| DOI / URN: |
10.1007/s11431-020-1623-8 |
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| Katalog-ID: |
SPR041917103 |
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| 520 | |a Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. | ||
| 650 | 4 | |a sodium alginate |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a hydrogel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a starvation therapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a chemical dynamic therapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhao, JiuLong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, YongKang |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, YuTing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, LingLing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, JiaYan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, YiYun |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, XiuYing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, ShiGe |e verfasserin |4 aut | |
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10.1007/s11431-020-1623-8 doi (DE-627)SPR041917103 (SPR)s11431-020-1623-8-e DE-627 ger DE-627 rakwb eng 600 ASE 600 ASE 50.00 bkl Li, JinFeng verfasserin aut Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. sodium alginate (dpeaa)DE-He213 hydrogel (dpeaa)DE-He213 starvation therapy (dpeaa)DE-He213 chemical dynamic therapy (dpeaa)DE-He213 Zhao, JiuLong verfasserin aut Chen, YongKang verfasserin aut Zheng, YuTing verfasserin aut Zhou, LingLing verfasserin aut Zhao, JiaYan verfasserin aut Liu, YiYun verfasserin aut Liu, XiuYing verfasserin aut Wang, ShiGe verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2020), 11 vom: 14. Aug., Seite 2403-2412 (DE-627)385614756 (DE-600)2142897-9 1862-281X nnns volume:63 year:2020 number:11 day:14 month:08 pages:2403-2412 https://dx.doi.org/10.1007/s11431-020-1623-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 50.00 ASE AR 63 2020 11 14 08 2403-2412 |
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10.1007/s11431-020-1623-8 doi (DE-627)SPR041917103 (SPR)s11431-020-1623-8-e DE-627 ger DE-627 rakwb eng 600 ASE 600 ASE 50.00 bkl Li, JinFeng verfasserin aut Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. sodium alginate (dpeaa)DE-He213 hydrogel (dpeaa)DE-He213 starvation therapy (dpeaa)DE-He213 chemical dynamic therapy (dpeaa)DE-He213 Zhao, JiuLong verfasserin aut Chen, YongKang verfasserin aut Zheng, YuTing verfasserin aut Zhou, LingLing verfasserin aut Zhao, JiaYan verfasserin aut Liu, YiYun verfasserin aut Liu, XiuYing verfasserin aut Wang, ShiGe verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2020), 11 vom: 14. Aug., Seite 2403-2412 (DE-627)385614756 (DE-600)2142897-9 1862-281X nnns volume:63 year:2020 number:11 day:14 month:08 pages:2403-2412 https://dx.doi.org/10.1007/s11431-020-1623-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 50.00 ASE AR 63 2020 11 14 08 2403-2412 |
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10.1007/s11431-020-1623-8 doi (DE-627)SPR041917103 (SPR)s11431-020-1623-8-e DE-627 ger DE-627 rakwb eng 600 ASE 600 ASE 50.00 bkl Li, JinFeng verfasserin aut Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. sodium alginate (dpeaa)DE-He213 hydrogel (dpeaa)DE-He213 starvation therapy (dpeaa)DE-He213 chemical dynamic therapy (dpeaa)DE-He213 Zhao, JiuLong verfasserin aut Chen, YongKang verfasserin aut Zheng, YuTing verfasserin aut Zhou, LingLing verfasserin aut Zhao, JiaYan verfasserin aut Liu, YiYun verfasserin aut Liu, XiuYing verfasserin aut Wang, ShiGe verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2020), 11 vom: 14. Aug., Seite 2403-2412 (DE-627)385614756 (DE-600)2142897-9 1862-281X nnns volume:63 year:2020 number:11 day:14 month:08 pages:2403-2412 https://dx.doi.org/10.1007/s11431-020-1623-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 50.00 ASE AR 63 2020 11 14 08 2403-2412 |
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10.1007/s11431-020-1623-8 doi (DE-627)SPR041917103 (SPR)s11431-020-1623-8-e DE-627 ger DE-627 rakwb eng 600 ASE 600 ASE 50.00 bkl Li, JinFeng verfasserin aut Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. sodium alginate (dpeaa)DE-He213 hydrogel (dpeaa)DE-He213 starvation therapy (dpeaa)DE-He213 chemical dynamic therapy (dpeaa)DE-He213 Zhao, JiuLong verfasserin aut Chen, YongKang verfasserin aut Zheng, YuTing verfasserin aut Zhou, LingLing verfasserin aut Zhao, JiaYan verfasserin aut Liu, YiYun verfasserin aut Liu, XiuYing verfasserin aut Wang, ShiGe verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2020), 11 vom: 14. Aug., Seite 2403-2412 (DE-627)385614756 (DE-600)2142897-9 1862-281X nnns volume:63 year:2020 number:11 day:14 month:08 pages:2403-2412 https://dx.doi.org/10.1007/s11431-020-1623-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 50.00 ASE AR 63 2020 11 14 08 2403-2412 |
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10.1007/s11431-020-1623-8 doi (DE-627)SPR041917103 (SPR)s11431-020-1623-8-e DE-627 ger DE-627 rakwb eng 600 ASE 600 ASE 50.00 bkl Li, JinFeng verfasserin aut Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. sodium alginate (dpeaa)DE-He213 hydrogel (dpeaa)DE-He213 starvation therapy (dpeaa)DE-He213 chemical dynamic therapy (dpeaa)DE-He213 Zhao, JiuLong verfasserin aut Chen, YongKang verfasserin aut Zheng, YuTing verfasserin aut Zhou, LingLing verfasserin aut Zhao, JiaYan verfasserin aut Liu, YiYun verfasserin aut Liu, XiuYing verfasserin aut Wang, ShiGe verfasserin aut Enthalten in Science in China Heidelberg : Springer, 1997 63(2020), 11 vom: 14. Aug., Seite 2403-2412 (DE-627)385614756 (DE-600)2142897-9 1862-281X nnns volume:63 year:2020 number:11 day:14 month:08 pages:2403-2412 https://dx.doi.org/10.1007/s11431-020-1623-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 50.00 ASE AR 63 2020 11 14 08 2403-2412 |
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Li, JinFeng @@aut@@ Zhao, JiuLong @@aut@@ Chen, YongKang @@aut@@ Zheng, YuTing @@aut@@ Zhou, LingLing @@aut@@ Zhao, JiaYan @@aut@@ Liu, YiYun @@aut@@ Liu, XiuYing @@aut@@ Wang, ShiGe @@aut@@ |
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design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity |
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Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity |
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Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. |
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Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. |
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Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. |
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In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. 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