Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries

Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of indi...
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Autor*in:	Dumancas, Gerard G. [verfasserIn] Rachal, Megan Zamora, Pia Regina Fatima C. de Castro, Romulo

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Genome-wide association study GWAS Developing country Feasibility Phenotype

Anmerkung:	© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Current epidemiology reports - Cham : Springer Internat. Publ., 2014, 9(2022), 4 vom: 25. Aug., Seite 376-386
Übergeordnetes Werk:	volume:9 ; year:2022 ; number:4 ; day:25 ; month:08 ; pages:376-386

Links:	Volltext

DOI / URN:	10.1007/s40471-022-00303-x

Katalog-ID:	SPR048775495

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520			\|a Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies.
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allfields	10.1007/s40471-022-00303-x doi (DE-627)SPR048775495 (SPR)s40471-022-00303-x-e DE-627 ger DE-627 rakwb eng Dumancas, Gerard G. verfasserin aut Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Genome-wide association study (dpeaa)DE-He213 GWAS (dpeaa)DE-He213 Developing country (dpeaa)DE-He213 Feasibility (dpeaa)DE-He213 Phenotype (dpeaa)DE-He213 Rachal, Megan aut Zamora, Pia Regina Fatima C. aut de Castro, Romulo aut Enthalten in Current epidemiology reports Cham : Springer Internat. Publ., 2014 9(2022), 4 vom: 25. Aug., Seite 376-386 (DE-627)780378342 (DE-600)2760296-5 2196-2995 nnns volume:9 year:2022 number:4 day:25 month:08 pages:376-386 https://dx.doi.org/10.1007/s40471-022-00303-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 4 25 08 376-386
spelling	10.1007/s40471-022-00303-x doi (DE-627)SPR048775495 (SPR)s40471-022-00303-x-e DE-627 ger DE-627 rakwb eng Dumancas, Gerard G. verfasserin aut Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Genome-wide association study (dpeaa)DE-He213 GWAS (dpeaa)DE-He213 Developing country (dpeaa)DE-He213 Feasibility (dpeaa)DE-He213 Phenotype (dpeaa)DE-He213 Rachal, Megan aut Zamora, Pia Regina Fatima C. aut de Castro, Romulo aut Enthalten in Current epidemiology reports Cham : Springer Internat. Publ., 2014 9(2022), 4 vom: 25. Aug., Seite 376-386 (DE-627)780378342 (DE-600)2760296-5 2196-2995 nnns volume:9 year:2022 number:4 day:25 month:08 pages:376-386 https://dx.doi.org/10.1007/s40471-022-00303-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 4 25 08 376-386
allfields_unstemmed	10.1007/s40471-022-00303-x doi (DE-627)SPR048775495 (SPR)s40471-022-00303-x-e DE-627 ger DE-627 rakwb eng Dumancas, Gerard G. verfasserin aut Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Genome-wide association study (dpeaa)DE-He213 GWAS (dpeaa)DE-He213 Developing country (dpeaa)DE-He213 Feasibility (dpeaa)DE-He213 Phenotype (dpeaa)DE-He213 Rachal, Megan aut Zamora, Pia Regina Fatima C. aut de Castro, Romulo aut Enthalten in Current epidemiology reports Cham : Springer Internat. Publ., 2014 9(2022), 4 vom: 25. Aug., Seite 376-386 (DE-627)780378342 (DE-600)2760296-5 2196-2995 nnns volume:9 year:2022 number:4 day:25 month:08 pages:376-386 https://dx.doi.org/10.1007/s40471-022-00303-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 4 25 08 376-386
allfieldsGer	10.1007/s40471-022-00303-x doi (DE-627)SPR048775495 (SPR)s40471-022-00303-x-e DE-627 ger DE-627 rakwb eng Dumancas, Gerard G. verfasserin aut Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Genome-wide association study (dpeaa)DE-He213 GWAS (dpeaa)DE-He213 Developing country (dpeaa)DE-He213 Feasibility (dpeaa)DE-He213 Phenotype (dpeaa)DE-He213 Rachal, Megan aut Zamora, Pia Regina Fatima C. aut de Castro, Romulo aut Enthalten in Current epidemiology reports Cham : Springer Internat. Publ., 2014 9(2022), 4 vom: 25. Aug., Seite 376-386 (DE-627)780378342 (DE-600)2760296-5 2196-2995 nnns volume:9 year:2022 number:4 day:25 month:08 pages:376-386 https://dx.doi.org/10.1007/s40471-022-00303-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 4 25 08 376-386
allfieldsSound	10.1007/s40471-022-00303-x doi (DE-627)SPR048775495 (SPR)s40471-022-00303-x-e DE-627 ger DE-627 rakwb eng Dumancas, Gerard G. verfasserin aut Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Genome-wide association study (dpeaa)DE-He213 GWAS (dpeaa)DE-He213 Developing country (dpeaa)DE-He213 Feasibility (dpeaa)DE-He213 Phenotype (dpeaa)DE-He213 Rachal, Megan aut Zamora, Pia Regina Fatima C. aut de Castro, Romulo aut Enthalten in Current epidemiology reports Cham : Springer Internat. Publ., 2014 9(2022), 4 vom: 25. Aug., Seite 376-386 (DE-627)780378342 (DE-600)2760296-5 2196-2995 nnns volume:9 year:2022 number:4 day:25 month:08 pages:376-386 https://dx.doi.org/10.1007/s40471-022-00303-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 9 2022 4 25 08 376-386
language	English
source	Enthalten in Current epidemiology reports 9(2022), 4 vom: 25. Aug., Seite 376-386 volume:9 year:2022 number:4 day:25 month:08 pages:376-386
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authorswithroles_txt_mv	Dumancas, Gerard G. @@aut@@ Rachal, Megan @@aut@@ Zamora, Pia Regina Fatima C. @@aut@@ de Castro, Romulo @@aut@@
publishDateDaySort_date	2022-08-25T00:00:00Z
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author	Dumancas, Gerard G.
spellingShingle	Dumancas, Gerard G. misc Genome-wide association study misc GWAS misc Developing country misc Feasibility misc Phenotype Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries
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title_sort	examining barriers and opportunities of conducting genome-wide association studies in developing countries
title_auth	Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries
abstract	Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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title_short	Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries
url	https://dx.doi.org/10.1007/s40471-022-00303-x
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author2	Rachal, Megan Zamora, Pia Regina Fatima C. de Castro, Romulo
author2Str	Rachal, Megan Zamora, Pia Regina Fatima C. de Castro, Romulo
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doi_str	10.1007/s40471-022-00303-x
up_date	2024-07-03T21:24:15.843Z
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Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries

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