P8.7 Vascular Endothelial Senescence and Metabolic Syndrome

Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is stil...
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Autor*in:	Terentes-Printzios, Dimitrios [verfasserIn] Vachopoulos, Charalambos Ioakeimidis, Nikolaos Aggelis, Athanasios Xaplanteris, Panagiotis Pietri, Panagiota Tousoulis, Dimitrios

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Anmerkung:	© Association for Research into Arterial Structure and Physiology 2015

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 12(2015), 1 vom: 23. Nov., Seite 35-36
Übergeordnetes Werk:	volume:12 ; year:2015 ; number:1 ; day:23 ; month:11 ; pages:35-36

Links:	Volltext

DOI / URN:	10.1016/j.artres.2015.10.329

Katalog-ID:	SPR054758939

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520			\|a Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate.
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700	1		\|a Pietri, Panagiota \|4 aut
700	1		\|a Tousoulis, Dimitrios \|4 aut
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allfields	10.1016/j.artres.2015.10.329 doi (DE-627)SPR054758939 (SPR)j.artres.2015.10.329-e DE-627 ger DE-627 rakwb eng Terentes-Printzios, Dimitrios verfasserin aut P8.7 Vascular Endothelial Senescence and Metabolic Syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2015 Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Vachopoulos, Charalambos aut Ioakeimidis, Nikolaos aut Aggelis, Athanasios aut Xaplanteris, Panagiotis aut Pietri, Panagiota aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 12(2015), 1 vom: 23. Nov., Seite 35-36 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:12 year:2015 number:1 day:23 month:11 pages:35-36 https://dx.doi.org/10.1016/j.artres.2015.10.329 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 23 11 35-36
spelling	10.1016/j.artres.2015.10.329 doi (DE-627)SPR054758939 (SPR)j.artres.2015.10.329-e DE-627 ger DE-627 rakwb eng Terentes-Printzios, Dimitrios verfasserin aut P8.7 Vascular Endothelial Senescence and Metabolic Syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2015 Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Vachopoulos, Charalambos aut Ioakeimidis, Nikolaos aut Aggelis, Athanasios aut Xaplanteris, Panagiotis aut Pietri, Panagiota aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 12(2015), 1 vom: 23. Nov., Seite 35-36 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:12 year:2015 number:1 day:23 month:11 pages:35-36 https://dx.doi.org/10.1016/j.artres.2015.10.329 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 23 11 35-36
allfields_unstemmed	10.1016/j.artres.2015.10.329 doi (DE-627)SPR054758939 (SPR)j.artres.2015.10.329-e DE-627 ger DE-627 rakwb eng Terentes-Printzios, Dimitrios verfasserin aut P8.7 Vascular Endothelial Senescence and Metabolic Syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2015 Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Vachopoulos, Charalambos aut Ioakeimidis, Nikolaos aut Aggelis, Athanasios aut Xaplanteris, Panagiotis aut Pietri, Panagiota aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 12(2015), 1 vom: 23. Nov., Seite 35-36 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:12 year:2015 number:1 day:23 month:11 pages:35-36 https://dx.doi.org/10.1016/j.artres.2015.10.329 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 23 11 35-36
allfieldsGer	10.1016/j.artres.2015.10.329 doi (DE-627)SPR054758939 (SPR)j.artres.2015.10.329-e DE-627 ger DE-627 rakwb eng Terentes-Printzios, Dimitrios verfasserin aut P8.7 Vascular Endothelial Senescence and Metabolic Syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2015 Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Vachopoulos, Charalambos aut Ioakeimidis, Nikolaos aut Aggelis, Athanasios aut Xaplanteris, Panagiotis aut Pietri, Panagiota aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 12(2015), 1 vom: 23. Nov., Seite 35-36 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:12 year:2015 number:1 day:23 month:11 pages:35-36 https://dx.doi.org/10.1016/j.artres.2015.10.329 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 23 11 35-36
allfieldsSound	10.1016/j.artres.2015.10.329 doi (DE-627)SPR054758939 (SPR)j.artres.2015.10.329-e DE-627 ger DE-627 rakwb eng Terentes-Printzios, Dimitrios verfasserin aut P8.7 Vascular Endothelial Senescence and Metabolic Syndrome 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2015 Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Vachopoulos, Charalambos aut Ioakeimidis, Nikolaos aut Aggelis, Athanasios aut Xaplanteris, Panagiotis aut Pietri, Panagiota aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 12(2015), 1 vom: 23. Nov., Seite 35-36 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:12 year:2015 number:1 day:23 month:11 pages:35-36 https://dx.doi.org/10.1016/j.artres.2015.10.329 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2015 1 23 11 35-36
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A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. 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title_sort	p8.7 vascular endothelial senescence and metabolic syndrome
title_auth	P8.7 Vascular Endothelial Senescence and Metabolic Syndrome
abstract	Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. © Association for Research into Arterial Structure and Physiology 2015
abstractGer	Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. © Association for Research into Arterial Structure and Physiology 2015
abstract_unstemmed	Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. © Association for Research into Arterial Structure and Physiology 2015
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P8.7 Vascular Endothelial Senescence and Metabolic Syndrome

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